TY  - JOUR
AU  - Vujić, Bojan
AU  - Vidaković, Vera
AU  - Jadranin, Milka
AU  - Novaković, Irena
AU  - Trifunović, Snežana
AU  - Tešević, Vele
AU  - Mandić, Boris
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3620
AB  - Helichrysum plicatum DC. is widely used in folk medicine in treating a variety of health disorders. The aim of this study was to examine the influence of different extraction solvents on the chemical composition, antioxidant potential, and antimicrobial activities of H. plicatum. Aerial parts were separately extracted with ethanol, dichloromethane, and sunflower oil. The oil extract (OE) was re-extracted with acetonitrile. A total of 142 compounds were tentatively identified in ethanolic (EE), dichloromethane (DCME), and acetonitrile (ACNE) extracts using HPLC-DAD/ESI-ToF-MS. The dominant compound class in all extracts were α-pyrones, alongside flavonoids in EE, terpenoids in DCME and ACNE, and phloroglucinols in DCME. The antioxidant potential of the extracts was assessed by the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) assay. EE and DCME possessed the most potent radical scavenging capacity. Antimicrobial activity was investigated on eight bacterial, two yeast, and one fungal species. All extracts exhibited high antifungal and notable antibacterial activities compared to control substances, with DCME being the most potent. DCME exhibited stronger antimicrobial activity against P. aeruginosa than the standard chloramphenicol.
PB  - Basel : MDPI
T2  - Plants
T1  - Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts
IS  - 3
VL  - 9
DO  - 10.3390/plants9030337
SP  - 337
ER  - 

@article{
author = "Vujić, Bojan and Vidaković, Vera and Jadranin, Milka and Novaković, Irena and Trifunović, Snežana and Tešević, Vele and Mandić, Boris",
year = "2020",
abstract = "Helichrysum plicatum DC. is widely used in folk medicine in treating a variety of health disorders. The aim of this study was to examine the influence of different extraction solvents on the chemical composition, antioxidant potential, and antimicrobial activities of H. plicatum. Aerial parts were separately extracted with ethanol, dichloromethane, and sunflower oil. The oil extract (OE) was re-extracted with acetonitrile. A total of 142 compounds were tentatively identified in ethanolic (EE), dichloromethane (DCME), and acetonitrile (ACNE) extracts using HPLC-DAD/ESI-ToF-MS. The dominant compound class in all extracts were α-pyrones, alongside flavonoids in EE, terpenoids in DCME and ACNE, and phloroglucinols in DCME. The antioxidant potential of the extracts was assessed by the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) assay. EE and DCME possessed the most potent radical scavenging capacity. Antimicrobial activity was investigated on eight bacterial, two yeast, and one fungal species. All extracts exhibited high antifungal and notable antibacterial activities compared to control substances, with DCME being the most potent. DCME exhibited stronger antimicrobial activity against P. aeruginosa than the standard chloramphenicol.",
publisher = "Basel : MDPI",
journal = "Plants",
title = "Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts",
number = "3",
volume = "9",
doi = "10.3390/plants9030337",
pages = "337"
}

Vujić, B., Vidaković, V., Jadranin, M., Novaković, I., Trifunović, S., Tešević, V.,& Mandić, B.. (2020). Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts. in Plants
Basel : MDPI., 9(3), 337.
https://doi.org/10.3390/plants9030337

Vujić B, Vidaković V, Jadranin M, Novaković I, Trifunović S, Tešević V, Mandić B. Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts. in Plants. 2020;9(3):337.
doi:10.3390/plants9030337 .

Vujić, Bojan, Vidaković, Vera, Jadranin, Milka, Novaković, Irena, Trifunović, Snežana, Tešević, Vele, Mandić, Boris, "Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts" in Plants, 9, no. 3 (2020):337,
https://doi.org/10.3390/plants9030337 . .

