TY  - JOUR
AU  - Edeler, David
AU  - Drača, Dijana
AU  - Petković, Vladana
AU  - Natalio, Filipe
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Schmidt, Harry
AU  - Kaluđerović, Goran N.
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0928493118329175?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3302
AB  - Herein appropriateness of nonfunctionalized mesoporous silica nanoparticles SBA-15 and functionalized with (3-chloropropyl)triethoxysilane (→ SBA-15~Cl) and (3-aminopropyl)triethoxysilane (→ SBA-15~NH2) on delivery of physically adsorbed Ph3Sn(CH2)6OH (Sn6) is evaluated. Fluorescent nanomaterial, bearing isatoic moiety, loaded with Sn6 (→ SBA-15~NF|Sn6) was used for cellular uptake study. The fluorescent nanomaterial is efficiently acquired and distributed into the cytoplasm of the cells even after 2 h of cultivation. According to the attained data, all SBA-15 materials loaded with Sn6 diminished cellular viability in dose dependent manner while carriers alone (SBA-15, SBA-15~Cl, SBA-15~NH2) did not show cytotoxicity against B16 cells. According to the MC50 values structural modification of SBA-15 did not improve the efficacy of tested drug. While progressive apoptosis was detected upon the treatment with SBA-15|Sn6, exposure of cells to SBA-15~NH2|Sn6 revealed extinguished apoptosis in time, accompanied with lower caspase activity. This effect is probably due to triggered autophagic process under the treatment with the SBA-15~NH2|Sn6, thus opposed to apoptosis. Presented results suggested that functionalization of SBA-15 was not beneficial for the efficacy of loaded drug, thus, all of them are almost equally efficient considering loaded Sn6 content. Importantly, functionalization of SBA-15 does have an influence on the mode of action and differentiation inducing properties.
T2  - Materials Science and Engineering: C
T1  - Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH
VL  - 100
DO  - 10.1016/J.MSEC.2019.03.010
SP  - 315
EP  - 322
ER  - 

@article{
author = "Edeler, David and Drača, Dijana and Petković, Vladana and Natalio, Filipe and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Schmidt, Harry and Kaluđerović, Goran N.",
year = "2019",
abstract = "Herein appropriateness of nonfunctionalized mesoporous silica nanoparticles SBA-15 and functionalized with (3-chloropropyl)triethoxysilane (→ SBA-15~Cl) and (3-aminopropyl)triethoxysilane (→ SBA-15~NH2) on delivery of physically adsorbed Ph3Sn(CH2)6OH (Sn6) is evaluated. Fluorescent nanomaterial, bearing isatoic moiety, loaded with Sn6 (→ SBA-15~NF|Sn6) was used for cellular uptake study. The fluorescent nanomaterial is efficiently acquired and distributed into the cytoplasm of the cells even after 2 h of cultivation. According to the attained data, all SBA-15 materials loaded with Sn6 diminished cellular viability in dose dependent manner while carriers alone (SBA-15, SBA-15~Cl, SBA-15~NH2) did not show cytotoxicity against B16 cells. According to the MC50 values structural modification of SBA-15 did not improve the efficacy of tested drug. While progressive apoptosis was detected upon the treatment with SBA-15|Sn6, exposure of cells to SBA-15~NH2|Sn6 revealed extinguished apoptosis in time, accompanied with lower caspase activity. This effect is probably due to triggered autophagic process under the treatment with the SBA-15~NH2|Sn6, thus opposed to apoptosis. Presented results suggested that functionalization of SBA-15 was not beneficial for the efficacy of loaded drug, thus, all of them are almost equally efficient considering loaded Sn6 content. Importantly, functionalization of SBA-15 does have an influence on the mode of action and differentiation inducing properties.",
journal = "Materials Science and Engineering: C",
title = "Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH",
volume = "100",
doi = "10.1016/J.MSEC.2019.03.010",
pages = "315-322"
}

Edeler, D., Drača, D., Petković, V., Natalio, F., Maksimović-Ivanić, D., Mijatović, S., Schmidt, H.,& Kaluđerović, G. N.. (2019). Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH. in Materials Science and Engineering: C, 100, 315-322.
https://doi.org/10.1016/J.MSEC.2019.03.010

Edeler D, Drača D, Petković V, Natalio F, Maksimović-Ivanić D, Mijatović S, Schmidt H, Kaluđerović GN. Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH. in Materials Science and Engineering: C. 2019;100:315-322.
doi:10.1016/J.MSEC.2019.03.010 .

