TY  - CHAP
AU  - Stanojlović, Olivera
AU  - Hrnčić, Dragan
AU  - Vojnović Milutinović, Danijela
AU  - Mladenović, Dušan
AU  - Šutulović, Nikola
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6330
AB  - Dysfunction of hypothalamic-pituitary-gonadal (HPG) axis can be caused by complex and multilevel interactions between altered sleep quality, behavioral disturbances,and chemicals that interfere with normal functioning of the endocrine system, known as endocrine disruptors (EDs). Sleep deprivation disrupts circadian 
rhythm and via modulation of melatonin secretion and hypothalamic neural outputs
inhibits gonadotropin-releasing hormone (GnRH) secretion and reduces the levels 
of gonadotropins and androgens. Although many evidence suggest that EDs may affect the function of HPG axis, the precise actions on EDs on reproductive health 
are still controversial. More studies have been performed in female than in male 
animals. Major mechanisms of deleterious action of EDs on HPG axis include 
stimulation or inhibition of nuclear hormone receptors via direct binding, alter
actions of steroid biosynthesis and degradation, and changes in neurotransmitter 
release and effects. Some EDs may also cause the apoptosis of GnRH neurons or
induce epigenetic changes that can be transmitted to the offspring. In ovaries, EDs 
may inhibit key steroidogenic enzymes and estrogen synthesis or directly injure
granulosa or theca cells. They can also have high affinity for estrogen, androgen,
progesterone, or glucocorticoid receptors, and to stimulate or inhibit different 
signaling pathways in the cell. All of these changes may impair oocyte maturation ,
increase the frequency of anovulatory cycles, and ultimately lead to disturbed 
puberty onset, reduced female fecundity, and premature ovarian failure. This 
chapter summarizes the current knowledge on the effects of sleep disturbances 
and major EDs on reproductive function from prenatal to adult period.
PB  - Cham: Springer
T2  - Environmental Endocrinology and Endocrine Disruptors: Endocrine and Endocrine-targeted Actions and Related Human Diseases
T1  - Environmental Impact on the Hypothalamus-Pituitary-Ovary Axis
DO  - 10.1007/978-3-030-39044-0_5
SP  - 129
EP  - 153
ER  - 

@inbook{
author = "Stanojlović, Olivera and Hrnčić, Dragan and Vojnović Milutinović, Danijela and Mladenović, Dušan and Šutulović, Nikola",
year = "2023",
abstract = "Dysfunction of hypothalamic-pituitary-gonadal (HPG) axis can be caused by complex and multilevel interactions between altered sleep quality, behavioral disturbances,and chemicals that interfere with normal functioning of the endocrine system, known as endocrine disruptors (EDs). Sleep deprivation disrupts circadian 
rhythm and via modulation of melatonin secretion and hypothalamic neural outputs
inhibits gonadotropin-releasing hormone (GnRH) secretion and reduces the levels 
of gonadotropins and androgens. Although many evidence suggest that EDs may affect the function of HPG axis, the precise actions on EDs on reproductive health 
are still controversial. More studies have been performed in female than in male 
animals. Major mechanisms of deleterious action of EDs on HPG axis include 
stimulation or inhibition of nuclear hormone receptors via direct binding, alter
actions of steroid biosynthesis and degradation, and changes in neurotransmitter 
release and effects. Some EDs may also cause the apoptosis of GnRH neurons or
induce epigenetic changes that can be transmitted to the offspring. In ovaries, EDs 
may inhibit key steroidogenic enzymes and estrogen synthesis or directly injure
granulosa or theca cells. They can also have high affinity for estrogen, androgen,
progesterone, or glucocorticoid receptors, and to stimulate or inhibit different 
signaling pathways in the cell. All of these changes may impair oocyte maturation ,
increase the frequency of anovulatory cycles, and ultimately lead to disturbed 
puberty onset, reduced female fecundity, and premature ovarian failure. This 
chapter summarizes the current knowledge on the effects of sleep disturbances 
and major EDs on reproductive function from prenatal to adult period.",
publisher = "Cham: Springer",
journal = "Environmental Endocrinology and Endocrine Disruptors: Endocrine and Endocrine-targeted Actions and Related Human Diseases",
booktitle = "Environmental Impact on the Hypothalamus-Pituitary-Ovary Axis",
doi = "10.1007/978-3-030-39044-0_5",
pages = "129-153"
}

Stanojlović, O., Hrnčić, D., Vojnović Milutinović, D., Mladenović, D.,& Šutulović, N.. (2023). Environmental Impact on the Hypothalamus-Pituitary-Ovary Axis. in Environmental Endocrinology and Endocrine Disruptors: Endocrine and Endocrine-targeted Actions and Related Human Diseases
Cham: Springer., 129-153.
https://doi.org/10.1007/978-3-030-39044-0_5

Stanojlović O, Hrnčić D, Vojnović Milutinović D, Mladenović D, Šutulović N. Environmental Impact on the Hypothalamus-Pituitary-Ovary Axis. in Environmental Endocrinology and Endocrine Disruptors: Endocrine and Endocrine-targeted Actions and Related Human Diseases. 2023;:129-153.
doi:10.1007/978-3-030-39044-0_5 .

Stanojlović, Olivera, Hrnčić, Dragan, Vojnović Milutinović, Danijela, Mladenović, Dušan, Šutulović, Nikola, "Environmental Impact on the Hypothalamus-Pituitary-Ovary Axis" in Environmental Endocrinology and Endocrine Disruptors: Endocrine and Endocrine-targeted Actions and Related Human Diseases (2023):129-153,
https://doi.org/10.1007/978-3-030-39044-0_5 . .