TY  - JOUR
AU  - Borković Mitić, Slavica
AU  - Stojsavljević, Aleksandar
AU  - Vujotić, Ljiljana
AU  - Matić, Siniša
AU  - Mitić, Bojan
AU  - Manojlović, Dragan
AU  - Pavlović, Slađan
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4344
AB  - There are only a few reports examining the impact of oxidative stress in patients with benign and
malignant brain tumors. In this study we investigated whether there are changes in antioxidant
system (AOS) parameters and key trace elements between control, benign and malignant brain
tissues. The study also aimed to examine correlations between the analyzed parameters. The study
enrolled both types of brain tumors, benign tumors (BT) and malignant tumors (MT). The results
were compared with control tissue (CT) without tumor infiltration collected from patients with BT.
The following antioxidant parameters were determined: activities of total, manganese‑containing,
and copper/zinc‑containing superoxide dismutase (TotSOD, MnSOD and CuZnSOD), activities of
catalase, glutathione peroxidase, glutathione S‑transferase, glutathione reductase and acetylcholine
esterase (AChE), the concentrations of glutathione and sulfhydryl groups and of manganese (Mn),
copper (Cu), zinc (Zn), and selenium (Se). BT and MT had altered activities/levels of multiple AOS
parameters as compared to CT, indicating that tumor cells had an altered cell metabolism and changes
in AOS represent adaptive response to increased oxidative stress. Low MnSOD and AChE and high
GST activities were significant for distinguishing between MT and CT. Malignant tissue was also
characterized by lower Mn and Cu concentrations relative to CT and BT. Principal Component Analysis
clearly discriminated BT from CT and MT (PC1, 66.97%), while PC2 clearly discriminated CT from BT
and MT (33.03%). Most correlative relationships were associated with Se in the BT group and Cu in the
MT group. The results of this study reveal differences between the AOS parameters and the essential
trace elements between the analyzed groups. The observed dysregulations show that oxidative stress
could have an important role in disrupting brain homeostasis and its presence in the pathogenesis of
benign and malignant brain tumors.
PB  - Springer Nature
T2  - Scientifc Reports
T1  - Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues
VL  - 11
DO  - 10.1038/s41598-021-94302-5
SP  - 14776
ER  - 

@article{
author = "Borković Mitić, Slavica and Stojsavljević, Aleksandar and Vujotić, Ljiljana and Matić, Siniša and Mitić, Bojan and Manojlović, Dragan and Pavlović, Slađan",
year = "2021",
abstract = "There are only a few reports examining the impact of oxidative stress in patients with benign and
malignant brain tumors. In this study we investigated whether there are changes in antioxidant
system (AOS) parameters and key trace elements between control, benign and malignant brain
tissues. The study also aimed to examine correlations between the analyzed parameters. The study
enrolled both types of brain tumors, benign tumors (BT) and malignant tumors (MT). The results
were compared with control tissue (CT) without tumor infiltration collected from patients with BT.
The following antioxidant parameters were determined: activities of total, manganese‑containing,
and copper/zinc‑containing superoxide dismutase (TotSOD, MnSOD and CuZnSOD), activities of
catalase, glutathione peroxidase, glutathione S‑transferase, glutathione reductase and acetylcholine
esterase (AChE), the concentrations of glutathione and sulfhydryl groups and of manganese (Mn),
copper (Cu), zinc (Zn), and selenium (Se). BT and MT had altered activities/levels of multiple AOS
parameters as compared to CT, indicating that tumor cells had an altered cell metabolism and changes
in AOS represent adaptive response to increased oxidative stress. Low MnSOD and AChE and high
GST activities were significant for distinguishing between MT and CT. Malignant tissue was also
characterized by lower Mn and Cu concentrations relative to CT and BT. Principal Component Analysis
clearly discriminated BT from CT and MT (PC1, 66.97%), while PC2 clearly discriminated CT from BT
and MT (33.03%). Most correlative relationships were associated with Se in the BT group and Cu in the
MT group. The results of this study reveal differences between the AOS parameters and the essential
trace elements between the analyzed groups. The observed dysregulations show that oxidative stress
could have an important role in disrupting brain homeostasis and its presence in the pathogenesis of
benign and malignant brain tumors.",
publisher = "Springer Nature",
journal = "Scientifc Reports",
title = "Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues",
volume = "11",
doi = "10.1038/s41598-021-94302-5",
pages = "14776"
}

Borković Mitić, S., Stojsavljević, A., Vujotić, L., Matić, S., Mitić, B., Manojlović, D.,& Pavlović, S.. (2021). Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues. in Scientifc Reports
Springer Nature., 11, 14776.
https://doi.org/10.1038/s41598-021-94302-5

Borković Mitić S, Stojsavljević A, Vujotić L, Matić S, Mitić B, Manojlović D, Pavlović S. Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues. in Scientifc Reports. 2021;11:14776.
doi:10.1038/s41598-021-94302-5 .

Borković Mitić, Slavica, Stojsavljević, Aleksandar, Vujotić, Ljiljana, Matić, Siniša, Mitić, Bojan, Manojlović, Dragan, Pavlović, Slađan, "Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues" in Scientifc Reports, 11 (2021):14776,
https://doi.org/10.1038/s41598-021-94302-5 . .