Edeler, David, Drača, Dijana, Petković, Vladana, Natalio, Filipe, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Schmidt, Harry, Kaluđerović, Goran N., "Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH" in Materials Science and Engineering: C, 100 (2019):315-322,
https://doi.org/10.1016/J.MSEC.2019.03.010 . .

TY  - JOUR
AU  - Momčilović, Miljana
AU  - Eichhorn, Thomas
AU  - Blaževski, Jana
AU  - Schmidt, Harry
AU  - Kaluđerović, Goran N.
AU  - Stošić-Grujičić, Stanislava
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1979
AB  - T cell differentiation into distinct T helper (Th) subpopulations is
   crucial in governing acquired immune responses as well as some
   inflammatory and autoimmune disorders. This study investigated potential
   of the novel neutral binuclear ruthenium(II) complexes 1-8 with general
   formula {[}\{RuCl2(eta(6)-p-cym)\}(2)mu-((NN)-N-a (c))] ((NN)-N-a (c) =
   bis(nicotinate)- and bis(iso-nicotinate)-polyethylene glycol esters;
   (3-py)COO(CH2CH2O) (n) CO(3-py) and (4-py)COO(CH2CH2O) (n) CO(4-py); n =
   1-4), as well as {[}RuCl2(eta(6)-p-cym)(nic)] (R1, nic = nicotinate) and
   {[}RuCl2(eta(6)-p-cym)(inic)] (R2, inic = isonicotinate) as an
   immunomodulatory agents capable to direct Th cell differentiation. From
   all investigated complexes,
   {[}\{RuCl2(eta(6)-p-cym)\}(2)mu-\{(3-py)COO(CH2CH2O)(4)CO(3-py)\}] (4)
   was selected for further study because it did not affect splenocyte
   viability (in concentration up to 50 mu M), but significantly reduced
   secretion of representative Th1 cytokine, IFN-gamma induced by T cell
   mitogen. Besides IFN-gamma, 4 inhibited dose dependently expression and
   production of representative Th17 cytokine, IL-17, in these cells.
   Otherwise, the production of anti-inflammatory cytokines IL-4 and IL-10
   was upregulated. Also, 4 significantly increased CD4(+)CD25(+)FoxP3(+)
   Treg cell frequency in the activated splenocytes. Moreover, ConA-induced
   expression of Th1 transcription factors, T-bet and STAT1, as well as of
   Th17-related protein STAT3 was attenuated upon exposure to 4, while the
   expression of Th2-related transcription factor GATA3 remained stable. In
   conclusion, ruthenium(II) complex 4 modulates immune system cell
   functions in vitro by inhibiting T cell differentiation towards
   pathogenic Th1/Th17 phenotype and inducing a regulatory phenotype
   characterized by IL-10 and IL-4 production, which may provide novel
   therapeutic opportunities for immune-inflammatory and/or autoimmune
   disorders.
T2  - Journal of Biological Inorganic Chemistry
T1  - In vitro effects of binuclear (eta (6)-p-cymene)ruthenium(II) complex
 containing bridging bis(nicotinate)-polyethylene glycol ester ligand on
 differentiation pathways of murine Th lymphocytes activated by T cell
 mitogen
IS  - 3
VL  - 20
DO  - 10.1007/s00775-015-1242-x
SP  - 575
EP  - 583
ER  - 

