TY  - JOUR
AU  - Krstić, Gordana
AU  - Stepanović, Ana
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Novaković, Miroslav
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
PY  - 2021
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4752
AB  - In the previous study fifteen jatrophane diterpenes were isolated from the Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The aim of this study was to determine whether and which jatro­phane diterpenes can be isolated from the root of the plant, and then to examine their inhibition power on P-glycoprotein of selected cancer cell lines (NCI-H460, DLD1, U87, NCI-H460/R, DLD1-TxR and U87-TxR). Two previously undes­cribed jatrophane diterpenes were isolated from the root of E. nicaeensis col­lected in Deliblato Sand (Serbia). The structures of the isolated compounds were determined using 1D and 2D NMR, as well as HRESIMS data. The results obtained by MTT assay showed different antitumor potential of these two jatrophanes. Compound 1 inhibited cell growth of non-small cell lung car­cinoma cell lines NCI-H460 and NCI-H460/R, as well as glioblastoma cell lines U87 and U87-TxR, while jatrophane 2 was almost completely inactive in the suppression of cancer cell growth in a given range of concentrations. The obtained results also showed that the isolated compounds have an inhibitory effect on P-glycoprotein, as well as that their inhibitory potential is similar.
PB  - Belgrade : Serbian Chemical Society
T2  - The Journal of the Serbian Chemical Society
T1  - Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis
IS  - 12
VL  - 86
DO  - 10.2298/JSC210806085K
SP  - 1219
EP  - 1228
ER  - 

@article{
author = "Krstić, Gordana and Stepanović, Ana and Jadranin, Milka and Pešić, Milica and Novaković, Miroslav and Aljančić, Ivana and Vajs, Vlatka",
year = "2021",
abstract = "In the previous study fifteen jatrophane diterpenes were isolated from the Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The aim of this study was to determine whether and which jatro­phane diterpenes can be isolated from the root of the plant, and then to examine their inhibition power on P-glycoprotein of selected cancer cell lines (NCI-H460, DLD1, U87, NCI-H460/R, DLD1-TxR and U87-TxR). Two previously undes­cribed jatrophane diterpenes were isolated from the root of E. nicaeensis col­lected in Deliblato Sand (Serbia). The structures of the isolated compounds were determined using 1D and 2D NMR, as well as HRESIMS data. The results obtained by MTT assay showed different antitumor potential of these two jatrophanes. Compound 1 inhibited cell growth of non-small cell lung car­cinoma cell lines NCI-H460 and NCI-H460/R, as well as glioblastoma cell lines U87 and U87-TxR, while jatrophane 2 was almost completely inactive in the suppression of cancer cell growth in a given range of concentrations. The obtained results also showed that the isolated compounds have an inhibitory effect on P-glycoprotein, as well as that their inhibitory potential is similar.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "The Journal of the Serbian Chemical Society",
title = "Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis",
number = "12",
volume = "86",
doi = "10.2298/JSC210806085K",
pages = "1219-1228"
}

Krstić, G., Stepanović, A., Jadranin, M., Pešić, M., Novaković, M., Aljančić, I.,& Vajs, V.. (2021). Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis. in The Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 86(12), 1219-1228.
https://doi.org/10.2298/JSC210806085K

Krstić G, Stepanović A, Jadranin M, Pešić M, Novaković M, Aljančić I, Vajs V. Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis. in The Journal of the Serbian Chemical Society. 2021;86(12):1219-1228.
doi:10.2298/JSC210806085K .

Krstić, Gordana, Stepanović, Ana, Jadranin, Milka, Pešić, Milica, Novaković, Miroslav, Aljančić, Ivana, Vajs, Vlatka, "Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis" in The Journal of the Serbian Chemical Society, 86, no. 12 (2021):1219-1228,
https://doi.org/10.2298/JSC210806085K . .

TY  - JOUR
AU  - Dinić, Jelena
AU  - Novaković, Miroslav
AU  - Podolski-Renić, Ana
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Isaković, Aleksandra
AU  - Pešić, Milica
PY  - 2016
UR  - https://www.sciencedirect.com/science/article/pii/S0009279716300552
UR  - https://radar.ibiss.bg.ac.rs/123456789/3876
AB  - Diarylheptanoids represent a group of plant secondary metabolites that possess multiple biological properties and are increasingly recognized for their therapeutic potential. A comparative study was performed on structurally analogous diarylheptanoids isolated from the bark of green (Alnus viridis) and black alder (Alnus glutinosa) to address their biological effects and determine structure-activity relationship. The structures and configurations of all compounds were elucidated by NMR, HR-ESI-MS, UV and IR. Diarylheptanoids actions were studied in human non-small cell lung carcinoma cells (NCI-H460) and normal keratinocytes (HaCaT). A. viridis compounds 3v, 5v, 8v and 9v that possess a carbonyl group at C-3 were considerably more potent than compounds without this group. A. viridis/A. glutinosa analogue pairs, 5v/5g and 9v/9g, which differ in the presence of 3' and 3″-OH groups, were evaluated for anticancer activity and selectivity. 5v and 9v that do not possess 3' and 3″-OH groups showed significantly higher cytotoxicity compared to analogues 5g and 9g. In addition, these two A. viridis compounds induced a more prominent apoptosis in both cell lines and an increase in subG0 cell cycle phase, compared to their A. glutinosa analogues. 5v and 9v treatment triggered intracellular superoxide anion accumulation and notably decreased mitochondrial transmembrane potential. In HaCaT cells, 9v and 9g with a 4,5 double bond caused a more prominent loss of mitochondrial transmembrane potential compared to 5v and 5g which possess a 5-methoxy group instead. Although green alder diarylheptanoids 5v and 9v displayed higher cytotoxicity, their analogues from black alder 5g and 9g could be more favorable for therapeutic use since they were more active in cancer cells than in normal keratinocytes. These results indicate that minor differences in the chemical structure can greatly influence the effect of diarylheptanoids on apoptosis and redox status and determine their selectivity towards cancer cells.
PB  - Shannon : Elsevier
T2  - Chemico-Biological Interactions
T1  - Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells
VL  - 249
DO  - 10.1016/j.cbi.2016.02.019
SP  - 36
EP  - 45
ER  - 

