@conference{
author = "Korać, Jelena and Stanković, Dalibor and Bogdanović Pristov, Jelena and Nikolić, Ljiljana and Spasojević, Ivan",
year = "2018",
abstract = "Epinephrine ((R)-4-(1-hydroxy-2-(methylamino)ethyl)-benzene-1,2-diol (Epi) is
catecholamine that is released by the sympathetic nervous system and adrenal medulla. It
is a physiologically important molecule that acts as a hormone, neurotransmitter, and
medication with a broad range of effects 1-3 . Coordinate and redox interaction of Epi with
iron affects the interactions with other molecules and its biological effects 4
. In this study,
we reported details of redox interactions of Epi with Fe 2+ at pH 7.4, which correspond to
the pH value of human plasma Epi and Fe 2+ form a complex that acts as a strong reducing
agent. Cyclic voltammetry showed that the positions of E pa and E pc potentials were at
approximately -480 and -1100 mV. This implies that Epi and Fe 2+ build a complex with
unique redox properties. E1/2 was significantly lower compared to E0' for O 2 /O 2•- (-350
mV). It is important to point out this because superoxide radical anion is produced via
spontaneous Fe 2+ reaction with O 2. In other words, Epi-Fe 2+ complex should be capable of
reducing transition metals in (patho)physiologicaly relevant complexes that are not
susceptible to reduction by O 2. Our results confirmed that Epi-Fe
2+ is capable of reducing
the S-S group of glutathione disulfide. On the other hand, Epi acted in a catalyst-like
fashion to promote Fe 2+ oxidation by molecular oxygen, and to a facilitated formation of
the Epi–Fe 3+ complexes, at physiological pH. In addition, we examined the effects of
epinepfrine and Epi/Fe3+ system on glioma cells. Epinephrine alone evokes changes in the
membrane currents of glioma cells, but such effects were not observed for the complex
with Fe 3+
. This implies that Epi-Fe 3+ might modulate neural activity of Epi in CNS.",
publisher = "Belgrade : Faculty of Chemistry : Serbian Biochemical Society",
journal = "Proceedings: Serbian Biochemical Society Eigth Conference with international participation: Coordination in Biochemistry and Life; 2018 Nov 16; Novi Sad, Serbia",
title = "Redox interactions of epinephrine with iron at physiological pH",
pages = "141",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5517"
}