TY  - JOUR
AU  - Bovan, Dijana
AU  - Krajnović, Tamara
AU  - Vuković, Nenad L.
AU  - Vukić, Milena D.
AU  - Mijatović, Sanja
AU  - Tanić, Nikola
AU  - Arsenijević, Nebojša
AU  - Maksimović-Ivanić, Danijela
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6576
AB  - Background: Shikonin is a naturally occurring naphthoquinone found in the roots of several genera of the Boraginaceae family, widely known for its numerous biological activities, such as antiinflammatory, antioxidant, antimicrobial and anticancer. In this study, the antitumor effect of six naphthoquinones isolated from the roots of Onosma visianii was evaluated using two cell lines, mouse melanoma B16 and highly aggressive rat glioma cell line C6. 
Methods and results: All examined shikonins dose-dependently decreased the viability of tested cells, with compounds 5 and 6 being the most potent ones and hence subjected to further analysis. The diminished viability of B16 melanoma cells was in correlation with detected caspase-mediated apoptosis. Importantly, observed altered cell morphology along with the loss of dividing potential upon exposure to both shikonins implied reprogram of B16 cell phenotype. Elevated expression of myelin basic protein indicated the acquirement of Schwann‐like cell phenotype, while detected autophagy might be connected to this phenomenon. On the contrary, upon exposure to both agents, C6 cells underwent specific cell death—anoikis, provoked by detachment from the extracellular matrix and compromised integrin signaling. Oppositely to compound 5, compound 6 realized anoikis in a caspase-independent manner and under sustained ERK1/2 activation, indicating the deviation from standard proanoikis signaling. 
Conclusions: Herein, we have pointed out the diversity and novelty in the mode of action of shikonin derivatives depending on the tumor cell features, which represents a good platform for new investigations of these promising natural compounds.
PB  - Springer Nature
T2  - Molecular Biology Reports
T1  - Anoikis and cancer cell differentiation: novel modes of shikonin derivatives anticancer action in vitro
IS  - 1
VL  - 51
DO  - 10.1007/s11033-023-09093-x
SP  - 218
ER  - 

@article{
author = "Bovan, Dijana and Krajnović, Tamara and Vuković, Nenad L. and Vukić, Milena D. and Mijatović, Sanja and Tanić, Nikola and Arsenijević, Nebojša and Maksimović-Ivanić, Danijela",
year = "2024",
abstract = "Background: Shikonin is a naturally occurring naphthoquinone found in the roots of several genera of the Boraginaceae family, widely known for its numerous biological activities, such as antiinflammatory, antioxidant, antimicrobial and anticancer. In this study, the antitumor effect of six naphthoquinones isolated from the roots of Onosma visianii was evaluated using two cell lines, mouse melanoma B16 and highly aggressive rat glioma cell line C6. 
Methods and results: All examined shikonins dose-dependently decreased the viability of tested cells, with compounds 5 and 6 being the most potent ones and hence subjected to further analysis. The diminished viability of B16 melanoma cells was in correlation with detected caspase-mediated apoptosis. Importantly, observed altered cell morphology along with the loss of dividing potential upon exposure to both shikonins implied reprogram of B16 cell phenotype. Elevated expression of myelin basic protein indicated the acquirement of Schwann‐like cell phenotype, while detected autophagy might be connected to this phenomenon. On the contrary, upon exposure to both agents, C6 cells underwent specific cell death—anoikis, provoked by detachment from the extracellular matrix and compromised integrin signaling. Oppositely to compound 5, compound 6 realized anoikis in a caspase-independent manner and under sustained ERK1/2 activation, indicating the deviation from standard proanoikis signaling. 
Conclusions: Herein, we have pointed out the diversity and novelty in the mode of action of shikonin derivatives depending on the tumor cell features, which represents a good platform for new investigations of these promising natural compounds.",
publisher = "Springer Nature",
journal = "Molecular Biology Reports",
title = "Anoikis and cancer cell differentiation: novel modes of shikonin derivatives anticancer action in vitro",
number = "1",
volume = "51",
doi = "10.1007/s11033-023-09093-x",
pages = "218"
}

Bovan, D., Krajnović, T., Vuković, N. L., Vukić, M. D., Mijatović, S., Tanić, N., Arsenijević, N.,& Maksimović-Ivanić, D.. (2024). Anoikis and cancer cell differentiation: novel modes of shikonin derivatives anticancer action in vitro. in Molecular Biology Reports
Springer Nature., 51(1), 218.
https://doi.org/10.1007/s11033-023-09093-x

Bovan D, Krajnović T, Vuković NL, Vukić MD, Mijatović S, Tanić N, Arsenijević N, Maksimović-Ivanić D. Anoikis and cancer cell differentiation: novel modes of shikonin derivatives anticancer action in vitro. in Molecular Biology Reports. 2024;51(1):218.
doi:10.1007/s11033-023-09093-x .

Bovan, Dijana, Krajnović, Tamara, Vuković, Nenad L., Vukić, Milena D., Mijatović, Sanja, Tanić, Nikola, Arsenijević, Nebojša, Maksimović-Ivanić, Danijela, "Anoikis and cancer cell differentiation: novel modes of shikonin derivatives anticancer action in vitro" in Molecular Biology Reports, 51, no. 1 (2024):218,
https://doi.org/10.1007/s11033-023-09093-x . .

