The effect of coenzyme Q10 on blood ascorbic acid, vitamin E and lipid peroxide in chronic cadmium intoxication
2001
Authors:
Pavlović, SlađanOgnjanović, Branka
Štajn, Andraš Š.
Žikić, Radoslav V.
Saičić, Zorica
Petrović, Vojislav M.
Document Type:
Article (Published version)
,
© 2001 by Begell House, Inc.
Metadata
Show full item recordAbstract:
The aim of our study was to investigate the possible protective role of coenizyme Q10 administration on ascorbic acid (AsA), vitamin E (vit E), and lipid peroxide (LP) concentrations in the blopd of rats chronically treated with cadmium. Results were compared to dtase obtained in control animals, as well as to those obtained in animals treated with olive pil. Compared to that of the control animals, the AsA concentration was aignificantiy Smeared in rats treated with Como olive oil, whereas vit E concentration cas significantly increased in animals treated with cadmium, CoQ10, or cadmium + CoQ10. A significant decrease in LP concentraiion was noted in arrivals treated with cadmium or with cadmium + CoO10, whereas a aig;iificant increase was seen in animals treated with olive oil. Compared to that of the animals treated uith olive oil, the ascorbic acid concentration was significantly decreased in rats treated with cadmium or with cadmium + CoQ10, whereas vit k concentration was significantly increased in an
61 Cdflt)y decreased in rats treated with cadmium, CoQ10 , or cadmium + CoQ10. Our study showed that CoQ10 administration in rats chronically exposed to exogenous cadmium exerts beneficial effects on the nonenzymatic components of the antioxidant defense system, such as AsA and vit E, resulting inâ decreased concentration of LP in the blood.
Keywords:
Cadmium; Coenzyme Q10; Ascorbic acid; Vitamin E; Lipid peroxidesSource:
Journal of Environmental Pathology, Toxicology and Oncology, 2001, 20, 2, 133-140Funding / projects:
- Serbian Ministry of Sciences, Yugoslavia, Grants No. 03E23 and 03E18.
DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i2.80