TY  - CHAP
AU  - Đurašević, Siniša
AU  - Todorović, Zoran
AU  - Pavlović, Slađan
AU  - Pejić, Snežana
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/B9780128144664000276?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3415
AB  - Oxidative stress (OS) represents an imbalance of free radicals production and antioxidant defense in which the extensive pro-oxidant production may cause damage to cell structures. OS is the major event occurring in pathogenesis of liver disorders, ranging from metabolic to proliferative disorders. Cadmium is a highly toxic and widespread toxicant. Cadmium itself is unable to generate free radicals directly, as cadmium does not undergo redox cycling. However, indirect generation of various radicals involving the superoxide radical, hydroxyl radical, and nitric oxide has been reported. One of the biologically most relevant features of C60 fullerene is the ability to quench various free radicals, behaving as a “free radical sponge.” Conversely, photosensitization of C60 yields highly reactive singlet oxygen or superoxide anion. Therefore, the dual property of fullerene to either quench or generate cell-damaging reactive oxygen species could be potentially exploited for their development as cytoprotective or cytotoxic agents.
PB  - Academic Press
T2  - Dietary Interventions in Liver Disease
T1  - Cadmium and Fullerenes in Liver Diseases
DO  - 10.1016/B978-0-12-814466-4.00027-6
SP  - 333
EP  - 344
ER  - 

@inbook{
editor = "Watson, Ronald Ross, Preedy, Victor R.",
author = "Đurašević, Siniša and Todorović, Zoran and Pavlović, Slađan and Pejić, Snežana",
year = "2019",
abstract = "Oxidative stress (OS) represents an imbalance of free radicals production and antioxidant defense in which the extensive pro-oxidant production may cause damage to cell structures. OS is the major event occurring in pathogenesis of liver disorders, ranging from metabolic to proliferative disorders. Cadmium is a highly toxic and widespread toxicant. Cadmium itself is unable to generate free radicals directly, as cadmium does not undergo redox cycling. However, indirect generation of various radicals involving the superoxide radical, hydroxyl radical, and nitric oxide has been reported. One of the biologically most relevant features of C60 fullerene is the ability to quench various free radicals, behaving as a “free radical sponge.” Conversely, photosensitization of C60 yields highly reactive singlet oxygen or superoxide anion. Therefore, the dual property of fullerene to either quench or generate cell-damaging reactive oxygen species could be potentially exploited for their development as cytoprotective or cytotoxic agents.",
publisher = "Academic Press",
journal = "Dietary Interventions in Liver Disease",
booktitle = "Cadmium and Fullerenes in Liver Diseases",
doi = "10.1016/B978-0-12-814466-4.00027-6",
pages = "333-344"
}

Watson, R. R., Preedy, V. R., Đurašević, S., Todorović, Z., Pavlović, S.,& Pejić, S.. (2019). Cadmium and Fullerenes in Liver Diseases. in Dietary Interventions in Liver Disease
Academic Press., 333-344.
https://doi.org/10.1016/B978-0-12-814466-4.00027-6

Watson RR, Preedy VR, Đurašević S, Todorović Z, Pavlović S, Pejić S. Cadmium and Fullerenes in Liver Diseases. in Dietary Interventions in Liver Disease. 2019;:333-344.
doi:10.1016/B978-0-12-814466-4.00027-6 .

Watson, Ronald Ross, Preedy, Victor R., Đurašević, Siniša, Todorović, Zoran, Pavlović, Slađan, Pejić, Snežana, "Cadmium and Fullerenes in Liver Diseases" in Dietary Interventions in Liver Disease (2019):333-344,
https://doi.org/10.1016/B978-0-12-814466-4.00027-6 . .

TY  - CHAP
AU  - Matić, Gordana
AU  - Vojnović-Milutinović, Danijela
AU  - Elaković, Ivana
AU  - Brkljačić, Jelena
AU  - Savić, Danka
PY  - 2016
UR  - http://link.springer.com/10.1007/978-3-319-08359-9_3
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2628
AB  - This chapter summarizes current research on glucocorticoid receptor (GR) functional alterations associated with trauma exposure, posttraumatic stress disorder (PTSD) psychopathology, and resilience and vulnerability to PTSD. Special attention is paid to hormone-binding activity of the receptor, the level of its expression, its ratio to mineralocorticoid receptor (MR), and the interactions of corticosteroid receptors with heat shock protein chaperones, Hsp90 and Hsp70. Determinations of GR number (Bmax) and assessments of lymphocyte sensitivity to glucocorticoids in trauma-exposed individuals with and without PTSD have yielded rather inconsistent results. The contribution of most other factors determining tissue responsiveness to glucocorticoid hormones to PTSD pathophysiology is currently under investigation. Thus, increased GR protein level in peripheral lymphocytes from current and lifetime PTSD patients in comparison to trauma-exposed non-PTSD individuals (trauma controls) appeared to be a possible correlate of vulnerability to PTSD. Besides, PTSD patients displayed the lowest and trauma controls the highest fractional occupancy of the GR, suggesting that the receptor redox status may be a factor contributing to vulnerability/resilience to PTSD. Estimates of the GR hormone-binding potency (Bmax/KD ratio) and of strength of correlation between Bmax and KD pointed to deterioration of glucocorticoid signaling in the lymphocytes as a characteristic of PTSD patients. Lymphocyte MR protein level, MR/GR ratio, and Hsp90 and Hsp70 levels were found to be unaffected by traumatic events and past or current PTSD symptoms. However, the association of GR and Hsp90 expression levels appeared as a candidate marker of trauma exposure, while that of MR and Hsp70 levels of vulnerability to PTSD.
PB  - Springer International Publishing
T2  - Comprehensive Guide to Post-Traumatic Stress Disorders
T1  - Level of Expression and Functional Properties of Lymphocyte Corticosteroid Receptors as Biological Correlates of PTSD, Trauma-Exposure, or Resilience to PTSD
DO  - 10.1007/978-3-319-08359-9_3
SP  - 961
EP  - 978
ER  - 

