TY  - JOUR
AU  - Pešić, Milica
AU  - Podolski-Renić, Ana
AU  - Stojković Burić, Sonja
AU  - Matovic, Branko
AU  - Zmejkoski, Danica
AU  - Kojic, Vesna
AU  - Bogdanovic, Gordana
AU  - Pavicevic, Aleksandra
AU  - Mojovic, Milos
AU  - Savic, Aleksandar
AU  - Milenkovic, Ivana
AU  - Kalauzi, Aleksandar
AU  - Radotic, Ksenija
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1957
AB  - Data on medical applications of cerium oxide nanoparticles CeO2 (CONP)
   are promising, yet information regarding their action in cells is
   incomplete and there are conflicting reports about in vitro toxicity.
   Herein, we have studied cytotoxic effect of CONP in several cancer and
   normal cell lines and their potential to change intracellular redox
   status. The IC50 was achieved only in two of eight tested cell lines,
   melanoma 518A2 and colorectal adenocarcinoma HT-29. Self-propagating
   room temperature method was applied to produce CONP with an average
   crystalline size of 4 nm. The results confirmed presence of Ce3+ and O2-
   vacancies. The induction of cell death by CONP and the production of
   reactive oxygen species (ROS) were analyzed by flow-cytometry. Free
   radicals related antioxidant capacity of the cells was studied by the
   reduction of stable free radical TEMPONE using electron spin resonance
   spectroscopy. CONP showed low or moderate cytotoxicity in cancer cell
   lines: adenocarcinoma DLD1 and multi-drug resistant DLD1-TxR, non-small
   cell lung carcinoma NCI-H460 and multi-drug resistant NCI-H460/R, while
   normal cell lines (keratinocytes HaCaT, lung fetal fibroblasts MRC-5)
   were insensitive. The most sensitive were 518A2 melanoma and HT-29
   colorectal adenocarcinoma cell lines, with the IC50 values being between
   100 and 200 mu M. Decreased rate of TEMPONE reduction and increased
   production of certain ROS species (peroxynitrite and hydrogen peroxide
   anion) indicates that free radical metabolism, thus redox status was
   changed, and antioxidant capacity damaged in the CONP treated 518A2 and
   HT-29 cells. In conclusion, changes in intracellular redox status
   induced by CONP are partly attributed to the prooxidant activity of the
   nanoparticles. Further, ROS induced cell damages might eventually lead
   to the cell death. However, low inhibitory potential of CONP in the
   other human cell lines tested indicates that CONP may be safe for human
   usage in industry and medicine. (C) 2015 Elsevier Ireland Ltd. All
   rights reserved.
T2  - Chemico-Biological Interactions
T1  - Anti-cancer effects of cerium oxide nanoparticles and its intracellular
 redox activity
VL  - 232
DO  - 10.1016/j.cbi.2015.03.013
SP  - 85
EP  - 93
ER  - 

