The Effects of Wild-Type and Mutant SOD1 on Smooth Muscle Contraction
2015
Autori:
Nikolić-Kokić, AleksandraOreščanin-Dušić, Zorana
Spasojević, Ivan
Blagojević, Duško
Stević, Zorica
Anđus, Pavle
Spasić, Mihajlo
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
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© 2015 by the Serbian Biological Society
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
In this work we compared the mutated liver copper zinc-containing superoxide dismutase (SOD1) protein G93A of the transgenic rat model of familial amyotrophic lateral sclerosis (FALS), to wild-type (WT) rat SOD1. We examined their enzymatic activities and effects on isometric contractions of uteri of healthy virgin rats. G93A SOD1 showed a slightly higher activity than WT SOD1 and, in contrast to WT SOD1, G93A SOD1 did not induce smooth muscle relaxation. This result indicates that effects on smooth muscles are not related to SOD1 enzyme activity and suggest that heterodimers of G93A SOD1 form an ion-conducting pore that diminishes the relaxatory effects of SOD1. We propose that this type of pathogenic feedback affects neurons in FALS.
Ključne reči:
FALS; mutation; G93A SOD1; WT SOD1; muscle relaxationIzvor:
Archives of Biological Sciences, 2015, 67, 1, 187-192Finansiranje / projekti:
- Molekularni mehanizmi redoks signalinga u homeostazi, adaptaciji i patologiji (RS-MESTD-Basic Research (BR or ON)-173014)
- Ispitivanje molekularno-genetskih, patohistoloških i biohemijskih karakteristika neuromišićnih bolesti (RS-MESTD-Basic Research (BR or ON)-175083)
DOI: 10.2298/ABS141006023N
ISSN: 0354-4664