TY  - JOUR
AU  - Prodanović, Radiša
AU  - Kirovski, Danijela
AU  - Vujanac, Ivan
AU  - Đorđević, Ana
AU  - Romić, Snježana
AU  - Pantelić, Marija
AU  - Korićanac, Goran
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5023
AB  - A number of alterations have been identified in lipid metabolism within adipose tissue and liver in obesity. Less is
known about the capacity of skeletal muscle for the metabolism of fatty acids in obesity-related insulin resistance,
though it is evident that dry cow muscles may contain increased triglyceride content. The current study
was therefore undertaken to evaluate the skeletal muscle expression of proteins of the fatty acid metabolism in
dry cows with different body condition scores (BCS). Sixteen Holstein-Friesian close-up cows were divided into 2
equal groups based on their BCS as optimal (3.25 ≤ BCS ≤ 3.5) and high (4.0 ≤ BCS ≤ 4.25). Blood samples
collection and skeletal muscle biopsies were carried out at day 10 before calving. Blood serum was assayed for
concentration of resistin using a bovine specific ELISA. Protein expression of insulin receptor beta subunit (IRβ),
glucose transporter 4 (GLUT4), fatty acid translocase (FAT/CD36), fatty acid transporter 1 (FATP1), carnitine
palmitoyltransferase 1 (CPT1), AMP-acitvated protein kinase (AMPK) and lipin 1 were analyzed in semitendinosus
muscle by immunoblot. Resistin differed non-significantly between high-BCS and optimal-BCS cows.
Insulin-resistant lipid metabolism in obese cows was paralleled with increased skeletal muscle expression of lipin
1 and GLUT4, and decreased expression of IRβ and FATP1. These data suggest that in obesity-related insulin
resistance, metabolic capacity in dry cow skeletal muscles appears to be organized towards the synthesis of
signaling intermediates rather than fatty acids oxidation and that altered fatty acid uptake does not contribute to
this disposition.
PB  - Amsterdam: Elsevier Ltd.
T2  - Research in Veterinary Science
T1  - Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle
VL  - 150
DO  - 10.1016/j.rvsc.2022.04.012
SP  - 189
EP  - 194
ER  - 

@article{
author = "Prodanović, Radiša and Kirovski, Danijela and Vujanac, Ivan and Đorđević, Ana and Romić, Snježana and Pantelić, Marija and Korićanac, Goran",
year = "2022",
abstract = "A number of alterations have been identified in lipid metabolism within adipose tissue and liver in obesity. Less is
known about the capacity of skeletal muscle for the metabolism of fatty acids in obesity-related insulin resistance,
though it is evident that dry cow muscles may contain increased triglyceride content. The current study
was therefore undertaken to evaluate the skeletal muscle expression of proteins of the fatty acid metabolism in
dry cows with different body condition scores (BCS). Sixteen Holstein-Friesian close-up cows were divided into 2
equal groups based on their BCS as optimal (3.25 ≤ BCS ≤ 3.5) and high (4.0 ≤ BCS ≤ 4.25). Blood samples
collection and skeletal muscle biopsies were carried out at day 10 before calving. Blood serum was assayed for
concentration of resistin using a bovine specific ELISA. Protein expression of insulin receptor beta subunit (IRβ),
glucose transporter 4 (GLUT4), fatty acid translocase (FAT/CD36), fatty acid transporter 1 (FATP1), carnitine
palmitoyltransferase 1 (CPT1), AMP-acitvated protein kinase (AMPK) and lipin 1 were analyzed in semitendinosus
muscle by immunoblot. Resistin differed non-significantly between high-BCS and optimal-BCS cows.
Insulin-resistant lipid metabolism in obese cows was paralleled with increased skeletal muscle expression of lipin
1 and GLUT4, and decreased expression of IRβ and FATP1. These data suggest that in obesity-related insulin
resistance, metabolic capacity in dry cow skeletal muscles appears to be organized towards the synthesis of
signaling intermediates rather than fatty acids oxidation and that altered fatty acid uptake does not contribute to
this disposition.",
publisher = "Amsterdam: Elsevier Ltd.",
journal = "Research in Veterinary Science",
title = "Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle",
volume = "150",
doi = "10.1016/j.rvsc.2022.04.012",
pages = "189-194"
}

Prodanović, R., Kirovski, D., Vujanac, I., Đorđević, A., Romić, S., Pantelić, M.,& Korićanac, G.. (2022). Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle. in Research in Veterinary Science
Amsterdam: Elsevier Ltd.., 150, 189-194.
https://doi.org/10.1016/j.rvsc.2022.04.012

Prodanović R, Kirovski D, Vujanac I, Đorđević A, Romić S, Pantelić M, Korićanac G. Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle. in Research in Veterinary Science. 2022;150:189-194.
doi:10.1016/j.rvsc.2022.04.012 .