@article{
author = "Pešić, Milica and Podolski-Renić, Ana and Stojković Burić, Sonja and Matovic, Branko and Zmejkoski, Danica and Kojic, Vesna and Bogdanovic, Gordana and Pavicevic, Aleksandra and Mojovic, Milos and Savic, Aleksandar and Milenkovic, Ivana and Kalauzi, Aleksandar and Radotic, Ksenija",
year = "2015",
abstract = "Data on medical applications of cerium oxide nanoparticles CeO2 (CONP)
   are promising, yet information regarding their action in cells is
   incomplete and there are conflicting reports about in vitro toxicity.
   Herein, we have studied cytotoxic effect of CONP in several cancer and
   normal cell lines and their potential to change intracellular redox
   status. The IC50 was achieved only in two of eight tested cell lines,
   melanoma 518A2 and colorectal adenocarcinoma HT-29. Self-propagating
   room temperature method was applied to produce CONP with an average
   crystalline size of 4 nm. The results confirmed presence of Ce3+ and O2-
   vacancies. The induction of cell death by CONP and the production of
   reactive oxygen species (ROS) were analyzed by flow-cytometry. Free
   radicals related antioxidant capacity of the cells was studied by the
   reduction of stable free radical TEMPONE using electron spin resonance
   spectroscopy. CONP showed low or moderate cytotoxicity in cancer cell
   lines: adenocarcinoma DLD1 and multi-drug resistant DLD1-TxR, non-small
   cell lung carcinoma NCI-H460 and multi-drug resistant NCI-H460/R, while
   normal cell lines (keratinocytes HaCaT, lung fetal fibroblasts MRC-5)
   were insensitive. The most sensitive were 518A2 melanoma and HT-29
   colorectal adenocarcinoma cell lines, with the IC50 values being between
   100 and 200 mu M. Decreased rate of TEMPONE reduction and increased
   production of certain ROS species (peroxynitrite and hydrogen peroxide
   anion) indicates that free radical metabolism, thus redox status was
   changed, and antioxidant capacity damaged in the CONP treated 518A2 and
   HT-29 cells. In conclusion, changes in intracellular redox status
   induced by CONP are partly attributed to the prooxidant activity of the
   nanoparticles. Further, ROS induced cell damages might eventually lead
   to the cell death. However, low inhibitory potential of CONP in the
   other human cell lines tested indicates that CONP may be safe for human
   usage in industry and medicine. (C) 2015 Elsevier Ireland Ltd. All
   rights reserved.",
journal = "Chemico-Biological Interactions",
title = "Anti-cancer effects of cerium oxide nanoparticles and its intracellular
 redox activity",
volume = "232",
doi = "10.1016/j.cbi.2015.03.013",
pages = "85-93"
}

Pešić, M., Podolski-Renić, A., Stojković Burić, S., Matovic, B., Zmejkoski, D., Kojic, V., Bogdanovic, G., Pavicevic, A., Mojovic, M., Savic, A., Milenkovic, I., Kalauzi, A.,& Radotic, K.. (2015). Anti-cancer effects of cerium oxide nanoparticles and its intracellular
 redox activity. in Chemico-Biological Interactions, 232, 85-93.
https://doi.org/10.1016/j.cbi.2015.03.013

Pešić M, Podolski-Renić A, Stojković Burić S, Matovic B, Zmejkoski D, Kojic V, Bogdanovic G, Pavicevic A, Mojovic M, Savic A, Milenkovic I, Kalauzi A, Radotic K. Anti-cancer effects of cerium oxide nanoparticles and its intracellular
 redox activity. in Chemico-Biological Interactions. 2015;232:85-93.
doi:10.1016/j.cbi.2015.03.013 .

Pešić, Milica, Podolski-Renić, Ana, Stojković Burić, Sonja, Matovic, Branko, Zmejkoski, Danica, Kojic, Vesna, Bogdanovic, Gordana, Pavicevic, Aleksandra, Mojovic, Milos, Savic, Aleksandar, Milenkovic, Ivana, Kalauzi, Aleksandar, Radotic, Ksenija, "Anti-cancer effects of cerium oxide nanoparticles and its intracellular
 redox activity" in Chemico-Biological Interactions, 232 (2015):85-93,
https://doi.org/10.1016/j.cbi.2015.03.013 . .

TY  - JOUR
AU  - Milic, Sonja
AU  - Pristov, Jelena Bogdanovic
AU  - Mutavdzic, Dragosav
AU  - Savic, Aleksandar
AU  - Spasić, Mihajlo
AU  - Spasojevic, Ivan
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1971
AB  - Herein we compared antioxidative activities (AA) of 25 free L-amino
   acids (FAA) against Fenton system-mediated hydroxyl radical (HO center
   dot) production in aqueous solution, and examined the relation between
   AA and a set of physicochemical properties. The tank order according -to
   AA was: Tip > notleucine > Phe, Lett > Ile > His
   >3,4-dihydrOxyphenylalanine, Arg > Val > Lys, Tyr, Pro > hydtoxyproline
   > alpha-aminobutyric acid > Gln, Thr, Ser > Glu, Ala, Gly, Asn, Asp.
   Sulfur-containing FAA generated different secondary reactive products,
   which were discriminated by the means of electron paramagnetic resonance
   spin-trapping spectroscopy. AA showed a general positive correlation
   with hydrophobicity. However, when taken separately, uncharged FAA
   exhibited strong positive correlation of AA with hydrophobicity whereas
   charged FAA showed negative or no significant correlation depending on
   the scale applied. A general strong negative correlation was found
   between AA and polarity. Steric parameters and hydration numbers
   correlated positively with AA of rtoripolar side-chain FAA. In addition)
   a decrease of temperature which promotes hydrophobic hydration resulted
   in increased AA. This implies that HO-provoked oxidation of FAA is
   strongly affected by hydrophobic hydration. Our findings are important
   for the understanding of oxidation processes in natural and waste
   waters.
T2  - Environmental Science & Technology
T1  - The Relationship of Physicochemical Properties to the Antioxidative
 Activity of Free Amino Acids in Fenton System
IS  - 7
VL  - 49
DO  - 10.1021/es5053396
SP  - 4245
EP  - 4254
ER  - 