@article{
author = "Momčilović, Miljana and Eichhorn, Thomas and Blaževski, Jana and Schmidt, Harry and Kaluđerović, Goran N. and Stošić-Grujičić, Stanislava",
year = "2015",
abstract = "T cell differentiation into distinct T helper (Th) subpopulations is
   crucial in governing acquired immune responses as well as some
   inflammatory and autoimmune disorders. This study investigated potential
   of the novel neutral binuclear ruthenium(II) complexes 1-8 with general
   formula {[}\{RuCl2(eta(6)-p-cym)\}(2)mu-((NN)-N-a (c))] ((NN)-N-a (c) =
   bis(nicotinate)- and bis(iso-nicotinate)-polyethylene glycol esters;
   (3-py)COO(CH2CH2O) (n) CO(3-py) and (4-py)COO(CH2CH2O) (n) CO(4-py); n =
   1-4), as well as {[}RuCl2(eta(6)-p-cym)(nic)] (R1, nic = nicotinate) and
   {[}RuCl2(eta(6)-p-cym)(inic)] (R2, inic = isonicotinate) as an
   immunomodulatory agents capable to direct Th cell differentiation. From
   all investigated complexes,
   {[}\{RuCl2(eta(6)-p-cym)\}(2)mu-\{(3-py)COO(CH2CH2O)(4)CO(3-py)\}] (4)
   was selected for further study because it did not affect splenocyte
   viability (in concentration up to 50 mu M), but significantly reduced
   secretion of representative Th1 cytokine, IFN-gamma induced by T cell
   mitogen. Besides IFN-gamma, 4 inhibited dose dependently expression and
   production of representative Th17 cytokine, IL-17, in these cells.
   Otherwise, the production of anti-inflammatory cytokines IL-4 and IL-10
   was upregulated. Also, 4 significantly increased CD4(+)CD25(+)FoxP3(+)
   Treg cell frequency in the activated splenocytes. Moreover, ConA-induced
   expression of Th1 transcription factors, T-bet and STAT1, as well as of
   Th17-related protein STAT3 was attenuated upon exposure to 4, while the
   expression of Th2-related transcription factor GATA3 remained stable. In
   conclusion, ruthenium(II) complex 4 modulates immune system cell
   functions in vitro by inhibiting T cell differentiation towards
   pathogenic Th1/Th17 phenotype and inducing a regulatory phenotype
   characterized by IL-10 and IL-4 production, which may provide novel
   therapeutic opportunities for immune-inflammatory and/or autoimmune
   disorders.",
journal = "Journal of Biological Inorganic Chemistry",
title = "In vitro effects of binuclear (eta (6)-p-cymene)ruthenium(II) complex
 containing bridging bis(nicotinate)-polyethylene glycol ester ligand on
 differentiation pathways of murine Th lymphocytes activated by T cell
 mitogen",
number = "3",
volume = "20",
doi = "10.1007/s00775-015-1242-x",
pages = "575-583"
}

Momčilović, M., Eichhorn, T., Blaževski, J., Schmidt, H., Kaluđerović, G. N.,& Stošić-Grujičić, S.. (2015). In vitro effects of binuclear (eta (6)-p-cymene)ruthenium(II) complex
 containing bridging bis(nicotinate)-polyethylene glycol ester ligand on
 differentiation pathways of murine Th lymphocytes activated by T cell
 mitogen. in Journal of Biological Inorganic Chemistry, 20(3), 575-583.
https://doi.org/10.1007/s00775-015-1242-x

Momčilović M, Eichhorn T, Blaževski J, Schmidt H, Kaluđerović GN, Stošić-Grujičić S. In vitro effects of binuclear (eta (6)-p-cymene)ruthenium(II) complex
 containing bridging bis(nicotinate)-polyethylene glycol ester ligand on
 differentiation pathways of murine Th lymphocytes activated by T cell
 mitogen. in Journal of Biological Inorganic Chemistry. 2015;20(3):575-583.
doi:10.1007/s00775-015-1242-x .

Momčilović, Miljana, Eichhorn, Thomas, Blaževski, Jana, Schmidt, Harry, Kaluđerović, Goran N., Stošić-Grujičić, Stanislava, "In vitro effects of binuclear (eta (6)-p-cymene)ruthenium(II) complex
 containing bridging bis(nicotinate)-polyethylene glycol ester ligand on
 differentiation pathways of murine Th lymphocytes activated by T cell
 mitogen" in Journal of Biological Inorganic Chemistry, 20, no. 3 (2015):575-583,
https://doi.org/10.1007/s00775-015-1242-x . .

