TY  - JOUR
AU  - Tomić, Mirko
AU  - Kundaković, Marija J.
AU  - Petrović, Silvana D.
PY  - 2005
PY  - 2005
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/178
AB  - Pharmaceutical preparations of valerian root and rhizome (Valeriana officinal is L., Valerianaceae) have widespread use for sedation and treatment of hysteric states, anxiety, stress and insomnia (Morazzoni and Bombardelli 1995; Houghton, 1999; Weiss and Fintelmann, 2000; Cropley et al., 2002). Pharmacological investigations of valerian were mostly concentrated on the components of the essential oil - valerenic acids, non-glycosidated iridoids named valepotriates and its degradative products - baldrinals, but also on several lignans.
T2  - Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
T1  - Farmakološki in vitro skrining centralnih monoaminoergičnih efekata ekstrakata Valeriana officinalis
T1  - Pharmacological in vitro screening of the central monoaminergic effects of Valeriana officinalis extracts
IS  - 2
VL  - 41
SP  - 87
EP  - 90
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_178
ER  - 

@article{
author = "Tomić, Mirko and Kundaković, Marija J. and Petrović, Silvana D.",
year = "2005, 2005",
abstract = "Pharmaceutical preparations of valerian root and rhizome (Valeriana officinal is L., Valerianaceae) have widespread use for sedation and treatment of hysteric states, anxiety, stress and insomnia (Morazzoni and Bombardelli 1995; Houghton, 1999; Weiss and Fintelmann, 2000; Cropley et al., 2002). Pharmacological investigations of valerian were mostly concentrated on the components of the essential oil - valerenic acids, non-glycosidated iridoids named valepotriates and its degradative products - baldrinals, but also on several lignans.",
journal = "Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta",
title = "Farmakološki in vitro skrining centralnih monoaminoergičnih efekata ekstrakata Valeriana officinalis, Pharmacological in vitro screening of the central monoaminergic effects of Valeriana officinalis extracts",
number = "2",
volume = "41",
pages = "87-90",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_178"
}

Tomić, M., Kundaković, M. J.,& Petrović, S. D.. (2005). Farmakološki in vitro skrining centralnih monoaminoergičnih efekata ekstrakata Valeriana officinalis. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 41(2), 87-90.
https://hdl.handle.net/21.15107/rcub_ibiss_178

Tomić M, Kundaković MJ, Petrović SD. Farmakološki in vitro skrining centralnih monoaminoergičnih efekata ekstrakata Valeriana officinalis. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta. 2005;41(2):87-90.
https://hdl.handle.net/21.15107/rcub_ibiss_178 .

Tomić, Mirko, Kundaković, Marija J., Petrović, Silvana D., "Farmakološki in vitro skrining centralnih monoaminoergičnih efekata ekstrakata Valeriana officinalis" in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 41, no. 2 (2005):87-90,
https://hdl.handle.net/21.15107/rcub_ibiss_178 .

TY  - JOUR
AU  - Tomić, Mirko
AU  - Kundaković, Marija
AU  - Butorović, Biljana
AU  - Petković, Branka
AU  - Andrić, Deana
AU  - Roglić, Goran
AU  - Ignjatović, Đurđica
AU  - Kostić-Rajačić, Slađana
PY  - 2004
UR  - https://www.sciencedirect.com/science/article/abs/pii/S0960894X04007462?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3805
AB  - Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and alpha(1) receptors. Two compounds with benztriazole group had a 5-HT2A/D-2 binding ratio characteristic for atypical neuroleptics (>1, pK(i) values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D-2, 5-HT2A and alpha1 receptors and a higher affinity for 5-HT1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats.
PB  - Pergamon-Elsevier Science Ltd
T2  - Bioorganic and Medicinal Chemistry Letters
T1  - Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential
IS  - 16
VL  - 14
DO  - 10.1016/j.bmcl.2004.06.005
SP  - 4263
EP  - 4266
ER  - 

@article{
author = "Tomić, Mirko and Kundaković, Marija and Butorović, Biljana and Petković, Branka and Andrić, Deana and Roglić, Goran and Ignjatović, Đurđica and Kostić-Rajačić, Slađana",
year = "2004",
abstract = "Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and alpha(1) receptors. Two compounds with benztriazole group had a 5-HT2A/D-2 binding ratio characteristic for atypical neuroleptics (>1, pK(i) values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D-2, 5-HT2A and alpha1 receptors and a higher affinity for 5-HT1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats.",
publisher = "Pergamon-Elsevier Science Ltd",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential",
number = "16",
volume = "14",
doi = "10.1016/j.bmcl.2004.06.005",
pages = "4263-4266"
}

Tomić, M., Kundaković, M., Butorović, B., Petković, B., Andrić, D., Roglić, G., Ignjatović, Đ.,& Kostić-Rajačić, S.. (2004). Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd., 14(16), 4263-4266.
https://doi.org/10.1016/j.bmcl.2004.06.005

Tomić M, Kundaković M, Butorović B, Petković B, Andrić D, Roglić G, Ignjatović Đ, Kostić-Rajačić S. Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters. 2004;14(16):4263-4266.
doi:10.1016/j.bmcl.2004.06.005 .

Tomić, Mirko, Kundaković, Marija, Butorović, Biljana, Petković, Branka, Andrić, Deana, Roglić, Goran, Ignjatović, Đurđica, Kostić-Rajačić, Slađana, "Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential" in Bioorganic and Medicinal Chemistry Letters, 14, no. 16 (2004):4263-4266,
https://doi.org/10.1016/j.bmcl.2004.06.005 . .