@article{
author = "Dinić, Jelena and Novaković, Miroslav and Podolski-Renić, Ana and Vajs, Vlatka and Tešević, Vele and Isaković, Aleksandra and Pešić, Milica",
year = "2016",
abstract = "Diarylheptanoids represent a group of plant secondary metabolites that possess multiple biological properties and are increasingly recognized for their therapeutic potential. A comparative study was performed on structurally analogous diarylheptanoids isolated from the bark of green (Alnus viridis) and black alder (Alnus glutinosa) to address their biological effects and determine structure-activity relationship. The structures and configurations of all compounds were elucidated by NMR, HR-ESI-MS, UV and IR. Diarylheptanoids actions were studied in human non-small cell lung carcinoma cells (NCI-H460) and normal keratinocytes (HaCaT). A. viridis compounds 3v, 5v, 8v and 9v that possess a carbonyl group at C-3 were considerably more potent than compounds without this group. A. viridis/A. glutinosa analogue pairs, 5v/5g and 9v/9g, which differ in the presence of 3' and 3″-OH groups, were evaluated for anticancer activity and selectivity. 5v and 9v that do not possess 3' and 3″-OH groups showed significantly higher cytotoxicity compared to analogues 5g and 9g. In addition, these two A. viridis compounds induced a more prominent apoptosis in both cell lines and an increase in subG0 cell cycle phase, compared to their A. glutinosa analogues. 5v and 9v treatment triggered intracellular superoxide anion accumulation and notably decreased mitochondrial transmembrane potential. In HaCaT cells, 9v and 9g with a 4,5 double bond caused a more prominent loss of mitochondrial transmembrane potential compared to 5v and 5g which possess a 5-methoxy group instead. Although green alder diarylheptanoids 5v and 9v displayed higher cytotoxicity, their analogues from black alder 5g and 9g could be more favorable for therapeutic use since they were more active in cancer cells than in normal keratinocytes. These results indicate that minor differences in the chemical structure can greatly influence the effect of diarylheptanoids on apoptosis and redox status and determine their selectivity towards cancer cells.",
publisher = "Shannon : Elsevier",
journal = "Chemico-Biological Interactions",
title = "Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells",
volume = "249",
doi = "10.1016/j.cbi.2016.02.019",
pages = "36-45"
}

Dinić, J., Novaković, M., Podolski-Renić, A., Vajs, V., Tešević, V., Isaković, A.,& Pešić, M.. (2016). Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells. in Chemico-Biological Interactions
Shannon : Elsevier., 249, 36-45.
https://doi.org/10.1016/j.cbi.2016.02.019

Dinić J, Novaković M, Podolski-Renić A, Vajs V, Tešević V, Isaković A, Pešić M. Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells. in Chemico-Biological Interactions. 2016;249:36-45.
doi:10.1016/j.cbi.2016.02.019 .

Dinić, Jelena, Novaković, Miroslav, Podolski-Renić, Ana, Vajs, Vlatka, Tešević, Vele, Isaković, Aleksandra, Pešić, Milica, "Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells" in Chemico-Biological Interactions, 249 (2016):36-45,
https://doi.org/10.1016/j.cbi.2016.02.019 . .

TY  - JOUR
AU  - Dinić, Jelena
AU  - Novaković, Miroslav
AU  - Podolski-Renić, Ana
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Isaković, Aleksandra
AU  - Pešić, Milica
PY  - 2016
UR  - http://www.scopus.com/inward/record.url?eid=2-s2.0-84960351174&partnerID=tZOtx3y1
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2535
AB  - Diarylheptanoids represent a group of plant secondary metabolites that possess multiple biological properties and are increasingly recognized for their therapeutic potential. A comparative study was performed on structurally analogous diarylheptanoids isolated from the bark of green (Alnus viridis) and black alder (Alnus glutinosa) to address their biological effects and determine structure-activity relationship. The structures and configurations of all compounds were elucidated by NMR, HR-ESI-MS, UV and IR. Diarylheptanoids actions were studied in human non-small cell lung carcinoma cells (NCI-H460) and normal keratinocytes (HaCaT). A. viridis compounds 3v, 5v, 8v and 9v that possess a carbonyl group at C-3 were considerably more potent than compounds without this group. A. viridis/A. glutinosa analogue pairs, 5v/5g and 9v/9g, which differ in the presence of 3' and 3″-OH groups, were evaluated for anticancer activity and selectivity. 5v and 9v that do not possess 3' and 3″-OH groups showed significantly higher cytotoxicity compared to analogues 5g and 9g. In addition, these two A. viridis compounds induced a more prominent apoptosis in both cell lines and an increase in subG0 cell cycle phase, compared to their A. glutinosa analogues. 5v and 9v treatment triggered intracellular superoxide anion accumulation and notably decreased mitochondrial transmembrane potential. In HaCaT cells, 9v and 9g with a 4,5 double bond caused a more prominent loss of mitochondrial transmembrane potential compared to 5v and 5g which possess a 5-methoxy group instead. Although green alder diarylheptanoids 5v and 9v displayed higher cytotoxicity, their analogues from black alder 5g and 9g could be more favorable for therapeutic use since they were more active in cancer cells than in normal keratinocytes. These results indicate that minor differences in the chemical structure can greatly influence the effect of diarylheptanoids on apoptosis and redox status and determine their selectivity towards cancer cells.
T2  - Chemico-Biological Interactions
T1  - Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells.
VL  - 249
DO  - 10.1016/j.cbi.2016.02.019
SP  - 36
EP  - 45
ER  - 

