The Effect of Cadmium and Selenium on the Antioxidant Enzyme Activities in Rat Heart
1998
Аутори:
Žikić, Radoslav V.Štajn, Andraš Š.
Ognjanović, Branka
Saičić, Zorica
Kostić, Milosav M.
Pavlović, Slađan
Petrović, Vojislav M.
Тип документа:
Чланак у часопису (Објављена верзија)
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© 1998 Begell House, Inc.
Метаподаци
Приказ свих података о документуАпстракт:
Two month-old Wistar male albino rats were exposed during a 30-day period to a daily oral intake ad libitum of either 200 Fig/mL Cd (as CdClt), 0.1 Fig/ mL Se (as Na-selenite), or the same dosages of Cd + Se in drinking water. The daily intake from the water was calculated to be 15 mg Cd/kg and 7 kg Se/kg. Cadmium (Cd) accumulates in the heart p < 0.005) and, in rats, decreases both body mass growth p < 0.005) and heart mass (p < 0.02). Selenium (Se) significantly decreases the negative effect of Cd on body mass growth. In the hearts of Cd-treated rats, cadmium caused the decrease (p < 0.05) of selenium-dependent glutathione peroxidase (GSH-Px, EC 1.11.1.9) activity. At the same time, the activities of total superoxide dismutase (total SOD, EC 1.15.1. 1), manganese-containing superoxide dismutase (Mn SOD), and copper-zinc-containing superoxide dismutase (CuZn SOD) were increased (p < 0.005).
The activities of total SOD, CuZn SOD (p < 0.005), GSH-Px (p < 0.02), and glutathione-S-transferase (GST, p < 0.005) were increased in the hearts of Se- treated rats. However, by concomitant administration of Cd and Se, these changes were diminished (total SOD, GST) or were completely eliminated (Mn SOD, GSH-Px). These results indicate that Se only partly diminishes the effects of Cd cardiotoxicity.
Кључне речи:
Selenium; Cadmium; Antioxidant defense system; Glutathione peroxidase; Glutathione S-transferase; Superoxide dismutaseИзвор:
Journal of Environmental Pathology, Toxicology and Oncology, 1998, 17, 3-4, 259-264Финансирање / пројекти:
- Serbian Ministry of Science and Technology, Grant No. 03E18