@article{
author = "Milic, Sonja and Pristov, Jelena Bogdanovic and Mutavdzic, Dragosav and Savic, Aleksandar and Spasić, Mihajlo and Spasojevic, Ivan",
year = "2015",
abstract = "Herein we compared antioxidative activities (AA) of 25 free L-amino
   acids (FAA) against Fenton system-mediated hydroxyl radical (HO center
   dot) production in aqueous solution, and examined the relation between
   AA and a set of physicochemical properties. The tank order according -to
   AA was: Tip > notleucine > Phe, Lett > Ile > His
   >3,4-dihydrOxyphenylalanine, Arg > Val > Lys, Tyr, Pro > hydtoxyproline
   > alpha-aminobutyric acid > Gln, Thr, Ser > Glu, Ala, Gly, Asn, Asp.
   Sulfur-containing FAA generated different secondary reactive products,
   which were discriminated by the means of electron paramagnetic resonance
   spin-trapping spectroscopy. AA showed a general positive correlation
   with hydrophobicity. However, when taken separately, uncharged FAA
   exhibited strong positive correlation of AA with hydrophobicity whereas
   charged FAA showed negative or no significant correlation depending on
   the scale applied. A general strong negative correlation was found
   between AA and polarity. Steric parameters and hydration numbers
   correlated positively with AA of rtoripolar side-chain FAA. In addition)
   a decrease of temperature which promotes hydrophobic hydration resulted
   in increased AA. This implies that HO-provoked oxidation of FAA is
   strongly affected by hydrophobic hydration. Our findings are important
   for the understanding of oxidation processes in natural and waste
   waters.",
journal = "Environmental Science & Technology",
title = "The Relationship of Physicochemical Properties to the Antioxidative
 Activity of Free Amino Acids in Fenton System",
number = "7",
volume = "49",
doi = "10.1021/es5053396",
pages = "4245-4254"
}

Milic, S., Pristov, J. B., Mutavdzic, D., Savic, A., Spasić, M.,& Spasojevic, I.. (2015). The Relationship of Physicochemical Properties to the Antioxidative
 Activity of Free Amino Acids in Fenton System. in Environmental Science & Technology, 49(7), 4245-4254.
https://doi.org/10.1021/es5053396

Milic S, Pristov JB, Mutavdzic D, Savic A, Spasić M, Spasojevic I. The Relationship of Physicochemical Properties to the Antioxidative
 Activity of Free Amino Acids in Fenton System. in Environmental Science & Technology. 2015;49(7):4245-4254.
doi:10.1021/es5053396 .

Milic, Sonja, Pristov, Jelena Bogdanovic, Mutavdzic, Dragosav, Savic, Aleksandar, Spasić, Mihajlo, Spasojevic, Ivan, "The Relationship of Physicochemical Properties to the Antioxidative
 Activity of Free Amino Acids in Fenton System" in Environmental Science & Technology, 49, no. 7 (2015):4245-4254,
https://doi.org/10.1021/es5053396 . .

