TY  - JOUR
AU  - Rašić-Marković, Aleksandra
AU  - Đurić, Emilija
AU  - Skrijelj, Daniel
AU  - Bjekić-Macut, Jelica
AU  - Ignjatović, Đurđica
AU  - Šutulović, Nikola
AU  - Hrnčić, Dragan
AU  - Mladenović, Dušan
AU  - Marković, Aleksandra
AU  - Radenković, Saša
AU  - Radić, Lena
AU  - Radunović, Nebojša
AU  - Stanojlović, Olivera
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6708
AB  - Neuroactive steroids are a type of steroid hormones produced within the nervous system or in peripheral glands and then transported to the brain to exert their neuromodulatory effects. Neuroactive steroids have pleiotropic effects, that include promoting myelination, neuroplasticity, and brain development. They also regulate important physiological functions, such as metabolism, feeding, reproduction, and stress response. The homoeostatic processes of metabolism and reproduction are closely linked and mutually dependent. Reproductive events, such as pregnancy, bring about significant changes in metabolism, and metabolic status may affect reproductive function in mammals. In females, the regulation of reproduction and energy balance is controlled by the fluctuations of oestradiol and progesterone throughout the menstrual cycle. Neurosteroids play a key role in the neuroendocrine control of reproduction. The synthesis of neuroestradiol and neuroprogesterone within the brain is a crucial process that facilitates the release of GnRH and LH, which in turn, regulate the transition from oestrogen-negative to oestrogen-positive feedback. In addition to their function in the reproductive system, oestrogen has a key role in the regulation of energy homoeostasis by acting at central and peripheral levels. The oestrogenic effects on body weight homoeostasis are primarily mediated by oestrogen receptors-α (ERα), which are abundantly expressed in multiple brain regions that are implicated in the regulation of food intake, basal metabolism, thermogenesis, and brown tissue distribution. The tight interplay between energy balance and reproductive physiology is facilitated by shared regulatory pathways, namely POMC, NPY and kisspeptin neurons, which are targets of oestrogen regulation and likely participate in different aspects of the joint control of energy balance and reproductive function. The aim of this review is to present a summary of the progress made in uncovering shared regulatory pathways that facilitate the tight coupling between energy balance and reproductive physiology, as well as their reciprocal interactions and the modulation induced by neurosteroids.
PB  - Springer Nature
T2  - Endocrine
T1  - Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction
DO  - 10.1007/s12020-024-03755-x
ER  - 

@article{
author = "Rašić-Marković, Aleksandra and Đurić, Emilija and Skrijelj, Daniel and Bjekić-Macut, Jelica and Ignjatović, Đurđica and Šutulović, Nikola and Hrnčić, Dragan and Mladenović, Dušan and Marković, Aleksandra and Radenković, Saša and Radić, Lena and Radunović, Nebojša and Stanojlović, Olivera",
year = "2024",
abstract = "Neuroactive steroids are a type of steroid hormones produced within the nervous system or in peripheral glands and then transported to the brain to exert their neuromodulatory effects. Neuroactive steroids have pleiotropic effects, that include promoting myelination, neuroplasticity, and brain development. They also regulate important physiological functions, such as metabolism, feeding, reproduction, and stress response. The homoeostatic processes of metabolism and reproduction are closely linked and mutually dependent. Reproductive events, such as pregnancy, bring about significant changes in metabolism, and metabolic status may affect reproductive function in mammals. In females, the regulation of reproduction and energy balance is controlled by the fluctuations of oestradiol and progesterone throughout the menstrual cycle. Neurosteroids play a key role in the neuroendocrine control of reproduction. The synthesis of neuroestradiol and neuroprogesterone within the brain is a crucial process that facilitates the release of GnRH and LH, which in turn, regulate the transition from oestrogen-negative to oestrogen-positive feedback. In addition to their function in the reproductive system, oestrogen has a key role in the regulation of energy homoeostasis by acting at central and peripheral levels. The oestrogenic effects on body weight homoeostasis are primarily mediated by oestrogen receptors-α (ERα), which are abundantly expressed in multiple brain regions that are implicated in the regulation of food intake, basal metabolism, thermogenesis, and brown tissue distribution. The tight interplay between energy balance and reproductive physiology is facilitated by shared regulatory pathways, namely POMC, NPY and kisspeptin neurons, which are targets of oestrogen regulation and likely participate in different aspects of the joint control of energy balance and reproductive function. The aim of this review is to present a summary of the progress made in uncovering shared regulatory pathways that facilitate the tight coupling between energy balance and reproductive physiology, as well as their reciprocal interactions and the modulation induced by neurosteroids.",
publisher = "Springer Nature",
journal = "Endocrine",
title = "Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction",
doi = "10.1007/s12020-024-03755-x"
}