TY  - JOUR
AU  - Su, Guo-Zhu
AU  - Wang, Shang-Yi
AU  - Yang, Xiu-Ying
AU  - Stevanović, Zora Dajić
AU  - Li, Na
AU  - Tanić, Nikola
AU  - Arsenijević, Nebojša
AU  - Yu, Shi-Shan
AU  - Li, Yong
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5165
AB  - Five undescribed dihydroflavonoid glycoside derivatives, namely albvisosides A‒E, together with two known compounds were isolated from the roots and stem leaves of Viscum album L. var. album. (European mistletoe). Their structures were determined by HRESIMS, 1D and 2D NMR, and ECD analysis. Albvisoside B exhibits significant inhibitory effect on hepatic lipid accumulation in HepG2 cells at very low concentrations (EC50: 0.7 nM). Using proteome integral solubility alteration assay, the direct targets or downstream effectors of albvisoside B were elucidated. As a result, 97 proteins were identified based on ligand-induced alterations in the protein thermal stability. Bioinformatics analysis indicated that albvisoside B primarily ameliorated oleic acid-induced lipid accumulation by regulating the selenoamino acids metabolism signaling pathway. RPL3, ADAM17, and RPL14 were likely to be involved in mediating the lipid-lowering effect of albvisoside B.
PB  - Oxford: Pergamon-Elsevier Science Ltd
T2  - Phytochemistry
T1  - Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification.
VL  - 204
DO  - 10.1016/j.phytochem.2022.113458
SP  - 113458
ER  - 

@article{
author = "Su, Guo-Zhu and Wang, Shang-Yi and Yang, Xiu-Ying and Stevanović, Zora Dajić and Li, Na and Tanić, Nikola and Arsenijević, Nebojša and Yu, Shi-Shan and Li, Yong",
year = "2022",
abstract = "Five undescribed dihydroflavonoid glycoside derivatives, namely albvisosides A‒E, together with two known compounds were isolated from the roots and stem leaves of Viscum album L. var. album. (European mistletoe). Their structures were determined by HRESIMS, 1D and 2D NMR, and ECD analysis. Albvisoside B exhibits significant inhibitory effect on hepatic lipid accumulation in HepG2 cells at very low concentrations (EC50: 0.7 nM). Using proteome integral solubility alteration assay, the direct targets or downstream effectors of albvisoside B were elucidated. As a result, 97 proteins were identified based on ligand-induced alterations in the protein thermal stability. Bioinformatics analysis indicated that albvisoside B primarily ameliorated oleic acid-induced lipid accumulation by regulating the selenoamino acids metabolism signaling pathway. RPL3, ADAM17, and RPL14 were likely to be involved in mediating the lipid-lowering effect of albvisoside B.",
publisher = "Oxford: Pergamon-Elsevier Science Ltd",
journal = "Phytochemistry",
title = "Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification.",
volume = "204",
doi = "10.1016/j.phytochem.2022.113458",
pages = "113458"
}

Su, G., Wang, S., Yang, X., Stevanović, Z. D., Li, N., Tanić, N., Arsenijević, N., Yu, S.,& Li, Y.. (2022). Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification.. in Phytochemistry
Oxford: Pergamon-Elsevier Science Ltd., 204, 113458.
https://doi.org/10.1016/j.phytochem.2022.113458

Su G, Wang S, Yang X, Stevanović ZD, Li N, Tanić N, Arsenijević N, Yu S, Li Y. Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification.. in Phytochemistry. 2022;204:113458.
doi:10.1016/j.phytochem.2022.113458 .

Su, Guo-Zhu, Wang, Shang-Yi, Yang, Xiu-Ying, Stevanović, Zora Dajić, Li, Na, Tanić, Nikola, Arsenijević, Nebojša, Yu, Shi-Shan, Li, Yong, "Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification." in Phytochemistry, 204 (2022):113458,
https://doi.org/10.1016/j.phytochem.2022.113458 . .

TY  - CONF
AU  - Jelača, Sanja
AU  - Drača, Dijana
AU  - Dajić-Stevanović, Zora
AU  - Jovanović, Ivan
AU  - Tanić, Nikola
AU  - Mijatović, Sanja
AU  - Arsenijević, Nebojša
AU  - Maksimović-Ivanić, Danijela
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5290
AB  - Alchemilla vulgaris is well known in traditional medicine especially for the treatment
of gynecological problems in women. Several ethnomedicinal studies for the territory
of Balkan reports its well known biological properties against many conditions such
as infertility, dysmenorrhea, cysts, menopausal complaints and endometriosis.
Concidering ethnomedicinal data on female illnesses, the aim of our study was to
determine whether ethanol extract of Alchemilla vulgaris agg. exert antitumor effect
against mouse breast cancer cells in vitro. Treatment with Alchemilla vulgaris agg. extract
decreased viability of mouse breast cancer cells (4T1) in dose-dependent manner after
72 h. The viability decrease was followed by loss of dividing potential after the treatment.
In parallel with this, certain percentage of 4T1 cells was subjected to programmed cell
death ̶ apoptosis. Detected apoptosis was followed with caspase activation while typical
apoptotic morphology of treated cells was observed by fluorescent microscopy. Apart
from inhibited cell division and induced apoptosis, decreased cell viability was due to
triggered autophagy cell death. In parallel, diminished metastatic potential of these
cells was confirmed by abrogated adhesion, invasion, migration and decreased colony
forming potential after the treatment. All mentioned effects can be connected with
enhanced production of ROS and intracellular NO after the treatment with Alchemilla
vulgaris agg. Taken together, the effect of Alchemilla vulgaris agg. against breast cancer
cells makes this plant worthwhile for further evaluation in the field of oncology.
AB  - Alchemilla vulgaris је добро позната у традиционалној медицини, посебно за
лечење гинеколошких тегоба код жена. Неколико етномедицинских студија за
територију Балкана описује благотворна дејства ове биљке против различитих
патолошких стања попут неплодности, дисменореје, циста, тегоба у менопаузи
и ендометриозе. Циљ нашег истраживања био је да се утврдe антитуморска свој-
ства етанолног екстракта Alchemilla vulgaris agg. на ћелијској линији тумора дојке
4Т1 in vitro. Третман екстрактом Alchemilla vulgaris agg. у трајању од 72 сата је
смањио вијабилитет 4Т1 ћелија на дозно-зависан начин. Смањење вијабилно-
сти праћено је губитком пролиферативног потенцијала ћелија. Поред тога, одре-
ђени проценат 4Т1 ћелија подлегао је програмираној ћелијској смрти познатој
као апоптоза. Детектована апоптоза је праћена активацијом каспаза и додатно
потврђена типичном морфологијом нуклеуса коришћењем флуоресцентне ми-
кроскопије. Свеукупној антитуморској активности екстракта Alchemilla vulgaris
agg. доприноси и ћелијска смрт аутофагијом. Паралелно, метастатски потенцијал
ових ћелија је смањен, што је потврђено смањеном адхезијом, инвазијом, мигра-
цијом и потенцијалом ћелија да формирају колоније. Сви поменути ефекти могу
бити у корелацији са повећаном продукцијом реактивних кисеоничних и азот-
них врста детектованом након третмана. У целини, добијени резултати о делова-
њу Alchemilla vulgaris agg. на ћелије рака дојке чине ову биљку вредном пажње за
даљу евалуацију у области експерименталне онкологије.
PB  - Serbian Society for Immunology, Molecular Oncology and Regenerative Medicine
C3  - Abstract Book: First Serbian molecular medicine congress; 2022 Jun 16-18; Foča, Bosnia and Herzegovina
T1  - Antitumor properites of alchemilla vulgaris agg.
SP  - 129
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5290
ER  - 