TY  - JOUR
AU  - Eichhorn, Thomas
AU  - Hey-Hawkins, Evamarie
AU  - Maksimović-Ivanić, Danijela
AU  - Mojić, Marija
AU  - Schmidt, Juergen
AU  - Mijatović, Sanja
AU  - Schmidt, Harry
AU  - Kaluđerović, Goran N.
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2099
AB  - Neutral binuclear ruthenium complexes 1, 2, 3, 4, 5, 6, 7, 8 of the
   general formula {[}\{RuCl2((6)-p-cym)\}(2)-(NN)] (NN=bis(nicotinate)-
   and bis(isonicotinate)-polyethylene glycol esters:
   (3-py)COO(CH2CH2O)(n)CO(3-py) and (4-py)COO(CH2CH2O)(n)CO(4-py), n
   =1-4), as well as mononuclear
   {[}RuCl2((6)-p-cym)((3-py)COO(CH2CH2OCH3)-N)], complex 9, were
   synthesized and characterized using elemental analysis and electrospray
   ionization high-resolution mass spectrometry, infrared, H-1 NMR and C-13
   NMR spectroscopies. Stability of the binuclear complexes in the presence
   of dimethylsulfoxide was studied. Furthermore, formation of a cationic
   complex containing bridging pyridine-based bidentate ligand was
   monitored using H-1 NMR spectroscopy. Ligand precursors, polyethylene
   glycol esters of nicotinic (L12HCl-L42HCl and L9HCl) and isonicotinic
   acid dihydrochlorides (L52HCl-L82HCl), binuclear ruthenium(II) complexes
   1, 2, 3, 4, 5, 6, 7, 8 and mononuclear complex 9 were tested for in
   vitro cytotoxicity against 518A2 (melanoma), 8505C (anaplastic thyroid
   cancer), A253 (head and neck tumour), MCF-7 (breast tumour) and SW480
   (colon carcinoma) cell lines. Copyright (c) 2014 John Wiley \& Sons,
   Ltd.
T2  - Applied Organometallic Chemistry
T1  - Binuclear dichlorido(eta(6)-p-cymene)ruthenium(II) complexes with
 bis(nicotinate)- and bis (isonicotinate)-polyethylene glycol ester
 ligands
IS  - 1
VL  - 29
DO  - 10.1002/aoc.3238
SP  - 20
EP  - 25
ER  - 

@article{
author = "Eichhorn, Thomas and Hey-Hawkins, Evamarie and Maksimović-Ivanić, Danijela and Mojić, Marija and Schmidt, Juergen and Mijatović, Sanja and Schmidt, Harry and Kaluđerović, Goran N.",
year = "2015",
abstract = "Neutral binuclear ruthenium complexes 1, 2, 3, 4, 5, 6, 7, 8 of the
   general formula {[}\{RuCl2((6)-p-cym)\}(2)-(NN)] (NN=bis(nicotinate)-
   and bis(isonicotinate)-polyethylene glycol esters:
   (3-py)COO(CH2CH2O)(n)CO(3-py) and (4-py)COO(CH2CH2O)(n)CO(4-py), n
   =1-4), as well as mononuclear
   {[}RuCl2((6)-p-cym)((3-py)COO(CH2CH2OCH3)-N)], complex 9, were
   synthesized and characterized using elemental analysis and electrospray
   ionization high-resolution mass spectrometry, infrared, H-1 NMR and C-13
   NMR spectroscopies. Stability of the binuclear complexes in the presence
   of dimethylsulfoxide was studied. Furthermore, formation of a cationic
   complex containing bridging pyridine-based bidentate ligand was
   monitored using H-1 NMR spectroscopy. Ligand precursors, polyethylene
   glycol esters of nicotinic (L12HCl-L42HCl and L9HCl) and isonicotinic
   acid dihydrochlorides (L52HCl-L82HCl), binuclear ruthenium(II) complexes
   1, 2, 3, 4, 5, 6, 7, 8 and mononuclear complex 9 were tested for in
   vitro cytotoxicity against 518A2 (melanoma), 8505C (anaplastic thyroid
   cancer), A253 (head and neck tumour), MCF-7 (breast tumour) and SW480
   (colon carcinoma) cell lines. Copyright (c) 2014 John Wiley \& Sons,
   Ltd.",
journal = "Applied Organometallic Chemistry",
title = "Binuclear dichlorido(eta(6)-p-cymene)ruthenium(II) complexes with
 bis(nicotinate)- and bis (isonicotinate)-polyethylene glycol ester
 ligands",
number = "1",
volume = "29",
doi = "10.1002/aoc.3238",
pages = "20-25"
}

