Cerebral hypoperfusion and progesterone treatment alter parameters of oxidative stress and antioxidant defence in male rats
2021
Аутори:
Guševac Stojanović, IvanaTodorović, Ana
Pejić, Snežana
Tatalović, Nikola
Blagojević, Duško
Martinović, Jelena
Grković, Ivana
Mitrović, Nataša
Zarić, Marina
Drakulić, Dunja
Остала ауторства
Čupić, ŽeljkoAnić, Slobodan
Тип документа:
Конференцијски прилог (Објављена верзија)
,
© 2021 by the Society of Physical Chemists of Serbia
Метаподаци
Приказ свих података о документуАпстракт:
Numerous natural compounds, like progesterone (P4), a sex steroid hormone, are highlighted as promising agents for treatment of different disorders including prolonged disturbance of blood flow. However, its action on several oxidative stress markers (pro/antioxidant balance, products of lipid peroxidation and phosphatidylcholine to lysophosphatidylcholine intensity ratio) and one of the major components of antioxidant system, superoxide dismutase in rat prefrontal cortex (PFC) following permanent bilateral occlusion of common carotid arteries (2VO) is not completely investigated. According to the obtained results, levels of investigated oxidative stress markers and SOD activity were altered in 2VO animals treated with vehicle, while P4 treatment returned them to control values. Overall, presented data indicate that P4 might manifest antioxidative features in PFC of 2VO rats.
Кључне речи:
superoxide dismutase; prefrontal cortex; cerebrovascular insufficiency; carotid arteries; lipid peroxidationФинансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
У:
- Čupić Ž, Anić S, editors. Proceeding: 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry: Physical Chemistry 2021: the Conference is dedicated to the 30th Anniversary of the founding of the Society of Physical Chemists of Serbia and 100th Anniversary of Bray-Liebhafsky reaction. Vol. 1; 2021 Sep 20-24; Belgrade, Serbia. Belgrade: Society of Physical Chemists of Serbia; 2021. p. 25-32.