TY  - JOUR
AU  - Rašić-Marković, Aleksandra
AU  - Đurić, Emilija
AU  - Skrijelj, Daniel
AU  - Bjekić-Macut, Jelica
AU  - Ignjatović, Đurđica
AU  - Šutulović, Nikola
AU  - Hrnčić, Dragan
AU  - Mladenović, Dušan
AU  - Marković, Aleksandra
AU  - Radenković, Saša
AU  - Radić, Lena
AU  - Radunović, Nebojša
AU  - Stanojlović, Olivera
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6708
AB  - Neuroactive steroids are a type of steroid hormones produced within the nervous system or in peripheral glands and then transported to the brain to exert their neuromodulatory effects. Neuroactive steroids have pleiotropic effects, that include promoting myelination, neuroplasticity, and brain development. They also regulate important physiological functions, such as metabolism, feeding, reproduction, and stress response. The homoeostatic processes of metabolism and reproduction are closely linked and mutually dependent. Reproductive events, such as pregnancy, bring about significant changes in metabolism, and metabolic status may affect reproductive function in mammals. In females, the regulation of reproduction and energy balance is controlled by the fluctuations of oestradiol and progesterone throughout the menstrual cycle. Neurosteroids play a key role in the neuroendocrine control of reproduction. The synthesis of neuroestradiol and neuroprogesterone within the brain is a crucial process that facilitates the release of GnRH and LH, which in turn, regulate the transition from oestrogen-negative to oestrogen-positive feedback. In addition to their function in the reproductive system, oestrogen has a key role in the regulation of energy homoeostasis by acting at central and peripheral levels. The oestrogenic effects on body weight homoeostasis are primarily mediated by oestrogen receptors-α (ERα), which are abundantly expressed in multiple brain regions that are implicated in the regulation of food intake, basal metabolism, thermogenesis, and brown tissue distribution. The tight interplay between energy balance and reproductive physiology is facilitated by shared regulatory pathways, namely POMC, NPY and kisspeptin neurons, which are targets of oestrogen regulation and likely participate in different aspects of the joint control of energy balance and reproductive function. The aim of this review is to present a summary of the progress made in uncovering shared regulatory pathways that facilitate the tight coupling between energy balance and reproductive physiology, as well as their reciprocal interactions and the modulation induced by neurosteroids.
PB  - Springer Nature
T2  - Endocrine
T1  - Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction
DO  - 10.1007/s12020-024-03755-x
ER  - 

@article{
author = "Rašić-Marković, Aleksandra and Đurić, Emilija and Skrijelj, Daniel and Bjekić-Macut, Jelica and Ignjatović, Đurđica and Šutulović, Nikola and Hrnčić, Dragan and Mladenović, Dušan and Marković, Aleksandra and Radenković, Saša and Radić, Lena and Radunović, Nebojša and Stanojlović, Olivera",
year = "2024",
abstract = "Neuroactive steroids are a type of steroid hormones produced within the nervous system or in peripheral glands and then transported to the brain to exert their neuromodulatory effects. Neuroactive steroids have pleiotropic effects, that include promoting myelination, neuroplasticity, and brain development. They also regulate important physiological functions, such as metabolism, feeding, reproduction, and stress response. The homoeostatic processes of metabolism and reproduction are closely linked and mutually dependent. Reproductive events, such as pregnancy, bring about significant changes in metabolism, and metabolic status may affect reproductive function in mammals. In females, the regulation of reproduction and energy balance is controlled by the fluctuations of oestradiol and progesterone throughout the menstrual cycle. Neurosteroids play a key role in the neuroendocrine control of reproduction. The synthesis of neuroestradiol and neuroprogesterone within the brain is a crucial process that facilitates the release of GnRH and LH, which in turn, regulate the transition from oestrogen-negative to oestrogen-positive feedback. In addition to their function in the reproductive system, oestrogen has a key role in the regulation of energy homoeostasis by acting at central and peripheral levels. The oestrogenic effects on body weight homoeostasis are primarily mediated by oestrogen receptors-α (ERα), which are abundantly expressed in multiple brain regions that are implicated in the regulation of food intake, basal metabolism, thermogenesis, and brown tissue distribution. The tight interplay between energy balance and reproductive physiology is facilitated by shared regulatory pathways, namely POMC, NPY and kisspeptin neurons, which are targets of oestrogen regulation and likely participate in different aspects of the joint control of energy balance and reproductive function. The aim of this review is to present a summary of the progress made in uncovering shared regulatory pathways that facilitate the tight coupling between energy balance and reproductive physiology, as well as their reciprocal interactions and the modulation induced by neurosteroids.",
publisher = "Springer Nature",
journal = "Endocrine",
title = "Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction",
doi = "10.1007/s12020-024-03755-x"
}

Rašić-Marković, A., Đurić, E., Skrijelj, D., Bjekić-Macut, J., Ignjatović, Đ., Šutulović, N., Hrnčić, D., Mladenović, D., Marković, A., Radenković, S., Radić, L., Radunović, N.,& Stanojlović, O.. (2024). Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction. in Endocrine
Springer Nature..
https://doi.org/10.1007/s12020-024-03755-x

Rašić-Marković A, Đurić E, Skrijelj D, Bjekić-Macut J, Ignjatović Đ, Šutulović N, Hrnčić D, Mladenović D, Marković A, Radenković S, Radić L, Radunović N, Stanojlović O. Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction. in Endocrine. 2024;.
doi:10.1007/s12020-024-03755-x .

Rašić-Marković, Aleksandra, Đurić, Emilija, Skrijelj, Daniel, Bjekić-Macut, Jelica, Ignjatović, Đurđica, Šutulović, Nikola, Hrnčić, Dragan, Mladenović, Dušan, Marković, Aleksandra, Radenković, Saša, Radić, Lena, Radunović, Nebojša, Stanojlović, Olivera, "Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction" in Endocrine (2024),
https://doi.org/10.1007/s12020-024-03755-x . .