TY  - JOUR
AU  - Dejanovic, Bratislav
AU  - Stevanovic, Ivana
AU  - Ninkovic, Milica
AU  - Stojanovic, Ivana
AU  - Lavrnja, Irena
AU  - Radicevic, Tatjana
AU  - Pavlovic, Milos
PY  - 2016
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1986
AB  - This study was conducted to investigate whether agmatine (AGM) provides
   protection against oxidative stress induced by treatment with
   chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive
   oxygen species and efficiency of antioxidant protection in the brain
   homogenates of forebrain cortexes prepared 48 h after treatment were
   investigated. Chlorpromazine was applied intraperitoneally (i.p.) in
   single dose of 38.7 mg/kg body weight (BW) The second group was treated
   with both CPZ and AGM (75 mg/kg BW). The control group was treated with
   0.9\% saline solution in the same manner. All tested compounds were
   administered i.p. in a single dose. Rats were sacrificed by decapitation
   48 h after treatment Treatment with AGM significantly attenuated the
   oxidative stress parameters and restored antioxidant capacity in the
   forebrain cortex. The data indicated that i.p. administered AGM exerted
   antioxidant action in CPZ-treated animals. Moreover, reactive astrocytes
   and microglia may contribute to secondary nerve-cell damage and
   participate in the balance of destructive vs. protective actions
   involved in the pathogenesis after poisoning.
T2  - Journal of Veterinary Science
T1  - Agmatine protection against chlorpromazine-induced forebrain cortex
 injury in rats
IS  - 1
VL  - 17
DO  - 10.4142/jvs.2016.17.1.53
SP  - 53
EP  - 61
ER  - 

@article{
author = "Dejanovic, Bratislav and Stevanovic, Ivana and Ninkovic, Milica and Stojanovic, Ivana and Lavrnja, Irena and Radicevic, Tatjana and Pavlovic, Milos",
year = "2016",
abstract = "This study was conducted to investigate whether agmatine (AGM) provides
   protection against oxidative stress induced by treatment with
   chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive
   oxygen species and efficiency of antioxidant protection in the brain
   homogenates of forebrain cortexes prepared 48 h after treatment were
   investigated. Chlorpromazine was applied intraperitoneally (i.p.) in
   single dose of 38.7 mg/kg body weight (BW) The second group was treated
   with both CPZ and AGM (75 mg/kg BW). The control group was treated with
   0.9\% saline solution in the same manner. All tested compounds were
   administered i.p. in a single dose. Rats were sacrificed by decapitation
   48 h after treatment Treatment with AGM significantly attenuated the
   oxidative stress parameters and restored antioxidant capacity in the
   forebrain cortex. The data indicated that i.p. administered AGM exerted
   antioxidant action in CPZ-treated animals. Moreover, reactive astrocytes
   and microglia may contribute to secondary nerve-cell damage and
   participate in the balance of destructive vs. protective actions
   involved in the pathogenesis after poisoning.",
journal = "Journal of Veterinary Science",
title = "Agmatine protection against chlorpromazine-induced forebrain cortex
 injury in rats",
number = "1",
volume = "17",
doi = "10.4142/jvs.2016.17.1.53",
pages = "53-61"
}

Dejanovic, B., Stevanovic, I., Ninkovic, M., Stojanovic, I., Lavrnja, I., Radicevic, T.,& Pavlovic, M.. (2016). Agmatine protection against chlorpromazine-induced forebrain cortex
 injury in rats. in Journal of Veterinary Science, 17(1), 53-61.
https://doi.org/10.4142/jvs.2016.17.1.53

Dejanovic B, Stevanovic I, Ninkovic M, Stojanovic I, Lavrnja I, Radicevic T, Pavlovic M. Agmatine protection against chlorpromazine-induced forebrain cortex
 injury in rats. in Journal of Veterinary Science. 2016;17(1):53-61.
doi:10.4142/jvs.2016.17.1.53 .

Dejanovic, Bratislav, Stevanovic, Ivana, Ninkovic, Milica, Stojanovic, Ivana, Lavrnja, Irena, Radicevic, Tatjana, Pavlovic, Milos, "Agmatine protection against chlorpromazine-induced forebrain cortex
 injury in rats" in Journal of Veterinary Science, 17, no. 1 (2016):53-61,
https://doi.org/10.4142/jvs.2016.17.1.53 . .