Prodanović, Radiša, Kirovski, Danijela, Vujanac, Ivan, Đorđević, Ana, Romić, Snježana, Pantelić, Marija, Korićanac, Goran, "Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle" in Research in Veterinary Science, 150 (2022):189-194,
https://doi.org/10.1016/j.rvsc.2022.04.012 . .

TY  - JOUR
AU  - Romić, Snježana
AU  - Đorđević, Ana
AU  - Tepavčević, Snežana
AU  - Ćulafić, Tijana
AU  - Stojiljković, Mojca
AU  - Bursać, Biljana
AU  - Stanišić, Jelena
AU  - Kostić, Milan
AU  - Gligorovska, Ljupka
AU  - Korićanac, Goran
PY  - 2020
UR  - http://www.ncbi.nlm.nih.gov/pubmed/31974538
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3629
AB  - Both a diet rich in fructose and chronic stress exposure induce metabolic and cardiovascular disturbances. The aim of this study was to examine the effects of the fructose-rich diet and chronic stress, separately and in combination, on insulin signaling and molecules regulating glycogen synthesis and ion transport in the heart, and to reveal whether these effects coincide with changes in glucocorticoid receptor (GR) activation. Male Wistar rats were subjected to 10% fructose in drinking water and/or to chronic unpredictable stress for 9 weeks. Protein expression and/or phosphorylation of the insulin receptor (IR), protein tyrosine phosphatase 1B, insulin receptor substrate 1 (IRS1), protein kinase B (Akt), extracellular signal-regulated kinase 1/2 (ERK1/2), glycogen synthase kinase-3β (GSK-3β) and Na+/K+-ATPase α-subunits in cardiac tissue were analyzed by western blot. GR distribution between cytosolic and nuclear fractions was also analyzed. The fructose-rich diet decreased the level of pERK1/2 (Thr202/Tyr204) and pGSK-3β (Ser9) independently of stress, while chronic stress increased the IRS1 content and prevented the fructose diet-induced decrease of the pAkt (Ser473) level. The fructose-rich diet in combination with chronic stress reduced the protein content of cardiac IR and attenuated IRS1 upregulation. Separate treatments increased the protein content of Na+/K+-ATPase α1- and α2-subunits, while after combined treatment the α2 content was at the control level and the α1 content was lower than the control level. The effect of combined treatment on cardiac IR and α2-subunit expression could be mediated by increased GR nuclear accumulation. Our study provides new insights into the effects of chronic stress and a combination of the fructose diet and chronic stress on the studied molecules in the heart.
T2  - Food and Function
T1  - Effects of a fructose-rich diet and chronic stress on insulin signaling and regulation of glycogen synthase kinase-3 beta and the sodium-potassium pump in the hearts of male rats.
IS  - 2
VL  - 11
DO  - 10.1039/c9fo02306b
SP  - 1455
EP  - 1466
ER  - 