TY  - JOUR
AU  - Trifunović-Momčilov, Milana
AU  - Krstić Milošević, Dijana
AU  - Trifunović, Snežana
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Jevremović, Slađana
AU  - Subotić, Angelina
PY  - 2019
UR  - http://eemj.eu/index.php/EEMJ/article/view/3962
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3592
AB  - Common centaury, Centaurium erythraea Rafn., represent the best known and the most investigated medicinal plant species of genus Centaurium. Centaury has been used for centuries in traditional medicine. Secondary metabolites such as bitter secoiridoid glucosides (gentiopicrin, swertiamarin and sweroside), xanthones (eustomin and demethyleustomin), and phenolic acids are the main constituents responsible for the therapeutic properties of centaury. Previous investigation showed that overexpression of the AtCKX genes in transgenic centaury plants did not result in a decrease of total cytokinin (CK) content, but in an altered CK profile leading to a decline of bioactive, the most important physiologically active group of CKs.The aim of this study was to investigate antibacterial and antifungal activity of transgenic centaury methanol extracts as well as pure secoiridoid and xanthone compounds on four Gram positive, four Gram negative bacteria and eight species of microfungi. All tested methanol extracts of control and transgenic AtCKX1 centaury shoots and roots showed better antibacterial activity, while pure compounds (gentiopicrin, swertiamarin, eustomin and demethyleustomin) showed better antifungal activity. The results obtained in this work suggest that centaury methanol extracts and pure compounds represent potential antimicrobials confirming the possibility of using these compounds in agronomy, veterinary, medicine or food industry.
PB  - Gheorghe Asachi Technical University of Iasi, Romania
T2  - Environmental Engineering and Management Journal
T1  - Antimicrobial activity, antioxidant potential and total phenolic content of transgenic ATCKX1 centaury (Centaurium erythraea Rafn.) Plants grown in vitro
IS  - 9
VL  - 18
SP  - 2063
EP  - 2072
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_3592
ER  - 

@article{
author = "Trifunović-Momčilov, Milana and Krstić Milošević, Dijana and Trifunović, Snežana and Ćirić, Ana and Glamočlija, Jasmina and Jevremović, Slađana and Subotić, Angelina",
year = "2019",
abstract = "Common centaury, Centaurium erythraea Rafn., represent the best known and the most investigated medicinal plant species of genus Centaurium. Centaury has been used for centuries in traditional medicine. Secondary metabolites such as bitter secoiridoid glucosides (gentiopicrin, swertiamarin and sweroside), xanthones (eustomin and demethyleustomin), and phenolic acids are the main constituents responsible for the therapeutic properties of centaury. Previous investigation showed that overexpression of the AtCKX genes in transgenic centaury plants did not result in a decrease of total cytokinin (CK) content, but in an altered CK profile leading to a decline of bioactive, the most important physiologically active group of CKs.The aim of this study was to investigate antibacterial and antifungal activity of transgenic centaury methanol extracts as well as pure secoiridoid and xanthone compounds on four Gram positive, four Gram negative bacteria and eight species of microfungi. All tested methanol extracts of control and transgenic AtCKX1 centaury shoots and roots showed better antibacterial activity, while pure compounds (gentiopicrin, swertiamarin, eustomin and demethyleustomin) showed better antifungal activity. The results obtained in this work suggest that centaury methanol extracts and pure compounds represent potential antimicrobials confirming the possibility of using these compounds in agronomy, veterinary, medicine or food industry.",
publisher = "Gheorghe Asachi Technical University of Iasi, Romania",
journal = "Environmental Engineering and Management Journal",
title = "Antimicrobial activity, antioxidant potential and total phenolic content of transgenic ATCKX1 centaury (Centaurium erythraea Rafn.) Plants grown in vitro",
number = "9",
volume = "18",
pages = "2063-2072",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_3592"
}

Trifunović-Momčilov, M., Krstić Milošević, D., Trifunović, S., Ćirić, A., Glamočlija, J., Jevremović, S.,& Subotić, A.. (2019). Antimicrobial activity, antioxidant potential and total phenolic content of transgenic ATCKX1 centaury (Centaurium erythraea Rafn.) Plants grown in vitro. in Environmental Engineering and Management Journal
Gheorghe Asachi Technical University of Iasi, Romania., 18(9), 2063-2072.
https://hdl.handle.net/21.15107/rcub_ibiss_3592

Trifunović-Momčilov M, Krstić Milošević D, Trifunović S, Ćirić A, Glamočlija J, Jevremović S, Subotić A. Antimicrobial activity, antioxidant potential and total phenolic content of transgenic ATCKX1 centaury (Centaurium erythraea Rafn.) Plants grown in vitro. in Environmental Engineering and Management Journal. 2019;18(9):2063-2072.
https://hdl.handle.net/21.15107/rcub_ibiss_3592 .

