TY  - JOUR
AU  - Stanisavljević, Suzana
AU  - Čepić, Aleksa
AU  - Bojić, Svetlana
AU  - Veljović, Katarina
AU  - Mihajlović, Sanja
AU  - Nikolovski, Neda
AU  - Jevtić, Bojan
AU  - Momčilović, Miljana
AU  - Lazarević, Milica
AU  - Mostarica Stojković, Marija
AU  - Miljković, Đorđe
AU  - Golić, Nataša
PY  - 2019
UR  - http://www.nature.com/articles/s41598-018-37505-7
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6351648
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3264
AB  - Gut microbiota dysbiosis has been considered the essential element in the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). Antibiotics were administered orally to Dark Agouti (DA) rats early in their life with the aim of perturbing gut microbiota and investigating the effects of such intervention on the course of EAE. As a result, the diversity of the gut microbiota was reduced under the influence of antibiotics. Mainly, Firmicutes and Actinobacteria were replaced by Proteobacteria and Bacteroidetes, while decreased proportions of Clostridia and Bacilli classes were accompanied by an increase in Gamma-Proteobacteria in antibiotic-treated animals. Interestingly, a notable decrease in the Helicobacteraceae, Spirochaetaceae and Turicibacteriaceae was scored in antibiotic-treated groups. Also, levels of short chain fatty acids were reduced in the faeces of antibiotic-treated rats. Consequently, aggravation of EAE, paralleled with stronger immune response in lymph nodes draining the site of immunization, and increased inflammation within the CNS, were observed in antibiotic-treated DA rats. Thus, the alteration of gut microbiota leads to an escalation of CNS-directed autoimmunity in DA rats. The results of this study indicate that antibiotic use in early life may have subsequent unfavourable effects on the regulation of the immune system.
T2  - Scientific Reports
T1  - Oral neonatal antibiotic treatment perturbs gut microbiota and aggravates central nervous system autoimmunity in Dark Agouti rats.
IS  - 1
VL  - 9
DO  - 10.1038/s41598-018-37505-7
SP  - 918
ER  - 

@article{
author = "Stanisavljević, Suzana and Čepić, Aleksa and Bojić, Svetlana and Veljović, Katarina and Mihajlović, Sanja and Nikolovski, Neda and Jevtić, Bojan and Momčilović, Miljana and Lazarević, Milica and Mostarica Stojković, Marija and Miljković, Đorđe and Golić, Nataša",
year = "2019",
abstract = "Gut microbiota dysbiosis has been considered the essential element in the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). Antibiotics were administered orally to Dark Agouti (DA) rats early in their life with the aim of perturbing gut microbiota and investigating the effects of such intervention on the course of EAE. As a result, the diversity of the gut microbiota was reduced under the influence of antibiotics. Mainly, Firmicutes and Actinobacteria were replaced by Proteobacteria and Bacteroidetes, while decreased proportions of Clostridia and Bacilli classes were accompanied by an increase in Gamma-Proteobacteria in antibiotic-treated animals. Interestingly, a notable decrease in the Helicobacteraceae, Spirochaetaceae and Turicibacteriaceae was scored in antibiotic-treated groups. Also, levels of short chain fatty acids were reduced in the faeces of antibiotic-treated rats. Consequently, aggravation of EAE, paralleled with stronger immune response in lymph nodes draining the site of immunization, and increased inflammation within the CNS, were observed in antibiotic-treated DA rats. Thus, the alteration of gut microbiota leads to an escalation of CNS-directed autoimmunity in DA rats. The results of this study indicate that antibiotic use in early life may have subsequent unfavourable effects on the regulation of the immune system.",
journal = "Scientific Reports",
title = "Oral neonatal antibiotic treatment perturbs gut microbiota and aggravates central nervous system autoimmunity in Dark Agouti rats.",
number = "1",
volume = "9",
doi = "10.1038/s41598-018-37505-7",
pages = "918"
}

Stanisavljević, S., Čepić, A., Bojić, S., Veljović, K., Mihajlović, S., Nikolovski, N., Jevtić, B., Momčilović, M., Lazarević, M., Mostarica Stojković, M., Miljković, Đ.,& Golić, N.. (2019). Oral neonatal antibiotic treatment perturbs gut microbiota and aggravates central nervous system autoimmunity in Dark Agouti rats.. in Scientific Reports, 9(1), 918.
https://doi.org/10.1038/s41598-018-37505-7

Stanisavljević S, Čepić A, Bojić S, Veljović K, Mihajlović S, Nikolovski N, Jevtić B, Momčilović M, Lazarević M, Mostarica Stojković M, Miljković Đ, Golić N. Oral neonatal antibiotic treatment perturbs gut microbiota and aggravates central nervous system autoimmunity in Dark Agouti rats.. in Scientific Reports. 2019;9(1):918.
doi:10.1038/s41598-018-37505-7 .