Eichhorn, T., Hey-Hawkins, E., Maksimović-Ivanić, D., Mojić, M., Schmidt, J., Mijatović, S., Schmidt, H.,& Kaluđerović, G. N.. (2015). Binuclear dichlorido(eta(6)-p-cymene)ruthenium(II) complexes with
 bis(nicotinate)- and bis (isonicotinate)-polyethylene glycol ester
 ligands. in Applied Organometallic Chemistry, 29(1), 20-25.
https://doi.org/10.1002/aoc.3238

Eichhorn T, Hey-Hawkins E, Maksimović-Ivanić D, Mojić M, Schmidt J, Mijatović S, Schmidt H, Kaluđerović GN. Binuclear dichlorido(eta(6)-p-cymene)ruthenium(II) complexes with
 bis(nicotinate)- and bis (isonicotinate)-polyethylene glycol ester
 ligands. in Applied Organometallic Chemistry. 2015;29(1):20-25.
doi:10.1002/aoc.3238 .

Eichhorn, Thomas, Hey-Hawkins, Evamarie, Maksimović-Ivanić, Danijela, Mojić, Marija, Schmidt, Juergen, Mijatović, Sanja, Schmidt, Harry, Kaluđerović, Goran N., "Binuclear dichlorido(eta(6)-p-cymene)ruthenium(II) complexes with
 bis(nicotinate)- and bis (isonicotinate)-polyethylene glycol ester
 ligands" in Applied Organometallic Chemistry, 29, no. 1 (2015):20-25,
https://doi.org/10.1002/aoc.3238 . .

TY  - JOUR
AU  - Bulatović, Mirna Z.
AU  - Maksimović-Ivanić, Danijela
AU  - Bensing, Christian
AU  - Gomez-Ruiz, Santiago
AU  - Steinborn, Dirk
AU  - Schmidt, Harry
AU  - Mojić, Marija
AU  - Korac, Aleksandra
AU  - Golic, Igor
AU  - Perez-Quintanilla, Damian
AU  - Momčilović, Miljana
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2205
AB  - The strong therapeutic potential of an organotin(IV) compound loaded in
   nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor
   growth in syngeneic C57BL/6 mice is almost completely abolished. In
   contrast to apoptosis as the basic mechanism of the anticancer action of
   numerous chemotherapeutics, the important advantage of this SBA-15pSn
   mesoporous material is the induction of cell differentiation, an effect
   unknown for metal-based drugs and nanomaterials alone. This
   non-aggressive mode of drug action is highly efficient against cancer
   cells but is in the concentration range used nontoxic for normal tissue.
   JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the
   development of the melanocyte-like nonproliferative phenotype of
   survived cells indicates the extraordinary potential of SBA-15pSn to
   suppress tumor growth without undesirable compensatory proliferation of
   malignant cells in response to neighboring cell death.
T2  - Angewandte Chemie-International Edition
T1  - Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment
IS  - 23
VL  - 53
DO  - 10.1002/anie.201400763
SP  - 5982
EP  - 5987
ER  - 

@article{
author = "Bulatović, Mirna Z. and Maksimović-Ivanić, Danijela and Bensing, Christian and Gomez-Ruiz, Santiago and Steinborn, Dirk and Schmidt, Harry and Mojić, Marija and Korac, Aleksandra and Golic, Igor and Perez-Quintanilla, Damian and Momčilović, Miljana and Mijatović, Sanja and Kaluđerović, Goran N.",
year = "2014",
abstract = "The strong therapeutic potential of an organotin(IV) compound loaded in
   nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor
   growth in syngeneic C57BL/6 mice is almost completely abolished. In
   contrast to apoptosis as the basic mechanism of the anticancer action of
   numerous chemotherapeutics, the important advantage of this SBA-15pSn
   mesoporous material is the induction of cell differentiation, an effect
   unknown for metal-based drugs and nanomaterials alone. This
   non-aggressive mode of drug action is highly efficient against cancer
   cells but is in the concentration range used nontoxic for normal tissue.
   JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the
   development of the melanocyte-like nonproliferative phenotype of
   survived cells indicates the extraordinary potential of SBA-15pSn to
   suppress tumor growth without undesirable compensatory proliferation of
   malignant cells in response to neighboring cell death.",
journal = "Angewandte Chemie-International Edition",
title = "Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment",
number = "23",
volume = "53",
doi = "10.1002/anie.201400763",
pages = "5982-5987"
}