@conference{
author = "Jelača, Sanja and Drača, Dijana and Dajić-Stevanović, Zora and Jovanović, Ivan and Tanić, Nikola and Mijatović, Sanja and Arsenijević, Nebojša and Maksimović-Ivanić, Danijela",
year = "2022",
abstract = "Alchemilla vulgaris is well known in traditional medicine especially for the treatment
of gynecological problems in women. Several ethnomedicinal studies for the territory
of Balkan reports its well known biological properties against many conditions such
as infertility, dysmenorrhea, cysts, menopausal complaints and endometriosis.
Concidering ethnomedicinal data on female illnesses, the aim of our study was to
determine whether ethanol extract of Alchemilla vulgaris agg. exert antitumor effect
against mouse breast cancer cells in vitro. Treatment with Alchemilla vulgaris agg. extract
decreased viability of mouse breast cancer cells (4T1) in dose-dependent manner after
72 h. The viability decrease was followed by loss of dividing potential after the treatment.
In parallel with this, certain percentage of 4T1 cells was subjected to programmed cell
death ̶ apoptosis. Detected apoptosis was followed with caspase activation while typical
apoptotic morphology of treated cells was observed by fluorescent microscopy. Apart
from inhibited cell division and induced apoptosis, decreased cell viability was due to
triggered autophagy cell death. In parallel, diminished metastatic potential of these
cells was confirmed by abrogated adhesion, invasion, migration and decreased colony
forming potential after the treatment. All mentioned effects can be connected with
enhanced production of ROS and intracellular NO after the treatment with Alchemilla
vulgaris agg. Taken together, the effect of Alchemilla vulgaris agg. against breast cancer
cells makes this plant worthwhile for further evaluation in the field of oncology., Alchemilla vulgaris је добро позната у традиционалној медицини, посебно за
лечење гинеколошких тегоба код жена. Неколико етномедицинских студија за
територију Балкана описује благотворна дејства ове биљке против различитих
патолошких стања попут неплодности, дисменореје, циста, тегоба у менопаузи
и ендометриозе. Циљ нашег истраживања био је да се утврдe антитуморска свој-
ства етанолног екстракта Alchemilla vulgaris agg. на ћелијској линији тумора дојке
4Т1 in vitro. Третман екстрактом Alchemilla vulgaris agg. у трајању од 72 сата је
смањио вијабилитет 4Т1 ћелија на дозно-зависан начин. Смањење вијабилно-
сти праћено је губитком пролиферативног потенцијала ћелија. Поред тога, одре-
ђени проценат 4Т1 ћелија подлегао је програмираној ћелијској смрти познатој
као апоптоза. Детектована апоптоза је праћена активацијом каспаза и додатно
потврђена типичном морфологијом нуклеуса коришћењем флуоресцентне ми-
кроскопије. Свеукупној антитуморској активности екстракта Alchemilla vulgaris
agg. доприноси и ћелијска смрт аутофагијом. Паралелно, метастатски потенцијал
ових ћелија је смањен, што је потврђено смањеном адхезијом, инвазијом, мигра-
цијом и потенцијалом ћелија да формирају колоније. Сви поменути ефекти могу
бити у корелацији са повећаном продукцијом реактивних кисеоничних и азот-
них врста детектованом након третмана. У целини, добијени резултати о делова-
њу Alchemilla vulgaris agg. на ћелије рака дојке чине ову биљку вредном пажње за
даљу евалуацију у области експерименталне онкологије.",
publisher = "Serbian Society for Immunology, Molecular Oncology and Regenerative Medicine",
journal = "Abstract Book: First Serbian molecular medicine congress; 2022 Jun 16-18; Foča, Bosnia and Herzegovina",
title = "Antitumor properites of alchemilla vulgaris agg.",
pages = "129",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5290"
}

Jelača, S., Drača, D., Dajić-Stevanović, Z., Jovanović, I., Tanić, N., Mijatović, S., Arsenijević, N.,& Maksimović-Ivanić, D.. (2022). Antitumor properites of alchemilla vulgaris agg.. in Abstract Book: First Serbian molecular medicine congress; 2022 Jun 16-18; Foča, Bosnia and Herzegovina
Serbian Society for Immunology, Molecular Oncology and Regenerative Medicine., 129.
https://hdl.handle.net/21.15107/rcub_ibiss_5290

Jelača S, Drača D, Dajić-Stevanović Z, Jovanović I, Tanić N, Mijatović S, Arsenijević N, Maksimović-Ivanić D. Antitumor properites of alchemilla vulgaris agg.. in Abstract Book: First Serbian molecular medicine congress; 2022 Jun 16-18; Foča, Bosnia and Herzegovina. 2022;:129.
https://hdl.handle.net/21.15107/rcub_ibiss_5290 .

Jelača, Sanja, Drača, Dijana, Dajić-Stevanović, Zora, Jovanović, Ivan, Tanić, Nikola, Mijatović, Sanja, Arsenijević, Nebojša, Maksimović-Ivanić, Danijela, "Antitumor properites of alchemilla vulgaris agg." in Abstract Book: First Serbian molecular medicine congress; 2022 Jun 16-18; Foča, Bosnia and Herzegovina (2022):129,
https://hdl.handle.net/21.15107/rcub_ibiss_5290 .

