TY  - JOUR
AU  - De Palo, Alice
AU  - Drača, Dijana
AU  - Murrali, Maria Grazia
AU  - Zacchini, Stefano
AU  - Pampaloni, Guido
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Marchetti, Fabio
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4424
AB  - Piano-stool iridium complexes based on the pentamethylcyclopentadienyl ligand (Cp*)
have been intensively investigated as anticancer drug candidates and hold much promise in this
setting. A systematic study aimed at outlining the effect of Cp* mono-derivatization on the an tiproliferative activity is presented here. Thus, the dinuclear complexes [Ir(η
5
-C5Me4R)Cl(µ-Cl)]2
(R = Me, 1a; R = H, 1b; R = Pr, 1c; R = 4-C6H4F, 1d; R = 4-C6H4OH, 1e), their 2-phenylpyridyl
mononuclear derivatives [Ir(η
5
-C5Me4R)(kN,kCPhPy)Cl] (2a–d), and the dimethylsulfoxide complex
[Ir{η
5
-C5Me4
(4-C6H4OH)}Cl2
(κS-Me2S=O)] (3) were synthesized, structurally characterized, and
assessed for their cytotoxicity towards a panel of six human and rodent cancer cell lines (mouse
melanoma, B16; rat glioma, C6; breast adenocarcinoma, MCF-7; colorectal carcinoma, SW620 and
HCT116; ovarian carcinoma, A2780) and one primary, human fetal lung fibroblast cell line (MRC5).
Complexes 2b (R = H) and 2d (4-C6H4F) emerged as the most active ones and were selected for further
investigation. They did not affect the viability of primary mouse peritoneal cells, and their tumorici dal action arises from the combined influence on cellular proliferation, apoptosis and senescence. The
latter is triggered by mitochondrial failure and production of reactive oxygen and nitrogen species.
PB  - Basel: MDPI
T2  - International Journal of Molecular Sciences
T1  - A Comparative Analysis of the In Vitro Anticancer Activity of Iridium(III) {η 5 -C5Me4R} Complexes with Variable R Groups
IS  - 14
VL  - 22
DO  - 10.3390/ijms22147422
SP  - 7422
ER  - 

@article{
author = "De Palo, Alice and Drača, Dijana and Murrali, Maria Grazia and Zacchini, Stefano and Pampaloni, Guido and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Marchetti, Fabio",
year = "2021",
abstract = "Piano-stool iridium complexes based on the pentamethylcyclopentadienyl ligand (Cp*)
have been intensively investigated as anticancer drug candidates and hold much promise in this
setting. A systematic study aimed at outlining the effect of Cp* mono-derivatization on the an tiproliferative activity is presented here. Thus, the dinuclear complexes [Ir(η
5
-C5Me4R)Cl(µ-Cl)]2
(R = Me, 1a; R = H, 1b; R = Pr, 1c; R = 4-C6H4F, 1d; R = 4-C6H4OH, 1e), their 2-phenylpyridyl
mononuclear derivatives [Ir(η
5
-C5Me4R)(kN,kCPhPy)Cl] (2a–d), and the dimethylsulfoxide complex
[Ir{η
5
-C5Me4
(4-C6H4OH)}Cl2
(κS-Me2S=O)] (3) were synthesized, structurally characterized, and
assessed for their cytotoxicity towards a panel of six human and rodent cancer cell lines (mouse
melanoma, B16; rat glioma, C6; breast adenocarcinoma, MCF-7; colorectal carcinoma, SW620 and
HCT116; ovarian carcinoma, A2780) and one primary, human fetal lung fibroblast cell line (MRC5).
Complexes 2b (R = H) and 2d (4-C6H4F) emerged as the most active ones and were selected for further
investigation. They did not affect the viability of primary mouse peritoneal cells, and their tumorici dal action arises from the combined influence on cellular proliferation, apoptosis and senescence. The
latter is triggered by mitochondrial failure and production of reactive oxygen and nitrogen species.",
publisher = "Basel: MDPI",
journal = "International Journal of Molecular Sciences",
title = "A Comparative Analysis of the In Vitro Anticancer Activity of Iridium(III) {η 5 -C5Me4R} Complexes with Variable R Groups",
number = "14",
volume = "22",
doi = "10.3390/ijms22147422",
pages = "7422"
}

De Palo, A., Drača, D., Murrali, M. G., Zacchini, S., Pampaloni, G., Mijatović, S., Maksimović-Ivanić, D.,& Marchetti, F.. (2021). A Comparative Analysis of the In Vitro Anticancer Activity of Iridium(III) {η 5 -C5Me4R} Complexes with Variable R Groups. in International Journal of Molecular Sciences
Basel: MDPI., 22(14), 7422.
https://doi.org/10.3390/ijms22147422

De Palo A, Drača D, Murrali MG, Zacchini S, Pampaloni G, Mijatović S, Maksimović-Ivanić D, Marchetti F. A Comparative Analysis of the In Vitro Anticancer Activity of Iridium(III) {η 5 -C5Me4R} Complexes with Variable R Groups. in International Journal of Molecular Sciences. 2021;22(14):7422.
doi:10.3390/ijms22147422 .

De Palo, Alice, Drača, Dijana, Murrali, Maria Grazia, Zacchini, Stefano, Pampaloni, Guido, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Marchetti, Fabio, "A Comparative Analysis of the In Vitro Anticancer Activity of Iridium(III) {η 5 -C5Me4R} Complexes with Variable R Groups" in International Journal of Molecular Sciences, 22, no. 14 (2021):7422,
https://doi.org/10.3390/ijms22147422 . .