Savremeni pristupi u istraživanju molekularne osnove karcinoma prostate
Modern approaches in research of the molecular basis of prostate cancer
2022
Authors:
Dobrijević, ZoranaMatijašević-Joković, Suzana
Branković, Ana
Đorđević, Ana
Popović, Milica
Brajušković, Goran
Document Type:
Book part (Published version)
,
© 2022 by the Institute of Molecular Genetics and Genetic Engineering, University of Belgrade
Metadata
Show full item recordAbstract:
This review-type paper will present the ten-year experience of the PROSTATSERBIA research team,
which has the molecular basis of prostate cancer (PCa) as its research topic. The Center for Human Mo-
lecular Genetics of the Faculty of Biology, University of Belgrade has a collection of samples and a
data bank for almost 1000 men with prostate diseases (PCa and benign prostatic hyperplasia) and for
over 350 men without signs of prostate diseases, all from Serbian population. Most of the studies
were designed as studies of association of selected genetic variants with the risk for development
and progression of PCa. In these case-control studies, genetic variants were examined both in genes
for proteins and non-coding RNAs, as well as in non-coding regions of the genome (so-called gene
deserts). In addition to case control studies, both meta-analyses and the analysis of statistical epista-
tic interactions of the analyzed genetic variants were conducted. The main goal of all these studies was
to create an algorithm for risk assessment for disease progression that would be used in the phase of
active monitoring of patients with early diagnosed PCa. Recently, we shifted our research focus on
exosomes and their macromolecular content (proteins and microRNAs) as potential biological mar-
kers of liquid prostate cancer biopsy. In addition, macromolecules at the exosome surface represent
target molecules for new PCa treatment strategies.
Keywords:
karcinom prostate; studije asocijacije; meta-analize; genetičke varijante; egzozomi; mikroRNK; PSMASource:
Trends in molecular biology, 2022, 2, 63-74Funding / projects:
- Analysis of the structural genome changes as a diagnostic and prognostic parameter of human diseases (RS-MESTD-Basic Research (BR or ON)-173016)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200178 (University of Belgrade, Faculty of Biology) (RS-MESTD-inst-2020-200178)