TY  - JOUR
AU  - Savic, Danka
AU  - Knezevic, Goran
AU  - Matić, Gordana
AU  - Damjanovic, Svetozar
AU  - Spiric, Zeljko
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1925
AB  - A disturbed beta-endorphin system can be a part of the post-traumatic
   stress disorder (PTSD) and depression allostasis. Study subjects (N=392)
   included those with PTSD and/or (stress-induced) depression, and healthy
   controls with and without traumas. The aim of the study was to examine
   the network of relations centered around plasma beta-endorphin. The
   network included anxiety (as a personality trait), traumatic events,
   pain, aggressiveness, depressive symptoms, and three clusters of PTSD
   symptoms: intrusions, avoidance, and hyperarousal. Beta-endorphin was
   represented by individual mean from 13 time points (BEmean), reflecting
   the total amount of the peripherally secreted hormone, and the
   coefficient of variation (BEvar), calculated as the ratio of standard
   deviation to the mean, reflecting the hormone's dynamics. BEvar
   correlated with all other variables, BEmean had no correlations.
   Structural equation modeling (SEM) was used to examine all
   interrelations (including their directions) of BEvar and the state/trait
   variables in the context of their entirety. The model revealed that
   hyperarousal and anxiety were the only direct agents of peripheral
   beta-endorphin fluctuations, mediating the effects of other variables.
   Traumatic events and intrusions act on BEvar via hyperarousal, while
   depressive symptoms, avoidance, and pain act via anxiety. Hyperarousal
   should be emphasized as the main agent not only because its effect on
   BEvar is larger than that of anxiety, but also because it increases
   anxiety itself (via avoidance and pain). All influences on BEvar are
   positive and they indicate long-term (sensitizing) effects (as opposed
   to direct stimulation, for example, by acute pain, anger, etc.).
   Relations apart from beta-endorphin are also discussed. (C) 2015
   Elsevier B.V. All rights reserved,
T2  - Journal of Affective Disorders
T1  - Posttraumatic and depressive symptoms in beta-endorphin dynamics
VL  - 181
DO  - 10.1016/j.jad.2015.03.063
SP  - 61
EP  - 66
ER  - 

@article{
author = "Savic, Danka and Knezevic, Goran and Matić, Gordana and Damjanovic, Svetozar and Spiric, Zeljko",
year = "2015",
abstract = "A disturbed beta-endorphin system can be a part of the post-traumatic
   stress disorder (PTSD) and depression allostasis. Study subjects (N=392)
   included those with PTSD and/or (stress-induced) depression, and healthy
   controls with and without traumas. The aim of the study was to examine
   the network of relations centered around plasma beta-endorphin. The
   network included anxiety (as a personality trait), traumatic events,
   pain, aggressiveness, depressive symptoms, and three clusters of PTSD
   symptoms: intrusions, avoidance, and hyperarousal. Beta-endorphin was
   represented by individual mean from 13 time points (BEmean), reflecting
   the total amount of the peripherally secreted hormone, and the
   coefficient of variation (BEvar), calculated as the ratio of standard
   deviation to the mean, reflecting the hormone's dynamics. BEvar
   correlated with all other variables, BEmean had no correlations.
   Structural equation modeling (SEM) was used to examine all
   interrelations (including their directions) of BEvar and the state/trait
   variables in the context of their entirety. The model revealed that
   hyperarousal and anxiety were the only direct agents of peripheral
   beta-endorphin fluctuations, mediating the effects of other variables.
   Traumatic events and intrusions act on BEvar via hyperarousal, while
   depressive symptoms, avoidance, and pain act via anxiety. Hyperarousal
   should be emphasized as the main agent not only because its effect on
   BEvar is larger than that of anxiety, but also because it increases
   anxiety itself (via avoidance and pain). All influences on BEvar are
   positive and they indicate long-term (sensitizing) effects (as opposed
   to direct stimulation, for example, by acute pain, anger, etc.).
   Relations apart from beta-endorphin are also discussed. (C) 2015
   Elsevier B.V. All rights reserved,",
journal = "Journal of Affective Disorders",
title = "Posttraumatic and depressive symptoms in beta-endorphin dynamics",
volume = "181",
doi = "10.1016/j.jad.2015.03.063",
pages = "61-66"
}

Savic, D., Knezevic, G., Matić, G., Damjanovic, S.,& Spiric, Z.. (2015). Posttraumatic and depressive symptoms in beta-endorphin dynamics. in Journal of Affective Disorders, 181, 61-66.
https://doi.org/10.1016/j.jad.2015.03.063

Savic D, Knezevic G, Matić G, Damjanovic S, Spiric Z. Posttraumatic and depressive symptoms in beta-endorphin dynamics. in Journal of Affective Disorders. 2015;181:61-66.
doi:10.1016/j.jad.2015.03.063 .

Savic, Danka, Knezevic, Goran, Matić, Gordana, Damjanovic, Svetozar, Spiric, Zeljko, "Posttraumatic and depressive symptoms in beta-endorphin dynamics" in Journal of Affective Disorders, 181 (2015):61-66,
https://doi.org/10.1016/j.jad.2015.03.063 . .