@article{
author = "Dinić, Jelena and Novaković, Miroslav and Podolski-Renić, Ana and Vajs, Vlatka and Tešević, Vele and Isaković, Aleksandra and Pešić, Milica",
year = "2016",
abstract = "Diarylheptanoids represent a group of plant secondary metabolites that possess multiple biological properties and are increasingly recognized for their therapeutic potential. A comparative study was performed on structurally analogous diarylheptanoids isolated from the bark of green (Alnus viridis) and black alder (Alnus glutinosa) to address their biological effects and determine structure-activity relationship. The structures and configurations of all compounds were elucidated by NMR, HR-ESI-MS, UV and IR. Diarylheptanoids actions were studied in human non-small cell lung carcinoma cells (NCI-H460) and normal keratinocytes (HaCaT). A. viridis compounds 3v, 5v, 8v and 9v that possess a carbonyl group at C-3 were considerably more potent than compounds without this group. A. viridis/A. glutinosa analogue pairs, 5v/5g and 9v/9g, which differ in the presence of 3' and 3″-OH groups, were evaluated for anticancer activity and selectivity. 5v and 9v that do not possess 3' and 3″-OH groups showed significantly higher cytotoxicity compared to analogues 5g and 9g. In addition, these two A. viridis compounds induced a more prominent apoptosis in both cell lines and an increase in subG0 cell cycle phase, compared to their A. glutinosa analogues. 5v and 9v treatment triggered intracellular superoxide anion accumulation and notably decreased mitochondrial transmembrane potential. In HaCaT cells, 9v and 9g with a 4,5 double bond caused a more prominent loss of mitochondrial transmembrane potential compared to 5v and 5g which possess a 5-methoxy group instead. Although green alder diarylheptanoids 5v and 9v displayed higher cytotoxicity, their analogues from black alder 5g and 9g could be more favorable for therapeutic use since they were more active in cancer cells than in normal keratinocytes. These results indicate that minor differences in the chemical structure can greatly influence the effect of diarylheptanoids on apoptosis and redox status and determine their selectivity towards cancer cells.",
journal = "Chemico-Biological Interactions",
title = "Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells.",
volume = "249",
doi = "10.1016/j.cbi.2016.02.019",
pages = "36-45"
}

Dinić, J., Novaković, M., Podolski-Renić, A., Vajs, V., Tešević, V., Isaković, A.,& Pešić, M.. (2016). Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells.. in Chemico-Biological Interactions, 249, 36-45.
https://doi.org/10.1016/j.cbi.2016.02.019

Dinić J, Novaković M, Podolski-Renić A, Vajs V, Tešević V, Isaković A, Pešić M. Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells.. in Chemico-Biological Interactions. 2016;249:36-45.
doi:10.1016/j.cbi.2016.02.019 .

Dinić, Jelena, Novaković, Miroslav, Podolski-Renić, Ana, Vajs, Vlatka, Tešević, Vele, Isaković, Aleksandra, Pešić, Milica, "Structural differences in diarylheptanoids analogues from Alnus viridis and Alnus glutinosa influence their activity and selectivity towards cancer cells." in Chemico-Biological Interactions, 249 (2016):36-45,
https://doi.org/10.1016/j.cbi.2016.02.019 . .

TY  - JOUR
AU  - Pavković-Lučić, Sofija
AU  - Todosijević, Marina
AU  - Savić, Tatjana
AU  - Vajs, Vlatka
AU  - Trajković, Jelena
AU  - Anđelković, Boban
AU  - Lučić, Luka
AU  - Krstić, Gordana
AU  - Makarov, Slobodan
AU  - Tomić, Vladimir
AU  - Miličić, Dragana
AU  - Vujisić, Ljubodrag
PY  - 2016
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3545
AB  - Cuticular hydrocarbons (CHCs) in Drosophila melanogaster represent the basis of chemical communication being involved in
many important biological functions. The aim of this study was to characterize chemical composition and variation of cuticular
profiles in five D. melanogaster strains. These strains were reared for approximately 300 generations on five diets: standard
cornmeal medium and substrates prepared with apple, banana, tomato, and carrot. Differences in quantity and/or quality in
CHCs were assumed as a result of activation of different metabolic pathways involved in food digestion and adaptations to the
particular diet type.
In total, independently of sex and strain, 66 chemical compounds were identified. In females of all strains, 60 compounds were
identified, while, in males, 47 compounds were extracted. Certain new chemical compounds for D. melanogaster were found.
MANOVA confirmed that CHC amounts significantly depend on sex and substrates, as well as on their interactions. Discriminant
analysis revealed that flies belonging to ÐappleÏ and ÐcarrotÏ strains exhibited the most noticeable differences in CHC repertoires.
A non-hydrocarbon pheromone, cis-vaccenyl acetate (cVA) also contributed to the variation in the pheromone bouquet among
the strains. Variability detected in CHCs and cVAmay be used in the explanation of differences in mating behaviour previously
determined in analyzed fly strains.
PB  - Verlag Helvetica Chimica Acta AG, Zürich
T2  - Chemistry & Biodiversity
T1  - "Does my Diet Affect my Perfume?" Identification and Quantification of Cuticular Compounds in Five Drosophila melanogaster Strains Maintained over 300 Generations on Different Diets
IS  - 2
VL  - 13
DO  - 10.1002/cbdv.201500064
SP  - 224
EP  - 232
ER  - 