@inbook{
editor = "Martin, Colin R., Preedy, Victor R., Patel, Vinood B.",
author = "Matić, Gordana and Vojnović-Milutinović, Danijela and Elaković, Ivana and Brkljačić, Jelena and Savić, Danka",
year = "2016",
abstract = "This chapter summarizes current research on glucocorticoid receptor (GR) functional alterations associated with trauma exposure, posttraumatic stress disorder (PTSD) psychopathology, and resilience and vulnerability to PTSD. Special attention is paid to hormone-binding activity of the receptor, the level of its expression, its ratio to mineralocorticoid receptor (MR), and the interactions of corticosteroid receptors with heat shock protein chaperones, Hsp90 and Hsp70. Determinations of GR number (Bmax) and assessments of lymphocyte sensitivity to glucocorticoids in trauma-exposed individuals with and without PTSD have yielded rather inconsistent results. The contribution of most other factors determining tissue responsiveness to glucocorticoid hormones to PTSD pathophysiology is currently under investigation. Thus, increased GR protein level in peripheral lymphocytes from current and lifetime PTSD patients in comparison to trauma-exposed non-PTSD individuals (trauma controls) appeared to be a possible correlate of vulnerability to PTSD. Besides, PTSD patients displayed the lowest and trauma controls the highest fractional occupancy of the GR, suggesting that the receptor redox status may be a factor contributing to vulnerability/resilience to PTSD. Estimates of the GR hormone-binding potency (Bmax/KD ratio) and of strength of correlation between Bmax and KD pointed to deterioration of glucocorticoid signaling in the lymphocytes as a characteristic of PTSD patients. Lymphocyte MR protein level, MR/GR ratio, and Hsp90 and Hsp70 levels were found to be unaffected by traumatic events and past or current PTSD symptoms. However, the association of GR and Hsp90 expression levels appeared as a candidate marker of trauma exposure, while that of MR and Hsp70 levels of vulnerability to PTSD.",
publisher = "Springer International Publishing",
journal = "Comprehensive Guide to Post-Traumatic Stress Disorders",
booktitle = "Level of Expression and Functional Properties of Lymphocyte Corticosteroid Receptors as Biological Correlates of PTSD, Trauma-Exposure, or Resilience to PTSD",
doi = "10.1007/978-3-319-08359-9_3",
pages = "961-978"
}

Martin, C. R., Preedy, V. R., Patel, V. B., Matić, G., Vojnović-Milutinović, D., Elaković, I., Brkljačić, J.,& Savić, D.. (2016). Level of Expression and Functional Properties of Lymphocyte Corticosteroid Receptors as Biological Correlates of PTSD, Trauma-Exposure, or Resilience to PTSD. in Comprehensive Guide to Post-Traumatic Stress Disorders
Springer International Publishing., 961-978.
https://doi.org/10.1007/978-3-319-08359-9_3

Martin CR, Preedy VR, Patel VB, Matić G, Vojnović-Milutinović D, Elaković I, Brkljačić J, Savić D. Level of Expression and Functional Properties of Lymphocyte Corticosteroid Receptors as Biological Correlates of PTSD, Trauma-Exposure, or Resilience to PTSD. in Comprehensive Guide to Post-Traumatic Stress Disorders. 2016;:961-978.
doi:10.1007/978-3-319-08359-9_3 .

Martin, Colin R., Preedy, Victor R., Patel, Vinood B., Matić, Gordana, Vojnović-Milutinović, Danijela, Elaković, Ivana, Brkljačić, Jelena, Savić, Danka, "Level of Expression and Functional Properties of Lymphocyte Corticosteroid Receptors as Biological Correlates of PTSD, Trauma-Exposure, or Resilience to PTSD" in Comprehensive Guide to Post-Traumatic Stress Disorders (2016):961-978,
https://doi.org/10.1007/978-3-319-08359-9_3 . .