TY  - JOUR
AU  - Markovic, Violeta
AU  - Debeljak, Nevena
AU  - Stanojkovic, Tatjana
AU  - Kolundzija, Branka
AU  - Sladic, Dusan
AU  - Vujcic, Miroslava
AU  - Janovic, Barbara
AU  - Tanić, Nikola
AU  - Perovic, Milka
AU  - Tesic, Vesna
AU  - Antic, Jadranka
AU  - Joksovic, Milan D.
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2021
AB  - Novel anthraquinone based chalcone compounds were synthesized starting
   from 1-acetylanthraquinone in a Claisen-Schmidt reaction and evaluated
   for their anticancer potential against three human cancer cell lines.
   Compounds 4a, 4b and 4j showed promising activity in inhibition of HeLa
   cells with IC50 values ranging from 2.36 to 2.73 mu M and low
   cytotoxicity against healthy MRC-5 cell lines. The effects that
   compounds produces on the cell cycle were investigated by flow
   cytometry. It was found that 4a, 4b and 4j cause the accumulation of
   cells in the S and G2/M phases in a dose-dependent manner and induce
   caspase-dependent apoptosis. All of three compounds exhibit calf thymus
   DNA-binding activity. The determined binding constants by absorption
   titrations (2.65 x 10(3) M-1, 1.36 x 10(3) M(-1)and 2.51 x 10(3) M-1 of
   4a/CT-DNA, 4b/CT-DNA and 4j/CT-DNA, respectively) together with
   fluorescence displacement analysis designate 4a, 4b and 4j as strong
   minor groove binders, but no cleavage of plasmid DNA was observed. (C)
   2014 Elsevier Masson SAS. All rights reserved.
T2  - European Journal of Medicinal Chemistry
T1  - Anthraquinone-chalcone hybrids: Synthesis, preliminary antiproliferative
 evaluation and DNA-interaction studies
VL  - 89
DO  - 10.1016/j.ejmech.2014.10.055
SP  - 401
EP  - 410
ER  - 

@article{
author = "Markovic, Violeta and Debeljak, Nevena and Stanojkovic, Tatjana and Kolundzija, Branka and Sladic, Dusan and Vujcic, Miroslava and Janovic, Barbara and Tanić, Nikola and Perovic, Milka and Tesic, Vesna and Antic, Jadranka and Joksovic, Milan D.",
year = "2015",
abstract = "Novel anthraquinone based chalcone compounds were synthesized starting
   from 1-acetylanthraquinone in a Claisen-Schmidt reaction and evaluated
   for their anticancer potential against three human cancer cell lines.
   Compounds 4a, 4b and 4j showed promising activity in inhibition of HeLa
   cells with IC50 values ranging from 2.36 to 2.73 mu M and low
   cytotoxicity against healthy MRC-5 cell lines. The effects that
   compounds produces on the cell cycle were investigated by flow
   cytometry. It was found that 4a, 4b and 4j cause the accumulation of
   cells in the S and G2/M phases in a dose-dependent manner and induce
   caspase-dependent apoptosis. All of three compounds exhibit calf thymus
   DNA-binding activity. The determined binding constants by absorption
   titrations (2.65 x 10(3) M-1, 1.36 x 10(3) M(-1)and 2.51 x 10(3) M-1 of
   4a/CT-DNA, 4b/CT-DNA and 4j/CT-DNA, respectively) together with
   fluorescence displacement analysis designate 4a, 4b and 4j as strong
   minor groove binders, but no cleavage of plasmid DNA was observed. (C)
   2014 Elsevier Masson SAS. All rights reserved.",
journal = "European Journal of Medicinal Chemistry",
title = "Anthraquinone-chalcone hybrids: Synthesis, preliminary antiproliferative
 evaluation and DNA-interaction studies",
volume = "89",
doi = "10.1016/j.ejmech.2014.10.055",
pages = "401-410"
}

Markovic, V., Debeljak, N., Stanojkovic, T., Kolundzija, B., Sladic, D., Vujcic, M., Janovic, B., Tanić, N., Perovic, M., Tesic, V., Antic, J.,& Joksovic, M. D.. (2015). Anthraquinone-chalcone hybrids: Synthesis, preliminary antiproliferative
 evaluation and DNA-interaction studies. in European Journal of Medicinal Chemistry, 89, 401-410.
https://doi.org/10.1016/j.ejmech.2014.10.055

Markovic V, Debeljak N, Stanojkovic T, Kolundzija B, Sladic D, Vujcic M, Janovic B, Tanić N, Perovic M, Tesic V, Antic J, Joksovic MD. Anthraquinone-chalcone hybrids: Synthesis, preliminary antiproliferative
 evaluation and DNA-interaction studies. in European Journal of Medicinal Chemistry. 2015;89:401-410.
doi:10.1016/j.ejmech.2014.10.055 .

Markovic, Violeta, Debeljak, Nevena, Stanojkovic, Tatjana, Kolundzija, Branka, Sladic, Dusan, Vujcic, Miroslava, Janovic, Barbara, Tanić, Nikola, Perovic, Milka, Tesic, Vesna, Antic, Jadranka, Joksovic, Milan D., "Anthraquinone-chalcone hybrids: Synthesis, preliminary antiproliferative
 evaluation and DNA-interaction studies" in European Journal of Medicinal Chemistry, 89 (2015):401-410,
https://doi.org/10.1016/j.ejmech.2014.10.055 . .

