TY  - JOUR
AU  - Milić, Ljiljana
AU  - Karamarković, Aleksandar
AU  - Popadić, Dušan
AU  - Šijački, Ana
AU  - Grigorov, Ilijana
AU  - Milošević, Emina
AU  - Ćuk, Vladica
AU  - Pesko, Predrag
PY  - 2019
UR  - https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-019-4310-4
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3362
AB  - Objective

Peptic ulcer disease is a condition in which an important role has infection with H. pylori. The most common complication of peptic ulcer is bleeding. The presence of H. pylori triggers local and systemic cytokine signaling which may affect processes such as healing, gastric or duodenal rupture, and carcinogenesis. In this study, we examined the concentrations of IL-1β, IL-6, IL-10, TNF, TGF-β and IL-17A in serum by enzyme immunoassay and their mRNA expressions in periulcer biopsies obtained from patients with bleeding peptic ulcer by means of real-time-PCR.
Results

We have shown that pro-inflammatory IL-6 and TNF concentrations in serum were significantly higher in patients who were infected with H. pylori, while the concentrations of TGF-β and IL-17A were significantly lower compared to non-infected subjects. IL-17A expression in periulcer mucosa was significantly higher in patients who were infected with H. pylori, while the expression of other cytokines, there was no significant difference compared to non-infected controls. Considering higher serum concentrations in non-infected subjects and higher IL-17A expression in mucosal tissue of infected patients, our data support the studies that found IL-17A has protective role in eradication of H. pylori infection in infected patients.
PB  - BioMed Central Ltd.
T2  - BMC Research Notes
T1  - Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer
VL  - 12
DO  - 10.1186/s13104-019-4310-4
SP  - 278
ER  - 

@article{
author = "Milić, Ljiljana and Karamarković, Aleksandar and Popadić, Dušan and Šijački, Ana and Grigorov, Ilijana and Milošević, Emina and Ćuk, Vladica and Pesko, Predrag",
year = "2019",
abstract = "Objective

Peptic ulcer disease is a condition in which an important role has infection with H. pylori. The most common complication of peptic ulcer is bleeding. The presence of H. pylori triggers local and systemic cytokine signaling which may affect processes such as healing, gastric or duodenal rupture, and carcinogenesis. In this study, we examined the concentrations of IL-1β, IL-6, IL-10, TNF, TGF-β and IL-17A in serum by enzyme immunoassay and their mRNA expressions in periulcer biopsies obtained from patients with bleeding peptic ulcer by means of real-time-PCR.
Results

We have shown that pro-inflammatory IL-6 and TNF concentrations in serum were significantly higher in patients who were infected with H. pylori, while the concentrations of TGF-β and IL-17A were significantly lower compared to non-infected subjects. IL-17A expression in periulcer mucosa was significantly higher in patients who were infected with H. pylori, while the expression of other cytokines, there was no significant difference compared to non-infected controls. Considering higher serum concentrations in non-infected subjects and higher IL-17A expression in mucosal tissue of infected patients, our data support the studies that found IL-17A has protective role in eradication of H. pylori infection in infected patients.",
publisher = "BioMed Central Ltd.",
journal = "BMC Research Notes",
title = "Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer",
volume = "12",
doi = "10.1186/s13104-019-4310-4",
pages = "278"
}

Milić, L., Karamarković, A., Popadić, D., Šijački, A., Grigorov, I., Milošević, E., Ćuk, V.,& Pesko, P.. (2019). Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer. in BMC Research Notes
BioMed Central Ltd.., 12, 278.
https://doi.org/10.1186/s13104-019-4310-4

Milić L, Karamarković A, Popadić D, Šijački A, Grigorov I, Milošević E, Ćuk V, Pesko P. Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer. in BMC Research Notes. 2019;12:278.
doi:10.1186/s13104-019-4310-4 .

Milić, Ljiljana, Karamarković, Aleksandar, Popadić, Dušan, Šijački, Ana, Grigorov, Ilijana, Milošević, Emina, Ćuk, Vladica, Pesko, Predrag, "Altered cytokine expression in Helicobacter pylori infected patients with bleeding duodenal ulcer" in BMC Research Notes, 12 (2019):278,
https://doi.org/10.1186/s13104-019-4310-4 . .