Malešević, Adam

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  • Malešević, Adam (2)
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Research on the correct use of antibiotics in dentistry

Tambur, Zoran; Aleksić, Ema; Milutinović, Jovana; Avramov, Stevan; Malešević, Adam; Biočanin, Vladimir

(Herceg Novi: Faculty of management Herceg Novi, Montenegro, 2023)

TY  - CONF
AU  - Tambur, Zoran
AU  - Aleksić, Ema
AU  - Milutinović, Jovana
AU  - Avramov, Stevan
AU  - Malešević, Adam
AU  - Biočanin, Vladimir
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6655
AB  - Izbor antibiotika se zasniva na principu “najbolje pretpostavke“, uz poznavanje
infektivnog oboljenja, najverovatnijeg uzročnika i njegovog uobičajenog profila
osetljivosti na antibiotike. Ovakva empirijska antibiotska terapija se najčešće primenjuje
u stomatologiji jer je većina infekcija uzrokovana sa više uzročnika, u ovim infekcijama
najčešće su uključene anaerobne Gram-negativne bakterije i prilikom uzimanja uzoraka
teško je izbeći kontaminaciju uzorka sa kolonizujućom mikroflorom. Potrebno je
pridržavati se osnovnih principa pravilne primene antibiotika. Potrebno je utvrditi da li je
oboljenje infektivne etiologije, i ako jeste pre primene antibiotika uzeti uzorak za
mikrobiološki pregled. Više faktora može da utiče na izbor antibiotika: istorija bolesti,
alergijske reakcije, toksični efekti leka i prethodne antimikrobne terapije. Dozu je
potrebno odrediti unapred, pre primene, da bi se postigla dovoljna koncentracija
antibiotika na mestu infekcije. Pri tome je potrebno voditi računa o postojećim oštećenjima
organa. Način primene antibiotika zavisi od težine oboljenja pa se kod teških infekcija bira
parenteralni, intravenski put primene. Sve češće se zapažaju interakcije antibiotika sa
drugim lekovima, zbog uvođenja novih lekova u kliničku praksu, pa je neophodno i ovaj
faktor uzeti u obzir prilikom određivanja antimikrobne terapije. Odstupanja od ovih
principa mogu dovesti do raznih nepravilnosti i neželjenih reakcija u terapiji. Preterana
empirijska upotreba antibiotika dovela je do enormnog razvoja rezistencije bakterija na
ove agense pa je danas sužen izbor terapijskih mogućnosti za lečenje mnogih infekcija i
moraju se koristiti često manje efikasni agensi.
AB  - Antibiotics are chosen on a "best guess" basis, with knowledge of the
infectious disease, the most likely pathogen and its usual antibiotic susceptibility profile.
This type of empirical antibiotic therapy is used in most situations in dentistry because
most infections are caused by multiple pathogens, anaerobic gramme-negative bacteria
are most commonly involved in these infections, and it's difficult to avoid contamination
of the specimen with the colonising microflora when taking samples. It's important to
follow the basic principles of the correct use of antibiotics. It must be determined whether
the disease has an infectious cause and if so, a sample must be taken for microbiological
examination before antibiotics are administered. Several factors may influence the choice
of antibiotic: medical history, allergic reactions, toxic effects of the drug and previous
antimicrobial therapy. Existing organ damage must be taken into account. The way
antibiotics are administered depends on the severity of the disease. For example, the
parenteral, intravenous route of administration is chosen for severe infections.
Interactions of antibiotics with other drugs are becoming more common due to the
introduction of new drugs into clinical practise, so this factor must be considered when
determining antimicrobial therapy. The over-empirical use of antibiotics has led to a
tremendous development of bacterial resistance to these agents, so that today the choice
of therapeutic options for the treatment of many infections is limited to less effective
agents.
PB  - Herceg Novi: Faculty of management Herceg Novi, Montenegro
C3  - Proceedings Coast 2023: 2nd International Conference on Advances in Science and Technology: 2023 May 31 - Jun 3; Herceg Novi, Montenegro
T1  - Research on the correct use of antibiotics in dentistry
T1  - Istraživanje pravilne primene antibiotika u stomatologij
SP  - 492
EP  - 514
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6655
ER  - 
@conference{
author = "Tambur, Zoran and Aleksić, Ema and Milutinović, Jovana and Avramov, Stevan and Malešević, Adam and Biočanin, Vladimir",
year = "2023",
abstract = "Izbor antibiotika se zasniva na principu “najbolje pretpostavke“, uz poznavanje
infektivnog oboljenja, najverovatnijeg uzročnika i njegovog uobičajenog profila