TY  - JOUR
AU  - Savic, Danka
AU  - Knezevic, Goran
AU  - Damjanovic, Svetozar
AU  - Antic, Jadranka
AU  - Matić, Gordana
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2140
AB  - Background: The hypothalamo-pituitary-adrenocortical (HPA) axis
   self-regulation is achieved via cortisol binding to mineralocorticoid
   (MR) and glucocorticoid receptors (GR). It is often disturbed in mental
   disorders, particularly in those where traumatic stress has been
   implicated, such as posttraumatic stress disorder and depression.
   Although dexamethasone suppression test (DST) is often used as
   diagnostic aid, the findings still vary. In search of the factors
   influencing the DST outcome, we examined the glucocorticoicl receptor
   (GR) gene Bell polymorphism.
   Methods: A total of 229 male subjects were classified into three Bell
   groups: two groups with homozygous carriers (of the G allele, N=108, and
   of the C allele, N=26), and one with heterozygous carriers (N=95).
   Multiple hierarchical linear regression analysis was clone, where the
   dependent variable was the clexamethasone-inclucecl cortisol
   suppression, and predictors included receptor variables. The
   interactions of the count of `G's with the predictors were introduced to
   single out the effects of the G allele.
   Results: The means of all studied variables, including suppression, are
   statistically the same in the three groups. However, the mechanism of
   suppression involves MRs only in the G allele carriers. Limitations: The
   subjects were selected by criteria suited for the aim of the large
   project whose part is this study, hence the relatively small number of
   CC carriers. Also, we did not assess MR functional properties that would
   probably sharpen the results.
   Conclusion: Our finding that MRs participate in cortisol suppression in
   the G allele carriers suggests that research aimed at refining HPA
   axis-based therapy might require its adjustment for such patients., (C)
   2014 Elsevier By. All rights reserved.
T2  - Journal of Affective Disorders
T1  - GR gene BclI polymorphysm changes the path, but not the level, of
 dexamethasone-induced cortisol suppression
VL  - 168
DO  - 10.1016/j.jad.2014.06.046
SP  - 1
EP  - 4
ER  - 

@article{
author = "Savic, Danka and Knezevic, Goran and Damjanovic, Svetozar and Antic, Jadranka and Matić, Gordana",
year = "2014",
abstract = "Background: The hypothalamo-pituitary-adrenocortical (HPA) axis
   self-regulation is achieved via cortisol binding to mineralocorticoid
   (MR) and glucocorticoid receptors (GR). It is often disturbed in mental
   disorders, particularly in those where traumatic stress has been
   implicated, such as posttraumatic stress disorder and depression.
   Although dexamethasone suppression test (DST) is often used as
   diagnostic aid, the findings still vary. In search of the factors
   influencing the DST outcome, we examined the glucocorticoicl receptor
   (GR) gene Bell polymorphism.
   Methods: A total of 229 male subjects were classified into three Bell
   groups: two groups with homozygous carriers (of the G allele, N=108, and
   of the C allele, N=26), and one with heterozygous carriers (N=95).
   Multiple hierarchical linear regression analysis was clone, where the
   dependent variable was the clexamethasone-inclucecl cortisol
   suppression, and predictors included receptor variables. The
   interactions of the count of `G's with the predictors were introduced to
   single out the effects of the G allele.
   Results: The means of all studied variables, including suppression, are
   statistically the same in the three groups. However, the mechanism of
   suppression involves MRs only in the G allele carriers. Limitations: The
   subjects were selected by criteria suited for the aim of the large
   project whose part is this study, hence the relatively small number of
   CC carriers. Also, we did not assess MR functional properties that would
   probably sharpen the results.
   Conclusion: Our finding that MRs participate in cortisol suppression in
   the G allele carriers suggests that research aimed at refining HPA
   axis-based therapy might require its adjustment for such patients., (C)
   2014 Elsevier By. All rights reserved.",
journal = "Journal of Affective Disorders",
title = "GR gene BclI polymorphysm changes the path, but not the level, of
 dexamethasone-induced cortisol suppression",
volume = "168",
doi = "10.1016/j.jad.2014.06.046",
pages = "1-4"
}

Savic, D., Knezevic, G., Damjanovic, S., Antic, J.,& Matić, G.. (2014). GR gene BclI polymorphysm changes the path, but not the level, of
 dexamethasone-induced cortisol suppression. in Journal of Affective Disorders, 168, 1-4.
https://doi.org/10.1016/j.jad.2014.06.046

Savic D, Knezevic G, Damjanovic S, Antic J, Matić G. GR gene BclI polymorphysm changes the path, but not the level, of
 dexamethasone-induced cortisol suppression. in Journal of Affective Disorders. 2014;168:1-4.
doi:10.1016/j.jad.2014.06.046 .

Savic, Danka, Knezevic, Goran, Damjanovic, Svetozar, Antic, Jadranka, Matić, Gordana, "GR gene BclI polymorphysm changes the path, but not the level, of
 dexamethasone-induced cortisol suppression" in Journal of Affective Disorders, 168 (2014):1-4,
https://doi.org/10.1016/j.jad.2014.06.046 . .