TY  - JOUR
AU  - Spasić, Slađana
AU  - Subotić, Srđan
AU  - Višnjić-Jeftić, Željka
AU  - Lenhardt, Mirjana
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3646
AB  - Fish erythrocytes released from erythropoietic sites are immature. During circulation, they increase their own surface, while the cell body and nuclei begin to become more elliptical and less spherical during maturation. The relative abundance of different developmental stages represents an erythron profile which could be a more sensitive indicator of contamination than classic hematological indices. In this study, we analyzed blood smears of the common nase (Chondrostoma nasus) and vimba bream (Vimba vimba) with the main goal to identify the determinants of the developmental stage of erythrocytes. Based on parameters developmental stages, erythrocytes are categorized into immature, intermediate or mature. In this investigation we have used four classification methods: the Two Step Cluster analysis, the K-Means Cluster analysis, and Neural Networks–Multilayer Perceptron and an Ordinal Regression model. Our findings clearly justify that Multilayers Perceptron and OLR models are appropriate to classify the developmental stage of fish erythrocytes in both species.
T2  - Pattern Recognition and Image Analysis
T1  - Application of Different Classification Methods to Determine the Developmental Stage of Fish Erythrocytes of the Common Nase (Chondrostoma nasus) and Vimba Bream (Vimba vimba)
IS  - 1
VL  - 30
DO  - 10.1134/s1054661820010150
SP  - 43
EP  - 51
ER  - 

@article{
author = "Spasić, Slađana and Subotić, Srđan and Višnjić-Jeftić, Željka and Lenhardt, Mirjana",
year = "2020",
abstract = "Fish erythrocytes released from erythropoietic sites are immature. During circulation, they increase their own surface, while the cell body and nuclei begin to become more elliptical and less spherical during maturation. The relative abundance of different developmental stages represents an erythron profile which could be a more sensitive indicator of contamination than classic hematological indices. In this study, we analyzed blood smears of the common nase (Chondrostoma nasus) and vimba bream (Vimba vimba) with the main goal to identify the determinants of the developmental stage of erythrocytes. Based on parameters developmental stages, erythrocytes are categorized into immature, intermediate or mature. In this investigation we have used four classification methods: the Two Step Cluster analysis, the K-Means Cluster analysis, and Neural Networks–Multilayer Perceptron and an Ordinal Regression model. Our findings clearly justify that Multilayers Perceptron and OLR models are appropriate to classify the developmental stage of fish erythrocytes in both species.",
journal = "Pattern Recognition and Image Analysis",
title = "Application of Different Classification Methods to Determine the Developmental Stage of Fish Erythrocytes of the Common Nase (Chondrostoma nasus) and Vimba Bream (Vimba vimba)",
number = "1",
volume = "30",
doi = "10.1134/s1054661820010150",
pages = "43-51"
}

Spasić, S., Subotić, S., Višnjić-Jeftić, Ž.,& Lenhardt, M.. (2020). Application of Different Classification Methods to Determine the Developmental Stage of Fish Erythrocytes of the Common Nase (Chondrostoma nasus) and Vimba Bream (Vimba vimba). in Pattern Recognition and Image Analysis, 30(1), 43-51.
https://doi.org/10.1134/s1054661820010150

Spasić S, Subotić S, Višnjić-Jeftić Ž, Lenhardt M. Application of Different Classification Methods to Determine the Developmental Stage of Fish Erythrocytes of the Common Nase (Chondrostoma nasus) and Vimba Bream (Vimba vimba). in Pattern Recognition and Image Analysis. 2020;30(1):43-51.
doi:10.1134/s1054661820010150 .

Spasić, Slađana, Subotić, Srđan, Višnjić-Jeftić, Željka, Lenhardt, Mirjana, "Application of Different Classification Methods to Determine the Developmental Stage of Fish Erythrocytes of the Common Nase (Chondrostoma nasus) and Vimba Bream (Vimba vimba)" in Pattern Recognition and Image Analysis, 30, no. 1 (2020):43-51,
https://doi.org/10.1134/s1054661820010150 . .