@article{
author = "Pavković-Lučić, Sofija and Todosijević, Marina and Savić, Tatjana and Vajs, Vlatka and Trajković, Jelena and Anđelković, Boban and Lučić, Luka and Krstić, Gordana and Makarov, Slobodan and Tomić, Vladimir and Miličić, Dragana and Vujisić, Ljubodrag",
year = "2016",
abstract = "Cuticular hydrocarbons (CHCs) in Drosophila melanogaster represent the basis of chemical communication being involved in
many important biological functions. The aim of this study was to characterize chemical composition and variation of cuticular
profiles in five D. melanogaster strains. These strains were reared for approximately 300 generations on five diets: standard
cornmeal medium and substrates prepared with apple, banana, tomato, and carrot. Differences in quantity and/or quality in
CHCs were assumed as a result of activation of different metabolic pathways involved in food digestion and adaptations to the
particular diet type.
In total, independently of sex and strain, 66 chemical compounds were identified. In females of all strains, 60 compounds were
identified, while, in males, 47 compounds were extracted. Certain new chemical compounds for D. melanogaster were found.
MANOVA confirmed that CHC amounts significantly depend on sex and substrates, as well as on their interactions. Discriminant
analysis revealed that flies belonging to ÐappleÏ and ÐcarrotÏ strains exhibited the most noticeable differences in CHC repertoires.
A non-hydrocarbon pheromone, cis-vaccenyl acetate (cVA) also contributed to the variation in the pheromone bouquet among
the strains. Variability detected in CHCs and cVAmay be used in the explanation of differences in mating behaviour previously
determined in analyzed fly strains.",
publisher = "Verlag Helvetica Chimica Acta AG, Zürich",
journal = "Chemistry & Biodiversity",
title = ""Does my Diet Affect my Perfume?" Identification and Quantification of Cuticular Compounds in Five Drosophila melanogaster Strains Maintained over 300 Generations on Different Diets",
number = "2",
volume = "13",
doi = "10.1002/cbdv.201500064",
pages = "224-232"
}

Pavković-Lučić, S., Todosijević, M., Savić, T., Vajs, V., Trajković, J., Anđelković, B., Lučić, L., Krstić, G., Makarov, S., Tomić, V., Miličić, D.,& Vujisić, L.. (2016). "Does my Diet Affect my Perfume?" Identification and Quantification of Cuticular Compounds in Five Drosophila melanogaster Strains Maintained over 300 Generations on Different Diets. in Chemistry & Biodiversity
Verlag Helvetica Chimica Acta AG, Zürich., 13(2), 224-232.
https://doi.org/10.1002/cbdv.201500064

Pavković-Lučić S, Todosijević M, Savić T, Vajs V, Trajković J, Anđelković B, Lučić L, Krstić G, Makarov S, Tomić V, Miličić D, Vujisić L. "Does my Diet Affect my Perfume?" Identification and Quantification of Cuticular Compounds in Five Drosophila melanogaster Strains Maintained over 300 Generations on Different Diets. in Chemistry & Biodiversity. 2016;13(2):224-232.
doi:10.1002/cbdv.201500064 .

Pavković-Lučić, Sofija, Todosijević, Marina, Savić, Tatjana, Vajs, Vlatka, Trajković, Jelena, Anđelković, Boban, Lučić, Luka, Krstić, Gordana, Makarov, Slobodan, Tomić, Vladimir, Miličić, Dragana, Vujisić, Ljubodrag, ""Does my Diet Affect my Perfume?" Identification and Quantification of Cuticular Compounds in Five Drosophila melanogaster Strains Maintained over 300 Generations on Different Diets" in Chemistry & Biodiversity, 13, no. 2 (2016):224-232,
https://doi.org/10.1002/cbdv.201500064 . .

