TY  - JOUR
AU  - Trifunović, Svetlana
AU  - Manojlović-Stojanoski, Milica
AU  - Ristić, Nataša
AU  - Šošić-Jurjević, Branka 
AU  - Rauš Balind, Snežana
AU  - Brajković, Gordana
AU  - Perčinić-Popovska, Florina
AU  - Milošević, Verica
PY  - 2016
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6105
AB  - Exposure to alcohol alters many physiological processes, including endocrine status. The present study examined whether prolonged alcohol (A) exposure could modulate selected stereological and hormonal aspects of pituitary somatotrophs (growth hormone-GH cells) and corticotrophs (adrenocorticotropic hormone-ACTH cells) in adult rats. Changes in pituitary gland volume; the volume density, total number and volume of GH and ACTH cells following alcohol exposure were evaluated using a stereological system (newCAST), while peripheral GH and ACTH levels were determined biochemically. Our results demonstrated the reduction (p < 0.05) of the volume density (37%) and volume of GH cells (29%) in the group A. Also, there was a tendency for the total number of GH cells to be smaller in the group A. Serum GH level was significantly decreased (p < 0.05; 70%) in the group A when compared to control values. Moreover, prolonged alcohol exposure induced declines (p < 0.05) in volume density (24%) and volume of ACTH cells (29%). The total number of ACTH cells and ACTH level were higher (p < 0.05; 42%) in the group A than in control rats. Collectively, these results indicate that prolonged alcohol exposure leads not only to changes in GH and ACTH hormone levels, but also to alterations of the morphological aspects of GH and ACTH cells within the pituitary.
PB  - Elsevier
T2  - Acta Histochemica
T1  - Effects of prolonged alcohol exposure on somatotrophs and corticotrophs in adult rats: Stereological and hormonal study
IS  - 4
VL  - 118
DO  - 10.1016/j.acthis.2016.03.005
SP  - 353
EP  - 360
ER  - 

@article{
author = "Trifunović, Svetlana and Manojlović-Stojanoski, Milica and Ristić, Nataša and Šošić-Jurjević, Branka  and Rauš Balind, Snežana and Brajković, Gordana and Perčinić-Popovska, Florina and Milošević, Verica",
year = "2016",
abstract = "Exposure to alcohol alters many physiological processes, including endocrine status. The present study examined whether prolonged alcohol (A) exposure could modulate selected stereological and hormonal aspects of pituitary somatotrophs (growth hormone-GH cells) and corticotrophs (adrenocorticotropic hormone-ACTH cells) in adult rats. Changes in pituitary gland volume; the volume density, total number and volume of GH and ACTH cells following alcohol exposure were evaluated using a stereological system (newCAST), while peripheral GH and ACTH levels were determined biochemically. Our results demonstrated the reduction (p < 0.05) of the volume density (37%) and volume of GH cells (29%) in the group A. Also, there was a tendency for the total number of GH cells to be smaller in the group A. Serum GH level was significantly decreased (p < 0.05; 70%) in the group A when compared to control values. Moreover, prolonged alcohol exposure induced declines (p < 0.05) in volume density (24%) and volume of ACTH cells (29%). The total number of ACTH cells and ACTH level were higher (p < 0.05; 42%) in the group A than in control rats. Collectively, these results indicate that prolonged alcohol exposure leads not only to changes in GH and ACTH hormone levels, but also to alterations of the morphological aspects of GH and ACTH cells within the pituitary.",
publisher = "Elsevier",
journal = "Acta Histochemica",
title = "Effects of prolonged alcohol exposure on somatotrophs and corticotrophs in adult rats: Stereological and hormonal study",
number = "4",
volume = "118",
doi = "10.1016/j.acthis.2016.03.005",
pages = "353-360"
}

Trifunović, S., Manojlović-Stojanoski, M., Ristić, N., Šošić-Jurjević, B., Rauš Balind, S., Brajković, G., Perčinić-Popovska, F.,& Milošević, V.. (2016). Effects of prolonged alcohol exposure on somatotrophs and corticotrophs in adult rats: Stereological and hormonal study. in Acta Histochemica
Elsevier., 118(4), 353-360.
https://doi.org/10.1016/j.acthis.2016.03.005

Trifunović S, Manojlović-Stojanoski M, Ristić N, Šošić-Jurjević B, Rauš Balind S, Brajković G, Perčinić-Popovska F, Milošević V. Effects of prolonged alcohol exposure on somatotrophs and corticotrophs in adult rats: Stereological and hormonal study. in Acta Histochemica. 2016;118(4):353-360.
doi:10.1016/j.acthis.2016.03.005 .

Trifunović, Svetlana, Manojlović-Stojanoski, Milica, Ristić, Nataša, Šošić-Jurjević, Branka , Rauš Balind, Snežana, Brajković, Gordana, Perčinić-Popovska, Florina, Milošević, Verica, "Effects of prolonged alcohol exposure on somatotrophs and corticotrophs in adult rats: Stereological and hormonal study" in Acta Histochemica, 118, no. 4 (2016):353-360,
https://doi.org/10.1016/j.acthis.2016.03.005 . .