Redox and metabolic reprogramming in breast cancer and cancer-associated adipose tissue
2023
Autori:
Zakić, TamaraPeković-Vaughan, Vanja
Čvoro, Aleksandra
Korać, Aleksandra
Janković, Aleksandra
Korać, Bato
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
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© 2023 Federation of European Biochemical Societies
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Redox and metabolic processes are tightly coupled in both physiological and pathological conditions. In cancer, their integration occurs at multiple levels and is characterized by synchronized reprogramming both in the tumor tissue and its specific but heterogeneous microenvironment. In breast cancer, the principal microenvironment is the cancer-associated adipose tissue (CAAT). Understanding how the redox-metabolic reprogramming becomes coordinated in human breast cancer is imperative both for cancer prevention and for the establishment of new therapeutic approaches. This review aims to provide an overview of the current knowledge of the redox profiles and regulation of intermediary metabolism in breast cancer while considering the tumor and CAAT of breast cancer as a unique Warburg's pseudo-organ. As cancer is now recognized as a systemic metabolic disease, we have paid particular attention to the cell-specific redox-metabolic reprogramming and the roles of estrogen receptors and circadian rhythms, as well as their crosstalk in the development, growth, progression, and prognosis of breast cancer.
Ključne reči:
adipose tissue; breast cancer; circadian rhythms; estrogen; redox-metabolic reprogramming; tumor microenvironmentIzvor:
FEBS Letters, 2023Finansiranje / projekti:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, grant No 451-03-47/2023-01/200
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- REFRAME - Exploring New Avenues in Breast Cancer Research: Redox and Metabolic Reprogramming of Cancer and Associated Adipose Tissue (RS-ScienceFundRS-Ideje-7750238)
DOI: 10.1002/1873-3468.14794
ISSN: 0014-5793
PubMed: 38140817