TY  - JOUR
AU  - Gođevac, Dejan
AU  - Soković, Marina
AU  - Vujisić, Ljubodrag
AU  - Vučković, Ivan
AU  - Vajs, Vlatka
AU  - Marin, Petar D.
AU  - Tešević, Vele
PY  - 2012
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/564
AB  - An investigation of the chemical composition and antimicrobial activity of the essential oil of Galatella linosyris is presented. The chemical analysis (GC/MS, NMR) showed that sabinene (40 %), β-pinene (35.5 %), α-pinene (4.5 %), limonene (4 %), γ-muurolene (4 %), and (E)-caryophyllene (3.3 %) were dominant components in this oil. Microdilution assays were used to evaluate the minimum inhibitory concentration (MIC) and the minimum bactericidal/ fungicidal concentrations (MBC/MFC). G. linosyris essential oil exhibited better antibacterial activity against some of the tested bacteria than antifungal activity.
AB  - U ovom radu je prikazano ispitivanje hemijskog sastava i antimikrobne aktivnosti etarskog ulja biljne vrste Galatella linosyris. Hemijskom analizom (GC-MS i NMR) je utvrđeno da su glavni sastojci ovog etarskog ulja sabinen (40 %), β-pinen (35,5 %) , α-pinen (4,5 %), limonen (4 %), γ-muurolen (4 %) i (E)-kariofilen (3,3 %). Za procenu minimalne inhibitorne koncentracije (MIC) i minimalne baktericidne/fungicidne koncentracije (MBC/ /MFC) korišćeni su testovi mikrorazblaženja. Etarsko ulje G. linosyris je pokazalo bolju antibakterijsku nego antifungalnu aktivnost.
T2  - Journal of the Serbian Chemical Society
T1  - Sastav i antimikrobna aktivnost etarskog ulja iz Galatella linosyris (L.) Rchb. f. (Asteraceae)
T1  - Composition and antimicrobial activity of the essential oil from Galatella linosyris (L.) Rchb. f. (Asteraceae)
IS  - 5
VL  - 77
SP  - 619
EP  - 626
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_564
ER  - 

@article{
author = "Gođevac, Dejan and Soković, Marina and Vujisić, Ljubodrag and Vučković, Ivan and Vajs, Vlatka and Marin, Petar D. and Tešević, Vele",
year = "2012, 2012",
abstract = "An investigation of the chemical composition and antimicrobial activity of the essential oil of Galatella linosyris is presented. The chemical analysis (GC/MS, NMR) showed that sabinene (40 %), β-pinene (35.5 %), α-pinene (4.5 %), limonene (4 %), γ-muurolene (4 %), and (E)-caryophyllene (3.3 %) were dominant components in this oil. Microdilution assays were used to evaluate the minimum inhibitory concentration (MIC) and the minimum bactericidal/ fungicidal concentrations (MBC/MFC). G. linosyris essential oil exhibited better antibacterial activity against some of the tested bacteria than antifungal activity., U ovom radu je prikazano ispitivanje hemijskog sastava i antimikrobne aktivnosti etarskog ulja biljne vrste Galatella linosyris. Hemijskom analizom (GC-MS i NMR) je utvrđeno da su glavni sastojci ovog etarskog ulja sabinen (40 %), β-pinen (35,5 %) , α-pinen (4,5 %), limonen (4 %), γ-muurolen (4 %) i (E)-kariofilen (3,3 %). Za procenu minimalne inhibitorne koncentracije (MIC) i minimalne baktericidne/fungicidne koncentracije (MBC/ /MFC) korišćeni su testovi mikrorazblaženja. Etarsko ulje G. linosyris je pokazalo bolju antibakterijsku nego antifungalnu aktivnost.",
journal = "Journal of the Serbian Chemical Society",
title = "Sastav i antimikrobna aktivnost etarskog ulja iz Galatella linosyris (L.) Rchb. f. (Asteraceae), Composition and antimicrobial activity of the essential oil from Galatella linosyris (L.) Rchb. f. (Asteraceae)",
number = "5",
volume = "77",
pages = "619-626",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_564"
}

Gođevac, D., Soković, M., Vujisić, L., Vučković, I., Vajs, V., Marin, P. D.,& Tešević, V.. (2012). Sastav i antimikrobna aktivnost etarskog ulja iz Galatella linosyris (L.) Rchb. f. (Asteraceae). in Journal of the Serbian Chemical Society, 77(5), 619-626.
https://hdl.handle.net/21.15107/rcub_ibiss_564

Gođevac D, Soković M, Vujisić L, Vučković I, Vajs V, Marin PD, Tešević V. Sastav i antimikrobna aktivnost etarskog ulja iz Galatella linosyris (L.) Rchb. f. (Asteraceae). in Journal of the Serbian Chemical Society. 2012;77(5):619-626.
https://hdl.handle.net/21.15107/rcub_ibiss_564 .

Gođevac, Dejan, Soković, Marina, Vujisić, Ljubodrag, Vučković, Ivan, Vajs, Vlatka, Marin, Petar D., Tešević, Vele, "Sastav i antimikrobna aktivnost etarskog ulja iz Galatella linosyris (L.) Rchb. f. (Asteraceae)" in Journal of the Serbian Chemical Society, 77, no. 5 (2012):619-626,
https://hdl.handle.net/21.15107/rcub_ibiss_564 .