Trifunović-Momčilov, Milana, Krstić Milošević, Dijana, Trifunović, Snežana, Ćirić, Ana, Glamočlija, Jasmina, Jevremović, Slađana, Subotić, Angelina, "Antimicrobial activity, antioxidant potential and total phenolic content of transgenic ATCKX1 centaury (Centaurium erythraea Rafn.) Plants grown in vitro" in Environmental Engineering and Management Journal, 18, no. 9 (2019):2063-2072,
https://hdl.handle.net/21.15107/rcub_ibiss_3592 .

TY  - JOUR
AU  - Banjanac, Tijana
AU  - Dragićević, Milan
AU  - Šiler, Branislav
AU  - Gašić, Uroš
AU  - Bohanec, Borut
AU  - Nestorović Živković, Jasmina
AU  - Trifunović, Snežana
AU  - Mišić, Danijela
PY  - 2017
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0031942217301541
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2742
AB  - Species within the genus Centaurium readily hybridize and polyploid complexes are often seen in natural populations. We describe phytochemical profiles of newly discovered allohexaploid hybrid, here named Centaurium pannonicum, and its parental tetraploid species C. erythraea and rare C. littorale ssp. compressum. Our aim was to examine chemodiversity of these taxa in the area of Vojvodina (North Serbia) and to perform metabolomics search for chemical classifiers which would provide high resolution discrimination of parental and hybrid individuals. In sum, UHPLC-MS/MS Orbitrap metabolomics fingerprinting revealed seventy compounds in methanol extracts. Despite the lack of qualitative chemical novelty in hybrid plants, UHPLC-qqqMS targeted metabolomics approach, aimed at three secoiridoid compounds and seventeen phenolics, pointed to considerable differences in quantitative composition of these dominant compounds among the plant taxa studied. In addition to the difference in the ploidy levels, the hybrid taxon was well distinguished from both parental species based on metabolite profiles, and, for most individuals, positioned intermediately to the parental taxa in both PCA and hierarchical clustering. After optimizing and comparing several statistical learning methods, it was possible to narrow the number of taxonomic classifiers to five (three xanthones, one secoiridoid glycoside, and one phenolic acid), while increasing the differentiation resolution. The presented metabolomics approach will certainly, along with morphometrics and molecular genetics studies, have high impact on further elucidation of complex relationships among taxa within the genus Centaurium.
T2  - Phytochemistry
T1  - Chemodiversity of two closely related tetraploid Centaurium species and their hexaploid hybrid: Metabolomic search for high-resolution taxonomic classifiers
VL  - 140
DO  - 10.1016/j.phytochem.2017.04.005
SP  - 27
EP  - 44
ER  - 

@article{
author = "Banjanac, Tijana and Dragićević, Milan and Šiler, Branislav and Gašić, Uroš and Bohanec, Borut and Nestorović Živković, Jasmina and Trifunović, Snežana and Mišić, Danijela",
year = "2017",
abstract = "Species within the genus Centaurium readily hybridize and polyploid complexes are often seen in natural populations. We describe phytochemical profiles of newly discovered allohexaploid hybrid, here named Centaurium pannonicum, and its parental tetraploid species C. erythraea and rare C. littorale ssp. compressum. Our aim was to examine chemodiversity of these taxa in the area of Vojvodina (North Serbia) and to perform metabolomics search for chemical classifiers which would provide high resolution discrimination of parental and hybrid individuals. In sum, UHPLC-MS/MS Orbitrap metabolomics fingerprinting revealed seventy compounds in methanol extracts. Despite the lack of qualitative chemical novelty in hybrid plants, UHPLC-qqqMS targeted metabolomics approach, aimed at three secoiridoid compounds and seventeen phenolics, pointed to considerable differences in quantitative composition of these dominant compounds among the plant taxa studied. In addition to the difference in the ploidy levels, the hybrid taxon was well distinguished from both parental species based on metabolite profiles, and, for most individuals, positioned intermediately to the parental taxa in both PCA and hierarchical clustering. After optimizing and comparing several statistical learning methods, it was possible to narrow the number of taxonomic classifiers to five (three xanthones, one secoiridoid glycoside, and one phenolic acid), while increasing the differentiation resolution. The presented metabolomics approach will certainly, along with morphometrics and molecular genetics studies, have high impact on further elucidation of complex relationships among taxa within the genus Centaurium.",
journal = "Phytochemistry",
title = "Chemodiversity of two closely related tetraploid Centaurium species and their hexaploid hybrid: Metabolomic search for high-resolution taxonomic classifiers",
volume = "140",
doi = "10.1016/j.phytochem.2017.04.005",
pages = "27-44"
}