TY  - CONF
AU  - Jelača, Sanja
AU  - Mijatović, Sanja
AU  - Dajić-Stevanović, Zora
AU  - Arsenijević, Nebojša
AU  - Maksimović-Ivanić, Danijela
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5286
AB  - Eryngium amethystinum is herb from Apiaceae family. It has been used as a food or in traditional medicine for the treatment of various diseases1. In the present work, we have evaluated its cytotoxic effect on a panel of human cancer cells (human breast carcinoma MCF7, human malignant melanoma A375, human colon carcinoma HCT116 and human lung cancer A549). Treatment with Eryngium amethystinum ethanol extract decreased viability of all cancer cell lines in a dose-dependent manner after 72 h. For further investigation of potential mechanism of action A549 cell line was selected. The observed viability decrease was followed by loss of dividing potential after the treatment. Aditionaly, 90% of A549 cells were subjected to programmed cell death ̶ apoptosis which was not followed with caspase activation. In paralel with this, typical apoptotic morphology of treated cells was observed by fluorescent microscopy. Apart from this decreased cell viability was due to triggered autophagic cell death. Taken together, the shown effect of Eryngium amethystinum makes this plant worthwhile for further evaluation in the field of oncology.
PB  - Belgrade: Faculty of Chemistry
C3  - Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia
T1  - Antitumor properties of Eryngium amethystinum extract
SP  - 75
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5286
ER  - 

@conference{
author = "Jelača, Sanja and Mijatović, Sanja and Dajić-Stevanović, Zora and Arsenijević, Nebojša and Maksimović-Ivanić, Danijela",
year = "2022",
abstract = "Eryngium amethystinum is herb from Apiaceae family. It has been used as a food or in traditional medicine for the treatment of various diseases1. In the present work, we have evaluated its cytotoxic effect on a panel of human cancer cells (human breast carcinoma MCF7, human malignant melanoma A375, human colon carcinoma HCT116 and human lung cancer A549). Treatment with Eryngium amethystinum ethanol extract decreased viability of all cancer cell lines in a dose-dependent manner after 72 h. For further investigation of potential mechanism of action A549 cell line was selected. The observed viability decrease was followed by loss of dividing potential after the treatment. Aditionaly, 90% of A549 cells were subjected to programmed cell death ̶ apoptosis which was not followed with caspase activation. In paralel with this, typical apoptotic morphology of treated cells was observed by fluorescent microscopy. Apart from this decreased cell viability was due to triggered autophagic cell death. Taken together, the shown effect of Eryngium amethystinum makes this plant worthwhile for further evaluation in the field of oncology.",
publisher = "Belgrade: Faculty of Chemistry",
journal = "Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia",
title = "Antitumor properties of Eryngium amethystinum extract",
pages = "75",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5286"
}

Jelača, S., Mijatović, S., Dajić-Stevanović, Z., Arsenijević, N.,& Maksimović-Ivanić, D.. (2022). Antitumor properties of Eryngium amethystinum extract. in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia
Belgrade: Faculty of Chemistry., 75.
https://hdl.handle.net/21.15107/rcub_ibiss_5286

Jelača S, Mijatović S, Dajić-Stevanović Z, Arsenijević N, Maksimović-Ivanić D. Antitumor properties of Eryngium amethystinum extract. in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia. 2022;:75.
https://hdl.handle.net/21.15107/rcub_ibiss_5286 .

Jelača, Sanja, Mijatović, Sanja, Dajić-Stevanović, Zora, Arsenijević, Nebojša, Maksimović-Ivanić, Danijela, "Antitumor properties of Eryngium amethystinum extract" in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia (2022):75,
https://hdl.handle.net/21.15107/rcub_ibiss_5286 .

TY  - CONF
AU  - Jelača, Sanja
AU  - Drača, Dijana
AU  - Dajić Stevanović, Zora
AU  - Jovanović, Ivan
AU  - Pavlović, Slađana
AU  - Gajović, Nevena
AU  - Mijatović, Sanja
AU  - Arsenijević, Nebojša
AU  - Maksimović-Ivanić, Danijela
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4432
UR  - https://onlinelibrary.wiley.com/toc/15214141/2021/51/S1
AB  - Several ethnobotanical reports on Alchemilla vulgaris L. pointed out diverse biological properties against problems such as dysmenorrhea, pruritus vulvae, menopausal complaints 
as  well  as  related  diseases  in  women.  Also  previous  studies  have  shown  that  Alchemilla  vulgaris  L.  extracts  are  exhibiting  antiinflammatory,  antioxidant,  wound  healing  and 
neuroprotective activity. The aim of this study was to evaluate the direct effect of Alchemilla vulgaris L. ethanol extract against melanoma cells in vitro and in vivo, as well as its effect 
on tumor microenvironment ex vivo. This study was performed on two different mouse melanoma cell lines, B16 and B16F10, and on syngeneic mouse melanoma model in vivo. 
Obtained results revealed dose‐dependent decrease of cell viability after 72 h‐ treatment with Alchemilla vulgaris L. extract. The observed effect was followed by loss of dividing 
potential in both tested cell lines. In parallel with this, certain percentage of B16F10 cells was subjected to programmed cell death in a caspase independent manner while in B16 cells 
estimation of the presence of autophagosomes by flow cytometry has shown that autophagy is occurring after the treatment and it is shown to be mechanism of death. Concerning in 
vivo studies Alchemilla vulgaris L. extract significantly reduced tumor growth in B16 melanoma model partly through stimulation of antitumor immune responce. It altered dendritic 
cells phenotype which activated cytotoxic and CD4+ T lymphocytes to successfully destroy tumor cells. In summary, these data indicate that Alchemilla vulgaris L. is valuable of further 
investigation in the field of experimental oncology.
PB  - Wiley‐VCH GmbH
C3  - 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting
T1  - Multiple effects of Alchemilla vulgaris L. extract on melanoma cells and tumor microenvironment
IS  - Suppl 1
VL  - 51
DO  - 10.1002/eji.202170200
SP  - 352
ER  - 