@article{
author = "Romić, Snježana and Đorđević, Ana and Tepavčević, Snežana and Ćulafić, Tijana and Stojiljković, Mojca and Bursać, Biljana and Stanišić, Jelena and Kostić, Milan and Gligorovska, Ljupka and Korićanac, Goran",
year = "2020",
abstract = "Both a diet rich in fructose and chronic stress exposure induce metabolic and cardiovascular disturbances. The aim of this study was to examine the effects of the fructose-rich diet and chronic stress, separately and in combination, on insulin signaling and molecules regulating glycogen synthesis and ion transport in the heart, and to reveal whether these effects coincide with changes in glucocorticoid receptor (GR) activation. Male Wistar rats were subjected to 10% fructose in drinking water and/or to chronic unpredictable stress for 9 weeks. Protein expression and/or phosphorylation of the insulin receptor (IR), protein tyrosine phosphatase 1B, insulin receptor substrate 1 (IRS1), protein kinase B (Akt), extracellular signal-regulated kinase 1/2 (ERK1/2), glycogen synthase kinase-3β (GSK-3β) and Na+/K+-ATPase α-subunits in cardiac tissue were analyzed by western blot. GR distribution between cytosolic and nuclear fractions was also analyzed. The fructose-rich diet decreased the level of pERK1/2 (Thr202/Tyr204) and pGSK-3β (Ser9) independently of stress, while chronic stress increased the IRS1 content and prevented the fructose diet-induced decrease of the pAkt (Ser473) level. The fructose-rich diet in combination with chronic stress reduced the protein content of cardiac IR and attenuated IRS1 upregulation. Separate treatments increased the protein content of Na+/K+-ATPase α1- and α2-subunits, while after combined treatment the α2 content was at the control level and the α1 content was lower than the control level. The effect of combined treatment on cardiac IR and α2-subunit expression could be mediated by increased GR nuclear accumulation. Our study provides new insights into the effects of chronic stress and a combination of the fructose diet and chronic stress on the studied molecules in the heart.",
journal = "Food and Function",
title = "Effects of a fructose-rich diet and chronic stress on insulin signaling and regulation of glycogen synthase kinase-3 beta and the sodium-potassium pump in the hearts of male rats.",
number = "2",
volume = "11",
doi = "10.1039/c9fo02306b",
pages = "1455-1466"
}

Romić, S., Đorđević, A., Tepavčević, S., Ćulafić, T., Stojiljković, M., Bursać, B., Stanišić, J., Kostić, M., Gligorovska, L.,& Korićanac, G.. (2020). Effects of a fructose-rich diet and chronic stress on insulin signaling and regulation of glycogen synthase kinase-3 beta and the sodium-potassium pump in the hearts of male rats.. in Food and Function, 11(2), 1455-1466.
https://doi.org/10.1039/c9fo02306b

Romić S, Đorđević A, Tepavčević S, Ćulafić T, Stojiljković M, Bursać B, Stanišić J, Kostić M, Gligorovska L, Korićanac G. Effects of a fructose-rich diet and chronic stress on insulin signaling and regulation of glycogen synthase kinase-3 beta and the sodium-potassium pump in the hearts of male rats.. in Food and Function. 2020;11(2):1455-1466.
doi:10.1039/c9fo02306b .

Romić, Snježana, Đorđević, Ana, Tepavčević, Snežana, Ćulafić, Tijana, Stojiljković, Mojca, Bursać, Biljana, Stanišić, Jelena, Kostić, Milan, Gligorovska, Ljupka, Korićanac, Goran, "Effects of a fructose-rich diet and chronic stress on insulin signaling and regulation of glycogen synthase kinase-3 beta and the sodium-potassium pump in the hearts of male rats." in Food and Function, 11, no. 2 (2020):1455-1466,
https://doi.org/10.1039/c9fo02306b . .

TY  - JOUR
AU  - Prodanović, Radiša
AU  - Korićanac, Goran
AU  - Vujanac, Ivan
AU  - Đorđević, Ana
AU  - Pantelić, Marija
AU  - Romić, Snježana
AU  - Stanimirović, Zoran
AU  - Kirovski, Danijela
PY  - 2016
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6086
AB  - We investigated the hypothesis that obesity in dairy cows enhanced expression of proteins involved in hepaticfatty acid uptake and metabolism. Sixteen Holstein-Friesian close-up cows were divided into 2 equal groupsbased on their body condition score (BCS) as optimal (3.25 ≤ BCS ≤ 3.5) and high (4.0 ≤ BCS ≤ 4.25). Intravenousglucose tolerance test (GTT) and liver biopsieswere carried out at day 10 before calving. Blood samples were collectedbefore (basal) and after glucose infusion, and glucose, insulin and non-esterified fatty acid (NEFA) levelswere determined at each sample point. In addition, β-hydroxybutyrate and triglycerides levels were measuredin the basal samples. The liver biopsieswere analyzed for total lipid content and protein expression of insulin receptorbeta (IRβ), fatty acid translocase (FAT/CD36) and sterol regulatory element-binding protein-1 (SREBP-1).Basal glucose and insulin were higher in high-BCS cows, which coincided with higher circulating triglyceridesand hepatic lipid content. Clearance rate and AUC for NEFA during GTT were higher in optimal-BCS cows. The developmentof insulin resistance and fatty liver in obese cows was paralleled by increased hepatic expression ofthe IRβ, CD36 and SREBP-1. These results suggest that increased expression of hepatic CD36 and SREBP-1 is relevantin the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.
PB  - Elsevier
T2  - Research in Veterinary Science
T1  - Obesity-driven prepartal hepatic lipid accumulation in dairy cows is associated with increased CD36 and SREBP-1 expression
VL  - 107
DO  - 10.1016/j.rvsc.2016.04.007
SP  - 16
EP  - 19
ER  - 

