Corticosterone and Glucocorticoid Receptor in the Cortex of Rats during Aging-The Effects of Long-Term Food Restriction.
2021
Autori:
Tešić, VesnaĆirić, Jelena
Jovanović Macura, Irena
Zogović, Nevena
Milanović, Desanka
Kanazir, Selma
Perović, Milka
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Numerous beneficial effects of food restriction on aging and age-related pathologies are well documented. It is also well-established that both short- and long-term food restriction regimens induce elevated circulating levels of glucocorticoids, stress-induced hormones produced by adrenal glands that can also exert deleterious effects on the brain. In the present study, we examined the effect of long-term food restriction on the glucocorticoid hormone/glucocorticoid receptor (GR) system in the cortex during aging, in 18- and 24-month-old rats. Corticosterone level was increased in the cortex of aged ad libitum-fed rats. Food restriction induced its further increase, accompanied with an increase in the level of 11β-hydroxysteroid dehydrogenase type 1. However, alterations in the level of GR phosphorylated at Ser232 were not detected in animals on food restriction, in line with unaltered CDK5 level, the decrease of Hsp90, and an increase in a negative regulator of GR function, FKBP51. Moreover, our data revealed that reduced food intake prevented age-related increase in the levels of NFκB, gfap, and bax, confirming its anti-inflammatory and anti-apoptotic effects. Along with an increase in the levels of c-fos, our study provides additional evidences that food restriction affects cortical responsiveness to glucocorticoids during aging.
Ključne reči:
11β-HSD1; GRα isoforms; c-fos; Food restriction; Glucocorticoids; Intermittent fastingIzvor:
Nutrients, 2021, 13, 12, 4526-Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
DOI: 10.3390/nu13124526
ISSN: 2072-6643
PubMed: 34960078
WoS: 000737052500001
Scopus: 2-s2.0-85121313661
URI
https://www.mdpi.com/2072-6643/13/12/4526http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC8703853
http://radar.ibiss.bg.ac.rs/handle/123456789/4760