TY  - JOUR
AU  - Vukčević, Marija
AU  - Šerović, Katarina
AU  - Despot, Mateja
AU  - Nikolić-Kokić, Aleksandra
AU  - Vujović, Aleksandra
AU  - Nikolić, Milan
AU  - Blagojević, Duško
AU  - Jovanović, Tanja
AU  - Despot, Dragana
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6495
AB  - Background: Several vaccines against COVID-19 have been developed and licensed to
enhance the immune response against SARS-CoV-2. Similarly, previous infection with SARS-CoV-
2 has been shown to provide significant protection against severe infection and hospitalization.
Methods: We investigated the effect of three doses of the Sinopharm vaccine and SARS-CoV-2
infection on the specific immune response in 103 volunteers, measuring neutralizing antibodies, anti-
S1 IgG, anti-RBD IgM, anti-N IgM, anti-N IgG antibodies, and INF γ. Results: Our results showed
that the presence of cardiovascular diseases increased the level of anti-N-IgG antibodies, while
endocrinological diseases decreased the level of neutralizing antibodies and anti-N IgG antibodies,
suggesting that these diseases alter the effect of vaccine-induced immunity. In addition, there was a
significant decrease in anti-S1 IgG levels at 6 months and in anti-N IgG levels 18 months post-infection,
while neutralizing antibodies and INF γ levels were constant at 3, 6, and 18 months post-infection.
Conclusions: Our results confirm the emergence of hybrid immunity, which is the strongest and
most durable compared to natural immunity or vaccine-induced immunity. Significant positive
correlations were found between humoral and cellular immunity markers: neutralizing antibodies,
anti-S1 IgG and anti-N IgG antibodies, and INF γ, indicating a unique coordinated response specific
to COVID-19.
PB  - Basel: MDPI
T2  - Pharmaceuticals
T1  - Humoral and Cellular Immune Response after Three Doses of Sinopharm [Vero Cell]-Inactivated COVID-19 Vaccine in Combination with SARS-CoV-2 Infection Leads to Hybrid Immunity
IS  - 1
VL  - 17
DO  - 10.3390/ph17010122
SP  - 122
ER  - 

@article{
author = "Vukčević, Marija and Šerović, Katarina and Despot, Mateja and Nikolić-Kokić, Aleksandra and Vujović, Aleksandra and Nikolić, Milan and Blagojević, Duško and Jovanović, Tanja and Despot, Dragana",
year = "2024",
abstract = "Background: Several vaccines against COVID-19 have been developed and licensed to
enhance the immune response against SARS-CoV-2. Similarly, previous infection with SARS-CoV-
2 has been shown to provide significant protection against severe infection and hospitalization.
Methods: We investigated the effect of three doses of the Sinopharm vaccine and SARS-CoV-2
infection on the specific immune response in 103 volunteers, measuring neutralizing antibodies, anti-
S1 IgG, anti-RBD IgM, anti-N IgM, anti-N IgG antibodies, and INF γ. Results: Our results showed
that the presence of cardiovascular diseases increased the level of anti-N-IgG antibodies, while
endocrinological diseases decreased the level of neutralizing antibodies and anti-N IgG antibodies,
suggesting that these diseases alter the effect of vaccine-induced immunity. In addition, there was a
significant decrease in anti-S1 IgG levels at 6 months and in anti-N IgG levels 18 months post-infection,
while neutralizing antibodies and INF γ levels were constant at 3, 6, and 18 months post-infection.
Conclusions: Our results confirm the emergence of hybrid immunity, which is the strongest and
most durable compared to natural immunity or vaccine-induced immunity. Significant positive
correlations were found between humoral and cellular immunity markers: neutralizing antibodies,
anti-S1 IgG and anti-N IgG antibodies, and INF γ, indicating a unique coordinated response specific
to COVID-19.",
publisher = "Basel: MDPI",
journal = "Pharmaceuticals",
title = "Humoral and Cellular Immune Response after Three Doses of Sinopharm [Vero Cell]-Inactivated COVID-19 Vaccine in Combination with SARS-CoV-2 Infection Leads to Hybrid Immunity",
number = "1",
volume = "17",
doi = "10.3390/ph17010122",
pages = "122"
}