Rašić-Marković, A., Đurić, E., Skrijelj, D., Bjekić-Macut, J., Ignjatović, Đ., Šutulović, N., Hrnčić, D., Mladenović, D., Marković, A., Radenković, S., Radić, L., Radunović, N.,& Stanojlović, O.. (2024). Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction. in Endocrine
Springer Nature..
https://doi.org/10.1007/s12020-024-03755-x

Rašić-Marković A, Đurić E, Skrijelj D, Bjekić-Macut J, Ignjatović Đ, Šutulović N, Hrnčić D, Mladenović D, Marković A, Radenković S, Radić L, Radunović N, Stanojlović O. Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction. in Endocrine. 2024;.
doi:10.1007/s12020-024-03755-x .

Rašić-Marković, Aleksandra, Đurić, Emilija, Skrijelj, Daniel, Bjekić-Macut, Jelica, Ignjatović, Đurđica, Šutulović, Nikola, Hrnčić, Dragan, Mladenović, Dušan, Marković, Aleksandra, Radenković, Saša, Radić, Lena, Radunović, Nebojša, Stanojlović, Olivera, "Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction" in Endocrine (2024),
https://doi.org/10.1007/s12020-024-03755-x . .

TY  - CHAP
AU  - Stanojlović, Olivera
AU  - Hrnčić, Dragan
AU  - Vojnović Milutinović, Danijela
AU  - Mladenović, Dušan
AU  - Šutulović, Nikola
PY  - 2023
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6330
AB  - Dysfunction of hypothalamic-pituitary-gonadal (HPG) axis can be caused by complex and multilevel interactions between altered sleep quality, behavioral disturbances,and chemicals that interfere with normal functioning of the endocrine system, known as endocrine disruptors (EDs). Sleep deprivation disrupts circadian 
rhythm and via modulation of melatonin secretion and hypothalamic neural outputs
inhibits gonadotropin-releasing hormone (GnRH) secretion and reduces the levels 
of gonadotropins and androgens. Although many evidence suggest that EDs may affect the function of HPG axis, the precise actions on EDs on reproductive health 
are still controversial. More studies have been performed in female than in male 
animals. Major mechanisms of deleterious action of EDs on HPG axis include 
stimulation or inhibition of nuclear hormone receptors via direct binding, alter
actions of steroid biosynthesis and degradation, and changes in neurotransmitter 
release and effects. Some EDs may also cause the apoptosis of GnRH neurons or
induce epigenetic changes that can be transmitted to the offspring. In ovaries, EDs 
may inhibit key steroidogenic enzymes and estrogen synthesis or directly injure
granulosa or theca cells. They can also have high affinity for estrogen, androgen,
progesterone, or glucocorticoid receptors, and to stimulate or inhibit different 
signaling pathways in the cell. All of these changes may impair oocyte maturation ,
increase the frequency of anovulatory cycles, and ultimately lead to disturbed 
puberty onset, reduced female fecundity, and premature ovarian failure. This 
chapter summarizes the current knowledge on the effects of sleep disturbances 
and major EDs on reproductive function from prenatal to adult period.
PB  - Cham: Springer
T2  - Environmental Endocrinology and Endocrine Disruptors: Endocrine and Endocrine-targeted Actions and Related Human Diseases
T1  - Environmental Impact on the Hypothalamus-Pituitary-Ovary Axis
DO  - 10.1007/978-3-030-39044-0_5
SP  - 129
EP  - 153
ER  - 