@conference{
author = "Jelača, Sanja and Drača, Dijana and Dajić Stevanović, Zora and Jovanović, Ivan and Pavlović, Slađana and Gajović, Nevena and Mijatović, Sanja and Arsenijević, Nebojša and Maksimović-Ivanić, Danijela",
year = "2021",
abstract = "Several ethnobotanical reports on Alchemilla vulgaris L. pointed out diverse biological properties against problems such as dysmenorrhea, pruritus vulvae, menopausal complaints 
as  well  as  related  diseases  in  women.  Also  previous  studies  have  shown  that  Alchemilla  vulgaris  L.  extracts  are  exhibiting  antiinflammatory,  antioxidant,  wound  healing  and 
neuroprotective activity. The aim of this study was to evaluate the direct effect of Alchemilla vulgaris L. ethanol extract against melanoma cells in vitro and in vivo, as well as its effect 
on tumor microenvironment ex vivo. This study was performed on two different mouse melanoma cell lines, B16 and B16F10, and on syngeneic mouse melanoma model in vivo. 
Obtained results revealed dose‐dependent decrease of cell viability after 72 h‐ treatment with Alchemilla vulgaris L. extract. The observed effect was followed by loss of dividing 
potential in both tested cell lines. In parallel with this, certain percentage of B16F10 cells was subjected to programmed cell death in a caspase independent manner while in B16 cells 
estimation of the presence of autophagosomes by flow cytometry has shown that autophagy is occurring after the treatment and it is shown to be mechanism of death. Concerning in 
vivo studies Alchemilla vulgaris L. extract significantly reduced tumor growth in B16 melanoma model partly through stimulation of antitumor immune responce. It altered dendritic 
cells phenotype which activated cytotoxic and CD4+ T lymphocytes to successfully destroy tumor cells. In summary, these data indicate that Alchemilla vulgaris L. is valuable of further 
investigation in the field of experimental oncology.",
publisher = "Wiley‐VCH GmbH",
journal = "6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting",
title = "Multiple effects of Alchemilla vulgaris L. extract on melanoma cells and tumor microenvironment",
number = "Suppl 1",
volume = "51",
doi = "10.1002/eji.202170200",
pages = "352"
}

Jelača, S., Drača, D., Dajić Stevanović, Z., Jovanović, I., Pavlović, S., Gajović, N., Mijatović, S., Arsenijević, N.,& Maksimović-Ivanić, D.. (2021). Multiple effects of Alchemilla vulgaris L. extract on melanoma cells and tumor microenvironment. in 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting
Wiley‐VCH GmbH., 51(Suppl 1), 352.
https://doi.org/10.1002/eji.202170200

Jelača S, Drača D, Dajić Stevanović Z, Jovanović I, Pavlović S, Gajović N, Mijatović S, Arsenijević N, Maksimović-Ivanić D. Multiple effects of Alchemilla vulgaris L. extract on melanoma cells and tumor microenvironment. in 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting. 2021;51(Suppl 1):352.
doi:10.1002/eji.202170200 .

Jelača, Sanja, Drača, Dijana, Dajić Stevanović, Zora, Jovanović, Ivan, Pavlović, Slađana, Gajović, Nevena, Mijatović, Sanja, Arsenijević, Nebojša, Maksimović-Ivanić, Danijela, "Multiple effects of Alchemilla vulgaris L. extract on melanoma cells and tumor microenvironment" in 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting, 51, no. Suppl 1 (2021):352,
https://doi.org/10.1002/eji.202170200 . .

TY  - CONF
AU  - Jelača, Sanja
AU  - Drača, Dijana
AU  - Dajić Stevanović, Zora
AU  - Mijatović, Sanja
AU  - Jovanović, Ivan
AU  - Jovanović, Marina
AU  - Jurišević, Marina
AU  - Arsenijević, Nebojša
AU  - Maksimović-Ivanić, Danijela
PY  - 2021
UR  - https://onlinelibrary.wiley.com/toc/15214141/2021/51/S1
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4426
AB  - Alchemilla vulgaris L. has long history of usage in folk medicine especially against gynecological problems. Ethnomedicinal reports for the territory of Balkan are mentioning its well 
known biological properties against dysmenorrhea, menopausal complaints, infertility, cysts and endometriosis. Based on ethnomedicinal data on female illnesses, the objective of 
our study was to determine the effect of Alchemilla vulgaris L. ethanol extract against breast cancer cells in vitro and in vivo. Our results have showed remarkable viability decrease 
of mouse (4T1) breast cancer cells in dose‐dependent manner after the treatment with Alchemilla vulgaris L. extract. Strong inhibition of cell prolifertion was observed in treated 
cells. In parallel with this, different types of cell death was found. Certain percentage of 4T1 cells was subjected to programmed cell death‐apoptosis which was followed with caspase 
activation and confirmed by fluorescent microscopy observing tipical morphologicas features of apoptosis in treated culture. Estimation of the presence of autophagosomes shown 
that autophagy contributing  to  the cytotoxicity of the  treatment. Also, enhanced production of ROS and intracellular NO after treatment with Alchemilla vulgaris L. was  found. 
In parallel, metastatic potential of this cells is diminished. Apart from the direct effect of A. Vulgaris L. extract on tumor cells, strong potentiation of antitumor immune responce 
manifested dominantly through enhanced accumulation of activated dendritic cells and subsequently CD8+ T cells in spleen and tumor microenvironment. Above briefly described 
mode of action of Alchemilla vulgaris L. against breast cancer cells makes this plant worthwhile for further evaluation in the field of oncology.
PB  - Wiley‐VCH GmbH
C3  - 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting
T1  - Antitumor potential of Alchemilla vulgaris L. in ortotopic mouse breast cancer model
IS  - Suppl 1
VL  - 51
DO  - 10.1002/eji.202170200
SP  - 351
ER  - 