TY  - JOUR
AU  - Subotić, Srđan
AU  - Višnjić-Jeftić, Željka
AU  - Đikanović, Vesna
AU  - Spasić, Slađana
AU  - Krpo-Ćetković, Jasmina
AU  - Lenhardt, Mirjana
PY  - 2019
UR  - http://link.springer.com/10.1007/s00128-019-02657-3
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3413
AB  - Accumulation of 17 elements in muscle and liver of common nase and vimba bream, caught between February and May 2016 in the Danube River (1173 river kilometer), were assessed by ICP-OES. The principal component analysis grouped muscle and liver samples based on element concentrations (muscle grouped by higher Ba and Sr values, and liver grouped by higher Al, B, Cd, Cr, Cu, Fe, Mn, and Zn values), but no grouping between the two species was observed. Concentrations of Ba, Cu, Fe, and Zn were significantly higher in muscle, and concentrations of Ba, Cd, Cu, and Mn in liver of common nase, while vimba bream had significantly higher concentrations of Cr and Fe in liver. Common nase has a higher affinity for bioaccumulation of Cu, Fe, and Zn in muscle, while vimba bream has a higher affinity for Al, Cd, and Cr in muscle.
T2  - Bulletin of Environmental Contamination and Toxicology
T1  - Metal Accumulation in Muscle and Liver of the Common Nase (Chondrostoma nasus) and Vimba Bream (Vimbavimba) from the Danube River, Serbia: Bioindicative Aspects.
VL  - 103
DO  - 10.1007/s00128-019-02657-3
SP  - 261
EP  - 266
ER  - 

@article{
author = "Subotić, Srđan and Višnjić-Jeftić, Željka and Đikanović, Vesna and Spasić, Slađana and Krpo-Ćetković, Jasmina and Lenhardt, Mirjana",
year = "2019",
abstract = "Accumulation of 17 elements in muscle and liver of common nase and vimba bream, caught between February and May 2016 in the Danube River (1173 river kilometer), were assessed by ICP-OES. The principal component analysis grouped muscle and liver samples based on element concentrations (muscle grouped by higher Ba and Sr values, and liver grouped by higher Al, B, Cd, Cr, Cu, Fe, Mn, and Zn values), but no grouping between the two species was observed. Concentrations of Ba, Cu, Fe, and Zn were significantly higher in muscle, and concentrations of Ba, Cd, Cu, and Mn in liver of common nase, while vimba bream had significantly higher concentrations of Cr and Fe in liver. Common nase has a higher affinity for bioaccumulation of Cu, Fe, and Zn in muscle, while vimba bream has a higher affinity for Al, Cd, and Cr in muscle.",
journal = "Bulletin of Environmental Contamination and Toxicology",
title = "Metal Accumulation in Muscle and Liver of the Common Nase (Chondrostoma nasus) and Vimba Bream (Vimbavimba) from the Danube River, Serbia: Bioindicative Aspects.",
volume = "103",
doi = "10.1007/s00128-019-02657-3",
pages = "261-266"
}

Subotić, S., Višnjić-Jeftić, Ž., Đikanović, V., Spasić, S., Krpo-Ćetković, J.,& Lenhardt, M.. (2019). Metal Accumulation in Muscle and Liver of the Common Nase (Chondrostoma nasus) and Vimba Bream (Vimbavimba) from the Danube River, Serbia: Bioindicative Aspects.. in Bulletin of Environmental Contamination and Toxicology, 103, 261-266.
https://doi.org/10.1007/s00128-019-02657-3

Subotić S, Višnjić-Jeftić Ž, Đikanović V, Spasić S, Krpo-Ćetković J, Lenhardt M. Metal Accumulation in Muscle and Liver of the Common Nase (Chondrostoma nasus) and Vimba Bream (Vimbavimba) from the Danube River, Serbia: Bioindicative Aspects.. in Bulletin of Environmental Contamination and Toxicology. 2019;103:261-266.
doi:10.1007/s00128-019-02657-3 .