TY  - JOUR
AU  - Soković, Marina
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan
AU  - Vajs, Vlatka
AU  - Đorđević, Iris
AU  - Lavadinović, Vera
AU  - Novaković, Miroslav
PY  - 2009
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/559
AB  - The chemical composition of the essential oil of fresh young needles with twigs of Douglas fir (Pseudosuga menziesii Mirb. Franco) obtained by hydrodistillation were analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). Ten compounds, accounting for 94.26 % of the oil, were identified. The main compounds found were bornyl acetate (34.65 %), camphene (29.82 %), α-pinene (11.65 %) and santene (5.45 %). The antifungal activity of the essential oil was tested against various fungal species. The minimum inhibitory concentration of Douglas fir essential oil ranged from 1.5 to 4 μg mL-1. The fungi most sensitive to the tested oil were Phomopsis helianthi, while Penicillium species, along with Microsporum canis, were the most resistant. Compared to the commercial fungicidal agent bifonazole, the studied essential oil demonstrated higher antifungal activity.
AB  - Hemijski sastav etarskog ulja mladih iglica sa grančicama duglazije (Pseudosuga menziesii Mirb. Franco) dobijenog destilacijom vodenom parom, analiziran je gasnom hromatografijom (GC) i kombinacijom gasne hromatografije i masene spektrometrije (GC/MS). Identifikovano je deset jedinjenja ukupne zastupljenosti 94,26 %. Kao glavne komponente su nađeni: bornil-acetat (34,65 %), kamfen (29,82 %), α-pinen (11,65 %) i santen (5,45 %). Pored toga, etarsko ulje je testirano na antifungalnu aktivnost. Etarsko ulje pokazuje mnogo bolju antifugalnu akivnost od komercijalnog fungicidnog agensa bifonazola. Minimalna inhibitorna koncentracija etarskog ulja duglazije je u opsegu od 0,6 do 1,4 μL mL-1. Najosetljiviji na testirano ulje je bio soj Phomopsis helianthi, dok sojevi Penicillium i Microsporum canis pokazuju najveću rezistentnost.
T2  - Journal of the Serbian Chemical Society
T1  - Hemijski sastav i antifungalna aktivnost etarskog ulja daglasove jele (Pseudosuga menziesii mirb. Franco) iz Srbije
T1  - Chemical composition and antifungal activity of the essential oil of Douglas fir (Pseudosuga menziesii mirb. Franco) from Serbia
IS  - 10
VL  - 74
SP  - 1035
EP  - 1040
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_559
ER  - 

@article{
author = "Soković, Marina and Tešević, Vele and Milosavljević, Slobodan and Vajs, Vlatka and Đorđević, Iris and Lavadinović, Vera and Novaković, Miroslav",
year = "2009, 2009",
abstract = "The chemical composition of the essential oil of fresh young needles with twigs of Douglas fir (Pseudosuga menziesii Mirb. Franco) obtained by hydrodistillation were analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). Ten compounds, accounting for 94.26 % of the oil, were identified. The main compounds found were bornyl acetate (34.65 %), camphene (29.82 %), α-pinene (11.65 %) and santene (5.45 %). The antifungal activity of the essential oil was tested against various fungal species. The minimum inhibitory concentration of Douglas fir essential oil ranged from 1.5 to 4 μg mL-1. The fungi most sensitive to the tested oil were Phomopsis helianthi, while Penicillium species, along with Microsporum canis, were the most resistant. Compared to the commercial fungicidal agent bifonazole, the studied essential oil demonstrated higher antifungal activity., Hemijski sastav etarskog ulja mladih iglica sa grančicama duglazije (Pseudosuga menziesii Mirb. Franco) dobijenog destilacijom vodenom parom, analiziran je gasnom hromatografijom (GC) i kombinacijom gasne hromatografije i masene spektrometrije (GC/MS). Identifikovano je deset jedinjenja ukupne zastupljenosti 94,26 %. Kao glavne komponente su nađeni: bornil-acetat (34,65 %), kamfen (29,82 %), α-pinen (11,65 %) i santen (5,45 %). Pored toga, etarsko ulje je testirano na antifungalnu aktivnost. Etarsko ulje pokazuje mnogo bolju antifugalnu akivnost od komercijalnog fungicidnog agensa bifonazola. Minimalna inhibitorna koncentracija etarskog ulja duglazije je u opsegu od 0,6 do 1,4 μL mL-1. Najosetljiviji na testirano ulje je bio soj Phomopsis helianthi, dok sojevi Penicillium i Microsporum canis pokazuju najveću rezistentnost.",
journal = "Journal of the Serbian Chemical Society",
title = "Hemijski sastav i antifungalna aktivnost etarskog ulja daglasove jele (Pseudosuga menziesii mirb. Franco) iz Srbije, Chemical composition and antifungal activity of the essential oil of Douglas fir (Pseudosuga menziesii mirb. Franco) from Serbia",
number = "10",
volume = "74",
pages = "1035-1040",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_559"
}

Soković, M., Tešević, V., Milosavljević, S., Vajs, V., Đorđević, I., Lavadinović, V.,& Novaković, M.. (2009). Hemijski sastav i antifungalna aktivnost etarskog ulja daglasove jele (Pseudosuga menziesii mirb. Franco) iz Srbije. in Journal of the Serbian Chemical Society, 74(10), 1035-1040.
https://hdl.handle.net/21.15107/rcub_ibiss_559

Soković M, Tešević V, Milosavljević S, Vajs V, Đorđević I, Lavadinović V, Novaković M. Hemijski sastav i antifungalna aktivnost etarskog ulja daglasove jele (Pseudosuga menziesii mirb. Franco) iz Srbije. in Journal of the Serbian Chemical Society. 2009;74(10):1035-1040.
https://hdl.handle.net/21.15107/rcub_ibiss_559 .

