TY  - GEN
AU  - Đurović, Jelena
AU  - Stojković, Oliver
AU  - Todorović, Jelena
AU  - Brajić, Aleksandra
AU  - Stanković, Sanja
AU  - Obradović, Svetlana
AU  - Stamenković, Gorana
PY  - 2016
UR  - https://www.tandfonline.com/doi/full/10.1080/14647273.2016.1255785
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2595
AB  - Reproductive failure (recurrent foetal loss, unexplained infertility and IVF implantation failure) may be, in a number of cases, explained by thrombophilia, either acquired or inherited. Several genes contribute to thrombophilia, some with major effect (Factor V, Factor II), and some with minor effect (MTHFR, PAI-1, ATIII, etc.). The aim of this study was to estimate frequency of thrombophilia-associated genotypes (FII20210G > A, FV1691G > A, MTHFR677C > T and PAI-1 -675 4G/5G) in a group of 1631 Serbian women experiencing reproductive failure, and compare it with a healthy, female control group. Our results showed marginally significant (p = 0.050) differences in allele frequencies between patients and controls for the FV1691 mutations. For the FII20210G > A, although the statistical significance was not achieved (p = 0.076), we found higher frequency of variant allele in patients compared to controls (1.87% vs. 0.38%, respectively) which may point to a possible role of this polymorphism in thrombotic events. For the MTHFR677C > T and PAI-1 -675 4G/5G, we found no difference in distributions of genotype or allele frequencies between these two groups (p > 0.05). For three subjects with very rare genotypes (two patients homozygous for FV1691G > A and one patient homozygous for FII20210G > A) we performed additional biochemical analyses for haemostasis, as well as genotyping of two polymorphisms (MTHFR1298A > C and ATIII786G > A).
T2  - Human Fertility
T1  - Genetics of suspected thrombophilia in Serbian females with infertility, including three cases, homozygous for FII 20210A or FV 1691A mutations
DO  - 10.1080/14647273.2016.1255785
SP  - 1
EP  - 8
ER  - 

@misc{
author = "Đurović, Jelena and Stojković, Oliver and Todorović, Jelena and Brajić, Aleksandra and Stanković, Sanja and Obradović, Svetlana and Stamenković, Gorana",
year = "2016",
abstract = "Reproductive failure (recurrent foetal loss, unexplained infertility and IVF implantation failure) may be, in a number of cases, explained by thrombophilia, either acquired or inherited. Several genes contribute to thrombophilia, some with major effect (Factor V, Factor II), and some with minor effect (MTHFR, PAI-1, ATIII, etc.). The aim of this study was to estimate frequency of thrombophilia-associated genotypes (FII20210G > A, FV1691G > A, MTHFR677C > T and PAI-1 -675 4G/5G) in a group of 1631 Serbian women experiencing reproductive failure, and compare it with a healthy, female control group. Our results showed marginally significant (p = 0.050) differences in allele frequencies between patients and controls for the FV1691 mutations. For the FII20210G > A, although the statistical significance was not achieved (p = 0.076), we found higher frequency of variant allele in patients compared to controls (1.87% vs. 0.38%, respectively) which may point to a possible role of this polymorphism in thrombotic events. For the MTHFR677C > T and PAI-1 -675 4G/5G, we found no difference in distributions of genotype or allele frequencies between these two groups (p > 0.05). For three subjects with very rare genotypes (two patients homozygous for FV1691G > A and one patient homozygous for FII20210G > A) we performed additional biochemical analyses for haemostasis, as well as genotyping of two polymorphisms (MTHFR1298A > C and ATIII786G > A).",
journal = "Human Fertility",
title = "Genetics of suspected thrombophilia in Serbian females with infertility, including three cases, homozygous for FII 20210A or FV 1691A mutations",
doi = "10.1080/14647273.2016.1255785",
pages = "1-8"
}

Đurović, J., Stojković, O., Todorović, J., Brajić, A., Stanković, S., Obradović, S.,& Stamenković, G.. (2016). Genetics of suspected thrombophilia in Serbian females with infertility, including three cases, homozygous for FII 20210A or FV 1691A mutations. in Human Fertility, 1-8.
https://doi.org/10.1080/14647273.2016.1255785

Đurović J, Stojković O, Todorović J, Brajić A, Stanković S, Obradović S, Stamenković G. Genetics of suspected thrombophilia in Serbian females with infertility, including three cases, homozygous for FII 20210A or FV 1691A mutations. in Human Fertility. 2016;:1-8.
doi:10.1080/14647273.2016.1255785 .

Đurović, Jelena, Stojković, Oliver, Todorović, Jelena, Brajić, Aleksandra, Stanković, Sanja, Obradović, Svetlana, Stamenković, Gorana, "Genetics of suspected thrombophilia in Serbian females with infertility, including three cases, homozygous for FII 20210A or FV 1691A mutations" in Human Fertility (2016):1-8,
https://doi.org/10.1080/14647273.2016.1255785 . .