Subotić, Srđan, Višnjić-Jeftić, Željka, Đikanović, Vesna, Spasić, Slađana, Krpo-Ćetković, Jasmina, Lenhardt, Mirjana, "Metal Accumulation in Muscle and Liver of the Common Nase (Chondrostoma nasus) and Vimba Bream (Vimbavimba) from the Danube River, Serbia: Bioindicative Aspects." in Bulletin of Environmental Contamination and Toxicology, 103 (2019):261-266,
https://doi.org/10.1007/s00128-019-02657-3 . .

TY  - CONF
AU  - Kesić, Srđan
AU  - Spasić, Slađana
AU  - Stojadinović, Gordana
AU  - Petković, Branka
AU  - Todorović, Dajana
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4027
AB  - Based on a wavelet analysis, this study introduces the relative wavelet energy (RWE)
as a new measure for classification of the frequency bands of neuronal population activity
in insects. The RWE is used to explore the effects of static magnetic field (SMF,
2 mT) and extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on longhorn
beetle antennal lobe neuronal activity. To study the influence of SMF and ELF MF on
the neuronal population activity, the experiments were performed on adult longhorn
beetles Morimus funereus (Coleoptera, Cerambycidae). Our study, based on a wavelet
analysis of the local field potentials (LFPs), showed for the first time that the effects of
prolonged and repeated exposure to the ELF MF on the LFPs were irreversible. Compared
to the control, the RWE of 4-8 Hz frequency band was increased after repeatedly
applied sine ELF MF (SnMF)/square ELF MF (SqMF). On the other hand, the RWE of
slower oscillations (1-2 Hz) was significantly decreased after repeated exposures to both
applied ELF MF waveforms. The SqMF decreased the fastest 64-128 Hz frequency
band. However, exposure to the SMF didn't have any effects on the neuronal population
activity. This study, successfully demonstrated new and useful application of the RWE
method for classification of the frequency bands and measuring the effects of SMF and
ELF MF on the neuronal population activity in M. funereus antennal lobe.
PB  - Belgrade: Serbian Physiological Society
C3  - 3rd Congress of Physiological Sciences of Serbia With International Participation
T1  - Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
SP  - 126
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4027
ER  - 

@conference{
author = "Kesić, Srđan and Spasić, Slađana and Stojadinović, Gordana and Petković, Branka and Todorović, Dajana",
year = "2014",
abstract = "Based on a wavelet analysis, this study introduces the relative wavelet energy (RWE)
as a new measure for classification of the frequency bands of neuronal population activity
in insects. The RWE is used to explore the effects of static magnetic field (SMF,
2 mT) and extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on longhorn
beetle antennal lobe neuronal activity. To study the influence of SMF and ELF MF on
the neuronal population activity, the experiments were performed on adult longhorn
beetles Morimus funereus (Coleoptera, Cerambycidae). Our study, based on a wavelet
analysis of the local field potentials (LFPs), showed for the first time that the effects of
prolonged and repeated exposure to the ELF MF on the LFPs were irreversible. Compared
to the control, the RWE of 4-8 Hz frequency band was increased after repeatedly
applied sine ELF MF (SnMF)/square ELF MF (SqMF). On the other hand, the RWE of
slower oscillations (1-2 Hz) was significantly decreased after repeated exposures to both
applied ELF MF waveforms. The SqMF decreased the fastest 64-128 Hz frequency
band. However, exposure to the SMF didn't have any effects on the neuronal population
activity. This study, successfully demonstrated new and useful application of the RWE
method for classification of the frequency bands and measuring the effects of SMF and
ELF MF on the neuronal population activity in M. funereus antennal lobe.",
publisher = "Belgrade: Serbian Physiological Society",
journal = "3rd Congress of Physiological Sciences of Serbia With International Participation",
title = "Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe",
pages = "126",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4027"
}