Soković, Marina, Tešević, Vele, Milosavljević, Slobodan, Vajs, Vlatka, Đorđević, Iris, Lavadinović, Vera, Novaković, Miroslav, "Hemijski sastav i antifungalna aktivnost etarskog ulja daglasove jele (Pseudosuga menziesii mirb. Franco) iz Srbije" in Journal of the Serbian Chemical Society, 74, no. 10 (2009):1035-1040,
https://hdl.handle.net/21.15107/rcub_ibiss_559 .

TY  - JOUR
AU  - Vajs, Vlatka
AU  - Soković, Marina
AU  - Trifunović, Snežana
AU  - Janaćković, Peđa T.
AU  - Milosavljević, Slobodan
AU  - Tešević, Vele
PY  - 2004
PY  - 2004
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/547
AB  - Five tetrahydrofuran sesquiterpenes, so-called davanones, and coumarin umbelliferone isolated from Artemisia lobelii All. var. canescens (DC) Briqu, were tested for antifungal activity. All the compounds inhibited the growth of the applied fungi. The overall activity of one of them 2-hydroxy-2,6,10-trimethyl-7,10-epoxydodeca- 3,11-dien-5-on, was comparable to that of the antibiotic bifonazole.
AB  - Pet tetrahidrofuranskih terpenoida davanonskog tipa i kumarin umbeliferon koji su prethodno izolovani iz biljne vrste Aretemisia lobelii var. conescens ispitivani su na antifungalnu aktivnost. Sva testirana jedinjenja inhibiraju rast primenjenih kultura gljiva. Najveću aktivnost, koja se može meriti sa aktivnošću komercijalnog antibiotika bifonazola, pokazuje 2-hidroksi-2,6,10-trimetil-7,10-epoksidodeka-3,11-dien-5-on.
T2  - Journal of the Serbian Chemical Society
T1  - Antifungalna aktivnost terpenoida davanonskog tipa izolovanih iz Artemisia lobelii Var. canescens
T1  - Antifungal activity of davanone-type sesquiterpenes from Artemisia lobelli var. conescens
IS  - 11
VL  - 69
SP  - 969
EP  - 972
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_547
ER  - 

@article{
author = "Vajs, Vlatka and Soković, Marina and Trifunović, Snežana and Janaćković, Peđa T. and Milosavljević, Slobodan and Tešević, Vele",
year = "2004, 2004",
abstract = "Five tetrahydrofuran sesquiterpenes, so-called davanones, and coumarin umbelliferone isolated from Artemisia lobelii All. var. canescens (DC) Briqu, were tested for antifungal activity. All the compounds inhibited the growth of the applied fungi. The overall activity of one of them 2-hydroxy-2,6,10-trimethyl-7,10-epoxydodeca- 3,11-dien-5-on, was comparable to that of the antibiotic bifonazole., Pet tetrahidrofuranskih terpenoida davanonskog tipa i kumarin umbeliferon koji su prethodno izolovani iz biljne vrste Aretemisia lobelii var. conescens ispitivani su na antifungalnu aktivnost. Sva testirana jedinjenja inhibiraju rast primenjenih kultura gljiva. Najveću aktivnost, koja se može meriti sa aktivnošću komercijalnog antibiotika bifonazola, pokazuje 2-hidroksi-2,6,10-trimetil-7,10-epoksidodeka-3,11-dien-5-on.",
journal = "Journal of the Serbian Chemical Society",
title = "Antifungalna aktivnost terpenoida davanonskog tipa izolovanih iz Artemisia lobelii Var. canescens, Antifungal activity of davanone-type sesquiterpenes from Artemisia lobelli var. conescens",
number = "11",
volume = "69",
pages = "969-972",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_547"
}

Vajs, V., Soković, M., Trifunović, S., Janaćković, P. T., Milosavljević, S.,& Tešević, V.. (2004). Antifungalna aktivnost terpenoida davanonskog tipa izolovanih iz Artemisia lobelii Var. canescens. in Journal of the Serbian Chemical Society, 69(11), 969-972.
https://hdl.handle.net/21.15107/rcub_ibiss_547

Vajs V, Soković M, Trifunović S, Janaćković PT, Milosavljević S, Tešević V. Antifungalna aktivnost terpenoida davanonskog tipa izolovanih iz Artemisia lobelii Var. canescens. in Journal of the Serbian Chemical Society. 2004;69(11):969-972.
https://hdl.handle.net/21.15107/rcub_ibiss_547 .

Vajs, Vlatka, Soković, Marina, Trifunović, Snežana, Janaćković, Peđa T., Milosavljević, Slobodan, Tešević, Vele, "Antifungalna aktivnost terpenoida davanonskog tipa izolovanih iz Artemisia lobelii Var. canescens" in Journal of the Serbian Chemical Society, 69, no. 11 (2004):969-972,
https://hdl.handle.net/21.15107/rcub_ibiss_547 .