@inbook{
author = "Stanojlović, Olivera and Hrnčić, Dragan and Vojnović Milutinović, Danijela and Mladenović, Dušan and Šutulović, Nikola",
year = "2023",
abstract = "Dysfunction of hypothalamic-pituitary-gonadal (HPG) axis can be caused by complex and multilevel interactions between altered sleep quality, behavioral disturbances,and chemicals that interfere with normal functioning of the endocrine system, known as endocrine disruptors (EDs). Sleep deprivation disrupts circadian 
rhythm and via modulation of melatonin secretion and hypothalamic neural outputs
inhibits gonadotropin-releasing hormone (GnRH) secretion and reduces the levels 
of gonadotropins and androgens. Although many evidence suggest that EDs may affect the function of HPG axis, the precise actions on EDs on reproductive health 
are still controversial. More studies have been performed in female than in male 
animals. Major mechanisms of deleterious action of EDs on HPG axis include 
stimulation or inhibition of nuclear hormone receptors via direct binding, alter
actions of steroid biosynthesis and degradation, and changes in neurotransmitter 
release and effects. Some EDs may also cause the apoptosis of GnRH neurons or
induce epigenetic changes that can be transmitted to the offspring. In ovaries, EDs 
may inhibit key steroidogenic enzymes and estrogen synthesis or directly injure
granulosa or theca cells. They can also have high affinity for estrogen, androgen,
progesterone, or glucocorticoid receptors, and to stimulate or inhibit different 
signaling pathways in the cell. All of these changes may impair oocyte maturation ,
increase the frequency of anovulatory cycles, and ultimately lead to disturbed 
puberty onset, reduced female fecundity, and premature ovarian failure. This 
chapter summarizes the current knowledge on the effects of sleep disturbances 
and major EDs on reproductive function from prenatal to adult period.",
publisher = "Cham: Springer",
journal = "Environmental Endocrinology and Endocrine Disruptors: Endocrine and Endocrine-targeted Actions and Related Human Diseases",
booktitle = "Environmental Impact on the Hypothalamus-Pituitary-Ovary Axis",
doi = "10.1007/978-3-030-39044-0_5",
pages = "129-153"
}

Stanojlović, O., Hrnčić, D., Vojnović Milutinović, D., Mladenović, D.,& Šutulović, N.. (2023). Environmental Impact on the Hypothalamus-Pituitary-Ovary Axis. in Environmental Endocrinology and Endocrine Disruptors: Endocrine and Endocrine-targeted Actions and Related Human Diseases
Cham: Springer., 129-153.
https://doi.org/10.1007/978-3-030-39044-0_5

Stanojlović O, Hrnčić D, Vojnović Milutinović D, Mladenović D, Šutulović N. Environmental Impact on the Hypothalamus-Pituitary-Ovary Axis. in Environmental Endocrinology and Endocrine Disruptors: Endocrine and Endocrine-targeted Actions and Related Human Diseases. 2023;:129-153.
doi:10.1007/978-3-030-39044-0_5 .

Stanojlović, Olivera, Hrnčić, Dragan, Vojnović Milutinović, Danijela, Mladenović, Dušan, Šutulović, Nikola, "Environmental Impact on the Hypothalamus-Pituitary-Ovary Axis" in Environmental Endocrinology and Endocrine Disruptors: Endocrine and Endocrine-targeted Actions and Related Human Diseases (2023):129-153,
https://doi.org/10.1007/978-3-030-39044-0_5 . .