Kesić, S., Spasić, S., Stojadinović, G., Petković, B.,& Todorović, D.. (2014). Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe. in 3rd Congress of Physiological Sciences of Serbia With International Participation
Belgrade: Serbian Physiological Society., 126.
https://hdl.handle.net/21.15107/rcub_ibiss_4027

Kesić S, Spasić S, Stojadinović G, Petković B, Todorović D. Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe. in 3rd Congress of Physiological Sciences of Serbia With International Participation. 2014;:126.
https://hdl.handle.net/21.15107/rcub_ibiss_4027 .

Kesić, Srđan, Spasić, Slađana, Stojadinović, Gordana, Petković, Branka, Todorović, Dajana, "Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe" in 3rd Congress of Physiological Sciences of Serbia With International Participation (2014):126,
https://hdl.handle.net/21.15107/rcub_ibiss_4027 .

TY  - CONF
AU  - Spasić, Slađana
AU  - Nikolić, Ljiljana
AU  - Mutavdžić, Dragosav
AU  - Kartelija, Gordana
AU  - Todorović, Dajana
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4031
AB  - Numerous studies have dealt with the effects of magnetic fields on the nervous system. In the present work we tested effect of 2.7 mT magnetic field on spontaneous Br neuron activity in subesophageal ganglia of garden snail Helix pomatia by Higuchi fractal dimension as a nonlinear measure of signal complexity in time domain. Fractal analysis was performed by estimating fractal dimension (FD) of bioelectric signals from Br neurons using Higuchi's algorithm. We used principal components analysis as a method of factor extraction in factor analysis of empirical distribution of FD. Shape of the empirical distribution of FD pointed out on bimodal pattern in complexity of spontaneous Br neuron activity. The factor analysis showed that there are two principal factors in empirical distribution of fractal dimension: F 1 and F2. The differences between factors F 1 and F2 in different experimental conditions ( control, under magnetic field (MF) and after exposure to the magnetic field (AMF)) were tested by Kolmogorov-Smimov Test. The analysis showed that there is no difference between F1 factors in control vs. MF condition, and in control vs. AMF condition. However, significant difference was found between f 2 factors in control vs. MF condition, and in control vs. AMF condition. Factor analysis also showed there is no difference between F2 factors in MF vs. AMF condition. Generally, results indicated that irreversible changes in complexity of Br neuron activity occurred after exposure to magnetic field compared to the control conditions.
PB  - Belgrade: Serbian Physiological Society
C3  - Second Congress of Physiological Sciences of Serbia with International Participation “Current Trends in Physiological Sciences”
T1  - Effect of static magnetic field on fractal complexity on spontaneous neuronal activity in snail
SP  - 180
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4031
ER  - 

@conference{
author = "Spasić, Slađana and Nikolić, Ljiljana and Mutavdžić, Dragosav and Kartelija, Gordana and Todorović, Dajana",
year = "2009",
abstract = "Numerous studies have dealt with the effects of magnetic fields on the nervous system. In the present work we tested effect of 2.7 mT magnetic field on spontaneous Br neuron activity in subesophageal ganglia of garden snail Helix pomatia by Higuchi fractal dimension as a nonlinear measure of signal complexity in time domain. Fractal analysis was performed by estimating fractal dimension (FD) of bioelectric signals from Br neurons using Higuchi's algorithm. We used principal components analysis as a method of factor extraction in factor analysis of empirical distribution of FD. Shape of the empirical distribution of FD pointed out on bimodal pattern in complexity of spontaneous Br neuron activity. The factor analysis showed that there are two principal factors in empirical distribution of fractal dimension: F 1 and F2. The differences between factors F 1 and F2 in different experimental conditions ( control, under magnetic field (MF) and after exposure to the magnetic field (AMF)) were tested by Kolmogorov-Smimov Test. The analysis showed that there is no difference between F1 factors in control vs. MF condition, and in control vs. AMF condition. However, significant difference was found between f 2 factors in control vs. MF condition, and in control vs. AMF condition. Factor analysis also showed there is no difference between F2 factors in MF vs. AMF condition. Generally, results indicated that irreversible changes in complexity of Br neuron activity occurred after exposure to magnetic field compared to the control conditions.",
publisher = "Belgrade: Serbian Physiological Society",
journal = "Second Congress of Physiological Sciences of Serbia with International Participation “Current Trends in Physiological Sciences”",
title = "Effect of static magnetic field on fractal complexity on spontaneous neuronal activity in snail",
pages = "180",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4031"
}

