TY  - JOUR
AU  - Jelenković, Ankica V.
AU  - Jovanovic, Marina D.
AU  - Stevanovic, Ivana
AU  - Petronijevic, Natasa
AU  - Bokonjic, Dubravko
AU  - Zivkovic, Jelena
AU  - Igic, Rajko
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2306
AB  - Aluminium may have an important role in the
   aetiology/pathogenesis/precipitation of Alzheimer's disease. Because
   green tea (Camellia sinensis L.) reportedly has health-promoting effects
   in the central nervous system, we evaluated the effects of green tea
   leaf extract (GTLE) on aluminium chloride (AlCl3) neurotoxicity in rats.
   All solutions were injected into the cornu ammonis region 1 hippocampal
   region. We measured the performance of active avoidance (AA) tasks,
   various enzyme activities and total glutathione content (TGC) in the
   forebrain cortex (FbC), striatum, basal forebrain (BFb), hippocampus,
   brain stem and cerebellum. AlCl3 markedly reduced AA performance and
   activities of cytochrome c oxidase (COX) and acetylcholinesterase (AChE)
   in all regions. It decreased TGC in the FbC, striatum, BFb, hippocampus,
   brain stem and cerebellum, and increased superoxide dismutase activity
   in the FbC, cerebellum and BFb. GTLE pretreatment completely reversed
   the damaging effects of AlCl3 on AA and superoxide dismutase activity,
   markedly corrected COX and AChE activities, and moderately improved TGC.
   GTLE alone increased COX and AChE activities in almost all regions. GTLE
   reduces AlCl3 neurotoxicity probably via antioxidative effects and
   improves mitochondrial and cholinergic synaptic functions through the
   actions of (-)-epigallocatechin gallate and (-)-epicatechin, compounds
   most abundantly found in GTLE. Our results suggest that green tea might
   be beneficial in Alzheimer's disease. Copyright (c) 2013 John Wiley \&
   Sons, Ltd.
T2  - Phytotherapy Research
T1  - Influence of the Green Tea Leaf Extract on Neurotoxicity of Aluminium
 Chloride in Rats
IS  - 1
VL  - 28
DO  - 10.1002/ptr.4962
SP  - 82
EP  - 87
ER  - 

@article{
author = "Jelenković, Ankica V. and Jovanovic, Marina D. and Stevanovic, Ivana and Petronijevic, Natasa and Bokonjic, Dubravko and Zivkovic, Jelena and Igic, Rajko",
year = "2014",
abstract = "Aluminium may have an important role in the
   aetiology/pathogenesis/precipitation of Alzheimer's disease. Because
   green tea (Camellia sinensis L.) reportedly has health-promoting effects
   in the central nervous system, we evaluated the effects of green tea
   leaf extract (GTLE) on aluminium chloride (AlCl3) neurotoxicity in rats.
   All solutions were injected into the cornu ammonis region 1 hippocampal
   region. We measured the performance of active avoidance (AA) tasks,
   various enzyme activities and total glutathione content (TGC) in the
   forebrain cortex (FbC), striatum, basal forebrain (BFb), hippocampus,
   brain stem and cerebellum. AlCl3 markedly reduced AA performance and
   activities of cytochrome c oxidase (COX) and acetylcholinesterase (AChE)
   in all regions. It decreased TGC in the FbC, striatum, BFb, hippocampus,
   brain stem and cerebellum, and increased superoxide dismutase activity
   in the FbC, cerebellum and BFb. GTLE pretreatment completely reversed
   the damaging effects of AlCl3 on AA and superoxide dismutase activity,
   markedly corrected COX and AChE activities, and moderately improved TGC.
   GTLE alone increased COX and AChE activities in almost all regions. GTLE
   reduces AlCl3 neurotoxicity probably via antioxidative effects and
   improves mitochondrial and cholinergic synaptic functions through the
   actions of (-)-epigallocatechin gallate and (-)-epicatechin, compounds
   most abundantly found in GTLE. Our results suggest that green tea might
   be beneficial in Alzheimer's disease. Copyright (c) 2013 John Wiley \&
   Sons, Ltd.",
journal = "Phytotherapy Research",
title = "Influence of the Green Tea Leaf Extract on Neurotoxicity of Aluminium
 Chloride in Rats",
number = "1",
volume = "28",
doi = "10.1002/ptr.4962",
pages = "82-87"
}

Jelenković, A. V., Jovanovic, M. D., Stevanovic, I., Petronijevic, N., Bokonjic, D., Zivkovic, J.,& Igic, R.. (2014). Influence of the Green Tea Leaf Extract on Neurotoxicity of Aluminium
 Chloride in Rats. in Phytotherapy Research, 28(1), 82-87.
https://doi.org/10.1002/ptr.4962

Jelenković AV, Jovanovic MD, Stevanovic I, Petronijevic N, Bokonjic D, Zivkovic J, Igic R. Influence of the Green Tea Leaf Extract on Neurotoxicity of Aluminium
 Chloride in Rats. in Phytotherapy Research. 2014;28(1):82-87.
doi:10.1002/ptr.4962 .

Jelenković, Ankica V., Jovanovic, Marina D., Stevanovic, Ivana, Petronijevic, Natasa, Bokonjic, Dubravko, Zivkovic, Jelena, Igic, Rajko, "Influence of the Green Tea Leaf Extract on Neurotoxicity of Aluminium
 Chloride in Rats" in Phytotherapy Research, 28, no. 1 (2014):82-87,
https://doi.org/10.1002/ptr.4962 . .