@conference{
author = "Jelača, Sanja and Drača, Dijana and Dajić Stevanović, Zora and Mijatović, Sanja and Jovanović, Ivan and Jovanović, Marina and Jurišević, Marina and Arsenijević, Nebojša and Maksimović-Ivanić, Danijela",
year = "2021",
abstract = "Alchemilla vulgaris L. has long history of usage in folk medicine especially against gynecological problems. Ethnomedicinal reports for the territory of Balkan are mentioning its well 
known biological properties against dysmenorrhea, menopausal complaints, infertility, cysts and endometriosis. Based on ethnomedicinal data on female illnesses, the objective of 
our study was to determine the effect of Alchemilla vulgaris L. ethanol extract against breast cancer cells in vitro and in vivo. Our results have showed remarkable viability decrease 
of mouse (4T1) breast cancer cells in dose‐dependent manner after the treatment with Alchemilla vulgaris L. extract. Strong inhibition of cell prolifertion was observed in treated 
cells. In parallel with this, different types of cell death was found. Certain percentage of 4T1 cells was subjected to programmed cell death‐apoptosis which was followed with caspase 
activation and confirmed by fluorescent microscopy observing tipical morphologicas features of apoptosis in treated culture. Estimation of the presence of autophagosomes shown 
that autophagy contributing  to  the cytotoxicity of the  treatment. Also, enhanced production of ROS and intracellular NO after treatment with Alchemilla vulgaris L. was  found. 
In parallel, metastatic potential of this cells is diminished. Apart from the direct effect of A. Vulgaris L. extract on tumor cells, strong potentiation of antitumor immune responce 
manifested dominantly through enhanced accumulation of activated dendritic cells and subsequently CD8+ T cells in spleen and tumor microenvironment. Above briefly described 
mode of action of Alchemilla vulgaris L. against breast cancer cells makes this plant worthwhile for further evaluation in the field of oncology.",
publisher = "Wiley‐VCH GmbH",
journal = "6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting",
title = "Antitumor potential of Alchemilla vulgaris L. in ortotopic mouse breast cancer model",
number = "Suppl 1",
volume = "51",
doi = "10.1002/eji.202170200",
pages = "351"
}

Jelača, S., Drača, D., Dajić Stevanović, Z., Mijatović, S., Jovanović, I., Jovanović, M., Jurišević, M., Arsenijević, N.,& Maksimović-Ivanić, D.. (2021). Antitumor potential of Alchemilla vulgaris L. in ortotopic mouse breast cancer model. in 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting
Wiley‐VCH GmbH., 51(Suppl 1), 351.
https://doi.org/10.1002/eji.202170200

Jelača S, Drača D, Dajić Stevanović Z, Mijatović S, Jovanović I, Jovanović M, Jurišević M, Arsenijević N, Maksimović-Ivanić D. Antitumor potential of Alchemilla vulgaris L. in ortotopic mouse breast cancer model. in 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting. 2021;51(Suppl 1):351.
doi:10.1002/eji.202170200 .

Jelača, Sanja, Drača, Dijana, Dajić Stevanović, Zora, Mijatović, Sanja, Jovanović, Ivan, Jovanović, Marina, Jurišević, Marina, Arsenijević, Nebojša, Maksimović-Ivanić, Danijela, "Antitumor potential of Alchemilla vulgaris L. in ortotopic mouse breast cancer model" in 6th European Congress of Immunology; 2021 Sep 1-4; Virtual Meeting, 51, no. Suppl 1 (2021):351,
https://doi.org/10.1002/eji.202170200 . .

TY  - CONF
AU  - Jelača, Sanja
AU  - Dajić-Stevanović, Zora
AU  - Vuković, Nenad
AU  - Trifunović, Srećko
AU  - Drača, Dijana
AU  - Tanić, Nikola
AU  - Arsenijević, Nebojša
AU  - Tanić, Nasta
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
PY  - 2019
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5591
AB  - U okviru projekta bilateralne saradnje Republike Srbije i Narodne Republike Kine testirana su antitumorska svojstva ukupnih ekstrakata izolovanih iz biljaka: rtanjski čaj (Satureja montana subsp. kitaibelii), trava iva (Teucrium montanum), virak (Alchemilla vulgaris agg.), bela imela (Viscum album subsp. album), zečiji trn (Ononis spinosa), detelina kamenjarka (Anthyllis vulneraria), čestoslavica (Veronica chamaedrys), različak (Centaurea cyanis), svećica (Gentiana asclepiadea), vilino sito (Carlina acaulis), mirisni zdravac (Geranium macrorrhyzum), kotrljan (Eryngium amethystinum), izop (Hyssopus officinalis) i slatinski pelin (Artemisia santonicum). Efekat ekstrakata ispitivan je na humanim ćelijskim linijama tumora dojke MCF-7, melanoma A375, karcinoma pluća A549 i kolona HCT116, kao i ćelijama peritonealnog eksudata miša. Uticaj na vijabilnost tumorskih ćelija praćen je sulforodamin (SRB) i testom mitohondrijalne dehidrogenaze (MTT). Ekstrakti biljaka svećice, različka, vilinog sita i izopa nisu redukovali vijabilitet tumorskih ćelija. Sa druge strane ekstrakti ive, virka, mirisnog zdravca i kotrljana su pokazali značajan potencijal da ograniče rast ćelijske linije karcinoma pluća inhibirajući deobu ćelija i indukujući kaspazama posredovanu apoptozu. Tumoricidna aktivnost ekstrakata deteline kamenjarke i rtanjskog čaja je bila najsnažnija na liniji kancera dojke dok je pad vijabilnosti najverovatnije posledica intenzivirane autofagije i smanjenog proliferativnog kapaciteta ćelija. Tretmani ćelija ispitivanim ekstraktima bili su praćeni smanjenjem produkcije slobodnih radikala kiseonika/ azota ukazujući na to da ekstrakti poseduju izvestan antioksidativni potencijal ali da ove reaktivne vrste nisu medijatori njihove tumoricidne aktivnosti. Testirani ekstrakti koji su ispoljili antitumorsku aktivnost, sa izuzetkom ekstrakta kotrljana, su bili u istom opsegu doza netoksični za ćelije peritonealnog eksudata zdravih miševa ukazujući na selektivnost prema malignom fenotipu.
PB  - Kragujevac: Fakultet medicinskih nauka Univerziteta
C3  - Knjiga sažetaka: Simpozijum Efekti aktivnih supstanci u eksperimentalnim in vitro i in vivo modelima; 2019 Dec 26; Kragujevac, Serbia
T1  - Antitumorska svojstva ekstrakata biljaka sa teritorije Balkana
T1  - Антитуморска својства eкстраката биљака са територије Балкана
SP  - 16
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5591
ER  - 

