TY  - JOUR
AU  - Todorovic, Ana
AU  - Pejic, Snezana
AU  - Stojiljkovic, Vesna
AU  - Gavrilovic, Ljubica
AU  - Popovic, Natasa
AU  - Pavlovic, Ivan
AU  - Saičić, Zorica
AU  - Pajovic, Snezana B.
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2332
AB  - Purpose Previously, we examined manganese superoxide dismutase (MnSOD),
   copper-zinc superoxide dismutase (CuZnSOD), and catalase (CAT)
   activities in rat brain irradiated with 2 or 3 Gy of gamma-rays. The
   results indicated that lower MnSOD activity and inducibility found in
   hippocampus might explain higher radiosensitivity of this brain region.
   Thus, in this study, we wanted to determine changes of MnSOD, CuZnSOD,
   and CAT activities after dose of 5 Gy and to find out if differences in
   MnSOD activity are caused by changes in its expression.
   Heads of 4-day-old female rats were irradiated with gamma-rays, using
   Co-60. Animals were sacrificed 1/24 h after exposure. Hippocampus and
   cortex tissues were prepared for enzyme activity measurements and
   Western blot analysis.
   One hour after exposure, gamma-rays significantly decreased MnSOD
   activity in both examined brain regions. Twenty-four hours later, MnSOD
   recovery showed dose and regional dependence. It was weaker at higher
   doses and in hippocampal region. MnSOD expression changed in the similar
   manner as MnSOD activity only at lower doses of gamma-rays. In both
   examined brain regions, gamma radiation significantly decreased CuZnSOD
   activity and did not change activity of CAT.
   Our results confirmed that MnSOD plays an important role in different
   regional radiosensitivity but also showed that depending on dose,
   radiation affects MnSOD level by utterly different mechanisms.
   Postradiation changes of CuZnSOD and CAT are not regionally specific and
   therefore, cannot account for the different radiosensitivity of the
   hippocampus and cortex.
T2  - Childs Nervous System
T1  - Antioxidative enzymes in irradiated rat brain-indicators of different
 regional radiosensitivity
IS  - 12
VL  - 31
DO  - 10.1007/s00381-015-2807-2
SP  - 2249
EP  - 2256
ER  - 

@article{
author = "Todorovic, Ana and Pejic, Snezana and Stojiljkovic, Vesna and Gavrilovic, Ljubica and Popovic, Natasa and Pavlovic, Ivan and Saičić, Zorica and Pajovic, Snezana B.",
year = "2015",
abstract = "Purpose Previously, we examined manganese superoxide dismutase (MnSOD),
   copper-zinc superoxide dismutase (CuZnSOD), and catalase (CAT)
   activities in rat brain irradiated with 2 or 3 Gy of gamma-rays. The
   results indicated that lower MnSOD activity and inducibility found in
   hippocampus might explain higher radiosensitivity of this brain region.
   Thus, in this study, we wanted to determine changes of MnSOD, CuZnSOD,
   and CAT activities after dose of 5 Gy and to find out if differences in
   MnSOD activity are caused by changes in its expression.
   Heads of 4-day-old female rats were irradiated with gamma-rays, using
   Co-60. Animals were sacrificed 1/24 h after exposure. Hippocampus and
   cortex tissues were prepared for enzyme activity measurements and
   Western blot analysis.
   One hour after exposure, gamma-rays significantly decreased MnSOD
   activity in both examined brain regions. Twenty-four hours later, MnSOD
   recovery showed dose and regional dependence. It was weaker at higher
   doses and in hippocampal region. MnSOD expression changed in the similar
   manner as MnSOD activity only at lower doses of gamma-rays. In both
   examined brain regions, gamma radiation significantly decreased CuZnSOD
   activity and did not change activity of CAT.
   Our results confirmed that MnSOD plays an important role in different
   regional radiosensitivity but also showed that depending on dose,
   radiation affects MnSOD level by utterly different mechanisms.
   Postradiation changes of CuZnSOD and CAT are not regionally specific and
   therefore, cannot account for the different radiosensitivity of the
   hippocampus and cortex.",
journal = "Childs Nervous System",
title = "Antioxidative enzymes in irradiated rat brain-indicators of different
 regional radiosensitivity",
number = "12",
volume = "31",
doi = "10.1007/s00381-015-2807-2",
pages = "2249-2256"
}

Todorovic, A., Pejic, S., Stojiljkovic, V., Gavrilovic, L., Popovic, N., Pavlovic, I., Saičić, Z.,& Pajovic, S. B.. (2015). Antioxidative enzymes in irradiated rat brain-indicators of different
 regional radiosensitivity. in Childs Nervous System, 31(12), 2249-2256.
https://doi.org/10.1007/s00381-015-2807-2

Todorovic A, Pejic S, Stojiljkovic V, Gavrilovic L, Popovic N, Pavlovic I, Saičić Z, Pajovic SB. Antioxidative enzymes in irradiated rat brain-indicators of different
 regional radiosensitivity. in Childs Nervous System. 2015;31(12):2249-2256.
doi:10.1007/s00381-015-2807-2 .

Todorovic, Ana, Pejic, Snezana, Stojiljkovic, Vesna, Gavrilovic, Ljubica, Popovic, Natasa, Pavlovic, Ivan, Saičić, Zorica, Pajovic, Snezana B., "Antioxidative enzymes in irradiated rat brain-indicators of different
 regional radiosensitivity" in Childs Nervous System, 31, no. 12 (2015):2249-2256,
https://doi.org/10.1007/s00381-015-2807-2 . .