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Different Alterations of Hippocampal and Reticulo-Thalamic GABAergic Parvalbumin-Expressing Interneurons Underlie Different States of Unconsciousness
dc.creator | Radovanović, Ljiljana | |
dc.creator | Novaković, Andrea | |
dc.creator | Petrović, Jelena | |
dc.creator | Šaponjić, Jasna | |
dc.date.accessioned | 2023-04-12T08:12:09Z | |
dc.date.available | 2023-04-12T08:12:09Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/5547 | |
dc.description.abstract | We traced the changes in GABAergic parvalbumin (PV)-expressing interneurons of the hippocampus and reticulo-thalamic nucleus (RT) as possible underlying mechanisms of the different local cortical and hippocampal electroencephalographic (EEG) microstructures during the non-rapid-eye movement (NREM) sleep compared with anesthesia-induced unconsciousness by two anesthetics with different main mechanisms of action (ketamine/diazepam versus propofol). After 3 h of recording their sleep, the rats were divided into two experimental groups: one half received ketamine/diazepam anesthesia and the other half received propofol anesthesia. We simultaneously recorded the EEG of the motor cortex and hippocampus during sleep and during 1 h of surgical anesthesia. We performed immunohistochemistry and analyzed the PV and postsynaptic density protein 95 (PSD-95) expression. PV suppression in the hippocampus and at RT underlies the global theta amplitude attenuation and hippocampal gamma augmentation that is a unique feature of ketamine-induced versus propofol-induced unconsciousness and NREM sleep. While PV suppression resulted in an increase in hippocampal PSD-95 expression, there was no imbalance between inhibition and excitation during ketamine/diazepam anesthesia compared with propofol anesthesia in RT. This increased excitation could be a consequence of a lower GABA interneuronal activity and an additional mechanism underlying the unique local EEG microstructure in the hippocampus during ketamine/diazepam anesthesia. | sr |
dc.language.iso | en | sr |
dc.publisher | Basel: MDPI | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | International Journal of Molecular Sciences | sr |
dc.subject | GABAergic parvalbumin-expressing interneurons | sr |
dc.subject | unconsciousness | sr |
dc.subject | sleep | sr |
dc.subject | anesthesia | sr |
dc.subject | hippocampus | sr |
dc.subject | reticulo-thalamic nucleus | sr |
dc.subject | postsynaptic density protein 95 (PSD-95) | sr |
dc.subject | EEG microstructure | sr |
dc.title | Different Alterations of Hippocampal and Reticulo-Thalamic GABAergic Parvalbumin-Expressing Interneurons Underlie Different States of Unconsciousness | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dc.rights.holder | © 2023 by the authors. Licensee MDPI, Basel, Switzerland | sr |
dc.citation.issue | 7 | |
dc.citation.volume | 24 | |
dc.identifier.doi | 10.3390/ijms24076769 | |
dc.citation.apa | Radovanovic, L., Novakovic, A., Petrovic, J., & Saponjic, J. (2023). Different Alterations of Hippocampal and Reticulo-Thalamic GABAergic Parvalbumin-Expressing Interneurons Underlie Different States of Unconsciousness. International Journal of Molecular Sciences, 24(7), 6769. | |
dc.citation.vancouver | Radovanovic L, Novakovic A, Petrovic J, Saponjic J. Different Alterations of Hippocampal and Reticulo-Thalamic GABAergic Parvalbumin-Expressing Interneurons Underlie Different States of Unconsciousness. Int J Mol Sci. 2023;24(7):6769. | |
dc.citation.spage | 6769 | |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/12757/bitstream_12757.pdf | |
dc.citation.rank | M21~ |