TY  - CONF
AU  - Filipović, Ljupka
AU  - Ristić, Nina
AU  - Perišić, Vojislav
AU  - Ignjatović, Đurđica
AU  - Đurović, Jelena
AU  - Obradović, Svetlana
AU  - Stevanović, Snežana
AU  - Stamenković, Gorana
PY  - 2015
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6768
AB  - Celiac disease (CD) is an intestinal inflammatory disorder triggered by gluten ingestion. It's strongly associated with HLA-DQ2 or HLA-DQ8 haplotypes: the absence of HLA-DQ haplotypes suggests that CD is unlikely. Lactose intolerance (LI) is gastrointestinal disorder caused by reduced lactase activity and is associated with C/T13910 polymorphism upstream of the lactase gene. Similar gastrointestinal symptoms in both diseases cause difficulties in establishing the correct diagnosis.
The aim of this study was to evaluate the importance of genetic analysis for clinical discrimination between CD and LI. The study group consisted of 70 patients from Serbia, with gastrointestinal symptoms suggesting CD. Control group for CD (62 individual) was previously published, while a novel group of 54 healthy individuals without gastrointestinal symptoms was genotyped for C/T13910. HLA haplotypes were established using reverse linc blot method. Polymorphism on C/113910 locus for lactose intolerance was genotyped by TaqMan assay.
As much as 60% of patients (significantly higher compared to published controls, p=0.026) in the studied group were positive for either HLA-DQ2 (49%) or HLA-DQ8 (11%) haplotypes, while 31% of patients were negative for both haplotypes. Complex HLA-DQ2/DQ8 haplotypes had 3% of patients. Remaining 6% of patients were not successfully genotyped by the method. For C/T13910, 51% of patients were homozygous for C allele (not significantly different compared to healthy controls, p=0.96). In addition, 41% of HLA negative patients, suggested the absence of CD, were positive for genetic predisposition for LI.
Our results imply importance of performing genetic analysis for better distinguishing between CD and LI.
PB  - Belgrade: Serbian Genetic Society
C3  - 11th Balkan Congress of Human Genetics; 2015 Sep 17-20; Belgrade, Serbia
T1  - Genetic predisposition for celiac disease and lactose intolerance in patient with gastrointestinal ailments – study in Serbia
IS  - 49
EP  - 50
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6768
ER  - 

@conference{
author = "Filipović, Ljupka and Ristić, Nina and Perišić, Vojislav and Ignjatović, Đurđica and Đurović, Jelena and Obradović, Svetlana and Stevanović, Snežana and Stamenković, Gorana",
year = "2015",
abstract = "Celiac disease (CD) is an intestinal inflammatory disorder triggered by gluten ingestion. It's strongly associated with HLA-DQ2 or HLA-DQ8 haplotypes: the absence of HLA-DQ haplotypes suggests that CD is unlikely. Lactose intolerance (LI) is gastrointestinal disorder caused by reduced lactase activity and is associated with C/T13910 polymorphism upstream of the lactase gene. Similar gastrointestinal symptoms in both diseases cause difficulties in establishing the correct diagnosis.
The aim of this study was to evaluate the importance of genetic analysis for clinical discrimination between CD and LI. The study group consisted of 70 patients from Serbia, with gastrointestinal symptoms suggesting CD. Control group for CD (62 individual) was previously published, while a novel group of 54 healthy individuals without gastrointestinal symptoms was genotyped for C/T13910. HLA haplotypes were established using reverse linc blot method. Polymorphism on C/113910 locus for lactose intolerance was genotyped by TaqMan assay.
As much as 60% of patients (significantly higher compared to published controls, p=0.026) in the studied group were positive for either HLA-DQ2 (49%) or HLA-DQ8 (11%) haplotypes, while 31% of patients were negative for both haplotypes. Complex HLA-DQ2/DQ8 haplotypes had 3% of patients. Remaining 6% of patients were not successfully genotyped by the method. For C/T13910, 51% of patients were homozygous for C allele (not significantly different compared to healthy controls, p=0.96). In addition, 41% of HLA negative patients, suggested the absence of CD, were positive for genetic predisposition for LI.
Our results imply importance of performing genetic analysis for better distinguishing between CD and LI.",
publisher = "Belgrade: Serbian Genetic Society",
journal = "11th Balkan Congress of Human Genetics; 2015 Sep 17-20; Belgrade, Serbia",
title = "Genetic predisposition for celiac disease and lactose intolerance in patient with gastrointestinal ailments – study in Serbia",
number = "49",
pages = "50",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6768"
}

Filipović, L., Ristić, N., Perišić, V., Ignjatović, Đ., Đurović, J., Obradović, S., Stevanović, S.,& Stamenković, G.. (2015). Genetic predisposition for celiac disease and lactose intolerance in patient with gastrointestinal ailments – study in Serbia. in 11th Balkan Congress of Human Genetics; 2015 Sep 17-20; Belgrade, Serbia
Belgrade: Serbian Genetic Society.(49).
https://hdl.handle.net/21.15107/rcub_ibiss_6768

Filipović L, Ristić N, Perišić V, Ignjatović Đ, Đurović J, Obradović S, Stevanović S, Stamenković G. Genetic predisposition for celiac disease and lactose intolerance in patient with gastrointestinal ailments – study in Serbia. in 11th Balkan Congress of Human Genetics; 2015 Sep 17-20; Belgrade, Serbia. 2015;(49):null-50.
https://hdl.handle.net/21.15107/rcub_ibiss_6768 .

Filipović, Ljupka, Ristić, Nina, Perišić, Vojislav, Ignjatović, Đurđica, Đurović, Jelena, Obradović, Svetlana, Stevanović, Snežana, Stamenković, Gorana, "Genetic predisposition for celiac disease and lactose intolerance in patient with gastrointestinal ailments – study in Serbia" in 11th Balkan Congress of Human Genetics; 2015 Sep 17-20; Belgrade, Serbia, no. 49 (2015),
https://hdl.handle.net/21.15107/rcub_ibiss_6768 .