Vukčević, M., Šerović, K., Despot, M., Nikolić-Kokić, A., Vujović, A., Nikolić, M., Blagojević, D., Jovanović, T.,& Despot, D.. (2024). Humoral and Cellular Immune Response after Three Doses of Sinopharm [Vero Cell]-Inactivated COVID-19 Vaccine in Combination with SARS-CoV-2 Infection Leads to Hybrid Immunity. in Pharmaceuticals
Basel: MDPI., 17(1), 122.
https://doi.org/10.3390/ph17010122

Vukčević M, Šerović K, Despot M, Nikolić-Kokić A, Vujović A, Nikolić M, Blagojević D, Jovanović T, Despot D. Humoral and Cellular Immune Response after Three Doses of Sinopharm [Vero Cell]-Inactivated COVID-19 Vaccine in Combination with SARS-CoV-2 Infection Leads to Hybrid Immunity. in Pharmaceuticals. 2024;17(1):122.
doi:10.3390/ph17010122 .

Vukčević, Marija, Šerović, Katarina, Despot, Mateja, Nikolić-Kokić, Aleksandra, Vujović, Aleksandra, Nikolić, Milan, Blagojević, Duško, Jovanović, Tanja, Despot, Dragana, "Humoral and Cellular Immune Response after Three Doses of Sinopharm [Vero Cell]-Inactivated COVID-19 Vaccine in Combination with SARS-CoV-2 Infection Leads to Hybrid Immunity" in Pharmaceuticals, 17, no. 1 (2024):122,
https://doi.org/10.3390/ph17010122 . .

TY  - JOUR
AU  - Canullo, Luigi
AU  - Pesce, Paolo
AU  - Botticelli, Daniele
AU  - Covani, Ugo
AU  - Janković, Saša
AU  - Jovanović, Tanja
AU  - Rakić, Mia
PY  - 2018
UR  - http://quintpub.com/journals/omi/abstract.php?iss2_id=1499&article_id=17993
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3002
AB  - PURPOSE To compare the qualitative and quantitative profile of Epstein-Barr virus (EBV) at external and internal implant surfaces between participants with peri-implantitis and healthy peri-implant tissues and to quantitatively assess the relation between EBV and periopathogens inside the microbiologic profile associated with peri-implantitis. MATERIALS AND METHODS Microbiologic specimens were retrieved from 84 patients wearing 190 implants to estimate the levels of EBV and 10 periopathogens in the peri-implant pocket and internal-implant connection using quantitative polymerase chain reaction. RESULTS The study sample consisted of 113 healthy and 77 peri-implantitis-affected implants. Statistical significance was not reached in EBV prevalence between peri-implantitis and healthy controls. EBV-positive participants demonstrated higher levels of Prevotella intermedia (Pi) and Campylobacter rectus (Cr) compared with EBV-negative participants. A positive correlation was demonstrated among EBV and Tannerella forsythia (Tf), Parvimonas micra (Pm), Fusobacterium nucleatum (Fn), and Cr levels in peri-implantitis-affected implants, while healthy controls demonstrated a positive correlation between EBV and Aggregatibacter actinomycetemcomitans (Aa), Pi, and Pm. CONCLUSION EBV cannot be considered as a microbiologic marker of peri-implantitis. However, EBV could be considered as a risk factor and a peri-implantitis enhancer based on its positive correlations with pathogens associated with peri-implantitis.
T2  - The International Journal of Oral and Maxillofacial Implants
T1  - What is the Impact of Epstein-Barr Virus in Peri-implant Infection?
IS  - 1
VL  - 33
DO  - 10.11607/jomi.5972
SP  - 58
EP  - 63
ER  - 

