TY  - JOUR
AU  - Krstić, Gordana
AU  - Stepanović, Ana
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Novaković, Miroslav
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
PY  - 2021
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4752
AB  - In the previous study fifteen jatrophane diterpenes were isolated from the Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The aim of this study was to determine whether and which jatro­phane diterpenes can be isolated from the root of the plant, and then to examine their inhibition power on P-glycoprotein of selected cancer cell lines (NCI-H460, DLD1, U87, NCI-H460/R, DLD1-TxR and U87-TxR). Two previously undes­cribed jatrophane diterpenes were isolated from the root of E. nicaeensis col­lected in Deliblato Sand (Serbia). The structures of the isolated compounds were determined using 1D and 2D NMR, as well as HRESIMS data. The results obtained by MTT assay showed different antitumor potential of these two jatrophanes. Compound 1 inhibited cell growth of non-small cell lung car­cinoma cell lines NCI-H460 and NCI-H460/R, as well as glioblastoma cell lines U87 and U87-TxR, while jatrophane 2 was almost completely inactive in the suppression of cancer cell growth in a given range of concentrations. The obtained results also showed that the isolated compounds have an inhibitory effect on P-glycoprotein, as well as that their inhibitory potential is similar.
PB  - Belgrade : Serbian Chemical Society
T2  - The Journal of the Serbian Chemical Society
T1  - Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis
IS  - 12
VL  - 86
DO  - 10.2298/JSC210806085K
SP  - 1219
EP  - 1228
ER  - 

@article{
author = "Krstić, Gordana and Stepanović, Ana and Jadranin, Milka and Pešić, Milica and Novaković, Miroslav and Aljančić, Ivana and Vajs, Vlatka",
year = "2021",
abstract = "In the previous study fifteen jatrophane diterpenes were isolated from the Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The aim of this study was to determine whether and which jatro­phane diterpenes can be isolated from the root of the plant, and then to examine their inhibition power on P-glycoprotein of selected cancer cell lines (NCI-H460, DLD1, U87, NCI-H460/R, DLD1-TxR and U87-TxR). Two previously undes­cribed jatrophane diterpenes were isolated from the root of E. nicaeensis col­lected in Deliblato Sand (Serbia). The structures of the isolated compounds were determined using 1D and 2D NMR, as well as HRESIMS data. The results obtained by MTT assay showed different antitumor potential of these two jatrophanes. Compound 1 inhibited cell growth of non-small cell lung car­cinoma cell lines NCI-H460 and NCI-H460/R, as well as glioblastoma cell lines U87 and U87-TxR, while jatrophane 2 was almost completely inactive in the suppression of cancer cell growth in a given range of concentrations. The obtained results also showed that the isolated compounds have an inhibitory effect on P-glycoprotein, as well as that their inhibitory potential is similar.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "The Journal of the Serbian Chemical Society",
title = "Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis",
number = "12",
volume = "86",
doi = "10.2298/JSC210806085K",
pages = "1219-1228"
}

Krstić, G., Stepanović, A., Jadranin, M., Pešić, M., Novaković, M., Aljančić, I.,& Vajs, V.. (2021). Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis. in The Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 86(12), 1219-1228.
https://doi.org/10.2298/JSC210806085K

Krstić G, Stepanović A, Jadranin M, Pešić M, Novaković M, Aljančić I, Vajs V. Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis. in The Journal of the Serbian Chemical Society. 2021;86(12):1219-1228.
doi:10.2298/JSC210806085K .

Krstić, Gordana, Stepanović, Ana, Jadranin, Milka, Pešić, Milica, Novaković, Miroslav, Aljančić, Ivana, Vajs, Vlatka, "Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis" in The Journal of the Serbian Chemical Society, 86, no. 12 (2021):1219-1228,
https://doi.org/10.2298/JSC210806085K . .

