TY  - JOUR
AU  - Culita, Daniela C.
AU  - Dyakova, Lora
AU  - Marinescu, Gabriela
AU  - Zhivkova, Tanya
AU  - Georgieva, Milena
AU  - Vasileva, Bela
AU  - Spasov, Rossen
AU  - Miloshev, George
AU  - Kalfin, Reni
AU  - Vidaković, Melita
AU  - Oprea, Ovidiu
AU  - Alexandrova, Radostina
PY  - 2021
UR  - https://farmaciajournal.com/issue-articles/synthesis-characterization-and-cytotoxicity-evaluation-of-niii-cuii-and-znii-complexes-with-deoxycholate-ligand/
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4446
AB  - Three new complexes of Ni(II), Cu(II) and Zn(II) with deoxycholate anion, of the type M(DCA)2 · nH2O (M = Cu(II) n = 4, M = Ni(II) n = 3 and M = Zn(II) n = 2) have been synthesized and characterized on the basis of elemental analysis, FTIR and UV-Vis spectroscopy, thermal analysis, molar conductivity and magnetic measurements. The cytotoxicity of the synthesized complexes was tested against HT29 human colorectal cancer cells. Applied at a concentration range of 10-200 µg/mL, sodium deoxycholate and its metal complexes have been found to decrease viability and growth of cultured HT29 cells in a time-and concentration-dependent manner in short-term and long-term experiments. The ability of the complexes to induce pathological changes, genotoxicity and apoptosis in the treated cells has also been proved. In addition, the complexes demonstrated a cytotoxic effect in HT29-OxPt (resistant to oxaliplatin) cells, allowing to conclude that they are more pronounced cytotoxic agents as compared to the sodium deoxycholate alone.
PB  - Bucuresti: Romanian Society for Pharmaceutical Sciences
T2  - Farmacia
T1  - Synthesis, characterization and cytotoxicity evaluation of ni(Ii), cu(ii) and zn(ii) complexes with deoxycholate ligand
IS  - 3
VL  - 69
DO  - 10.31925/farmacia.2021.3.7
SP  - 446
EP  - 460
ER  - 

@article{
author = "Culita, Daniela C. and Dyakova, Lora and Marinescu, Gabriela and Zhivkova, Tanya and Georgieva, Milena and Vasileva, Bela and Spasov, Rossen and Miloshev, George and Kalfin, Reni and Vidaković, Melita and Oprea, Ovidiu and Alexandrova, Radostina",
year = "2021",
abstract = "Three new complexes of Ni(II), Cu(II) and Zn(II) with deoxycholate anion, of the type M(DCA)2 · nH2O (M = Cu(II) n = 4, M = Ni(II) n = 3 and M = Zn(II) n = 2) have been synthesized and characterized on the basis of elemental analysis, FTIR and UV-Vis spectroscopy, thermal analysis, molar conductivity and magnetic measurements. The cytotoxicity of the synthesized complexes was tested against HT29 human colorectal cancer cells. Applied at a concentration range of 10-200 µg/mL, sodium deoxycholate and its metal complexes have been found to decrease viability and growth of cultured HT29 cells in a time-and concentration-dependent manner in short-term and long-term experiments. The ability of the complexes to induce pathological changes, genotoxicity and apoptosis in the treated cells has also been proved. In addition, the complexes demonstrated a cytotoxic effect in HT29-OxPt (resistant to oxaliplatin) cells, allowing to conclude that they are more pronounced cytotoxic agents as compared to the sodium deoxycholate alone.",
publisher = "Bucuresti: Romanian Society for Pharmaceutical Sciences",
journal = "Farmacia",
title = "Synthesis, characterization and cytotoxicity evaluation of ni(Ii), cu(ii) and zn(ii) complexes with deoxycholate ligand",
number = "3",
volume = "69",
doi = "10.31925/farmacia.2021.3.7",
pages = "446-460"
}

Culita, D. C., Dyakova, L., Marinescu, G., Zhivkova, T., Georgieva, M., Vasileva, B., Spasov, R., Miloshev, G., Kalfin, R., Vidaković, M., Oprea, O.,& Alexandrova, R.. (2021). Synthesis, characterization and cytotoxicity evaluation of ni(Ii), cu(ii) and zn(ii) complexes with deoxycholate ligand. in Farmacia
Bucuresti: Romanian Society for Pharmaceutical Sciences., 69(3), 446-460.
https://doi.org/10.31925/farmacia.2021.3.7

Culita DC, Dyakova L, Marinescu G, Zhivkova T, Georgieva M, Vasileva B, Spasov R, Miloshev G, Kalfin R, Vidaković M, Oprea O, Alexandrova R. Synthesis, characterization and cytotoxicity evaluation of ni(Ii), cu(ii) and zn(ii) complexes with deoxycholate ligand. in Farmacia. 2021;69(3):446-460.
doi:10.31925/farmacia.2021.3.7 .

Culita, Daniela C., Dyakova, Lora, Marinescu, Gabriela, Zhivkova, Tanya, Georgieva, Milena, Vasileva, Bela, Spasov, Rossen, Miloshev, George, Kalfin, Reni, Vidaković, Melita, Oprea, Ovidiu, Alexandrova, Radostina, "Synthesis, characterization and cytotoxicity evaluation of ni(Ii), cu(ii) and zn(ii) complexes with deoxycholate ligand" in Farmacia, 69, no. 3 (2021):446-460,
https://doi.org/10.31925/farmacia.2021.3.7 . .