@article{
author = "Prodanović, Radiša and Korićanac, Goran and Vujanac, Ivan and Đorđević, Ana and Pantelić, Marija and Romić, Snježana and Stanimirović, Zoran and Kirovski, Danijela",
year = "2016",
abstract = "We investigated the hypothesis that obesity in dairy cows enhanced expression of proteins involved in hepaticfatty acid uptake and metabolism. Sixteen Holstein-Friesian close-up cows were divided into 2 equal groupsbased on their body condition score (BCS) as optimal (3.25 ≤ BCS ≤ 3.5) and high (4.0 ≤ BCS ≤ 4.25). Intravenousglucose tolerance test (GTT) and liver biopsieswere carried out at day 10 before calving. Blood samples were collectedbefore (basal) and after glucose infusion, and glucose, insulin and non-esterified fatty acid (NEFA) levelswere determined at each sample point. In addition, β-hydroxybutyrate and triglycerides levels were measuredin the basal samples. The liver biopsieswere analyzed for total lipid content and protein expression of insulin receptorbeta (IRβ), fatty acid translocase (FAT/CD36) and sterol regulatory element-binding protein-1 (SREBP-1).Basal glucose and insulin were higher in high-BCS cows, which coincided with higher circulating triglyceridesand hepatic lipid content. Clearance rate and AUC for NEFA during GTT were higher in optimal-BCS cows. The developmentof insulin resistance and fatty liver in obese cows was paralleled by increased hepatic expression ofthe IRβ, CD36 and SREBP-1. These results suggest that increased expression of hepatic CD36 and SREBP-1 is relevantin the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.",
publisher = "Elsevier",
journal = "Research in Veterinary Science",
title = "Obesity-driven prepartal hepatic lipid accumulation in dairy cows is associated with increased CD36 and SREBP-1 expression",
volume = "107",
doi = "10.1016/j.rvsc.2016.04.007",
pages = "16-19"
}

Prodanović, R., Korićanac, G., Vujanac, I., Đorđević, A., Pantelić, M., Romić, S., Stanimirović, Z.,& Kirovski, D.. (2016). Obesity-driven prepartal hepatic lipid accumulation in dairy cows is associated with increased CD36 and SREBP-1 expression. in Research in Veterinary Science
Elsevier., 107, 16-19.
https://doi.org/10.1016/j.rvsc.2016.04.007

Prodanović R, Korićanac G, Vujanac I, Đorđević A, Pantelić M, Romić S, Stanimirović Z, Kirovski D. Obesity-driven prepartal hepatic lipid accumulation in dairy cows is associated with increased CD36 and SREBP-1 expression. in Research in Veterinary Science. 2016;107:16-19.
doi:10.1016/j.rvsc.2016.04.007 .

Prodanović, Radiša, Korićanac, Goran, Vujanac, Ivan, Đorđević, Ana, Pantelić, Marija, Romić, Snježana, Stanimirović, Zoran, Kirovski, Danijela, "Obesity-driven prepartal hepatic lipid accumulation in dairy cows is associated with increased CD36 and SREBP-1 expression" in Research in Veterinary Science, 107 (2016):16-19,
https://doi.org/10.1016/j.rvsc.2016.04.007 . .