Banjanac, T., Dragićević, M., Šiler, B., Gašić, U., Bohanec, B., Nestorović Živković, J., Trifunović, S.,& Mišić, D.. (2017). Chemodiversity of two closely related tetraploid Centaurium species and their hexaploid hybrid: Metabolomic search for high-resolution taxonomic classifiers. in Phytochemistry, 140, 27-44.
https://doi.org/10.1016/j.phytochem.2017.04.005

Banjanac T, Dragićević M, Šiler B, Gašić U, Bohanec B, Nestorović Živković J, Trifunović S, Mišić D. Chemodiversity of two closely related tetraploid Centaurium species and their hexaploid hybrid: Metabolomic search for high-resolution taxonomic classifiers. in Phytochemistry. 2017;140:27-44.
doi:10.1016/j.phytochem.2017.04.005 .

Banjanac, Tijana, Dragićević, Milan, Šiler, Branislav, Gašić, Uroš, Bohanec, Borut, Nestorović Živković, Jasmina, Trifunović, Snežana, Mišić, Danijela, "Chemodiversity of two closely related tetraploid Centaurium species and their hexaploid hybrid: Metabolomic search for high-resolution taxonomic classifiers" in Phytochemistry, 140 (2017):27-44,
https://doi.org/10.1016/j.phytochem.2017.04.005 . .

TY  - JOUR
AU  - Milošev, Milorad Z
AU  - Jakovljević, Katarina
AU  - Joksović, Milan D
AU  - Stanojković, Tatjana
AU  - Matić, Ivana Z
AU  - Perović, Milka
AU  - Tešić, Vesna
AU  - Kanazir, Selma
AU  - Mladenović, Milan
AU  - Rodić, Marko V
AU  - Leovac, Vukadin M
AU  - Trifunović, Snežana
AU  - Marković, Violeta
PY  - 2017
UR  - http://doi.wiley.com/10.1111/cbdd.12920
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27933733
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2753
AB  - A series of 18 novel N-Mannich bases derived from 5-adamantyl-1,2,4-triazole-3-thione was synthesized and characterized using NMR spectroscopy and X-ray diffraction technique. All derivatives were evaluated for their anticancer potential against four human cancer cell lines. Several tested compounds exerted good cytotoxic activities on K562 and HL-60 cell lines, along with pronounced selectivity, showing lower cytotoxicity against normal fibroblasts MRC-5 compared to cancer cells. The effects of compounds 5b, 5e, and 5j on the cell cycle were investigated by flow cytometric analysis. It was found that these compounds cause the accumulation of cells in the subG1 and G1 phases of the cell cycle and induce caspase-dependent apoptosis, while the anti-angiogenic effects of 5b, 5e, and 5j have been confirmed in EA.hy926 cells using a tube formation assay. Further, the interaction of Bax protein with compound 5b was investigated by means of molecular modeling, applying the combined molecular docking/molecular dynamics approach.
T2  - Chemical Biology & Drug Design
T1  - Mannich bases of 1,2,4-triazole-3-thione containing adamantane moiety: Synthesis, preliminary anticancer evaluation, and molecular modeling studies
IS  - 6
VL  - 89
DO  - 10.1111/cbdd.12920
SP  - 943
EP  - 952
ER  - 