Spasić, S., Nikolić, L., Mutavdžić, D., Kartelija, G.,& Todorović, D.. (2009). Effect of static magnetic field on fractal complexity on spontaneous neuronal activity in snail. in Second Congress of Physiological Sciences of Serbia with International Participation “Current Trends in Physiological Sciences”
Belgrade: Serbian Physiological Society., 180.
https://hdl.handle.net/21.15107/rcub_ibiss_4031

Spasić S, Nikolić L, Mutavdžić D, Kartelija G, Todorović D. Effect of static magnetic field on fractal complexity on spontaneous neuronal activity in snail. in Second Congress of Physiological Sciences of Serbia with International Participation “Current Trends in Physiological Sciences”. 2009;:180.
https://hdl.handle.net/21.15107/rcub_ibiss_4031 .

Spasić, Slađana, Nikolić, Ljiljana, Mutavdžić, Dragosav, Kartelija, Gordana, Todorović, Dajana, "Effect of static magnetic field on fractal complexity on spontaneous neuronal activity in snail" in Second Congress of Physiological Sciences of Serbia with International Participation “Current Trends in Physiological Sciences” (2009):180,
https://hdl.handle.net/21.15107/rcub_ibiss_4031 .

TY  - JOUR
AU  - Stojadinović, Gordana
AU  - Ćulić, Milka
AU  - Martać, Ljiljana
AU  - Kesić, Srđan
AU  - Soković, Marina
AU  - Spasić, Slađana
AU  - Đoković, Dejan
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/356
AB  - We have decided to detect the seizure brain activity induced by camphor essential oil in rats, as there are still reports of severe intoxication in humans by camphor. The experiments were performed on adult Wistar male rats. The surgery and the acute electrophysiological recordings were done under pentobarbital sodium anesthesia. Local field potentials of cerebral parietal cortex were recorded. The rats were injected by camphor essential oil (150-675 μl/kg b.w., in 1 ml of saline, i.p). We analyzed by Fast Fourier Transform the digitized electrocortical signals before and up 2-3 h after essential oil administration at the sampling rate of 256 Hz. There was a great increase of the mean total power spectra, a relative increase of the power in delta range and decreases of theta and beta ranges when seizural activity with spikes and waves of large amplitude occurred at the level of cerebral cortex 5-30 min after administration of camphor oil at doses >300 μl/kg b.w. It is necessary to investigate further the dose dependent effectiveness of each terpenoid constituent of camphor essential oil on brain activity in order to elucidate the relative safety of the usage of essential oils with these terpenoids.
AB  - Odlučili smo se za istraživanje pojave epileptičnih napada kod pacova izazvanih kamforovim esencijalnim uljem jer se još uvek pojavljuju slučajevi teške intoksikacije kamforom u ljudi. Eksperimenti su izvedeni na odraslim pacovima muškog pola Wistar soja. Operativni zahvati i akutna registrovanja elektrofizioloških signala su obavljeni pod Nembutal anestezijom. Registrovani su lokalni potencijali polja parijetalnog dela kore velikog mozga. Kamforovo esencijalno ulje je pacovima intraperitonealno ubrizgavano (150-675 μl/kg, t.m. u l ml fiziološkog rastvora, i.p). Pomoću brze Furijeove transformacije analizirali smo elektrokortikalne signale pre i oko 2-3 h posle intraperitonealnog ubrizgavanja kamforovog ulja, pri frekvenciji semplovanja od 256/s. Pojavio se veliki porast ukupne snage i relativno povećanje snage u delta opsegu, a smanjenje u teta i beta opsegu kada se pojavila epileptična aktivnost kore velikog mozga - šiljci i talasi potencijala velike amplitude i to tek pri dozi kamforovog ulja većoj od 300 μl/kg, a 5-30 min po ubrizgavanju ulja. Neophodno je dalje ispitivati doznu zavisnost efekta svake od glavnih terpenskih komponenti kamforovog ulja na aktivnost mozga pacova kako bi se obezbedila relativna sigurnost upotrebe esencijalnih ulja.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Trovanje kamforom - spektralna analiza aktivnosti mozga pacova
T1  - Camphor oil poisoning: Spectral analysis of rat brain activity
IS  - 3
VL  - 42
SP  - 233
EP  - 238
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_356
ER  - 