@article{
author = "Canullo, Luigi and Pesce, Paolo and Botticelli, Daniele and Covani, Ugo and Janković, Saša and Jovanović, Tanja and Rakić, Mia",
year = "2018",
abstract = "PURPOSE To compare the qualitative and quantitative profile of Epstein-Barr virus (EBV) at external and internal implant surfaces between participants with peri-implantitis and healthy peri-implant tissues and to quantitatively assess the relation between EBV and periopathogens inside the microbiologic profile associated with peri-implantitis. MATERIALS AND METHODS Microbiologic specimens were retrieved from 84 patients wearing 190 implants to estimate the levels of EBV and 10 periopathogens in the peri-implant pocket and internal-implant connection using quantitative polymerase chain reaction. RESULTS The study sample consisted of 113 healthy and 77 peri-implantitis-affected implants. Statistical significance was not reached in EBV prevalence between peri-implantitis and healthy controls. EBV-positive participants demonstrated higher levels of Prevotella intermedia (Pi) and Campylobacter rectus (Cr) compared with EBV-negative participants. A positive correlation was demonstrated among EBV and Tannerella forsythia (Tf), Parvimonas micra (Pm), Fusobacterium nucleatum (Fn), and Cr levels in peri-implantitis-affected implants, while healthy controls demonstrated a positive correlation between EBV and Aggregatibacter actinomycetemcomitans (Aa), Pi, and Pm. CONCLUSION EBV cannot be considered as a microbiologic marker of peri-implantitis. However, EBV could be considered as a risk factor and a peri-implantitis enhancer based on its positive correlations with pathogens associated with peri-implantitis.",
journal = "The International Journal of Oral and Maxillofacial Implants",
title = "What is the Impact of Epstein-Barr Virus in Peri-implant Infection?",
number = "1",
volume = "33",
doi = "10.11607/jomi.5972",
pages = "58-63"
}

Canullo, L., Pesce, P., Botticelli, D., Covani, U., Janković, S., Jovanović, T.,& Rakić, M.. (2018). What is the Impact of Epstein-Barr Virus in Peri-implant Infection?. in The International Journal of Oral and Maxillofacial Implants, 33(1), 58-63.
https://doi.org/10.11607/jomi.5972

Canullo L, Pesce P, Botticelli D, Covani U, Janković S, Jovanović T, Rakić M. What is the Impact of Epstein-Barr Virus in Peri-implant Infection?. in The International Journal of Oral and Maxillofacial Implants. 2018;33(1):58-63.
doi:10.11607/jomi.5972 .

Canullo, Luigi, Pesce, Paolo, Botticelli, Daniele, Covani, Ugo, Janković, Saša, Jovanović, Tanja, Rakić, Mia, "What is the Impact of Epstein-Barr Virus in Peri-implant Infection?" in The International Journal of Oral and Maxillofacial Implants, 33, no. 1 (2018):58-63,
https://doi.org/10.11607/jomi.5972 . .

TY  - CONF
AU  - Canadanović-Brunet, Jasna M
AU  - Bogdanović, Gordana M
AU  - Andrić, Nebojsa L
AU  - Stanić, Bojana Đ
AU  - Spasić, Mihajlo
AU  - Jovanović, Tanja P
AU  - Baltić, Vladimir V
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1370
C3  - Ejc Supplements
T1  - The effects of proanthocyanidins on cardiotoxic and antitumour activity of doxorubicin
IS  - 5
VL  - 8
EP  - 63
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1370
ER  - 

@conference{
author = "Canadanović-Brunet, Jasna M and Bogdanović, Gordana M and Andrić, Nebojsa L and Stanić, Bojana Đ and Spasić, Mihajlo and Jovanović, Tanja P and Baltić, Vladimir V",
year = "2010",
journal = "Ejc Supplements",
title = "The effects of proanthocyanidins on cardiotoxic and antitumour activity of doxorubicin",
number = "5",
volume = "8",
pages = "63",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1370"
}

Canadanović-Brunet, J. M., Bogdanović, G. M., Andrić, N. L., Stanić, B. Đ., Spasić, M., Jovanović, T. P.,& Baltić, V. V.. (2010). The effects of proanthocyanidins on cardiotoxic and antitumour activity of doxorubicin. in Ejc Supplements, 8(5).
https://hdl.handle.net/21.15107/rcub_ibiss_1370

Canadanović-Brunet JM, Bogdanović GM, Andrić NL, Stanić BĐ, Spasić M, Jovanović TP, Baltić VV. The effects of proanthocyanidins on cardiotoxic and antitumour activity of doxorubicin. in Ejc Supplements. 2010;8(5):null-63.
https://hdl.handle.net/21.15107/rcub_ibiss_1370 .

Canadanović-Brunet, Jasna M, Bogdanović, Gordana M, Andrić, Nebojsa L, Stanić, Bojana Đ, Spasić, Mihajlo, Jovanović, Tanja P, Baltić, Vladimir V, "The effects of proanthocyanidins on cardiotoxic and antitumour activity of doxorubicin" in Ejc Supplements, 8, no. 5 (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1370 .