TY  - JOUR
AU  - Bukvicki, Danka
AU  - Stojković, Dejan
AU  - Soković, Marina
AU  - Vannini, Lucia
AU  - Montanari, Chiara
AU  - Pejin, Boris
AU  - Savic, Aleksandar
AU  - Veljic, Milan
AU  - Grujic, Slavica
AU  - Mann, Petar D.
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2236
AB  - The dominant compounds in Satureja horvatii oil were p-cymene (33.14\%),
   thymol (26.11\%) and thymol methyl ether (15.08\%). The minimum
   inhibitory concentration (MIC) varied from 0.03 to 0.57 mg/mL for
   bacteria, and from 0.56 to 2.23 mg/mL for yeast strains, while minimum
   bactericidal/yeast-cidal concentration (MBC/MYC) varied from 0.07 to
   1.15 mg/mL and 1.11 to 5.57 mg/mL for bacteria and yeasts, respectively.
   The antiradical potential of the essential oil was evaluated using
   hydroxyl radical (center dot OH) generated in Fenton reaction. The meat
   preserving potential of essential oil from Satureja horvatii was
   investigated against L monocytogenes. Essential oil successfully
   inhibited development of L monocytogenes in pork meat. Sensorial
   evaluation on flavor and color of meat was performed. The color and
   flavor of meat treated with essential oil improved after 4 days of
   storage. S. horvatii essential oil can act as a potent inhibitor of food
   spoiling microorganisms, in meat products and also can be a useful
   source of natural antioxidants. (C) 2013 Elsevier Ltd. All rights
   reserved.
T2  - Meat Science
T1  - Satureja horvatii essential oil: In vitro antimicrobial and antiradical
 properties and in situ control of Listeria monocytogenes in pork meat
IS  - 3
VL  - 96
DO  - 10.1016/j.meatsci.2013.11.024
SP  - 1355
EP  - 1360
ER  - 

@article{
author = "Bukvicki, Danka and Stojković, Dejan and Soković, Marina and Vannini, Lucia and Montanari, Chiara and Pejin, Boris and Savic, Aleksandar and Veljic, Milan and Grujic, Slavica and Mann, Petar D.",
year = "2014",
abstract = "The dominant compounds in Satureja horvatii oil were p-cymene (33.14\%),
   thymol (26.11\%) and thymol methyl ether (15.08\%). The minimum
   inhibitory concentration (MIC) varied from 0.03 to 0.57 mg/mL for
   bacteria, and from 0.56 to 2.23 mg/mL for yeast strains, while minimum
   bactericidal/yeast-cidal concentration (MBC/MYC) varied from 0.07 to
   1.15 mg/mL and 1.11 to 5.57 mg/mL for bacteria and yeasts, respectively.
   The antiradical potential of the essential oil was evaluated using
   hydroxyl radical (center dot OH) generated in Fenton reaction. The meat
   preserving potential of essential oil from Satureja horvatii was
   investigated against L monocytogenes. Essential oil successfully
   inhibited development of L monocytogenes in pork meat. Sensorial
   evaluation on flavor and color of meat was performed. The color and
   flavor of meat treated with essential oil improved after 4 days of
   storage. S. horvatii essential oil can act as a potent inhibitor of food
   spoiling microorganisms, in meat products and also can be a useful
   source of natural antioxidants. (C) 2013 Elsevier Ltd. All rights
   reserved.",
journal = "Meat Science",
title = "Satureja horvatii essential oil: In vitro antimicrobial and antiradical
 properties and in situ control of Listeria monocytogenes in pork meat",
number = "3",
volume = "96",
doi = "10.1016/j.meatsci.2013.11.024",
pages = "1355-1360"
}

Bukvicki, D., Stojković, D., Soković, M., Vannini, L., Montanari, C., Pejin, B., Savic, A., Veljic, M., Grujic, S.,& Mann, P. D.. (2014). Satureja horvatii essential oil: In vitro antimicrobial and antiradical
 properties and in situ control of Listeria monocytogenes in pork meat. in Meat Science, 96(3), 1355-1360.
https://doi.org/10.1016/j.meatsci.2013.11.024

Bukvicki D, Stojković D, Soković M, Vannini L, Montanari C, Pejin B, Savic A, Veljic M, Grujic S, Mann PD. Satureja horvatii essential oil: In vitro antimicrobial and antiradical
 properties and in situ control of Listeria monocytogenes in pork meat. in Meat Science. 2014;96(3):1355-1360.
doi:10.1016/j.meatsci.2013.11.024 .