@article{
author = "Stojadinović, Gordana and Ćulić, Milka and Martać, Ljiljana and Kesić, Srđan and Soković, Marina and Spasić, Slađana and Đoković, Dejan",
year = "2006, 2006",
abstract = "We have decided to detect the seizure brain activity induced by camphor essential oil in rats, as there are still reports of severe intoxication in humans by camphor. The experiments were performed on adult Wistar male rats. The surgery and the acute electrophysiological recordings were done under pentobarbital sodium anesthesia. Local field potentials of cerebral parietal cortex were recorded. The rats were injected by camphor essential oil (150-675 μl/kg b.w., in 1 ml of saline, i.p). We analyzed by Fast Fourier Transform the digitized electrocortical signals before and up 2-3 h after essential oil administration at the sampling rate of 256 Hz. There was a great increase of the mean total power spectra, a relative increase of the power in delta range and decreases of theta and beta ranges when seizural activity with spikes and waves of large amplitude occurred at the level of cerebral cortex 5-30 min after administration of camphor oil at doses >300 μl/kg b.w. It is necessary to investigate further the dose dependent effectiveness of each terpenoid constituent of camphor essential oil on brain activity in order to elucidate the relative safety of the usage of essential oils with these terpenoids., Odlučili smo se za istraživanje pojave epileptičnih napada kod pacova izazvanih kamforovim esencijalnim uljem jer se još uvek pojavljuju slučajevi teške intoksikacije kamforom u ljudi. Eksperimenti su izvedeni na odraslim pacovima muškog pola Wistar soja. Operativni zahvati i akutna registrovanja elektrofizioloških signala su obavljeni pod Nembutal anestezijom. Registrovani su lokalni potencijali polja parijetalnog dela kore velikog mozga. Kamforovo esencijalno ulje je pacovima intraperitonealno ubrizgavano (150-675 μl/kg, t.m. u l ml fiziološkog rastvora, i.p). Pomoću brze Furijeove transformacije analizirali smo elektrokortikalne signale pre i oko 2-3 h posle intraperitonealnog ubrizgavanja kamforovog ulja, pri frekvenciji semplovanja od 256/s. Pojavio se veliki porast ukupne snage i relativno povećanje snage u delta opsegu, a smanjenje u teta i beta opsegu kada se pojavila epileptična aktivnost kore velikog mozga - šiljci i talasi potencijala velike amplitude i to tek pri dozi kamforovog ulja većoj od 300 μl/kg, a 5-30 min po ubrizgavanju ulja. Neophodno je dalje ispitivati doznu zavisnost efekta svake od glavnih terpenskih komponenti kamforovog ulja na aktivnost mozga pacova kako bi se obezbedila relativna sigurnost upotrebe esencijalnih ulja.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Trovanje kamforom - spektralna analiza aktivnosti mozga pacova, Camphor oil poisoning: Spectral analysis of rat brain activity",
number = "3",
volume = "42",
pages = "233-238",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_356"
}

