TY  - JOUR
AU  - Janković, Aleksandra
AU  - Ferreri, Carla
AU  - Filipović, Miloš
AU  - Ivanović-Burmazović, Ivana
AU  - Stančić, Ana
AU  - Otašević, Vesna
AU  - Korać, Aleksandra
AU  - Buzadžić, Biljana
AU  - Korać, Bato
PY  - 2016
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6211
AB  - Setting the correct ratio of superoxide anion (O2•-) and nitric oxide (•NO) radicals seems to be crucial in restoring disrupted redox signaling in diabetic skin and improvement of •NO physiological action for prevention and treatment of skin injuries in diabetes. In this study we examined the effects of L-arginine and manganese(II)-pentaazamacrocyclic superoxide dismutase (SOD) mimic - M40403 in diabetic rat skin. Following induction of diabetes by alloxan (blood glucose level ≥12 mMol l -1) non-diabetic and diabetic male Mill Hill hybrid hooded rats were divided into three subgroups: (i) control, and receiving: (ii) L-arginine, (iii) M40403. Treatment of diabetic animals started after diabetes induction and lasted for 7 days. Compared to control, lower cutaneous immuno-expression of endothelial NO synthase (eNOS), heme oxygenase 1 (HO1), manganese SOD (MnSOD) and glutathione peroxidase (GSH-Px), in parallel with increased NFE2-related factor 2 (Nrf2) and nitrotyrosine levels characterized diabetic skin. L-arginine and M40403 treatments normalized alloxan-induced increase in nitrotyrosine. This was accompanied by the improvement/restitution of eNOS and HO1 or MnSOD and GSH-Px protein expression levels in diabetic skin following L-arginine, i.e. SOD mimic treatments, respectively. The results indicate that L-arginine and M40403 stabilize redox balance in diabetic skin and suggest the underlying molecular mechanisms. Restitution of skin redox balance by L-arginine and M40403 may represent an effective strategy to ameliorate therapy of diabetic skin.
PB  - Taylor & Francis
T2  - Free Radical Research
T1  - Targeting the superoxide/nitric oxide ratio by L arginine and SOD mimic in rat diabetic skin
IS  - Sup1
VL  - 50
DO  - 10.1080/10715762.2016.1232483
SP  - S51
EP  - S63
ER  - 

@article{
author = "Janković, Aleksandra and Ferreri, Carla and Filipović, Miloš and Ivanović-Burmazović, Ivana and Stančić, Ana and Otašević, Vesna and Korać, Aleksandra and Buzadžić, Biljana and Korać, Bato",
year = "2016",
abstract = "Setting the correct ratio of superoxide anion (O2•-) and nitric oxide (•NO) radicals seems to be crucial in restoring disrupted redox signaling in diabetic skin and improvement of •NO physiological action for prevention and treatment of skin injuries in diabetes. In this study we examined the effects of L-arginine and manganese(II)-pentaazamacrocyclic superoxide dismutase (SOD) mimic - M40403 in diabetic rat skin. Following induction of diabetes by alloxan (blood glucose level ≥12 mMol l -1) non-diabetic and diabetic male Mill Hill hybrid hooded rats were divided into three subgroups: (i) control, and receiving: (ii) L-arginine, (iii) M40403. Treatment of diabetic animals started after diabetes induction and lasted for 7 days. Compared to control, lower cutaneous immuno-expression of endothelial NO synthase (eNOS), heme oxygenase 1 (HO1), manganese SOD (MnSOD) and glutathione peroxidase (GSH-Px), in parallel with increased NFE2-related factor 2 (Nrf2) and nitrotyrosine levels characterized diabetic skin. L-arginine and M40403 treatments normalized alloxan-induced increase in nitrotyrosine. This was accompanied by the improvement/restitution of eNOS and HO1 or MnSOD and GSH-Px protein expression levels in diabetic skin following L-arginine, i.e. SOD mimic treatments, respectively. The results indicate that L-arginine and M40403 stabilize redox balance in diabetic skin and suggest the underlying molecular mechanisms. Restitution of skin redox balance by L-arginine and M40403 may represent an effective strategy to ameliorate therapy of diabetic skin.",
publisher = "Taylor & Francis",
journal = "Free Radical Research",
title = "Targeting the superoxide/nitric oxide ratio by L arginine and SOD mimic in rat diabetic skin",
number = "Sup1",
volume = "50",
doi = "10.1080/10715762.2016.1232483",
pages = "S51-S63"
}

Janković, A., Ferreri, C., Filipović, M., Ivanović-Burmazović, I., Stančić, A., Otašević, V., Korać, A., Buzadžić, B.,& Korać, B.. (2016). Targeting the superoxide/nitric oxide ratio by L arginine and SOD mimic in rat diabetic skin. in Free Radical Research
Taylor & Francis., 50(Sup1), S51-S63.
https://doi.org/10.1080/10715762.2016.1232483

Janković A, Ferreri C, Filipović M, Ivanović-Burmazović I, Stančić A, Otašević V, Korać A, Buzadžić B, Korać B. Targeting the superoxide/nitric oxide ratio by L arginine and SOD mimic in rat diabetic skin. in Free Radical Research. 2016;50(Sup1):S51-S63.
doi:10.1080/10715762.2016.1232483 .

Janković, Aleksandra, Ferreri, Carla, Filipović, Miloš, Ivanović-Burmazović, Ivana, Stančić, Ana, Otašević, Vesna, Korać, Aleksandra, Buzadžić, Biljana, Korać, Bato, "Targeting the superoxide/nitric oxide ratio by L arginine and SOD mimic in rat diabetic skin" in Free Radical Research, 50, no. Sup1 (2016):S51-S63,
https://doi.org/10.1080/10715762.2016.1232483 . .