Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study
2023
Autori:
Đuran, BorisTatić, Zoran
Perunović, Neda
Pejčić, Nataša
Vuković, Jovana
Petković-Ćurčin, Aleksandra
Vojvodić, Danilo
Rakić, Mia
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Peri-implant diseases are an emerging public health problem, and it's considered that limitations of standard diagnostics play the role herein. The study objective was the estimation of pathological bone resorption at clinical and biological level in patients with peri-implant mucositis (PIM) and peri-implantitis (PI) before and 6 months after standard treatment and to compare them with healthy controls (HC). The split-mouth interventional study included 60 patients affected with PIM or PI. Patients that also presented at least one more HC were enrolled in the study and underwent standard non-surgical and surgical treatment, respectively. Standard clinical parameters and soluble levels of RANKL were measured in peri-implant crevicular fluid baseline and 6 months following treatment. Clinical parameters and RANKL significantly decreased following treatment in PIM and PI. However, bleeding on probing and probing depth remained significantly increased when compared to HC. RANKL answered requests for biomarker of peri-implant diseases, its baseline levels were significantly increased in PIM and PI, they decreased following treatment and reached HC in peri-implantitis, while in PIM RANKL remained significantly increased. Presence of pathological bone resorption in patients lacked its clinical signs, and respective persistence following treatment suggest the need for biomarker-supported diagnosis for timely diagnosis of peri-implantitis and appropriate orientation of respective management strategies.
Ključne reči:
biomarker; bone loss; early diagnosis; peri-implant diseases; peri-implant mucositis; peri-implantitis; precision medicine; public health; treatmentIzvor:
International Journal of Environmental Research and Public Health, 2023, 20, 1, 477-Finansiranje / projekti:
- Plastičnost mozga tokom starenja: uticaj dijetalne restrikcije i anestezije (RS-MESTD-Basic Research (BR or ON)-173056)
- Interakcija etiopatogenetskih mehanizama parodontopatije i paeriimplantitisa sa sistemskim bolestima današnjice (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41008)
- Medical Military Academy, Republic of Serbia (MFVMA 07/22-24)
DOI: 10.3390/ijerph20010477
ISSN: 1660-4601
PubMed: 36612810
WoS: 000909357000001
Scopus: 2-s2.0-85145979149
URI
https://www.mdpi.com/1660-4601/20/1/477http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9819861
http://radar.ibiss.bg.ac.rs/handle/123456789/5403