Increased incidence of clostridium-like species and lower diversity of common commensal bacteria in gut microbiota of children with neurodevelopmental disorders
2019
Аутори:
Ignjatović, ĐurđicaSoković-Bajić, Svetlana
Bojović, Katarina
Vojnović-Milutinović, Danijela
Tomić, Mirko
Golić, Nataša
Tolinački, Maja
Тип документа:
Конференцијски прилог (Објављена верзија)
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© 2020 Wolters Kluwer Health, Inc.
Метаподаци
Приказ свих података о документуАпстракт:
Objective: Clinical reports indicated increased incidence of gastrointestinal (GI) disturbances and dysbiosis in children with neurodevelopmental disorders (NDD) as well as acceleration of the recovery after the dysbiosis treatment. The aim of this study was to evaluate gut microbiota diversity and to identify bacterial strains which incidences were different between patients’ and control group. This is the first study evaluating gut microbiota diversity and composition in children with NDD.
Conclusions: Our study reveals that the intestinal microbiota from children with NDDs differs from the microbiota of healthy children. Similarity of microbiota composition in patient groups with similar neurological and behavioral symptoms indicate that intestinal microbiota might have role in pathophysiology of NDD. Supplementation with several health promoting strains, could be safe adjuvant therapy in treatment of NDD accompanied with GI disturbances.
Финансирање / пројекти:
- Изучавање гена и молекуларних механизама у основи пробиотичке активности бактерија млечне киселине изолованих са подручја западног Балкана (RS-MESTD-Basic Research (BR or ON)-173019)
- Биолошки механизми, нутритивни унос и статус полинезасићених масних киселина и фолата: Унапређење исхране у Србији (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
У:
- 10th Probiotics, prebiotics and new foods, nutraceuticals and botanicals for nutrition and human and microbiota health and 1st Science; 2019 Sep 8-10; Rome, Italy. Wolters Kluwer Health; 2020. p. 100. (Journal of Clinical Gastroenterology; Vol. 54; Suppl. 1)