osetljivosti na antibiotike. Ovakva empirijska antibiotska terapija se najčešće primenjuje
u stomatologiji jer je većina infekcija uzrokovana sa više uzročnika, u ovim infekcijama
najčešće su uključene anaerobne Gram-negativne bakterije i prilikom uzimanja uzoraka
teško je izbeći kontaminaciju uzorka sa kolonizujućom mikroflorom. Potrebno je
pridržavati se osnovnih principa pravilne primene antibiotika. Potrebno je utvrditi da li je
oboljenje infektivne etiologije, i ako jeste pre primene antibiotika uzeti uzorak za
mikrobiološki pregled. Više faktora može da utiče na izbor antibiotika: istorija bolesti,
alergijske reakcije, toksični efekti leka i prethodne antimikrobne terapije. Dozu je
potrebno odrediti unapred, pre primene, da bi se postigla dovoljna koncentracija
antibiotika na mestu infekcije. Pri tome je potrebno voditi računa o postojećim oštećenjima
organa. Način primene antibiotika zavisi od težine oboljenja pa se kod teških infekcija bira
parenteralni, intravenski put primene. Sve češće se zapažaju interakcije antibiotika sa
drugim lekovima, zbog uvođenja novih lekova u kliničku praksu, pa je neophodno i ovaj
faktor uzeti u obzir prilikom određivanja antimikrobne terapije. Odstupanja od ovih
principa mogu dovesti do raznih nepravilnosti i neželjenih reakcija u terapiji. Preterana
empirijska upotreba antibiotika dovela je do enormnog razvoja rezistencije bakterija na
ove agense pa je danas sužen izbor terapijskih mogućnosti za lečenje mnogih infekcija i
moraju se koristiti često manje efikasni agensi., Antibiotics are chosen on a "best guess" basis, with knowledge of the
infectious disease, the most likely pathogen and its usual antibiotic susceptibility profile.
This type of empirical antibiotic therapy is used in most situations in dentistry because
most infections are caused by multiple pathogens, anaerobic gramme-negative bacteria
are most commonly involved in these infections, and it's difficult to avoid contamination
of the specimen with the colonising microflora when taking samples. It's important to
follow the basic principles of the correct use of antibiotics. It must be determined whether
the disease has an infectious cause and if so, a sample must be taken for microbiological
examination before antibiotics are administered. Several factors may influence the choice
of antibiotic: medical history, allergic reactions, toxic effects of the drug and previous
antimicrobial therapy. Existing organ damage must be taken into account. The way
antibiotics are administered depends on the severity of the disease. For example, the
parenteral, intravenous route of administration is chosen for severe infections.
Interactions of antibiotics with other drugs are becoming more common due to the
introduction of new drugs into clinical practise, so this factor must be considered when
determining antimicrobial therapy. The over-empirical use of antibiotics has led to a
tremendous development of bacterial resistance to these agents, so that today the choice
of therapeutic options for the treatment of many infections is limited to less effective
agents.",
publisher = "Herceg Novi: Faculty of management Herceg Novi, Montenegro",
journal = "Proceedings Coast 2023: 2nd International Conference on Advances in Science and Technology: 2023 May 31 - Jun 3; Herceg Novi, Montenegro",
title = "Research on the correct use of antibiotics in dentistry, Istraživanje pravilne primene antibiotika u stomatologij",
pages = "492-514",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6655"
}
Tambur, Z., Aleksić, E., Milutinović, J., Avramov, S., Malešević, A.,& Biočanin, V.. (2023). Research on the correct use of antibiotics in dentistry. in Proceedings Coast 2023: 2nd International Conference on Advances in Science and Technology: 2023 May 31 - Jun 3; Herceg Novi, Montenegro
Herceg Novi: Faculty of management Herceg Novi, Montenegro., 492-514.
https://hdl.handle.net/21.15107/rcub_ibiss_6655
Tambur Z, Aleksić E, Milutinović J, Avramov S, Malešević A, Biočanin V. Research on the correct use of antibiotics in dentistry. in Proceedings Coast 2023: 2nd International Conference on Advances in Science and Technology: 2023 May 31 - Jun 3; Herceg Novi, Montenegro. 2023;:492-514.
https://hdl.handle.net/21.15107/rcub_ibiss_6655 .
Tambur, Zoran, Aleksić, Ema, Milutinović, Jovana, Avramov, Stevan, Malešević, Adam, Biočanin, Vladimir, "Research on the correct use of antibiotics in dentistry" in Proceedings Coast 2023: 2nd International Conference on Advances in Science and Technology: 2023 May 31 - Jun 3; Herceg Novi, Montenegro (2023):492-514,
https://hdl.handle.net/21.15107/rcub_ibiss_6655 .