TY  - JOUR
AU  - Matić, Gordana
AU  - Vojnović-Milutinović, Danijela
AU  - Brkljačić, Jelena
AU  - Elaković, Ivana
AU  - Manitašević Jovanović, Sanja
AU  - Elzaedi, Younis Mouftah
AU  - Perisic, Tatjana
AU  - Dunderski, Jadranka
AU  - Damjanovic, Svetozar
AU  - Knezevic, Goran
AU  - Spiric, Zeljko
AU  - Vermetten, Eric
AU  - Savic, Danka
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2244
AB  - Alterations in the number and functional status of mineralocorticoid
   (MR) and glucocorticoid receptors (GR) may contribute to vulnerability
   to posttraumatic stress disorder (PTSD). Corticosteroid receptors are
   chaperoned by heat shock proteins Hsp90 and Hsp70. We examined relations
   between corticosteroid receptor and heat shock protein expression
   levels, and related them with war trauma exposure, PTSD and resilience
   to PTSD. Relative levels of MR. Hsp90 and Hsp70 were determined by
   immunoblotting in lymphocytes from war trauma-exposed men with current
   PTSD (current PTSD group, n=113), with lifetime PTSD (life-time PTSD
   group, n=61) and without PTSD (trauma control group, n=88), and from
   non-traumatized healthy controls (healthy control group, n=85).
   Between-group differences in MR, Hsp90 and Hsp70 levels and in MR/GR
   ratio were not observed. The level of MR was correlated with both Hsp90
   and Hsp70 levels in trauma control and healthy control groups. On the
   other hand, GR level was correlated only with Hsp90 level, and this
   correlation was evident in current PTSD and trauma control groups. In
   conclusion, PTSD and exposure to trauma are not related to changes in
   lymphocyte MR, Hsp90 or Hsp70 levels, but may be associated with
   disturbances in corticosteroid receptors interaction with heat shock
   proteins. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
T2  - Psychiatry Research
T1  - Mineralocorticoid receptor and heat shock protein expression levels in
 peripheral lymphocytes from war trauma-exposed men with and without PTSD
IS  - 2
VL  - 215
DO  - 10.1016/j.psychres.2013.11.022
SP  - 379
EP  - 385
ER  - 

@article{
author = "Matić, Gordana and Vojnović-Milutinović, Danijela and Brkljačić, Jelena and Elaković, Ivana and Manitašević Jovanović, Sanja and Elzaedi, Younis Mouftah and Perisic, Tatjana and Dunderski, Jadranka and Damjanovic, Svetozar and Knezevic, Goran and Spiric, Zeljko and Vermetten, Eric and Savic, Danka",
year = "2014",
abstract = "Alterations in the number and functional status of mineralocorticoid
   (MR) and glucocorticoid receptors (GR) may contribute to vulnerability
   to posttraumatic stress disorder (PTSD). Corticosteroid receptors are
   chaperoned by heat shock proteins Hsp90 and Hsp70. We examined relations
   between corticosteroid receptor and heat shock protein expression
   levels, and related them with war trauma exposure, PTSD and resilience
   to PTSD. Relative levels of MR. Hsp90 and Hsp70 were determined by
   immunoblotting in lymphocytes from war trauma-exposed men with current
   PTSD (current PTSD group, n=113), with lifetime PTSD (life-time PTSD
   group, n=61) and without PTSD (trauma control group, n=88), and from
   non-traumatized healthy controls (healthy control group, n=85).
   Between-group differences in MR, Hsp90 and Hsp70 levels and in MR/GR
   ratio were not observed. The level of MR was correlated with both Hsp90
   and Hsp70 levels in trauma control and healthy control groups. On the
   other hand, GR level was correlated only with Hsp90 level, and this
   correlation was evident in current PTSD and trauma control groups. In
   conclusion, PTSD and exposure to trauma are not related to changes in
   lymphocyte MR, Hsp90 or Hsp70 levels, but may be associated with
   disturbances in corticosteroid receptors interaction with heat shock
   proteins. (C) 2013 Elsevier Ireland Ltd. All rights reserved.",
journal = "Psychiatry Research",
title = "Mineralocorticoid receptor and heat shock protein expression levels in
 peripheral lymphocytes from war trauma-exposed men with and without PTSD",
number = "2",
volume = "215",
doi = "10.1016/j.psychres.2013.11.022",
pages = "379-385"
}

Matić, G., Vojnović-Milutinović, D., Brkljačić, J., Elaković, I., Manitašević Jovanović, S., Elzaedi, Y. M., Perisic, T., Dunderski, J., Damjanovic, S., Knezevic, G., Spiric, Z., Vermetten, E.,& Savic, D.. (2014). Mineralocorticoid receptor and heat shock protein expression levels in
 peripheral lymphocytes from war trauma-exposed men with and without PTSD. in Psychiatry Research, 215(2), 379-385.
https://doi.org/10.1016/j.psychres.2013.11.022

Matić G, Vojnović-Milutinović D, Brkljačić J, Elaković I, Manitašević Jovanović S, Elzaedi YM, Perisic T, Dunderski J, Damjanovic S, Knezevic G, Spiric Z, Vermetten E, Savic D. Mineralocorticoid receptor and heat shock protein expression levels in
 peripheral lymphocytes from war trauma-exposed men with and without PTSD. in Psychiatry Research. 2014;215(2):379-385.
doi:10.1016/j.psychres.2013.11.022 .

Matić, Gordana, Vojnović-Milutinović, Danijela, Brkljačić, Jelena, Elaković, Ivana, Manitašević Jovanović, Sanja, Elzaedi, Younis Mouftah, Perisic, Tatjana, Dunderski, Jadranka, Damjanovic, Svetozar, Knezevic, Goran, Spiric, Zeljko, Vermetten, Eric, Savic, Danka, "Mineralocorticoid receptor and heat shock protein expression levels in
 peripheral lymphocytes from war trauma-exposed men with and without PTSD" in Psychiatry Research, 215, no. 2 (2014):379-385,
https://doi.org/10.1016/j.psychres.2013.11.022 . .