Thiamine and benfotiamine: Focus on their therapeutic potential
2023
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Thiamine, also known as vitamin B1, is an essential nutrient that plays a crucial role in energy
metabolism and overall health. It is a water-soluble vitamin that plays an important role in the
conversion of carbohydrates into energy in the body. Thiamine is essential for the proper functioning of the nervous system, heart and muscles. Thiamine deficiency is a life-threatening disease
that leads to various disorders and lesions in the nerves and brain, at least in vertebrates. Several
thiamine precursors with higher bioavailability have been developed to compensate for thiamine
deficiency, including benfotiamine. Benfotiamine is more bioavailable and has higher tissue
penetration than thiamine. Studies have shown its antioxidant and anti-inflammatory potential in
activated immune and glial cells. It also improves complications observed in type 2 diabetes and
has beneficial effects in mouse models of neurodegenerative disease. Benfotiamine represents an
off-the-shelf agent used to support nerve health, promote healthy aging and support glucose
metabolism. Accordingly, the present review aimed to provide an overview of the neuroprotective
effects of thiamine/benfotiamine in the context of inflammation and oxidative stress.
Izvor:
Heliyon, 2023, 9, 11, e21839-Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)