Comparison of bromazepam and ibuprofen influence on tooth pulp-evoked potentials in humans

Vukovic, Branislava; Lazic, Zoran; Avramov, Stevan; Pavlović, Maja; Čabrilo-Lazić, Milana; Malešević, Adam; Trifunović, Jovanka; Nikolić, Živorad

(Belgrade: Serbian Medical Society, 2022)

TY  - JOUR
AU  - Vukovic, Branislava
AU  - Lazic, Zoran
AU  - Avramov, Stevan
AU  - Pavlović, Maja
AU  - Čabrilo-Lazić, Milana
AU  - Malešević, Adam
AU  - Trifunović, Jovanka
AU  - Nikolić, Živorad
PY  - 2022
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0370-81792200047V
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5077
AB  - Introduction/Objective. Somatosensory evoked potentials are a neurophysiological tool for testing the effects of drugs in humans and animals. The aim of this study was to estimate the way that bromazepam and ibuprofen had on tooth pulp-evoked potentials (TPEPs) after non-painful stimuli, as well as to detect possible differences in this activity. Methods. Sixty young healthy subjects were included in the study. They were arranged into three groups: ibuprofen, bromazepam, and placebo. To record TPEPs response, dental pulp were electrically stimulated through intact enamel with non-painful stimuli. For stimulation and registration we used Xltek Protektor 32 system, software EPWorks, version 5.0 (Natus Medical Incorporated, Oakville, ON, Canada). The experiment consisted of two testing sessions. Five recordings were performed in each session. The first test session was before, and the second was 45 minutes after administration of a single dose of the ibuprofen (400 mg), bromazepam (1.5 mg) or placebo. Results. The results of the present study exhibit that both ibuprofen and bromazepam significantly increased all the latencies; ibuprofen decreased amplitudes of all the waves except the first one (p 0.05). Additionally, there were no significant differences in influence on TPEPs between bromazepam and ibuprofen (p > 0.05). Conclusion. Our study showed that both bromazepam and ibuprofen had the same influence on TPEPs after non-painful stimuli. That indicates that anxiolytic dose of bromazepam affects neurotransmission in the same manner as non-opioid analgesics ibuprofen.
PB  - Belgrade: Serbian Medical Society
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Comparison of bromazepam and ibuprofen influence on tooth pulp-evoked potentials in humans
IS  - 5-6
VL  - 150
DO  - 10.2298/SARH220131047V
SP  - 267
EP  - 273
ER  - 
@article{
author = "Vukovic, Branislava and Lazic, Zoran and Avramov, Stevan and Pavlović, Maja and Čabrilo-Lazić, Milana and Malešević, Adam and Trifunović, Jovanka and Nikolić, Živorad",
year = "2022",
abstract = "Introduction/Objective. Somatosensory evoked potentials are a neurophysiological tool for testing the effects of drugs in humans and animals. The aim of this study was to estimate the way that bromazepam and ibuprofen had on tooth pulp-evoked potentials (TPEPs) after non-painful stimuli, as well as to detect possible differences in this activity. Methods. Sixty young healthy subjects were included in the study. They were arranged into three groups: ibuprofen, bromazepam, and placebo. To record TPEPs response, dental pulp were electrically stimulated through intact enamel with non-painful stimuli. For stimulation and registration we used Xltek Protektor 32 system, software EPWorks, version 5.0 (Natus Medical Incorporated, Oakville, ON, Canada). The experiment consisted of two testing sessions. Five recordings were performed in each session. The first test session was before, and the second was 45 minutes after administration of a single dose of the ibuprofen (400 mg), bromazepam (1.5 mg) or placebo. Results. The results of the present study exhibit that both ibuprofen and bromazepam significantly increased all the latencies; ibuprofen decreased amplitudes of all the waves except the first one (p 0.05). Additionally, there were no significant differences in influence on TPEPs between bromazepam and ibuprofen (p > 0.05). Conclusion. Our study showed that both bromazepam and ibuprofen had the same influence on TPEPs after non-painful stimuli. That indicates that anxiolytic dose of bromazepam affects neurotransmission in the same manner as non-opioid analgesics ibuprofen.",
publisher = "Belgrade: Serbian Medical Society",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Comparison of bromazepam and ibuprofen influence on tooth pulp-evoked potentials in humans",
number = "5-6",
volume = "150",
doi = "10.2298/SARH220131047V",
pages = "267-273"
}
Vukovic, B., Lazic, Z., Avramov, S., Pavlović, M., Čabrilo-Lazić, M., Malešević, A., Trifunović, J.,& Nikolić, Ž.. (2022). Comparison of bromazepam and ibuprofen influence on tooth pulp-evoked potentials in humans. in Srpski arhiv za celokupno lekarstvo
Belgrade: Serbian Medical Society., 150(5-6), 267-273.
https://doi.org/10.2298/SARH220131047V
Vukovic B, Lazic Z, Avramov S, Pavlović M, Čabrilo-Lazić M, Malešević A, Trifunović J, Nikolić Ž. Comparison of bromazepam and ibuprofen influence on tooth pulp-evoked potentials in humans. in Srpski arhiv za celokupno lekarstvo. 2022;150(5-6):267-273.
doi:10.2298/SARH220131047V .
Vukovic, Branislava, Lazic, Zoran, Avramov, Stevan, Pavlović, Maja, Čabrilo-Lazić, Milana, Malešević, Adam, Trifunović, Jovanka, Nikolić, Živorad, "Comparison of bromazepam and ibuprofen influence on tooth pulp-evoked potentials in humans" in Srpski arhiv za celokupno lekarstvo, 150, no. 5-6 (2022):267-273,
https://doi.org/10.2298/SARH220131047V . .