@article{
author = "Milošev, Milorad Z and Jakovljević, Katarina and Joksović, Milan D and Stanojković, Tatjana and Matić, Ivana Z and Perović, Milka and Tešić, Vesna and Kanazir, Selma and Mladenović, Milan and Rodić, Marko V and Leovac, Vukadin M and Trifunović, Snežana and Marković, Violeta",
year = "2017",
abstract = "A series of 18 novel N-Mannich bases derived from 5-adamantyl-1,2,4-triazole-3-thione was synthesized and characterized using NMR spectroscopy and X-ray diffraction technique. All derivatives were evaluated for their anticancer potential against four human cancer cell lines. Several tested compounds exerted good cytotoxic activities on K562 and HL-60 cell lines, along with pronounced selectivity, showing lower cytotoxicity against normal fibroblasts MRC-5 compared to cancer cells. The effects of compounds 5b, 5e, and 5j on the cell cycle were investigated by flow cytometric analysis. It was found that these compounds cause the accumulation of cells in the subG1 and G1 phases of the cell cycle and induce caspase-dependent apoptosis, while the anti-angiogenic effects of 5b, 5e, and 5j have been confirmed in EA.hy926 cells using a tube formation assay. Further, the interaction of Bax protein with compound 5b was investigated by means of molecular modeling, applying the combined molecular docking/molecular dynamics approach.",
journal = "Chemical Biology & Drug Design",
title = "Mannich bases of 1,2,4-triazole-3-thione containing adamantane moiety: Synthesis, preliminary anticancer evaluation, and molecular modeling studies",
number = "6",
volume = "89",
doi = "10.1111/cbdd.12920",
pages = "943-952"
}

Milošev, M. Z., Jakovljević, K., Joksović, M. D., Stanojković, T., Matić, I. Z., Perović, M., Tešić, V., Kanazir, S., Mladenović, M., Rodić, M. V., Leovac, V. M., Trifunović, S.,& Marković, V.. (2017). Mannich bases of 1,2,4-triazole-3-thione containing adamantane moiety: Synthesis, preliminary anticancer evaluation, and molecular modeling studies. in Chemical Biology & Drug Design, 89(6), 943-952.
https://doi.org/10.1111/cbdd.12920

Milošev MZ, Jakovljević K, Joksović MD, Stanojković T, Matić IZ, Perović M, Tešić V, Kanazir S, Mladenović M, Rodić MV, Leovac VM, Trifunović S, Marković V. Mannich bases of 1,2,4-triazole-3-thione containing adamantane moiety: Synthesis, preliminary anticancer evaluation, and molecular modeling studies. in Chemical Biology & Drug Design. 2017;89(6):943-952.
doi:10.1111/cbdd.12920 .

Milošev, Milorad Z, Jakovljević, Katarina, Joksović, Milan D, Stanojković, Tatjana, Matić, Ivana Z, Perović, Milka, Tešić, Vesna, Kanazir, Selma, Mladenović, Milan, Rodić, Marko V, Leovac, Vukadin M, Trifunović, Snežana, Marković, Violeta, "Mannich bases of 1,2,4-triazole-3-thione containing adamantane moiety: Synthesis, preliminary anticancer evaluation, and molecular modeling studies" in Chemical Biology & Drug Design, 89, no. 6 (2017):943-952,
https://doi.org/10.1111/cbdd.12920 . .

TY  - CHAP
AU  - Trifunović-Momčilov, Milana
AU  - Krstić Milošević, Dijana
AU  - Trifunović, Snežana
AU  - Podolski-Renić, Ana
AU  - Pešić, Milica
AU  - Subotić, Angelina
PY  - 2016
UR  - http://link.springer.com/10.1007/978-3-319-27490-4_5-2
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2565
AB  - The genus Centaurium includes about 50 plant species found throughout the northern hemisphere. Plant species Centaurium erythraea Rafn., commonly known as common centaury, has been used for centuries for medical purposes. Centaury is used to treat anemia, jaundice, and gout and to cure febrile conditions and regulate blood sugar. So far, centaury species were genetically transformed mostly using Agrobacterium rhizogenes. Only one report has described A. tumefaciens-mediated gene delivery for the production of transgenic centaury plants. Genetic transformation of centaury using AtCKX genes did not influence the quality but influenced the quantity of xanthones in shoots and roots. The majority of AtCKX transformed centaury lines grown in vitro produced increased eustomin and/or demethyleustomin content than untransformed control plants. This work clearly demonstrates, for the first time, the effect of centaury secoiridoids and xanthones on colorectal cancer cell line (DLD1) and its resistant counterpart (DLD1-TxR). The xanthone eustomin showed the most significant cell growth inhibition effects. Since xanthones are increasingly being used for their pharmacological properties, AtCKX transgenic centaury plants could be used as a useful source of plant material for the production of novel drugs.
PB  - Springer International Publishing, Cham
T2  - Transgenesis and Secondary Metabolism
T1  - Secondary Metabolite Profile of Transgenic Centaury (Centaurium erythraea Rafn.) Plants, Potential Producers of Anticancer Compounds
DO  - 10.1007/978-3-319-27490-4_5-2
SP  - 1
EP  - 26
ER  - 