@conference{
author = "Jelača, Sanja and Dajić-Stevanović, Zora and Vuković, Nenad and Trifunović, Srećko and Drača, Dijana and Tanić, Nikola and Arsenijević, Nebojša and Tanić, Nasta and Mijatović, Sanja and Maksimović-Ivanić, Danijela",
year = "2019",
abstract = "U okviru projekta bilateralne saradnje Republike Srbije i Narodne Republike Kine testirana su antitumorska svojstva ukupnih ekstrakata izolovanih iz biljaka: rtanjski čaj (Satureja montana subsp. kitaibelii), trava iva (Teucrium montanum), virak (Alchemilla vulgaris agg.), bela imela (Viscum album subsp. album), zečiji trn (Ononis spinosa), detelina kamenjarka (Anthyllis vulneraria), čestoslavica (Veronica chamaedrys), različak (Centaurea cyanis), svećica (Gentiana asclepiadea), vilino sito (Carlina acaulis), mirisni zdravac (Geranium macrorrhyzum), kotrljan (Eryngium amethystinum), izop (Hyssopus officinalis) i slatinski pelin (Artemisia santonicum). Efekat ekstrakata ispitivan je na humanim ćelijskim linijama tumora dojke MCF-7, melanoma A375, karcinoma pluća A549 i kolona HCT116, kao i ćelijama peritonealnog eksudata miša. Uticaj na vijabilnost tumorskih ćelija praćen je sulforodamin (SRB) i testom mitohondrijalne dehidrogenaze (MTT). Ekstrakti biljaka svećice, različka, vilinog sita i izopa nisu redukovali vijabilitet tumorskih ćelija. Sa druge strane ekstrakti ive, virka, mirisnog zdravca i kotrljana su pokazali značajan potencijal da ograniče rast ćelijske linije karcinoma pluća inhibirajući deobu ćelija i indukujući kaspazama posredovanu apoptozu. Tumoricidna aktivnost ekstrakata deteline kamenjarke i rtanjskog čaja je bila najsnažnija na liniji kancera dojke dok je pad vijabilnosti najverovatnije posledica intenzivirane autofagije i smanjenog proliferativnog kapaciteta ćelija. Tretmani ćelija ispitivanim ekstraktima bili su praćeni smanjenjem produkcije slobodnih radikala kiseonika/ azota ukazujući na to da ekstrakti poseduju izvestan antioksidativni potencijal ali da ove reaktivne vrste nisu medijatori njihove tumoricidne aktivnosti. Testirani ekstrakti koji su ispoljili antitumorsku aktivnost, sa izuzetkom ekstrakta kotrljana, su bili u istom opsegu doza netoksični za ćelije peritonealnog eksudata zdravih miševa ukazujući na selektivnost prema malignom fenotipu.",
publisher = "Kragujevac: Fakultet medicinskih nauka Univerziteta",
journal = "Knjiga sažetaka: Simpozijum Efekti aktivnih supstanci u eksperimentalnim in vitro i in vivo modelima; 2019 Dec 26; Kragujevac, Serbia",
title = "Antitumorska svojstva ekstrakata biljaka sa teritorije Balkana, Антитуморска својства eкстраката биљака са територије Балкана",
pages = "16",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5591"
}

Jelača, S., Dajić-Stevanović, Z., Vuković, N., Trifunović, S., Drača, D., Tanić, N., Arsenijević, N., Tanić, N., Mijatović, S.,& Maksimović-Ivanić, D.. (2019). Antitumorska svojstva ekstrakata biljaka sa teritorije Balkana. in Knjiga sažetaka: Simpozijum Efekti aktivnih supstanci u eksperimentalnim in vitro i in vivo modelima; 2019 Dec 26; Kragujevac, Serbia
Kragujevac: Fakultet medicinskih nauka Univerziteta., 16.
https://hdl.handle.net/21.15107/rcub_ibiss_5591

Jelača S, Dajić-Stevanović Z, Vuković N, Trifunović S, Drača D, Tanić N, Arsenijević N, Tanić N, Mijatović S, Maksimović-Ivanić D. Antitumorska svojstva ekstrakata biljaka sa teritorije Balkana. in Knjiga sažetaka: Simpozijum Efekti aktivnih supstanci u eksperimentalnim in vitro i in vivo modelima; 2019 Dec 26; Kragujevac, Serbia. 2019;:16.
https://hdl.handle.net/21.15107/rcub_ibiss_5591 .

Jelača, Sanja, Dajić-Stevanović, Zora, Vuković, Nenad, Trifunović, Srećko, Drača, Dijana, Tanić, Nikola, Arsenijević, Nebojša, Tanić, Nasta, Mijatović, Sanja, Maksimović-Ivanić, Danijela, "Antitumorska svojstva ekstrakata biljaka sa teritorije Balkana" in Knjiga sažetaka: Simpozijum Efekti aktivnih supstanci u eksperimentalnim in vitro i in vivo modelima; 2019 Dec 26; Kragujevac, Serbia (2019):16,
https://hdl.handle.net/21.15107/rcub_ibiss_5591 .