Bulatović, M. Z., Maksimović-Ivanić, D., Bensing, C., Gomez-Ruiz, S., Steinborn, D., Schmidt, H., Mojić, M., Korac, A., Golic, I., Perez-Quintanilla, D., Momčilović, M., Mijatović, S.,& Kaluđerović, G. N.. (2014). Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment. in Angewandte Chemie-International Edition, 53(23), 5982-5987.
https://doi.org/10.1002/anie.201400763

Bulatović MZ, Maksimović-Ivanić D, Bensing C, Gomez-Ruiz S, Steinborn D, Schmidt H, Mojić M, Korac A, Golic I, Perez-Quintanilla D, Momčilović M, Mijatović S, Kaluđerović GN. Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment. in Angewandte Chemie-International Edition. 2014;53(23):5982-5987.
doi:10.1002/anie.201400763 .

Bulatović, Mirna Z., Maksimović-Ivanić, Danijela, Bensing, Christian, Gomez-Ruiz, Santiago, Steinborn, Dirk, Schmidt, Harry, Mojić, Marija, Korac, Aleksandra, Golic, Igor, Perez-Quintanilla, Damian, Momčilović, Miljana, Mijatović, Sanja, Kaluđerović, Goran N., "Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in
 Cancer Treatment" in Angewandte Chemie-International Edition, 53, no. 23 (2014):5982-5987,
https://doi.org/10.1002/anie.201400763 . .

TY  - JOUR
AU  - Kaluđerović, Goran N.
AU  - Mijatović, Sanja
AU  - Zmejkovski, Bojana B
AU  - Bulatović, Mirna Z.
AU  - Gomez-Ruiz, Santiago
AU  - Mojić, Marija
AU  - Steinborn, Dirk
AU  - Miljković, Đorđe
AU  - Schmidt, Harry
AU  - Stošić-Grujičić, Stanislava
AU  - Sabo, Tibor J
AU  - Maksimović-Ivanić, Danijela
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1223
AB  - Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.
T2  - Metallomics
T1  - Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells
IS  - 9
VL  - 4
EP  - 987
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1223
ER  - 

@article{
author = "Kaluđerović, Goran N. and Mijatović, Sanja and Zmejkovski, Bojana B and Bulatović, Mirna Z. and Gomez-Ruiz, Santiago and Mojić, Marija and Steinborn, Dirk and Miljković, Đorđe and Schmidt, Harry and Stošić-Grujičić, Stanislava and Sabo, Tibor J and Maksimović-Ivanić, Danijela",
year = "2012",
abstract = "Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.",
journal = "Metallomics",
title = "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells",
number = "9",
volume = "4",
pages = "987",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1223"
}

Kaluđerović, G. N., Mijatović, S., Zmejkovski, B. B., Bulatović, M. Z., Gomez-Ruiz, S., Mojić, M., Steinborn, D., Miljković, Đ., Schmidt, H., Stošić-Grujičić, S., Sabo, T. J.,& Maksimović-Ivanić, D.. (2012). Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics, 4(9).
https://hdl.handle.net/21.15107/rcub_ibiss_1223

Kaluđerović GN, Mijatović S, Zmejkovski BB, Bulatović MZ, Gomez-Ruiz S, Mojić M, Steinborn D, Miljković Đ, Schmidt H, Stošić-Grujičić S, Sabo TJ, Maksimović-Ivanić D. Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. in Metallomics. 2012;4(9):null-987.
https://hdl.handle.net/21.15107/rcub_ibiss_1223 .

Kaluđerović, Goran N., Mijatović, Sanja, Zmejkovski, Bojana B, Bulatović, Mirna Z., Gomez-Ruiz, Santiago, Mojić, Marija, Steinborn, Dirk, Miljković, Đorđe, Schmidt, Harry, Stošić-Grujičić, Stanislava, Sabo, Tibor J, Maksimović-Ivanić, Danijela, "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells" in Metallomics, 4, no. 9 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1223 .