TY  - CONF
AU  - Pualić, Stefan
AU  - Ćirić, Ana
AU  - Soković, Marina
AU  - Dimić, Dušan
AU  - Dimitrić Marković, Jasmina
AU  - Pejin, Boris
PY  - 2018
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4365
AB  - The aim of this work to screen for the first time anti-quorum sensing activity of dopamine (a food ingredient) and 
related compounds towards Pseudomonas aeruginosa PAO1, due to the possible discovery of a new lead compound 
for design of an effective antibiotic. The obtained experimental data suggest that derivatives of homovanillic acid and 
norepinephrine (compounds that also represent food ingredients) might be used as the platform of a new drug 
(antibiotic) for this multiresistant bacterium.
AB  - Cilј ovog rada bio je da se po prvi put ispita anti-kvorum aktivnost dopamina (sastojka hrane) i njemu srodnih jedinjenja u hemijskom smislu na bakterijski soj Pseudomonas aeruginosa PAO1, radi mogućeg otkrića nove vodeće strukture (eng. lead compound) u dizajnu efikasnog antibiotika. Na osnovu eksperimentalno dobijenih podataka može se zaklјučiti da bi, na prvom mestu, derivati homovanilinske kiseline i norepinefrina (koji, takođe, predstavlјaju sastojke hrane) mogli da inspirišu dizajn novog leka (antibiotika) za ovu multirezistentnu bakteriju.
PB  - Belgrade: University of Belgrade
C3  - UNIFood Conference; 2018 Oct 5-6; Belgrade, Serbia
T1  - Anti-quorum sensing activity of dopamine and related compounds
T1  - Anti-kvorum aktivnost dopamina i srodnih jedinjenja
SP  - 153
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4365
ER  - 

@conference{
author = "Pualić, Stefan and Ćirić, Ana and Soković, Marina and Dimić, Dušan and Dimitrić Marković, Jasmina and Pejin, Boris",
year = "2018",
abstract = "The aim of this work to screen for the first time anti-quorum sensing activity of dopamine (a food ingredient) and 
related compounds towards Pseudomonas aeruginosa PAO1, due to the possible discovery of a new lead compound 
for design of an effective antibiotic. The obtained experimental data suggest that derivatives of homovanillic acid and 
norepinephrine (compounds that also represent food ingredients) might be used as the platform of a new drug 
(antibiotic) for this multiresistant bacterium., Cilј ovog rada bio je da se po prvi put ispita anti-kvorum aktivnost dopamina (sastojka hrane) i njemu srodnih jedinjenja u hemijskom smislu na bakterijski soj Pseudomonas aeruginosa PAO1, radi mogućeg otkrića nove vodeće strukture (eng. lead compound) u dizajnu efikasnog antibiotika. Na osnovu eksperimentalno dobijenih podataka može se zaklјučiti da bi, na prvom mestu, derivati homovanilinske kiseline i norepinefrina (koji, takođe, predstavlјaju sastojke hrane) mogli da inspirišu dizajn novog leka (antibiotika) za ovu multirezistentnu bakteriju.",
publisher = "Belgrade: University of Belgrade",
journal = "UNIFood Conference; 2018 Oct 5-6; Belgrade, Serbia",
title = "Anti-quorum sensing activity of dopamine and related compounds, Anti-kvorum aktivnost dopamina i srodnih jedinjenja",
pages = "153",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4365"
}

Pualić, S., Ćirić, A., Soković, M., Dimić, D., Dimitrić Marković, J.,& Pejin, B.. (2018). Anti-quorum sensing activity of dopamine and related compounds. in UNIFood Conference; 2018 Oct 5-6; Belgrade, Serbia
Belgrade: University of Belgrade., 153.
https://hdl.handle.net/21.15107/rcub_ibiss_4365

Pualić S, Ćirić A, Soković M, Dimić D, Dimitrić Marković J, Pejin B. Anti-quorum sensing activity of dopamine and related compounds. in UNIFood Conference; 2018 Oct 5-6; Belgrade, Serbia. 2018;:153.
https://hdl.handle.net/21.15107/rcub_ibiss_4365 .

Pualić, Stefan, Ćirić, Ana, Soković, Marina, Dimić, Dušan, Dimitrić Marković, Jasmina, Pejin, Boris, "Anti-quorum sensing activity of dopamine and related compounds" in UNIFood Conference; 2018 Oct 5-6; Belgrade, Serbia (2018):153,
https://hdl.handle.net/21.15107/rcub_ibiss_4365 .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ćirić, Ana
AU  - Dimitrić Marković, Jasmina
AU  - Glamočlija, Jasmina
AU  - Nikolić, Miloš
AU  - Soković, Marina
PY  - 2017
UR  - https://www.tandfonline.com/doi/full/10.1080/14786419.2016.1222386
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27539815
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2623
AB  - Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25 μg/mL) being the most active (43%). In comparison, ampicillin (c 93.75 μg/mL) and streptomycin (c 21.25 μg/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225 μg/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins.
T2  - Natural product research
T1  - An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1.
IS  - 10
VL  - 31
DO  - 10.1080/14786419.2016.1222386
SP  - 1177
EP  - 1180
ER  - 

@article{
author = "Pejin, Boris and Ćirić, Ana and Dimitrić Marković, Jasmina and Glamočlija, Jasmina and Nikolić, Miloš and Soković, Marina",
year = "2017",
abstract = "Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25 μg/mL) being the most active (43%). In comparison, ampicillin (c 93.75 μg/mL) and streptomycin (c 21.25 μg/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225 μg/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins.",
journal = "Natural product research",
title = "An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1.",
number = "10",
volume = "31",
doi = "10.1080/14786419.2016.1222386",
pages = "1177-1180"
}

Pejin, B., Ćirić, A., Dimitrić Marković, J., Glamočlija, J., Nikolić, M.,& Soković, M.. (2017). An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1.. in Natural product research, 31(10), 1177-1180.
https://doi.org/10.1080/14786419.2016.1222386

Pejin B, Ćirić A, Dimitrić Marković J, Glamočlija J, Nikolić M, Soković M. An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1.. in Natural product research. 2017;31(10):1177-1180.
doi:10.1080/14786419.2016.1222386 .

Pejin, Boris, Ćirić, Ana, Dimitrić Marković, Jasmina, Glamočlija, Jasmina, Nikolić, Miloš, Soković, Marina, "An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1." in Natural product research, 31, no. 10 (2017):1177-1180,
https://doi.org/10.1080/14786419.2016.1222386 . .