TY  - JOUR
AU  - Prodanović, Radiša
AU  - Korićanac, Goran
AU  - Vujanac, Ivan
AU  - Đorđević, Ana
AU  - Pantelić, Marija
AU  - Romić, Snježana
AU  - Stanimirović, Zoran
AU  - Kirovski, Danijela
PY  - 2016
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6085
AB  - We investigated the hypothesis that obesity in dairy cows enhanced expression of proteins involved in hepatic
fatty acid uptake and metabolism. Sixteen Holstein-Friesian close-up cows were divided into 2 equal groups
based on their body condition score (BCS) as optimal (3.25 ≤ BCS ≤ 3.5) and high (4.0 ≤ BCS ≤ 4.25). Intravenous
glucose tolerance test (GTT) and liver biopsieswere carried out at day 10 before calving. Blood samples were collected
before (basal) and after glucose infusion, and glucose, insulin and non-esterified fatty acid (NEFA) levels
were determined at each sample point. In addition, β-hydroxybutyrate and triglycerides levels were measured
in the basal samples. The liver biopsieswere analyzed for total lipid content and protein expression of insulin receptor
beta (IRβ), fatty acid translocase (FAT/CD36) and sterol regulatory element-binding protein-1 (SREBP-1).
Basal glucose and insulin were higher in high-BCS cows, which coincided with higher circulating triglycerides
and hepatic lipid content. Clearance rate and AUC for NEFA during GTT were higher in optimal-BCS cows. The development
of insulin resistance and fatty liver in obese cows was paralleled by increased hepatic expression of
the IRβ, CD36 and SREBP-1. These results suggest that increased expression of hepatic CD36 and SREBP-1 is relevant
in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.
PB  - Elsevier
T2  - Research in Veterinary Science
T1  - Obesity-driven prepartal hepatic lipid accumulation in dairy cows is associated with increased CD36 and SREBP-1 expression
VL  - 107
DO  - 10.1016/j.rvsc.2016.04.007
SP  - 16
EP  - 19
ER  - 

@article{
author = "Prodanović, Radiša and Korićanac, Goran and Vujanac, Ivan and Đorđević, Ana and Pantelić, Marija and Romić, Snježana and Stanimirović, Zoran and Kirovski, Danijela",
year = "2016",
abstract = "We investigated the hypothesis that obesity in dairy cows enhanced expression of proteins involved in hepatic
fatty acid uptake and metabolism. Sixteen Holstein-Friesian close-up cows were divided into 2 equal groups
based on their body condition score (BCS) as optimal (3.25 ≤ BCS ≤ 3.5) and high (4.0 ≤ BCS ≤ 4.25). Intravenous
glucose tolerance test (GTT) and liver biopsieswere carried out at day 10 before calving. Blood samples were collected
before (basal) and after glucose infusion, and glucose, insulin and non-esterified fatty acid (NEFA) levels
were determined at each sample point. In addition, β-hydroxybutyrate and triglycerides levels were measured
in the basal samples. The liver biopsieswere analyzed for total lipid content and protein expression of insulin receptor
beta (IRβ), fatty acid translocase (FAT/CD36) and sterol regulatory element-binding protein-1 (SREBP-1).
Basal glucose and insulin were higher in high-BCS cows, which coincided with higher circulating triglycerides
and hepatic lipid content. Clearance rate and AUC for NEFA during GTT were higher in optimal-BCS cows. The development
of insulin resistance and fatty liver in obese cows was paralleled by increased hepatic expression of
the IRβ, CD36 and SREBP-1. These results suggest that increased expression of hepatic CD36 and SREBP-1 is relevant
in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.",
publisher = "Elsevier",
journal = "Research in Veterinary Science",
title = "Obesity-driven prepartal hepatic lipid accumulation in dairy cows is associated with increased CD36 and SREBP-1 expression",
volume = "107",
doi = "10.1016/j.rvsc.2016.04.007",
pages = "16-19"
}

Prodanović, R., Korićanac, G., Vujanac, I., Đorđević, A., Pantelić, M., Romić, S., Stanimirović, Z.,& Kirovski, D.. (2016). Obesity-driven prepartal hepatic lipid accumulation in dairy cows is associated with increased CD36 and SREBP-1 expression. in Research in Veterinary Science
Elsevier., 107, 16-19.
https://doi.org/10.1016/j.rvsc.2016.04.007

Prodanović R, Korićanac G, Vujanac I, Đorđević A, Pantelić M, Romić S, Stanimirović Z, Kirovski D. Obesity-driven prepartal hepatic lipid accumulation in dairy cows is associated with increased CD36 and SREBP-1 expression. in Research in Veterinary Science. 2016;107:16-19.
doi:10.1016/j.rvsc.2016.04.007 .

Prodanović, Radiša, Korićanac, Goran, Vujanac, Ivan, Đorđević, Ana, Pantelić, Marija, Romić, Snježana, Stanimirović, Zoran, Kirovski, Danijela, "Obesity-driven prepartal hepatic lipid accumulation in dairy cows is associated with increased CD36 and SREBP-1 expression" in Research in Veterinary Science, 107 (2016):16-19,
https://doi.org/10.1016/j.rvsc.2016.04.007 . .