Stojadinović, G., Ćulić, M., Martać, L., Kesić, S., Soković, M., Spasić, S.,& Đoković, D.. (2006). Trovanje kamforom - spektralna analiza aktivnosti mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 233-238.
https://hdl.handle.net/21.15107/rcub_ibiss_356

Stojadinović G, Ćulić M, Martać L, Kesić S, Soković M, Spasić S, Đoković D. Trovanje kamforom - spektralna analiza aktivnosti mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):233-238.
https://hdl.handle.net/21.15107/rcub_ibiss_356 .

Stojadinović, Gordana, Ćulić, Milka, Martać, Ljiljana, Kesić, Srđan, Soković, Marina, Spasić, Slađana, Đoković, Dejan, "Trovanje kamforom - spektralna analiza aktivnosti mozga pacova" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):233-238,
https://hdl.handle.net/21.15107/rcub_ibiss_356 .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Kesić, Srđan
AU  - Ćulić, Milka
AU  - Stojadinović, Gordana
AU  - Spasić, Slađana
AU  - Sekulić, Slobodan
AU  - Lalošević, Dušan
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/333
AB  - The aim of our study was to investigate the electrophysiological effects of aluminium neurotoxicity. This animal model of neurodegenerative dementia was induced by chronic treatment of Wistarrats with aluminum chloride for 4 weeks - 2mg Al/kg, i.p, per day. Electrophysiological recordings of left and right somatosensory cortical areas of animals treated by aluminium and the control rats were done under Nembutal anesthesia. Analog to the digital one conversion of the recorded signals was performed at the sampling rate of 256 Hz. Spectral analysis of electrocortical activity during sequences of 120 s (divided in epochs of 8s) was obtained by Fast Fourier Transformation while fractal dimension (FD) of these signals was calculated by Higuchi's algorithm. The relative power spectra of cerebral activity were increased in delta frequency range and decreased in (8.1-32.0 Hz) range in aluminium treated animals compared to the controls. The average fractal dimension of electrocortical activity in aluminium treated animals was lower - 1.290 than the average fractal dimension of electrocortical activity in the control rats - 1.377. Spectral and fractal characteristics of brain activity could bean electrophysiological sign of developing neurodegenerative process similar to the Alzheimer's dementia.
AB  - Predmet ovog istraživanja je bio da se elektrofiziološki prouče efekti aluminijumske neurotoksičnosti. Animalni model neurodegenerativne demencije postignut je hroničnim tretmanom Wistar pacova sa aluminium hloridom u toku 4 nedelje u dozi od 2 mg/kg aluminijuma dnevno. Elektrofiziološko registrovanje levog i desnog somatosenzornog korteksa pacova tretiranih aluminijumom i kontrolnih pacova je vršeno pod Nembutalskom anestezijom. Analogno-digitalna konverzija registrovanih signala je izvršena pri frekvenciji semplovanja 256Hz. Spektralna analiza elektrokortikalne aktivnosti u trajanju od 120s (podeljena u epohe od 8s) je izvršena Furijeovom transformacijom, a fraktalna dimenzija ovih signala je izračunata Higučijevim algoritmom. Relativni spektri snage cerebralne aktivnosti u delta frekventnom opsegu su bili povećani, a u (8.1-15.0 Hz) frekventnom opsegu su bili smanjeni kod aluminijumom tretiranih životinja u odnosu na kontrolne. Srednja fraktalna dimenzija elektrokortikalne aktivnosti kod tretiranih pacova je manja - 1,290 u odnosu na srednju fraktalnu dimenziju elektrokortikalne aktivnosti kontrolnih pacova - 1,377. Spektralne i fraktalne karakteristike mogu biti elektrofiziološki znak razvitka neurodegenerativnih procesa kao kod Alchajmerove bolesti.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova
T1  - Effect of aluminium neurotoxicity on the rat brain electrocortical activity
IS  - 3
VL  - 42
SP  - 219
EP  - 225
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_333
ER  - 