TY  - JOUR
AU  - Vesović, Nikola
AU  - Ćurčić, Srećko
AU  - Vujisić, Ljubodrag
AU  - Nenadić, Marija
AU  - Krstić, Gordana
AU  - Perić Mataruga, Vesna
AU  - Milosavljević, Slobodan
AU  - Antić, Dragan
AU  - Mandić, Boris
AU  - Petković, Matija
AU  - Vučković, Ivan
AU  - Marković, Đorđe
AU  - Vrbica, Maja
AU  - Ćurčić, Božidar
AU  - Makarov, Slobodan
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1947
AB  - Three adult cave-dwelling ground beetle species were induced to
   discharge secretions of their pygidial glands into vials.
   Dichloromethane extraction was used to obtain the secretions. In total,
   42 compounds were identified by GC/MS analysis. Pheggomisetes ninae
   contained 32 glandular compounds, Laemostenus (Pristonychus) punctatus
   13, whereas Duvalius (Paraduvalius) milutini had nine compounds.
   Caproic, oleic, palmitic, and stearic acids were present in the samples
   of all analyzed species. Undecane was predominant in the extract of L.
   punctatus. Palmitic acid was the major component in the secretion of D.
   milutini. Finally, the most abundant compounds in P. ninae secretion
   were heptacosene and nonacosadienes. Herein, we present the first data
   on the identification of pygidial gland secretion components in both
   troglophilous and troglobite cave-dwelling ground beetles. Some
   compounds are reported for the first time in the secretions of ground
   beetles and other higher or lower taxa. The adaptation to underground
   life has not led to a reduction or changes in the chemical defense
   mechanism in the analyzed troglophilous and troglobitic Platyninae and
   Trechinae taxa.
PB  - Springer New York LLC
T2  - Journal of Chemical Ecology
T1  - Molecular Diversity of Compounds from Pygidial Gland Secretions of
 Cave-Dwelling Ground Beetles: The First Evidence
IS  - 6
VL  - 41
DO  - 10.1007/s10886-015-0593-7
SP  - 533
EP  - 539
ER  - 

@article{
author = "Vesović, Nikola and Ćurčić, Srećko and Vujisić, Ljubodrag and Nenadić, Marija and Krstić, Gordana and Perić Mataruga, Vesna and Milosavljević, Slobodan and Antić, Dragan and Mandić, Boris and Petković, Matija and Vučković, Ivan and Marković, Đorđe and Vrbica, Maja and Ćurčić, Božidar and Makarov, Slobodan",
year = "2015",
abstract = "Three adult cave-dwelling ground beetle species were induced to
   discharge secretions of their pygidial glands into vials.
   Dichloromethane extraction was used to obtain the secretions. In total,
   42 compounds were identified by GC/MS analysis. Pheggomisetes ninae
   contained 32 glandular compounds, Laemostenus (Pristonychus) punctatus
   13, whereas Duvalius (Paraduvalius) milutini had nine compounds.
   Caproic, oleic, palmitic, and stearic acids were present in the samples
   of all analyzed species. Undecane was predominant in the extract of L.
   punctatus. Palmitic acid was the major component in the secretion of D.
   milutini. Finally, the most abundant compounds in P. ninae secretion
   were heptacosene and nonacosadienes. Herein, we present the first data
   on the identification of pygidial gland secretion components in both
   troglophilous and troglobite cave-dwelling ground beetles. Some
   compounds are reported for the first time in the secretions of ground
   beetles and other higher or lower taxa. The adaptation to underground
   life has not led to a reduction or changes in the chemical defense
   mechanism in the analyzed troglophilous and troglobitic Platyninae and
   Trechinae taxa.",
publisher = "Springer New York LLC",
journal = "Journal of Chemical Ecology",
title = "Molecular Diversity of Compounds from Pygidial Gland Secretions of
 Cave-Dwelling Ground Beetles: The First Evidence",
number = "6",
volume = "41",
doi = "10.1007/s10886-015-0593-7",
pages = "533-539"
}

Vesović, N., Ćurčić, S., Vujisić, L., Nenadić, M., Krstić, G., Perić Mataruga, V., Milosavljević, S., Antić, D., Mandić, B., Petković, M., Vučković, I., Marković, Đ., Vrbica, M., Ćurčić, B.,& Makarov, S.. (2015). Molecular Diversity of Compounds from Pygidial Gland Secretions of
 Cave-Dwelling Ground Beetles: The First Evidence. in Journal of Chemical Ecology
Springer New York LLC., 41(6), 533-539.
https://doi.org/10.1007/s10886-015-0593-7

Vesović N, Ćurčić S, Vujisić L, Nenadić M, Krstić G, Perić Mataruga V, Milosavljević S, Antić D, Mandić B, Petković M, Vučković I, Marković Đ, Vrbica M, Ćurčić B, Makarov S. Molecular Diversity of Compounds from Pygidial Gland Secretions of
 Cave-Dwelling Ground Beetles: The First Evidence. in Journal of Chemical Ecology. 2015;41(6):533-539.
doi:10.1007/s10886-015-0593-7 .

Vesović, Nikola, Ćurčić, Srećko, Vujisić, Ljubodrag, Nenadić, Marija, Krstić, Gordana, Perić Mataruga, Vesna, Milosavljević, Slobodan, Antić, Dragan, Mandić, Boris, Petković, Matija, Vučković, Ivan, Marković, Đorđe, Vrbica, Maja, Ćurčić, Božidar, Makarov, Slobodan, "Molecular Diversity of Compounds from Pygidial Gland Secretions of
 Cave-Dwelling Ground Beetles: The First Evidence" in Journal of Chemical Ecology, 41, no. 6 (2015):533-539,
https://doi.org/10.1007/s10886-015-0593-7 . .