TY  - JOUR
AU  - Korićanac, G.
AU  - Đorđević, Ana
AU  - Žakula, Zorica
AU  - Vojnović-Milutinović, Danijela
AU  - Tepavčević, Snežana
AU  - Veličković, Nataša
AU  - Milosavljević, Tijana
AU  - Stojiljković, Mojca
AU  - Romić, Snježana
AU  - Matić, Gordana
PY  - 2013
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/335
AB  - We analyzed the effects of a fructose-rich diet (FRD) to test the assumption that the expression of metabolic syndrome phenotype is different in male and female rats. Two-way ANOVA revealed a significant effect of FRD on feeding behavior and carbohydrate/lipid metabolism. The increased caloric intake in FRD rats of both sexes was followed by a cluster of gender-specific changes typical for the metabolic syndrome. Female rats were characterized by decreased glycemia, increased triglycerides, enlarged visceral adipose tissue and increased absolute mass of liver, without changes in systolic blood pressure and insulin sensitivity. In contrast, male rats developed less disturbances in physical and biochemical characteristics, but blood pressure and insulin sensitivity were impaired by FRD. The results emphasize the detrimental effects of fructose consumption on cardiovascular risk and insulin action in males, whereas females are affected by other metabolic disturbances. These results support the idea of gender-dependent differences in the expression of the metabolic syndrome phenotype.
T2  - Archives of Biological Sciences
T1  - Gender modulates development of the metabolic syndrome phenotype in fructose-fed rats
IS  - 2
VL  - 65
SP  - 455
EP  - 464
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_335
ER  - 

@article{
author = "Korićanac, G. and Đorđević, Ana and Žakula, Zorica and Vojnović-Milutinović, Danijela and Tepavčević, Snežana and Veličković, Nataša and Milosavljević, Tijana and Stojiljković, Mojca and Romić, Snježana and Matić, Gordana",
year = "2013, 2013",
abstract = "We analyzed the effects of a fructose-rich diet (FRD) to test the assumption that the expression of metabolic syndrome phenotype is different in male and female rats. Two-way ANOVA revealed a significant effect of FRD on feeding behavior and carbohydrate/lipid metabolism. The increased caloric intake in FRD rats of both sexes was followed by a cluster of gender-specific changes typical for the metabolic syndrome. Female rats were characterized by decreased glycemia, increased triglycerides, enlarged visceral adipose tissue and increased absolute mass of liver, without changes in systolic blood pressure and insulin sensitivity. In contrast, male rats developed less disturbances in physical and biochemical characteristics, but blood pressure and insulin sensitivity were impaired by FRD. The results emphasize the detrimental effects of fructose consumption on cardiovascular risk and insulin action in males, whereas females are affected by other metabolic disturbances. These results support the idea of gender-dependent differences in the expression of the metabolic syndrome phenotype.",
journal = "Archives of Biological Sciences",
title = "Gender modulates development of the metabolic syndrome phenotype in fructose-fed rats",
number = "2",
volume = "65",
pages = "455-464",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_335"
}

Korićanac, G., Đorđević, A., Žakula, Z., Vojnović-Milutinović, D., Tepavčević, S., Veličković, N., Milosavljević, T., Stojiljković, M., Romić, S.,& Matić, G.. (2013). Gender modulates development of the metabolic syndrome phenotype in fructose-fed rats. in Archives of Biological Sciences, 65(2), 455-464.
https://hdl.handle.net/21.15107/rcub_ibiss_335

Korićanac G, Đorđević A, Žakula Z, Vojnović-Milutinović D, Tepavčević S, Veličković N, Milosavljević T, Stojiljković M, Romić S, Matić G. Gender modulates development of the metabolic syndrome phenotype in fructose-fed rats. in Archives of Biological Sciences. 2013;65(2):455-464.
https://hdl.handle.net/21.15107/rcub_ibiss_335 .

Korićanac, G., Đorđević, Ana, Žakula, Zorica, Vojnović-Milutinović, Danijela, Tepavčević, Snežana, Veličković, Nataša, Milosavljević, Tijana, Stojiljković, Mojca, Romić, Snježana, Matić, Gordana, "Gender modulates development of the metabolic syndrome phenotype in fructose-fed rats" in Archives of Biological Sciences, 65, no. 2 (2013):455-464,
https://hdl.handle.net/21.15107/rcub_ibiss_335 .