Watson, Ronald Ross

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Cadmium and Fullerenes in Liver Diseases

Watson, Ronald Ross; Preedy, Victor R.; Đurašević, Siniša; Todorović, Zoran; Pavlović, Slađan; Pejić, Snežana

(Academic Press, 2019)

TY  - CHAP
AU  - Đurašević, Siniša
AU  - Todorović, Zoran
AU  - Pavlović, Slađan
AU  - Pejić, Snežana
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/B9780128144664000276?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3415
AB  - Oxidative stress (OS) represents an imbalance of free radicals production and antioxidant defense in which the extensive pro-oxidant production may cause damage to cell structures. OS is the major event occurring in pathogenesis of liver disorders, ranging from metabolic to proliferative disorders. Cadmium is a highly toxic and widespread toxicant. Cadmium itself is unable to generate free radicals directly, as cadmium does not undergo redox cycling. However, indirect generation of various radicals involving the superoxide radical, hydroxyl radical, and nitric oxide has been reported. One of the biologically most relevant features of C60 fullerene is the ability to quench various free radicals, behaving as a “free radical sponge.” Conversely, photosensitization of C60 yields highly reactive singlet oxygen or superoxide anion. Therefore, the dual property of fullerene to either quench or generate cell-damaging reactive oxygen species could be potentially exploited for their development as cytoprotective or cytotoxic agents.
PB  - Academic Press
T2  - Dietary Interventions in Liver Disease
T1  - Cadmium and Fullerenes in Liver Diseases
DO  - 10.1016/B978-0-12-814466-4.00027-6
SP  - 333
EP  - 344
ER  - 
@inbook{
editor = "Watson, Ronald Ross, Preedy, Victor R.",
author = "Đurašević, Siniša and Todorović, Zoran and Pavlović, Slađan and Pejić, Snežana",
year = "2019",
abstract = "Oxidative stress (OS) represents an imbalance of free radicals production and antioxidant defense in which the extensive pro-oxidant production may cause damage to cell structures. OS is the major event occurring in pathogenesis of liver disorders, ranging from metabolic to proliferative disorders. Cadmium is a highly toxic and widespread toxicant. Cadmium itself is unable to generate free radicals directly, as cadmium does not undergo redox cycling. However, indirect generation of various radicals involving the superoxide radical, hydroxyl radical, and nitric oxide has been reported. One of the biologically most relevant features of C60 fullerene is the ability to quench various free radicals, behaving as a “free radical sponge.” Conversely, photosensitization of C60 yields highly reactive singlet oxygen or superoxide anion. Therefore, the dual property of fullerene to either quench or generate cell-damaging reactive oxygen species could be potentially exploited for their development as cytoprotective or cytotoxic agents.",
publisher = "Academic Press",
journal = "Dietary Interventions in Liver Disease",
booktitle = "Cadmium and Fullerenes in Liver Diseases",
doi = "10.1016/B978-0-12-814466-4.00027-6",
pages = "333-344"
}
Watson, R. R., Preedy, V. R., Đurašević, S., Todorović, Z., Pavlović, S.,& Pejić, S.. (2019). Cadmium and Fullerenes in Liver Diseases. in Dietary Interventions in Liver Disease
Academic Press., 333-344.
https://doi.org/10.1016/B978-0-12-814466-4.00027-6
Watson RR, Preedy VR, Đurašević S, Todorović Z, Pavlović S, Pejić S. Cadmium and Fullerenes in Liver Diseases. in Dietary Interventions in Liver Disease. 2019;:333-344.
doi:10.1016/B978-0-12-814466-4.00027-6 .
Watson, Ronald Ross, Preedy, Victor R., Đurašević, Siniša, Todorović, Zoran, Pavlović, Slađan, Pejić, Snežana, "Cadmium and Fullerenes in Liver Diseases" in Dietary Interventions in Liver Disease (2019):333-344,
https://doi.org/10.1016/B978-0-12-814466-4.00027-6 . .
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