TY  - JOUR
AU  - Radović, Miloš
AU  - Šiler, Branislav
AU  - Nestorović Živković, Jasmina
AU  - Banjanac, Tijana
AU  - Živković, Suzana
AU  - Nikolić, Miloš
AU  - Soković, Marina
AU  - Mišić, Danijela
PY  - 2013
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5446
AB  - With regard to world’s increasing demand for biologically active compounds, a novel source of xanthones and secoiridoid glycosides has been studied. Zeltnera beyrichii (Torr. & A. Gray) Mans., an
insufficiently acknowledged North American medicinal plant species, may be considered a pharmacological substitute for commercial C. erythraea Rafn, since it accumulates in aerial parts nearly the same amount of secoiridoid glycosides: swertiamarin, gentiopicrin, and sweroside (13.76, 7.56, and 0.17 mmol per 100 g dry weight, respectively) in plants grown under greenhouse condition, and a considerable amount of xanthones: decussatin and eustomin. Additionally, Z. beyrichii produced as much biomass during cultivation in RITA® temporary immersion bioreactors as greenhouse-grown plants, in a third of the time. Plants grown in bioreactors contained moderate levels of total phenolics and total flavonoids, and possessed modest antioxidant activity and antimicrobial potential against eight bacterial and eight fungal species. Therefore, this species may be highly recommended for cultivation either in natural environment, or in bioreactors under in vitro conditions, for producing compounds of interest of modern pharmacology and food industry.
PB  - ACG Publications
T2  - Records of Natural Products
T1  - Bioreactor cultivation of Zeltnera beyrichii (Torr. & A. Gray) Mans.: A novel source of biologically active compounds
IS  - 4
VL  - 7
SP  - 266
EP  - 280
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5446
ER  - 

@article{
author = "Radović, Miloš and Šiler, Branislav and Nestorović Živković, Jasmina and Banjanac, Tijana and Živković, Suzana and Nikolić, Miloš and Soković, Marina and Mišić, Danijela",
year = "2013",
abstract = "With regard to world’s increasing demand for biologically active compounds, a novel source of xanthones and secoiridoid glycosides has been studied. Zeltnera beyrichii (Torr. & A. Gray) Mans., an
insufficiently acknowledged North American medicinal plant species, may be considered a pharmacological substitute for commercial C. erythraea Rafn, since it accumulates in aerial parts nearly the same amount of secoiridoid glycosides: swertiamarin, gentiopicrin, and sweroside (13.76, 7.56, and 0.17 mmol per 100 g dry weight, respectively) in plants grown under greenhouse condition, and a considerable amount of xanthones: decussatin and eustomin. Additionally, Z. beyrichii produced as much biomass during cultivation in RITA® temporary immersion bioreactors as greenhouse-grown plants, in a third of the time. Plants grown in bioreactors contained moderate levels of total phenolics and total flavonoids, and possessed modest antioxidant activity and antimicrobial potential against eight bacterial and eight fungal species. Therefore, this species may be highly recommended for cultivation either in natural environment, or in bioreactors under in vitro conditions, for producing compounds of interest of modern pharmacology and food industry.",
publisher = "ACG Publications",
journal = "Records of Natural Products",
title = "Bioreactor cultivation of Zeltnera beyrichii (Torr. & A. Gray) Mans.: A novel source of biologically active compounds",
number = "4",
volume = "7",
pages = "266-280",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5446"
}

Radović, M., Šiler, B., Nestorović Živković, J., Banjanac, T., Živković, S., Nikolić, M., Soković, M.,& Mišić, D.. (2013). Bioreactor cultivation of Zeltnera beyrichii (Torr. & A. Gray) Mans.: A novel source of biologically active compounds. in Records of Natural Products
ACG Publications., 7(4), 266-280.
https://hdl.handle.net/21.15107/rcub_ibiss_5446

Radović M, Šiler B, Nestorović Živković J, Banjanac T, Živković S, Nikolić M, Soković M, Mišić D. Bioreactor cultivation of Zeltnera beyrichii (Torr. & A. Gray) Mans.: A novel source of biologically active compounds. in Records of Natural Products. 2013;7(4):266-280.
https://hdl.handle.net/21.15107/rcub_ibiss_5446 .

Radović, Miloš, Šiler, Branislav, Nestorović Živković, Jasmina, Banjanac, Tijana, Živković, Suzana, Nikolić, Miloš, Soković, Marina, Mišić, Danijela, "Bioreactor cultivation of Zeltnera beyrichii (Torr. & A. Gray) Mans.: A novel source of biologically active compounds" in Records of Natural Products, 7, no. 4 (2013):266-280,
https://hdl.handle.net/21.15107/rcub_ibiss_5446 .