Bukvicki, Danka, Stojković, Dejan, Soković, Marina, Vannini, Lucia, Montanari, Chiara, Pejin, Boris, Savic, Aleksandar, Veljic, Milan, Grujic, Slavica, Mann, Petar D., "Satureja horvatii essential oil: In vitro antimicrobial and antiradical
 properties and in situ control of Listeria monocytogenes in pork meat" in Meat Science, 96, no. 3 (2014):1355-1360,
https://doi.org/10.1016/j.meatsci.2013.11.024 . .

TY  - JOUR
AU  - Mojić, Marija
AU  - Savic, Aleksandar
AU  - Arion, Vladimir B.
AU  - Bulatović, Mirna Z.
AU  - Poljarevic, Jelena M.
AU  - Miljković, Đorđe
AU  - Sabo, Tibor J.
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Grguric-Sipka, Sanja
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2310
AB  - Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and
   isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl)
   propanoic acid as ligands were prepared from p-cymene ruthenium
   dichloride dimer and corresponding ester. All compounds have been
   characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR
   spectroscopy. Single crystal X-ray structure diffraction analysis of C1
   shows the usual piano-stool geometry of complexes, with coordination of
   ester ligand via nitrogen donor atoms. Ligands exhibit moderate
   anticancer activity (IC50 > 50 mu M), while the complexes were
   significantly more cytotoxic towards various cancer cell lines,
   including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0
   mu M). We stress that cisplatin resistant HCT116 cell line was highly
   sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M
   versus IC50 > 120 mu M for cisplatin). In parallel, primary
   fibroblasts-MRC-5 were remarkably less affected by these compounds. (C)
   2013 Elsevier B. V. All rights reserved.
T2  - Journal of Organometallic Chemistry
T1  - Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes
VL  - 749
DO  - 10.1016/j.jorganchem.2013.08.041
SP  - 142
EP  - 149
ER  - 

@article{
author = "Mojić, Marija and Savic, Aleksandar and Arion, Vladimir B. and Bulatović, Mirna Z. and Poljarevic, Jelena M. and Miljković, Đorđe and Sabo, Tibor J. and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Grguric-Sipka, Sanja",
year = "2014",
abstract = "Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and
   isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl)
   propanoic acid as ligands were prepared from p-cymene ruthenium
   dichloride dimer and corresponding ester. All compounds have been
   characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR
   spectroscopy. Single crystal X-ray structure diffraction analysis of C1
   shows the usual piano-stool geometry of complexes, with coordination of
   ester ligand via nitrogen donor atoms. Ligands exhibit moderate
   anticancer activity (IC50 > 50 mu M), while the complexes were
   significantly more cytotoxic towards various cancer cell lines,
   including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0
   mu M). We stress that cisplatin resistant HCT116 cell line was highly
   sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M
   versus IC50 > 120 mu M for cisplatin). In parallel, primary
   fibroblasts-MRC-5 were remarkably less affected by these compounds. (C)
   2013 Elsevier B. V. All rights reserved.",
journal = "Journal of Organometallic Chemistry",
title = "Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes",
volume = "749",
doi = "10.1016/j.jorganchem.2013.08.041",
pages = "142-149"
}

Mojić, M., Savic, A., Arion, V. B., Bulatović, M. Z., Poljarevic, J. M., Miljković, Đ., Sabo, T. J., Mijatović, S., Maksimović-Ivanić, D.,& Grguric-Sipka, S.. (2014). Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes. in Journal of Organometallic Chemistry, 749, 142-149.
https://doi.org/10.1016/j.jorganchem.2013.08.041

Mojić M, Savic A, Arion VB, Bulatović MZ, Poljarevic JM, Miljković Đ, Sabo TJ, Mijatović S, Maksimović-Ivanić D, Grguric-Sipka S. Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes. in Journal of Organometallic Chemistry. 2014;749:142-149.
doi:10.1016/j.jorganchem.2013.08.041 .

Mojić, Marija, Savic, Aleksandar, Arion, Vladimir B., Bulatović, Mirna Z., Poljarevic, Jelena M., Miljković, Đorđe, Sabo, Tibor J., Mijatović, Sanja, Maksimović-Ivanić, Danijela, Grguric-Sipka, Sanja, "Synthesis, X-ray structure and strong in vitro cytotoxicity of novel
 organoruthenium complexes" in Journal of Organometallic Chemistry, 749 (2014):142-149,
https://doi.org/10.1016/j.jorganchem.2013.08.041 . .