TY  - GEN
AU  - Gazdić, Marina
AU  - Simović Marković, Bojana
AU  - Vučićević, Ljubica
AU  - Nikolić, Tamara
AU  - Đonov, Valentin
AU  - Arsenijević, Nebojša
AU  - Trajković, Vladimir
AU  - Lukić, Miodrag L.
AU  - Volarević, Vladislav
PY  - 2018
UR  - http://doi.wiley.com/10.1002/term.2452
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2833
AB  - The effects of mesenchymal stem cells (MSCs) on the phenotype and function of natural killer T (NKT) cells is not understood. We used concanavalin A (Con A) and α-galactosylceramide (α-GalCer)-induced liver injury to evaluate the effects of MSCs on NKT-dependent hepatotoxicity. Mouse MSCs (mMSCs) significantly reduced Con A- and α-GalCer-mediated hepatitis in C57Bl/6 mice, as demonstrated by histopathological and biochemical analysis, attenuated the influx of inflammatory [T-bet + , tumour necrosis factor-α (TNF-α), interferon-γ (IFN-γ)-producing and GATA3 + , interleukin-4 (IL-4)-producing] liver NKT cells and downregulated TNF-α, IFN-γ and IL-4 levels in the sera. The liver NKT cells cultured in vitro with mMSCs produced lower amounts of inflammatory cytokines (TNF-α, IFN-γ, IL-4) and higher amounts of immunosuppressive IL-10 upon α-GalCer stimulation. mMSC treatment attenuated expression of apoptosis-inducing ligands on liver NKT cells and suppressed the expression of pro-apoptotic genes in the livers of α-GalCer-treated mice. mMSCs reduced the cytotoxicity of liver NKT cells against hepatocytes in vitro. The presence of 1-methyl-dl-tryptophan, a specific inhibitor of indoleamine 2,3-dioxygenase (IDO), or l-N G -monomethyl arginine citrate, a specific inhibitor of inducible nitric oxide synthase (iNOS), in mMSC-conditioned medium injected into α-GalCer-treated mice, counteracted the hepatoprotective effect of mMSCs in vivo and restored pro-inflammatory cytokine production and cytotoxicity of NKT cells in vitro. Human MSCs attenuated the production of inflammatory cytokines in α-GalCer-stimulated human peripheral blood mononuclear cells in an iNOS- and IDO-dependent manner and reduced their cytotoxicity against HepG2 cells. In conclusion, MSCs protect from acute liver injury by attenuating the cytotoxicity and capacity of liver NKT cells to produce inflammatory cytokines in an iNOS- and IDO-dependent manner.
T2  - Journal of Tissue Engineering and Regenerative Medicine
T1  - Mesenchymal stem cells protect from acute liver injury by attenuating hepatotoxicity of liver natural killer T cells in an inducible nitric oxide synthase- and indoleamine 2,3-dioxygenase-dependent manner
IS  - 2
VL  - 12
DO  - 10.1002/term.2452
SP  - e1173
EP  - e1185
ER  - 

@misc{
author = "Gazdić, Marina and Simović Marković, Bojana and Vučićević, Ljubica and Nikolić, Tamara and Đonov, Valentin and Arsenijević, Nebojša and Trajković, Vladimir and Lukić, Miodrag L. and Volarević, Vladislav",
year = "2018",
abstract = "The effects of mesenchymal stem cells (MSCs) on the phenotype and function of natural killer T (NKT) cells is not understood. We used concanavalin A (Con A) and α-galactosylceramide (α-GalCer)-induced liver injury to evaluate the effects of MSCs on NKT-dependent hepatotoxicity. Mouse MSCs (mMSCs) significantly reduced Con A- and α-GalCer-mediated hepatitis in C57Bl/6 mice, as demonstrated by histopathological and biochemical analysis, attenuated the influx of inflammatory [T-bet + , tumour necrosis factor-α (TNF-α), interferon-γ (IFN-γ)-producing and GATA3 + , interleukin-4 (IL-4)-producing] liver NKT cells and downregulated TNF-α, IFN-γ and IL-4 levels in the sera. The liver NKT cells cultured in vitro with mMSCs produced lower amounts of inflammatory cytokines (TNF-α, IFN-γ, IL-4) and higher amounts of immunosuppressive IL-10 upon α-GalCer stimulation. mMSC treatment attenuated expression of apoptosis-inducing ligands on liver NKT cells and suppressed the expression of pro-apoptotic genes in the livers of α-GalCer-treated mice. mMSCs reduced the cytotoxicity of liver NKT cells against hepatocytes in vitro. The presence of 1-methyl-dl-tryptophan, a specific inhibitor of indoleamine 2,3-dioxygenase (IDO), or l-N G -monomethyl arginine citrate, a specific inhibitor of inducible nitric oxide synthase (iNOS), in mMSC-conditioned medium injected into α-GalCer-treated mice, counteracted the hepatoprotective effect of mMSCs in vivo and restored pro-inflammatory cytokine production and cytotoxicity of NKT cells in vitro. Human MSCs attenuated the production of inflammatory cytokines in α-GalCer-stimulated human peripheral blood mononuclear cells in an iNOS- and IDO-dependent manner and reduced their cytotoxicity against HepG2 cells. In conclusion, MSCs protect from acute liver injury by attenuating the cytotoxicity and capacity of liver NKT cells to produce inflammatory cytokines in an iNOS- and IDO-dependent manner.",
journal = "Journal of Tissue Engineering and Regenerative Medicine",
title = "Mesenchymal stem cells protect from acute liver injury by attenuating hepatotoxicity of liver natural killer T cells in an inducible nitric oxide synthase- and indoleamine 2,3-dioxygenase-dependent manner",
number = "2",
volume = "12",
doi = "10.1002/term.2452",
pages = "e1173-e1185"
}

Gazdić, M., Simović Marković, B., Vučićević, L., Nikolić, T., Đonov, V., Arsenijević, N., Trajković, V., Lukić, M. L.,& Volarević, V.. (2018). Mesenchymal stem cells protect from acute liver injury by attenuating hepatotoxicity of liver natural killer T cells in an inducible nitric oxide synthase- and indoleamine 2,3-dioxygenase-dependent manner. in Journal of Tissue Engineering and Regenerative Medicine, 12(2), e1173-e1185.
https://doi.org/10.1002/term.2452

Gazdić M, Simović Marković B, Vučićević L, Nikolić T, Đonov V, Arsenijević N, Trajković V, Lukić ML, Volarević V. Mesenchymal stem cells protect from acute liver injury by attenuating hepatotoxicity of liver natural killer T cells in an inducible nitric oxide synthase- and indoleamine 2,3-dioxygenase-dependent manner. in Journal of Tissue Engineering and Regenerative Medicine. 2018;12(2):e1173-e1185.
doi:10.1002/term.2452 .

Gazdić, Marina, Simović Marković, Bojana, Vučićević, Ljubica, Nikolić, Tamara, Đonov, Valentin, Arsenijević, Nebojša, Trajković, Vladimir, Lukić, Miodrag L., Volarević, Vladislav, "Mesenchymal stem cells protect from acute liver injury by attenuating hepatotoxicity of liver natural killer T cells in an inducible nitric oxide synthase- and indoleamine 2,3-dioxygenase-dependent manner" in Journal of Tissue Engineering and Regenerative Medicine, 12, no. 2 (2018):e1173-e1185,
https://doi.org/10.1002/term.2452 . .