@inbook{
editor = "Jha, Sumita",
author = "Trifunović-Momčilov, Milana and Krstić Milošević, Dijana and Trifunović, Snežana and Podolski-Renić, Ana and Pešić, Milica and Subotić, Angelina",
year = "2016",
abstract = "The genus Centaurium includes about 50 plant species found throughout the northern hemisphere. Plant species Centaurium erythraea Rafn., commonly known as common centaury, has been used for centuries for medical purposes. Centaury is used to treat anemia, jaundice, and gout and to cure febrile conditions and regulate blood sugar. So far, centaury species were genetically transformed mostly using Agrobacterium rhizogenes. Only one report has described A. tumefaciens-mediated gene delivery for the production of transgenic centaury plants. Genetic transformation of centaury using AtCKX genes did not influence the quality but influenced the quantity of xanthones in shoots and roots. The majority of AtCKX transformed centaury lines grown in vitro produced increased eustomin and/or demethyleustomin content than untransformed control plants. This work clearly demonstrates, for the first time, the effect of centaury secoiridoids and xanthones on colorectal cancer cell line (DLD1) and its resistant counterpart (DLD1-TxR). The xanthone eustomin showed the most significant cell growth inhibition effects. Since xanthones are increasingly being used for their pharmacological properties, AtCKX transgenic centaury plants could be used as a useful source of plant material for the production of novel drugs.",
publisher = "Springer International Publishing, Cham",
journal = "Transgenesis and Secondary Metabolism",
booktitle = "Secondary Metabolite Profile of Transgenic Centaury (Centaurium erythraea Rafn.) Plants, Potential Producers of Anticancer Compounds",
doi = "10.1007/978-3-319-27490-4_5-2",
pages = "1-26"
}

Jha, S., Trifunović-Momčilov, M., Krstić Milošević, D., Trifunović, S., Podolski-Renić, A., Pešić, M.,& Subotić, A.. (2016). Secondary Metabolite Profile of Transgenic Centaury (Centaurium erythraea Rafn.) Plants, Potential Producers of Anticancer Compounds. in Transgenesis and Secondary Metabolism
Springer International Publishing, Cham., 1-26.
https://doi.org/10.1007/978-3-319-27490-4_5-2

Jha S, Trifunović-Momčilov M, Krstić Milošević D, Trifunović S, Podolski-Renić A, Pešić M, Subotić A. Secondary Metabolite Profile of Transgenic Centaury (Centaurium erythraea Rafn.) Plants, Potential Producers of Anticancer Compounds. in Transgenesis and Secondary Metabolism. 2016;:1-26.
doi:10.1007/978-3-319-27490-4_5-2 .

Jha, Sumita, Trifunović-Momčilov, Milana, Krstić Milošević, Dijana, Trifunović, Snežana, Podolski-Renić, Ana, Pešić, Milica, Subotić, Angelina, "Secondary Metabolite Profile of Transgenic Centaury (Centaurium erythraea Rafn.) Plants, Potential Producers of Anticancer Compounds" in Transgenesis and Secondary Metabolism (2016):1-26,
https://doi.org/10.1007/978-3-319-27490-4_5-2 . .

