Alpha to Omicron (Variants of Concern): Mutation Journey, Vaccines, and Therapy
2023
Autori:
Hamad, MohamadAlKhamach, Dana M H
Alsayadi, Lujain Majed
Sarhan, Sirin Abdulkafi
Saeed, Balsam Qubais
Soković, Marina
Ben Hadda, Taibi
Soliman, Sameh S M
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
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© 2023 Mary Ann Liebert, Inc., publishers.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initially emerged in December 2019 and has subsequently expanded globally, leading to the ongoing pandemic. The extensive spread of various SARS-CoV-2 variants possesses a serious public health threat. An extensive literature search along with deep analysis was performed to describe and evaluate the characteristics of SARS-CoV-2 variants of concern in relation to the effectiveness of the current vaccines and therapeutics. The obtained results showed that several significant mutations have evolved during the COVID-19 pandemic. The developed variants and their various structural mutations can compromise the effectiveness of several vaccines, escape the neutralizing antibodies, and limit the efficiency of available therapeutics. Furthermore, deep analysis of the available data enables the prediction of the future impact of virus mutations on the ongoing pandemic along with the selection of appropriate vaccines and therapeutics.
Ključne reči:
Omicron; SARS-CoV-2; therapies; vaccines; variants of concernIzvor:
Viral Immunology, 2023Finansiranje / projekti:
- Sandooq Al-Watanand University of Sharjah
- University of Sharjah
URI
https://www.liebertpub.com/doi/10.1089/vim.2022.0122http://radar.ibiss.bg.ac.rs/handle/123456789/5466