@article{
author = "Martać, Ljiljana and Kesić, Srđan and Ćulić, Milka and Stojadinović, Gordana and Spasić, Slađana and Sekulić, Slobodan and Lalošević, Dušan",
year = "2006, 2006",
abstract = "The aim of our study was to investigate the electrophysiological effects of aluminium neurotoxicity. This animal model of neurodegenerative dementia was induced by chronic treatment of Wistarrats with aluminum chloride for 4 weeks - 2mg Al/kg, i.p, per day. Electrophysiological recordings of left and right somatosensory cortical areas of animals treated by aluminium and the control rats were done under Nembutal anesthesia. Analog to the digital one conversion of the recorded signals was performed at the sampling rate of 256 Hz. Spectral analysis of electrocortical activity during sequences of 120 s (divided in epochs of 8s) was obtained by Fast Fourier Transformation while fractal dimension (FD) of these signals was calculated by Higuchi's algorithm. The relative power spectra of cerebral activity were increased in delta frequency range and decreased in (8.1-32.0 Hz) range in aluminium treated animals compared to the controls. The average fractal dimension of electrocortical activity in aluminium treated animals was lower - 1.290 than the average fractal dimension of electrocortical activity in the control rats - 1.377. Spectral and fractal characteristics of brain activity could bean electrophysiological sign of developing neurodegenerative process similar to the Alzheimer's dementia., Predmet ovog istraživanja je bio da se elektrofiziološki prouče efekti aluminijumske neurotoksičnosti. Animalni model neurodegenerativne demencije postignut je hroničnim tretmanom Wistar pacova sa aluminium hloridom u toku 4 nedelje u dozi od 2 mg/kg aluminijuma dnevno. Elektrofiziološko registrovanje levog i desnog somatosenzornog korteksa pacova tretiranih aluminijumom i kontrolnih pacova je vršeno pod Nembutalskom anestezijom. Analogno-digitalna konverzija registrovanih signala je izvršena pri frekvenciji semplovanja 256Hz. Spektralna analiza elektrokortikalne aktivnosti u trajanju od 120s (podeljena u epohe od 8s) je izvršena Furijeovom transformacijom, a fraktalna dimenzija ovih signala je izračunata Higučijevim algoritmom. Relativni spektri snage cerebralne aktivnosti u delta frekventnom opsegu su bili povećani, a u (8.1-15.0 Hz) frekventnom opsegu su bili smanjeni kod aluminijumom tretiranih životinja u odnosu na kontrolne. Srednja fraktalna dimenzija elektrokortikalne aktivnosti kod tretiranih pacova je manja - 1,290 u odnosu na srednju fraktalnu dimenziju elektrokortikalne aktivnosti kontrolnih pacova - 1,377. Spektralne i fraktalne karakteristike mogu biti elektrofiziološki znak razvitka neurodegenerativnih procesa kao kod Alchajmerove bolesti.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova, Effect of aluminium neurotoxicity on the rat brain electrocortical activity",
number = "3",
volume = "42",
pages = "219-225",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_333"
}

Martać, L., Kesić, S., Ćulić, M., Stojadinović, G., Spasić, S., Sekulić, S.,& Lalošević, D.. (2006). Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 219-225.
https://hdl.handle.net/21.15107/rcub_ibiss_333

Martać L, Kesić S, Ćulić M, Stojadinović G, Spasić S, Sekulić S, Lalošević D. Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):219-225.
https://hdl.handle.net/21.15107/rcub_ibiss_333 .

Martać, Ljiljana, Kesić, Srđan, Ćulić, Milka, Stojadinović, Gordana, Spasić, Slađana, Sekulić, Slobodan, Lalošević, Dušan, "Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):219-225,
https://hdl.handle.net/21.15107/rcub_ibiss_333 .