Phenolic Composition and Biological Properties of Cynara cardunculus L. var. altilis Petioles: Influence of the Maturity Stage.
2021
Аутори:
Mandim, FilipaPetropoulos, Spyridon A.
Dias, Maria Inês
Pinela, José
Kostić, Marina
Soković, Marina
Santos-Buelga, Celestino
Ferreira, Isabel C. F. R.
Barros, Lillian
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Hydroethanolic extracts of cardoon petioles collected at sixteen growth stages (P1-P16) were characterized in terms of their phenolic composition and bioactive potential (antioxidant, cytotoxic, anti-inflammatory, and antimicrobial activities). Fifteen phenolic compounds were tentatively identified (i.e., ten phenolic acids and five flavonoid glycosides); the main compounds were 5-O-caffeoylquinic and 1,5-di-O-caffeoylquinic acids. Samples collected at early maturity (P1-P4) presented a weak positive correlation between the higher content in polyphenols (P3: 101-mg/g extract) and better inhibition capacity against thiobarbituric acid reactive substance formation (TBARS; P3: IC50 = 5.0 µg/mL). Samples at intermediate maturation stages (P9) presented higher cytotoxic and anti-inflammatory potential. Moreover, immature petioles showed greater antihemolytic (OxHLIA; P4: IC50 = 65 and 180 µg/mL for Δt of 60 and 120 min, respectively) and antibacterial activity. The antifungal activity varied depending on the maturation stage and the fungi strain. In conclusion, the maturation stage may greatly affect the polyphenols composition and content and the bioactive potential of cardoon petioles.
Кључне речи:
Anti-inflammatory activity; Antimicrobial properties; Antioxidant activity; Cardoon; Oxidative hemolysis; Phenolic composition; Seasonal changesИзвор:
Antioxidants (Basel, Switzerland), 2021, 10, 12, 1907-Финансирање / пројекти:
- Portuguese Foundation for Science and Technology
- national funds FCT/MCTES to CIMO
DOI: 10.3390/antiox10121907
ISSN: 2076-3921
PubMed: 34943010
WoS: 000735730800001
Scopus: 2-s2.0-85119962008
URI
https://www.mdpi.com/2076-3921/10/12/1907http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC8750300
http://radar.ibiss.bg.ac.rs/handle/123456789/4741