Stanisavljević, Suzana, Čepić, Aleksa, Bojić, Svetlana, Veljović, Katarina, Mihajlović, Sanja, Nikolovski, Neda, Jevtić, Bojan, Momčilović, Miljana, Lazarević, Milica, Mostarica Stojković, Marija, Miljković, Đorđe, Golić, Nataša, "Oral neonatal antibiotic treatment perturbs gut microbiota and aggravates central nervous system autoimmunity in Dark Agouti rats." in Scientific Reports, 9, no. 1 (2019):918,
https://doi.org/10.1038/s41598-018-37505-7 . .

TY  - CONF
AU  - Volarević, Vladislav
AU  - Paunović, Verica
AU  - Marković, Zoran
AU  - Marković-Simović, Bojana
AU  - Misirkić Marjanović, Maja
AU  - Todorović-Marković, Biljana
AU  - Bojić, Svetlana
AU  - Vučićević, Ljubica
AU  - Jovanović, Svetlana P
AU  - Arsenijević, Nebojša
AU  - Holclajtner-Antunović, Ivanka
AU  - Milosavljević, Momir
AU  - Dramičanin, Miroslav
AU  - Kravić-Stevović, Tamara
AU  - Ćirić, Darko
AU  - Lukić, Miodrag L.
AU  - Trajković, Vladimir
PY  - 2015
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6774
PB  - Amsterdam, Netherlands: Elsevier
C3  - Abstracts of The International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver; 2015 Apr 23-25;  Vienna, AustriaApr 22-26, 2015, Vienna, Austria
T1  - Graphene quantum dots attenuate Concanavalin A-induced hepatitis
DO  - 10.1016/S0168-8278(15)30665-6
SP  - S483
EP  - S484
ER  - 

@conference{
author = "Volarević, Vladislav and Paunović, Verica and Marković, Zoran and Marković-Simović, Bojana and Misirkić Marjanović, Maja and Todorović-Marković, Biljana and Bojić, Svetlana and Vučićević, Ljubica and Jovanović, Svetlana P and Arsenijević, Nebojša and Holclajtner-Antunović, Ivanka and Milosavljević, Momir and Dramičanin, Miroslav and Kravić-Stevović, Tamara and Ćirić, Darko and Lukić, Miodrag L. and Trajković, Vladimir",
year = "2015",
publisher = "Amsterdam, Netherlands: Elsevier",
journal = "Abstracts of The International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver; 2015 Apr 23-25;  Vienna, AustriaApr 22-26, 2015, Vienna, Austria",
title = "Graphene quantum dots attenuate Concanavalin A-induced hepatitis",
doi = "10.1016/S0168-8278(15)30665-6",
pages = "S483-S484"
}

Volarević, V., Paunović, V., Marković, Z., Marković-Simović, B., Misirkić Marjanović, M., Todorović-Marković, B., Bojić, S., Vučićević, L., Jovanović, S. P., Arsenijević, N., Holclajtner-Antunović, I., Milosavljević, M., Dramičanin, M., Kravić-Stevović, T., Ćirić, D., Lukić, M. L.,& Trajković, V.. (2015). Graphene quantum dots attenuate Concanavalin A-induced hepatitis. in Abstracts of The International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver; 2015 Apr 23-25;  Vienna, AustriaApr 22-26, 2015, Vienna, Austria
Amsterdam, Netherlands: Elsevier., S483-S484.
https://doi.org/10.1016/S0168-8278(15)30665-6

Volarević V, Paunović V, Marković Z, Marković-Simović B, Misirkić Marjanović M, Todorović-Marković B, Bojić S, Vučićević L, Jovanović SP, Arsenijević N, Holclajtner-Antunović I, Milosavljević M, Dramičanin M, Kravić-Stevović T, Ćirić D, Lukić ML, Trajković V. Graphene quantum dots attenuate Concanavalin A-induced hepatitis. in Abstracts of The International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver; 2015 Apr 23-25;  Vienna, AustriaApr 22-26, 2015, Vienna, Austria. 2015;:S483-S484.
doi:10.1016/S0168-8278(15)30665-6 .

Volarević, Vladislav, Paunović, Verica, Marković, Zoran, Marković-Simović, Bojana, Misirkić Marjanović, Maja, Todorović-Marković, Biljana, Bojić, Svetlana, Vučićević, Ljubica, Jovanović, Svetlana P, Arsenijević, Nebojša, Holclajtner-Antunović, Ivanka, Milosavljević, Momir, Dramičanin, Miroslav, Kravić-Stevović, Tamara, Ćirić, Darko, Lukić, Miodrag L., Trajković, Vladimir, "Graphene quantum dots attenuate Concanavalin A-induced hepatitis" in Abstracts of The International Liver Congress™ 2015 – 50th Annual meeting of the European Association for the Study of the Liver; 2015 Apr 23-25;  Vienna, AustriaApr 22-26, 2015, Vienna, Austria (2015):S483-S484,
https://doi.org/10.1016/S0168-8278(15)30665-6 . .