TY  - JOUR
AU  - Vajs, Vlatka
AU  - Soković, Marina
AU  - Trifunović, Snežana
AU  - Janaćković, Peđa T.
AU  - Milosavljević, Slobodan
AU  - Tešević, Vele
PY  - 2004
PY  - 2004
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/547
AB  - Five tetrahydrofuran sesquiterpenes, so-called davanones, and coumarin umbelliferone isolated from Artemisia lobelii All. var. canescens (DC) Briqu, were tested for antifungal activity. All the compounds inhibited the growth of the applied fungi. The overall activity of one of them 2-hydroxy-2,6,10-trimethyl-7,10-epoxydodeca- 3,11-dien-5-on, was comparable to that of the antibiotic bifonazole.
AB  - Pet tetrahidrofuranskih terpenoida davanonskog tipa i kumarin umbeliferon koji su prethodno izolovani iz biljne vrste Aretemisia lobelii var. conescens ispitivani su na antifungalnu aktivnost. Sva testirana jedinjenja inhibiraju rast primenjenih kultura gljiva. Najveću aktivnost, koja se može meriti sa aktivnošću komercijalnog antibiotika bifonazola, pokazuje 2-hidroksi-2,6,10-trimetil-7,10-epoksidodeka-3,11-dien-5-on.
T2  - Journal of the Serbian Chemical Society
T1  - Antifungalna aktivnost terpenoida davanonskog tipa izolovanih iz Artemisia lobelii Var. canescens
T1  - Antifungal activity of davanone-type sesquiterpenes from Artemisia lobelli var. conescens
IS  - 11
VL  - 69
SP  - 969
EP  - 972
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_547
ER  - 

@article{
author = "Vajs, Vlatka and Soković, Marina and Trifunović, Snežana and Janaćković, Peđa T. and Milosavljević, Slobodan and Tešević, Vele",
year = "2004, 2004",
abstract = "Five tetrahydrofuran sesquiterpenes, so-called davanones, and coumarin umbelliferone isolated from Artemisia lobelii All. var. canescens (DC) Briqu, were tested for antifungal activity. All the compounds inhibited the growth of the applied fungi. The overall activity of one of them 2-hydroxy-2,6,10-trimethyl-7,10-epoxydodeca- 3,11-dien-5-on, was comparable to that of the antibiotic bifonazole., Pet tetrahidrofuranskih terpenoida davanonskog tipa i kumarin umbeliferon koji su prethodno izolovani iz biljne vrste Aretemisia lobelii var. conescens ispitivani su na antifungalnu aktivnost. Sva testirana jedinjenja inhibiraju rast primenjenih kultura gljiva. Najveću aktivnost, koja se može meriti sa aktivnošću komercijalnog antibiotika bifonazola, pokazuje 2-hidroksi-2,6,10-trimetil-7,10-epoksidodeka-3,11-dien-5-on.",
journal = "Journal of the Serbian Chemical Society",
title = "Antifungalna aktivnost terpenoida davanonskog tipa izolovanih iz Artemisia lobelii Var. canescens, Antifungal activity of davanone-type sesquiterpenes from Artemisia lobelli var. conescens",
number = "11",
volume = "69",
pages = "969-972",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_547"
}

Vajs, V., Soković, M., Trifunović, S., Janaćković, P. T., Milosavljević, S.,& Tešević, V.. (2004). Antifungalna aktivnost terpenoida davanonskog tipa izolovanih iz Artemisia lobelii Var. canescens. in Journal of the Serbian Chemical Society, 69(11), 969-972.
https://hdl.handle.net/21.15107/rcub_ibiss_547

Vajs V, Soković M, Trifunović S, Janaćković PT, Milosavljević S, Tešević V. Antifungalna aktivnost terpenoida davanonskog tipa izolovanih iz Artemisia lobelii Var. canescens. in Journal of the Serbian Chemical Society. 2004;69(11):969-972.
https://hdl.handle.net/21.15107/rcub_ibiss_547 .

Vajs, Vlatka, Soković, Marina, Trifunović, Snežana, Janaćković, Peđa T., Milosavljević, Slobodan, Tešević, Vele, "Antifungalna aktivnost terpenoida davanonskog tipa izolovanih iz Artemisia lobelii Var. canescens" in Journal of the Serbian Chemical Society, 69, no. 11 (2004):969-972,
https://hdl.handle.net/21.15107/rcub_ibiss_547 .