Transdermal toxicity of topically applied anticoagulant rodenticide warfarin in rats
2016
Аутори:
Subota, VesnaMirkov, Ivana
Demenesku, Jelena
Popov Aleksandrov, Aleksandra
Ninkov, Marina
Mileusnić, Dina
Kataranovski, Dragan
Kataranovski, Milena
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2015 Elsevier B.V.
Метаподаци
Приказ свих података о документуАпстракт:
Occupational/accidental exposure data have showed hemorrhage as a result of transdermal exposure to
warfarin, however, other effects are not known. In the present study, the impact of epicutaneous application of 10 g or 100 g of warfarin (three times, once a day) on peripheral blood polymorphonuclear
(PMN) and mononuclear cells (PBMC) was examined in rats. Both doses resulted in prolongation of prothrombin time and changes in hematologic parameters. Increases in PMN intracellular myeloperoxidase
(MPO) activity were seen at higher warfarin dose and both doses resulted in higher percentages of granular CD11b+ cells. In contrast, a decrease in PMN TNF and IL-6 production (ELISA) and gene expression
(RT-PCR) was observed. Epicutaneous application of warfarin resulted in decreased numbers of PBMC,
higher numbers of mononuclear CD11b+ cells, but without effect on PMBC cytokine production. The data
obtained showed differential effects of transdermal exposure to warfarin depending on leukocyte type
and activity.
Кључне речи:
Rats; Rats Transdermal warfarin exposure; Peripheral blood leukocytesИзвор:
Environmental Toxicology and Pharmacology, 2016, 41, 232-240Финансирање / пројекти:
- Имуномодулаторни ефекти ксенобиотика и биотичких фактора животне средине на популације мишоликих глодара (RS-MESTD-Basic Research (BR or ON)-173039)
DOI: 10.1016/j.etap.2015.12.006
ISSN: 1382-6689
PubMed: 26742017