Saquinavir-NO inhibits S6 kinase activity, impairs secretion of the encephalytogenic cytokines interleukin-17 and interferon-gamma and ameliorates experimental autoimmune encephalomyelitis
2013
Аутори:
Petković, FilipBlaževski, Jana
Momčilović, Miljana
Timotijević, Gordana
Zocca, Mai-Britt
Mijatović, Sanja
Maksimović-Ivanić, Danijela
Mangano, Katia
Fagone, Paolo
Stošić-Grujičić, Stanislava
Nicoletti, Ferdinando
Miljković, Đorđe
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2013 Elsevier B.V.
Метаподаци
Приказ свих података о документуАпстракт:
NO-hybridization of the HIV protease inhibitor Saquinavir generates a new chemical entity named Saq-NO, that retains the anti-viral activity and exerts lower toxicity. We show that Saq-NO inhibited the generation of various cytokines in ConA-stimulated unfractionated murine spleen cells and rat lymph nodes stimulated with ConA as well as in purified CD4(+) T cells in vitro and reduced the circulating levels of cytokines in mice challenged with anti-CD3 antibody. Furthermore, Saq-NO reduced IL-17 and IFN-gamma production in myelin basic protein (MBP)-specific cells isolated from rats immunized with MBP. These findings translated well into the in vivo setting as Saq-NO ameliorated the course of the disease in two preclinical models of multiple sclerosis. Our results demonstrate that Saq-NO exerts immunomodulatory effects that warrant studies on its application in autoimmune diseases. (c) 2013 Elsevier B.V. All rights reserved.
Извор:
Journal of Neuroimmunology, 2013, 259, 1-2, 55-65
DOI: 10.1016/j.jneuroim.2013.03.010
ISSN: 0165-5728
PubMed: 23602714