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Saquinavir-NO inhibits S6 kinase activity, impairs secretion of the encephalytogenic cytokines interleukin-17 and interferon-gamma and ameliorates experimental autoimmune encephalomyelitis
dc.creator | Petković, Filip | |
dc.creator | Blaževski, Jana | |
dc.creator | Momčilović, Miljana | |
dc.creator | Timotijević, Gordana | |
dc.creator | Zocca, Mai-Britt | |
dc.creator | Mijatović, Sanja | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Mangano, Katia | |
dc.creator | Fagone, Paolo | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Nicoletti, Ferdinando | |
dc.creator | Miljković, Đorđe | |
dc.date.accessioned | 2017-11-23T11:11:58Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2013 | sr |
dc.identifier.issn | 0165-5728 | sr |
dc.identifier.other | Rad_konverzija_2993 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/998 | |
dc.description.abstract | NO-hybridization of the HIV protease inhibitor Saquinavir generates a new chemical entity named Saq-NO, that retains the anti-viral activity and exerts lower toxicity. We show that Saq-NO inhibited the generation of various cytokines in ConA-stimulated unfractionated murine spleen cells and rat lymph nodes stimulated with ConA as well as in purified CD4(+) T cells in vitro and reduced the circulating levels of cytokines in mice challenged with anti-CD3 antibody. Furthermore, Saq-NO reduced IL-17 and IFN-gamma production in myelin basic protein (MBP)-specific cells isolated from rats immunized with MBP. These findings translated well into the in vivo setting as Saq-NO ameliorated the course of the disease in two preclinical models of multiple sclerosis. Our results demonstrate that Saq-NO exerts immunomodulatory effects that warrant studies on its application in autoimmune diseases. (c) 2013 Elsevier B.V. All rights reserved. | en |
dc.description.sponsorship | Ministry of Education and Science of the Republic of Serbia [173035, 173013] | sr |
dc.language.iso | English | sr |
dc.publisher | Amsterdam: Elsevier | |
dc.rights | restrictedAccess | |
dc.source | Journal of Neuroimmunology | sr |
dc.title | Saquinavir-NO inhibits S6 kinase activity, impairs secretion of the encephalytogenic cytokines interleukin-17 and interferon-gamma and ameliorates experimental autoimmune encephalomyelitis | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Миљковић, Ђорђе М.; Петковић, Филип; Момчиловић, Миљана Б.; Блажевски, Јана; Стошић-Грујичић, Станислава Д.; Тимотијевић, Гордана С; Зоцца, Маи-Бритт; Мангано, Катиа; Максимовић-Иванић, Данијела Д.; Фагоне, Паоло; Мијатовић, Сања A.; Ницолетти, Фердинандо; | |
dc.rights.holder | © 2013 Elsevier B.V. | |
dc.citation.issue | 1-2 | sr |
dc.citation.volume | 259 | sr |
dc.identifier.doi | 10.1016/j.jneuroim.2013.03.010 | |
dc.identifier.pmid | 23602714 | |
dc.identifier.scopus | 2-s2.0-84877600866 | |
dc.identifier.wos | 000319848100007 | |
dc.citation.spage | 55 | sr |
dc.citation.epage | 65 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_998 |