TY  - CONF
AU  - Srbovan, Maja
AU  - Prpa, Ksenija
AU  - Tešić, Vesna
AU  - Milanović, Desanka
AU  - Perović, Milka
AU  - Kanazir, Selma
PY  - 2019
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5908
AB  - Aim: Food restriction has been widely associated with beneficial effects on brain aging and age-related neurodegenerative diseases such as Alzheimer’s disease (AD). In the present study, the effects of every-other-day (EOD) feeding regimen were studied in the hippocampus of 5XFAD mice, a well characterized animal model of AD. Parvalbumin (PV) inhibitory interneurons that are crucial for maintaining proper excitatory/inhibitory balance were examined.
Methods: Female 5xFAD mice (Tg) and their non-transgenic littermates (non-Tg) were exposed to ad libitum (AL) or intermittent, EOD feeding regimen, beginning at 2 months of age. Neurons expressing PV were detected by immunohistochemistry, in the dorsal hippocampus of 6-month-old animals. The number of parvalbumin-expressing neurons was determined independently in CA1, CA3, and DG hippocampal subregions.
Results: Immunohistochemical analysis revealed a substantial increase in the number of parvalbumin inhibitory neurons in the dorsal hippocampus of Tg-AL mice in comparison to non-Tg animals. In Tg-EOD mice, however, alterations in the number of PV-expressing neurons were subregion-specific comparing to Tg-AL mice of the same age.
Conlusions: The results of our study clearly indicate that PV-expressing interneurons are of importance in further understanding of neural basis of AD-like-associated cognitive impairments and EOD-induced effects in 5xFAD mouse model of AD.
PB  - Belgrade: Serbian Neuroscience Society
C3  - Book of Abstract: Federation of European Neuroscience Societies (FENS) Regional Meeting; 2019 Jul 10-13; Belgrade, Serbia
T1  - The effect of intermittent feeding on the number of parvalbumin-expressing neurons in the hippocampus of 5XFAD mice
IS  - 299
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5908
ER  - 

@conference{
author = "Srbovan, Maja and Prpa, Ksenija and Tešić, Vesna and Milanović, Desanka and Perović, Milka and Kanazir, Selma",
year = "2019",
abstract = "Aim: Food restriction has been widely associated with beneficial effects on brain aging and age-related neurodegenerative diseases such as Alzheimer’s disease (AD). In the present study, the effects of every-other-day (EOD) feeding regimen were studied in the hippocampus of 5XFAD mice, a well characterized animal model of AD. Parvalbumin (PV) inhibitory interneurons that are crucial for maintaining proper excitatory/inhibitory balance were examined.
Methods: Female 5xFAD mice (Tg) and their non-transgenic littermates (non-Tg) were exposed to ad libitum (AL) or intermittent, EOD feeding regimen, beginning at 2 months of age. Neurons expressing PV were detected by immunohistochemistry, in the dorsal hippocampus of 6-month-old animals. The number of parvalbumin-expressing neurons was determined independently in CA1, CA3, and DG hippocampal subregions.
Results: Immunohistochemical analysis revealed a substantial increase in the number of parvalbumin inhibitory neurons in the dorsal hippocampus of Tg-AL mice in comparison to non-Tg animals. In Tg-EOD mice, however, alterations in the number of PV-expressing neurons were subregion-specific comparing to Tg-AL mice of the same age.
Conlusions: The results of our study clearly indicate that PV-expressing interneurons are of importance in further understanding of neural basis of AD-like-associated cognitive impairments and EOD-induced effects in 5xFAD mouse model of AD.",
publisher = "Belgrade: Serbian Neuroscience Society",
journal = "Book of Abstract: Federation of European Neuroscience Societies (FENS) Regional Meeting; 2019 Jul 10-13; Belgrade, Serbia",
title = "The effect of intermittent feeding on the number of parvalbumin-expressing neurons in the hippocampus of 5XFAD mice",
number = "299",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5908"
}

Srbovan, M., Prpa, K., Tešić, V., Milanović, D., Perović, M.,& Kanazir, S.. (2019). The effect of intermittent feeding on the number of parvalbumin-expressing neurons in the hippocampus of 5XFAD mice. in Book of Abstract: Federation of European Neuroscience Societies (FENS) Regional Meeting; 2019 Jul 10-13; Belgrade, Serbia
Belgrade: Serbian Neuroscience Society.(299).
https://hdl.handle.net/21.15107/rcub_ibiss_5908

Srbovan M, Prpa K, Tešić V, Milanović D, Perović M, Kanazir S. The effect of intermittent feeding on the number of parvalbumin-expressing neurons in the hippocampus of 5XFAD mice. in Book of Abstract: Federation of European Neuroscience Societies (FENS) Regional Meeting; 2019 Jul 10-13; Belgrade, Serbia. 2019;(299).
https://hdl.handle.net/21.15107/rcub_ibiss_5908 .

Srbovan, Maja, Prpa, Ksenija, Tešić, Vesna, Milanović, Desanka, Perović, Milka, Kanazir, Selma, "The effect of intermittent feeding on the number of parvalbumin-expressing neurons in the hippocampus of 5XFAD mice" in Book of Abstract: Federation of European Neuroscience Societies (FENS) Regional Meeting; 2019 Jul 10-13; Belgrade, Serbia, no. 299 (2019),
https://hdl.handle.net/21.15107/rcub_ibiss_5908 .