TY  - JOUR
AU  - Sinan, Kouadio Ibrahime
AU  - Aktumsek, Abdurrahman
AU  - Cádiz-Gurrea, María de la Luz
AU  - Leyva-Jiménez, Francisco Javier
AU  - Fernández-Ochoa, Álvaro
AU  - Segura-Carretero, Antonio
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Nenadic, Marija
AU  - Zengin, Gokhan
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4295
AB  - The article reports the chemical composition, antioxidant, six key enzymes inhibitory and antimicrobial
activities of two solvent extracts (water and methanol) of leaves and stem bark of Uapaca togoensis. For chemical composition, methanol extract of stem bark exhibited significant higher total phenolic (129.86 mg GAE/g) and flavanol (10.44 mg CE/g) contents. Methanol extract of leaves and water extract of stem bark showed high flavonoids (20.94 mg RE/g) and phenolic acid (90.40 mg CAE/g) content, respectively. In addition, HPLC-ESI-TOFMS analysis revealed that U. togoensis was rich in procyanidins. The methanol and water extracts of stem bark had overall superior antioxidant activity; however, only methanol extract of stem bark showed higher inhibition of cholinesterase (AChE: 2.57 mg GALAE/g; BChE: 4.69 mg GALAE/g), tyrosinase (69.53 mg KAE/g) and elastase (2.73 mmol CE/g). Potent metal chelating ability was showed by water extract of leaves (18.94 mg EDTAE/g), higher inhibition of amylase was detected for water extracts of leaves (0.94 mmol ACAE/g) and stem bark (0.92 mmol ACAE/g). The tested extracts have shown wide-spectrum antibacterial properties and these effects have shown to be more effective against Aspergillus ochraceus, Penicillium funiculosum, Trichoderma viride, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. The results revealed that the antioxidant, enzyme inhibitory and antimicrobial activities depended on the extraction solvents and the parts of plant. Bioinformatics analysis on the 17 major compounds showed modulation of pathway associated with cancer. In brief, U. togoensis might be valuable as potential source of natural agents for therapeutic application.
PB  - Zurich, Switzerland: Wiley-VHCA AG
T2  - Chemistry &  Biodiversity
T1  - A Prospective of Multiple Biopharmaceutical Activities of Procyanidins-Rich Uapaca togoensis Pax Extracts: HPLC-ESI-TOF-MS Coupled with Bioinformatics Analysis
IS  - 8
VL  - 18
DO  - 10.1002/cbdv.202100299
SP  - e2100299
ER  - 

@article{
author = "Sinan, Kouadio Ibrahime and Aktumsek, Abdurrahman and Cádiz-Gurrea, María de la Luz and Leyva-Jiménez, Francisco Javier and Fernández-Ochoa, Álvaro and Segura-Carretero, Antonio and Glamočlija, Jasmina and Soković, Marina and Nenadic, Marija and Zengin, Gokhan",
year = "2021",
abstract = "The article reports the chemical composition, antioxidant, six key enzymes inhibitory and antimicrobial
activities of two solvent extracts (water and methanol) of leaves and stem bark of Uapaca togoensis. For chemical composition, methanol extract of stem bark exhibited significant higher total phenolic (129.86 mg GAE/g) and flavanol (10.44 mg CE/g) contents. Methanol extract of leaves and water extract of stem bark showed high flavonoids (20.94 mg RE/g) and phenolic acid (90.40 mg CAE/g) content, respectively. In addition, HPLC-ESI-TOFMS analysis revealed that U. togoensis was rich in procyanidins. The methanol and water extracts of stem bark had overall superior antioxidant activity; however, only methanol extract of stem bark showed higher inhibition of cholinesterase (AChE: 2.57 mg GALAE/g; BChE: 4.69 mg GALAE/g), tyrosinase (69.53 mg KAE/g) and elastase (2.73 mmol CE/g). Potent metal chelating ability was showed by water extract of leaves (18.94 mg EDTAE/g), higher inhibition of amylase was detected for water extracts of leaves (0.94 mmol ACAE/g) and stem bark (0.92 mmol ACAE/g). The tested extracts have shown wide-spectrum antibacterial properties and these effects have shown to be more effective against Aspergillus ochraceus, Penicillium funiculosum, Trichoderma viride, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. The results revealed that the antioxidant, enzyme inhibitory and antimicrobial activities depended on the extraction solvents and the parts of plant. Bioinformatics analysis on the 17 major compounds showed modulation of pathway associated with cancer. In brief, U. togoensis might be valuable as potential source of natural agents for therapeutic application.",
publisher = "Zurich, Switzerland: Wiley-VHCA AG",
journal = "Chemistry &  Biodiversity",
title = "A Prospective of Multiple Biopharmaceutical Activities of Procyanidins-Rich Uapaca togoensis Pax Extracts: HPLC-ESI-TOF-MS Coupled with Bioinformatics Analysis",
number = "8",
volume = "18",
doi = "10.1002/cbdv.202100299",
pages = "e2100299"
}

Sinan, K. I., Aktumsek, A., Cádiz-Gurrea, M. d. l. L., Leyva-Jiménez, F. J., Fernández-Ochoa, Á., Segura-Carretero, A., Glamočlija, J., Soković, M., Nenadic, M.,& Zengin, G.. (2021). A Prospective of Multiple Biopharmaceutical Activities of Procyanidins-Rich Uapaca togoensis Pax Extracts: HPLC-ESI-TOF-MS Coupled with Bioinformatics Analysis. in Chemistry &  Biodiversity
Zurich, Switzerland: Wiley-VHCA AG., 18(8), e2100299.
https://doi.org/10.1002/cbdv.202100299

Sinan KI, Aktumsek A, Cádiz-Gurrea MDLL, Leyva-Jiménez FJ, Fernández-Ochoa Á, Segura-Carretero A, Glamočlija J, Soković M, Nenadic M, Zengin G. A Prospective of Multiple Biopharmaceutical Activities of Procyanidins-Rich Uapaca togoensis Pax Extracts: HPLC-ESI-TOF-MS Coupled with Bioinformatics Analysis. in Chemistry &  Biodiversity. 2021;18(8):e2100299.
doi:10.1002/cbdv.202100299 .

Sinan, Kouadio Ibrahime, Aktumsek, Abdurrahman, Cádiz-Gurrea, María de la Luz, Leyva-Jiménez, Francisco Javier, Fernández-Ochoa, Álvaro, Segura-Carretero, Antonio, Glamočlija, Jasmina, Soković, Marina, Nenadic, Marija, Zengin, Gokhan, "A Prospective of Multiple Biopharmaceutical Activities of Procyanidins-Rich Uapaca togoensis Pax Extracts: HPLC-ESI-TOF-MS Coupled with Bioinformatics Analysis" in Chemistry &  Biodiversity, 18, no. 8 (2021):e2100299,
https://doi.org/10.1002/cbdv.202100299 . .