TY  - JOUR
AU  - Soković, Marina
AU  - Marin, P.D.
AU  - Vajs, Vlatka
AU  - Milosavljević, S.
AU  - Đoković, D.
AU  - Tešević, V.
AU  - Janaćković, P.
PY  - 2000
PY  - 2000
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/66
AB  - The essential oil from the leaves of Phlomis fruticosa L. (Lamiaceae) was prepared by hydrodistillation. Plants were collected every three months during the period January - October, 1997. Eighteen components contained in essential oil were identified by GC-MS analysis. The main components were α-pinene, 1,8-cineole and β-caryophyllene. The results indicate seasonal differences in oil composition, especially in concentrations of two dominant components, α-pinene and 1,8-cineole. .
AB  - Biljni materijal je sakupljan tokom 1997. godine u Baru (Voluvica). Crna Gora. Etarsko ulje je izolovano metodom hidrodestilacije, nakon čega su gasnom hromatografijom i masenom spektrometrijom identifikovane pojedinačne komponente. Identifikovano je 18 komponenti. Glavne komponente etarskog ulja su α-pinen, 1.8-cineol i β-kariofilen. Monoterpenski ugljovodonici prisutni su sa 7.9-63.7%. seskviterpenski ugljovodonici sa 2.4-9.8%, oksidovani monoterpeni sa 2.6-13.8% i oksidovani ugljovodonici sa 0.4-15.9%. U etarskom ulju ispitivane vrste najzastupljeniji su monoterpenski ugljovodonici. Rezultati ukazuju na sezonsku varijabilnost prinosa i sastava etarskog ulja. Prinos etarskog ulja u periodu od avgusta do januara je 0.04%, dok je u periodu od maja do avgusta 0.06%. Primećene su značajne razlike u zastupljenosti dominantnih komponenti sa sezonskim promenama, α-pinen i 1.8-cineol najzastupljeniji su u julu, dok je β-kariofilen u tom periodu prisutan sa najmanjim procentom. Rezultati ukazuju da sezonske promene mogu bitno uticati na karakteristike etarskog ulja. Praćenje sezonske varijabilnosti etarskog ulja može biti od velike važnosti prilikom korišćenja lekovitih i aromatičnih biljaka u farmaciji i medicini. .
T2  - Archives of Biological Sciences
T1  - Kompozicija i sezonska varijabilnost etarskog ulja Phlomis fruticosa L.
T1  - Composition and seasonal variability of Phlomis fruticosa L. essential oils
IS  - 3
VL  - 52
SP  - 165
EP  - 168
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_66
ER  - 

@article{
author = "Soković, Marina and Marin, P.D. and Vajs, Vlatka and Milosavljević, S. and Đoković, D. and Tešević, V. and Janaćković, P.",
year = "2000, 2000",
abstract = "The essential oil from the leaves of Phlomis fruticosa L. (Lamiaceae) was prepared by hydrodistillation. Plants were collected every three months during the period January - October, 1997. Eighteen components contained in essential oil were identified by GC-MS analysis. The main components were α-pinene, 1,8-cineole and β-caryophyllene. The results indicate seasonal differences in oil composition, especially in concentrations of two dominant components, α-pinene and 1,8-cineole. ., Biljni materijal je sakupljan tokom 1997. godine u Baru (Voluvica). Crna Gora. Etarsko ulje je izolovano metodom hidrodestilacije, nakon čega su gasnom hromatografijom i masenom spektrometrijom identifikovane pojedinačne komponente. Identifikovano je 18 komponenti. Glavne komponente etarskog ulja su α-pinen, 1.8-cineol i β-kariofilen. Monoterpenski ugljovodonici prisutni su sa 7.9-63.7%. seskviterpenski ugljovodonici sa 2.4-9.8%, oksidovani monoterpeni sa 2.6-13.8% i oksidovani ugljovodonici sa 0.4-15.9%. U etarskom ulju ispitivane vrste najzastupljeniji su monoterpenski ugljovodonici. Rezultati ukazuju na sezonsku varijabilnost prinosa i sastava etarskog ulja. Prinos etarskog ulja u periodu od avgusta do januara je 0.04%, dok je u periodu od maja do avgusta 0.06%. Primećene su značajne razlike u zastupljenosti dominantnih komponenti sa sezonskim promenama, α-pinen i 1.8-cineol najzastupljeniji su u julu, dok je β-kariofilen u tom periodu prisutan sa najmanjim procentom. Rezultati ukazuju da sezonske promene mogu bitno uticati na karakteristike etarskog ulja. Praćenje sezonske varijabilnosti etarskog ulja može biti od velike važnosti prilikom korišćenja lekovitih i aromatičnih biljaka u farmaciji i medicini. .",
journal = "Archives of Biological Sciences",
title = "Kompozicija i sezonska varijabilnost etarskog ulja Phlomis fruticosa L., Composition and seasonal variability of Phlomis fruticosa L. essential oils",
number = "3",
volume = "52",
pages = "165-168",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_66"
}

Soković, M., Marin, P.D., Vajs, V., Milosavljević, S., Đoković, D., Tešević, V.,& Janaćković, P.. (2000). Kompozicija i sezonska varijabilnost etarskog ulja Phlomis fruticosa L.. in Archives of Biological Sciences, 52(3), 165-168.
https://hdl.handle.net/21.15107/rcub_ibiss_66

Soković M, Marin P, Vajs V, Milosavljević S, Đoković D, Tešević V, Janaćković P. Kompozicija i sezonska varijabilnost etarskog ulja Phlomis fruticosa L.. in Archives of Biological Sciences. 2000;52(3):165-168.
https://hdl.handle.net/21.15107/rcub_ibiss_66 .

Soković, Marina, Marin, P.D., Vajs, Vlatka, Milosavljević, S., Đoković, D., Tešević, V., Janaćković, P., "Kompozicija i sezonska varijabilnost etarskog ulja Phlomis fruticosa L." in Archives of Biological Sciences, 52, no. 3 (2000):165-168,
https://hdl.handle.net/21.15107/rcub_ibiss_66 .